X-linked Kx blood group (McLeod syndrome) (XK) - coding DNA reference sequence

(used for variant description)

(last modified December 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_021083.2 in the XK gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007473.1, covering XK transcript NM_021083.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       ctcgggcaacggccgccgccgc       c.-61

 .         .         .         .         .         .                g.5082
 cacagccacacagccgccgccactgcgtccgtccccggtgagcgccgctgacgcgcggag       c.-1

          .         .         .         .         .         .       g.5142
 ATGAAATTCCCGGCCTCGGTGCTGGCGTCCGTGTTCCTGTTCGTGGCCGAGACAACGGCG       c.60
 M  K  F  P  A  S  V  L  A  S  V  F  L  F  V  A  E  T  T  A         p.20

          .         .         .         .         .         .       g.5202
 GCGCTCAGCCTGAGCAGCACCTACCGCTCGGGCGGGGACCGCATGTGGCAGGCGCTGACG       c.120
 A  L  S  L  S  S  T  Y  R  S  G  G  D  R  M  W  Q  A  L  T         p.40

          .         .         .         .         .         .       g.5262
 TTGCTTTTCTCGCTACTGCCTTGCGCGCTCGTGCAGCTCACGCTTCTCTTCGTACACCGC       c.180
 L  L  F  S  L  L  P  C  A  L  V  Q  L  T  L  L  F  V  H  R         p.60

          .         .         .         .         .         .       g.5322
 GACCTCAGCCGCGACCGCCCGCTCGTACTGCTGCTGCACCTGCTGCAACTTGGGCCCCTT       c.240
 D  L  S  R  D  R  P  L  V  L  L  L  H  L  L  Q  L  G  P  L         p.80

       | 02  .         .         .         .         .         .    g.13481
 TTCAG | GTGTTTTGAAGTCTTCTGCATCTACTTTCAGTCAGGCAACAATGAAGAGCCTTAT    c.300
 F  R  |  C  F  E  V  F  C  I  Y  F  Q  S  G  N  N  E  E  P  Y      p.100

          .         .         .         .         .         .       g.13541
 GTCAGTATCACCAAGAAGAGGCAAATGCCAAAAAATGGCCTCTCAGAGGAGATTGAGAAG       c.360
 V  S  I  T  K  K  R  Q  M  P  K  N  G  L  S  E  E  I  E  K         p.120

          .         .         .         .         .         .       g.13601
 GAGGTGGGCCAGGCAGAAGGCAAACTAATCACCCACCGATCAGCGTTCAGCCGGGCGTCG       c.420
 E  V  G  Q  A  E  G  K  L  I  T  H  R  S  A  F  S  R  A  S         p.140

          .         .         .         .         .         .       g.13661
 GTGATCCAGGCTTTCTTGGGCTCAGCCCCCCAGCTGACCCTACAGCTGTACATAAGTGTC       c.480
 V  I  Q  A  F  L  G  S  A  P  Q  L  T  L  Q  L  Y  I  S  V         p.160

          .         .         | 03         .         .         .    g.46808
 ATGCAGCAGGACGTCACTGTTGGAAGAA | GTCTCCTCATGACCATATCCCTGTTGTCCATT    c.540
 M  Q  Q  D  V  T  V  G  R  S |   L  L  M  T  I  S  L  L  S  I      p.180

          .         .         .         .         .         .       g.46868
 GTGTATGGAGCCTTGCGCTGCAACATCCTAGCCATCAAAATCAAGTACGATGAGTATGAA       c.600
 V  Y  G  A  L  R  C  N  I  L  A  I  K  I  K  Y  D  E  Y  E         p.200

          .         .         .         .         .         .       g.46928
 GTCAAAGTGAAGCCTCTGGCCTATGTCTGTATCTTCCTGTGGAGGAGCTTTGAGATTGCC       c.660
 V  K  V  K  P  L  A  Y  V  C  I  F  L  W  R  S  F  E  I  A         p.220

          .         .         .         .         .         .       g.46988
 ACTCGAGTTGTAGTCCTGGTCCTCTTTACCTCCGTCCTGAAGACCTGGGTGGTGGTTATA       c.720
 T  R  V  V  V  L  V  L  F  T  S  V  L  K  T  W  V  V  V  I         p.240

          .         .         .         .         .         .       g.47048
 ATACTCATCAACTTCTTCAGTTTCTTCTTGTACCCCTGGATCCTCTTCTGGTGCAGTGGT       c.780
 I  L  I  N  F  F  S  F  F  L  Y  P  W  I  L  F  W  C  S  G         p.260

          .         .         .         .         .         .       g.47108
 TCCCCATTCCCTGAGAACATAGAGAAGGCCCTCAGTAGAGTGGGCACCACCATTGTACTA       c.840
 S  P  F  P  E  N  I  E  K  A  L  S  R  V  G  T  T  I  V  L         p.280

          .         .         .         .         .         .       g.47168
 TGCTTTCTAACTTTACTCTATACTGGTATCAACATGTTCTGCTGGTCTGCTGTACAGCTG       c.900
 C  F  L  T  L  L  Y  T  G  I  N  M  F  C  W  S  A  V  Q  L         p.300

          .         .         .         .         .         .       g.47228
 AAAATTGACAGCCCTGACCTCATCAGCAAGTCCCATAATTGGTACCAGCTACTGGTGTAT       c.960
 K  I  D  S  P  D  L  I  S  K  S  H  N  W  Y  Q  L  L  V  Y         p.320

          .         .         .         .         .         .       g.47288
 TACATGATAAGATTCATCGAGAATGCCATCCTCCTCCTCCTGTGGTATCTTTTCAAGACT       c.1020
 Y  M  I  R  F  I  E  N  A  I  L  L  L  L  W  Y  L  F  K  T         p.340

          .         .         .         .         .         .       g.47348
 GACATCTATATGTATGTGTGCGCACCTCTGTTGGTCCTGCAGCTGCTCATTGGGTACTGC       c.1080
 D  I  Y  M  Y  V  C  A  P  L  L  V  L  Q  L  L  I  G  Y  C         p.360

          .         .         .         .         .         .       g.47408
 ACAGCCATTCTCTTCATGCTTGTATTCTATCAGTTCTTCCACCCTTGCAAAAAGCTCTTT       c.1140
 T  A  I  L  F  M  L  V  F  Y  Q  F  F  H  P  C  K  K  L  F         p.380

          .         .         .         .         .         .       g.47468
 TCTTCCAGTGTTTCTGAAGGCTTTCAGAGGTGGCTCAGGTGTTTTTGCTGGGCCTGCAGG       c.1200
 S  S  S  V  S  E  G  F  Q  R  W  L  R  C  F  C  W  A  C  R         p.400

          .         .         .         .         .         .       g.47528
 CAGCAAAAACCCTGTGAGCCGATAGGAAAGGAAGATCTACAGTCATCCAGAGATAGAGAT       c.1260
 Q  Q  K  P  C  E  P  I  G  K  E  D  L  Q  S  S  R  D  R  D         p.420

          .         .         .         .         .         .       g.47588
 GAGACACCTTCTAGCAGTAAAACAAGTCCTGAGCCTGGTCAGTTCTTGAATGCTGAAGAT       c.1320
 E  T  P  S  S  S  K  T  S  P  E  P  G  Q  F  L  N  A  E  D         p.440

          .                                                         g.47603
 CTCTGCTCTGCTTAA                                                    c.1335
 L  C  S  A  X                                                      p.444

          .         .         .         .         .         .       g.47663
 tgggacccaaggtctcagagcacaggcatattattttctgggtttgatactcgttattca       c.*60

          .         .         .         .         .         .       g.47723
 tacaaataatgagccctacacagggaacaaggcaggaagttagctgttaactccttgtga       c.*120

          .         .         .         .         .         .       g.47783
 gctgcttctctttatagagctcttgggtatgtagaactgtatgggaagaagccaggaaaa       c.*180

          .         .         .         .         .         .       g.47843
 cctctgagtgttgaaggggcaacccaaggcatcacagttcacaggtaaccatgttgtgtt       c.*240

          .         .         .         .         .         .       g.47903
 cttctaggcattactggccttttcactgacaagttacccctgaaatctgagttgtactgg       c.*300

          .         .         .         .         .         .       g.47963
 ttagattcattaggttgaatgaggagaggggcttacctgttctctagttttccagactgc       c.*360

          .         .         .         .         .         .       g.48023
 tggtttgggtaacctgaagttttatgatccctgaacatagttttcacccaagagctgtcc       c.*420

          .         .         .         .         .         .       g.48083
 tggtgaccaaaaaagattactagggttttgccatcagcaacatcattcctgtcagagctt       c.*480

          .         .         .         .         .         .       g.48143
 tcagggagggctgttcaagtttggtttttgaatagacagaggtttcattttcatctcatt       c.*540

          .         .         .         .         .         .       g.48203
 agggcttttttgtacatagccaactgtagccaccctggcatgctgtctctaattgattca       c.*600

          .         .         .         .         .         .       g.48263
 agggcctagatttggagactttgttccttagcatccatggatgcagaaatgagtgataaa       c.*660

          .         .         .         .         .         .       g.48323
 tttggccatgaaagccctggaattttaggaaagttgtgattctttgatatgttgatgaaa       c.*720

          .         .         .         .         .         .       g.48383
 ttctggatcaggaggggtgttaaaacatcaaaatgatggcgacttgtataagtagaattc       c.*780

          .         .         .         .         .         .       g.48443
 ttaccatcttactcctgcctccccattccttgcctgtcaggaccattttagaagagttac       c.*840

          .         .         .         .         .         .       g.48503
 cttggttaacttaagggttttttagaaaaccccacagaaatctctcacccagttcaggtg       c.*900

          .         .         .         .         .         .       g.48563
 tatagggaattttcattttcattatttcaaggaatagagttttcctcactaccacttgta       c.*960

          .         .         .         .         .         .       g.48623
 attagagattgacttcagaaactttttctaaattataaagacggaatgaccagaaaattt       c.*1020

          .         .         .         .         .         .       g.48683
 ttgtctttcatggaatgcaatttgacttggcataattgtgagttaatttgataaagatct       c.*1080

          .         .         .         .         .         .       g.48743
 ccagttgtatcctctgacaccctttaatgttctatataatttttcctttaatcggagacc       c.*1140

          .         .         .         .         .         .       g.48803
 ctatttgtttcattaaagaggattgggtagcatatcctcaattatcttggaaaaatgcgt       c.*1200

          .         .         .         .         .         .       g.48863
 agatctagtgccattatttctaccattaaaatcttgaaagcgaaatacttgaaaagaggt       c.*1260

          .         .         .         .         .         .       g.48923
 gaccataaagatcacaccaatttagaatgaatattaaagtctgagaaatttacaaaaggg       c.*1320

          .         .         .         .         .         .       g.48983
 actctatggactcgattttaccatatggaatagggatccacttctctgttaacctacaaa       c.*1380

          .         .         .         .         .         .       g.49043
 acgtatttatctggccattgcacttcggataattttcatttttaattcctcttggtgtca       c.*1440

          .         .         .         .         .         .       g.49103
 aatttttaagtaatttcatgcacacaggagaaaatgcaatttgataatcagtttccacta       c.*1500

          .         .         .         .         .         .       g.49163
 cattcggaggtcaagaaagcagtatatattctttcacaaggcatccatactgtttaatat       c.*1560

          .         .         .         .         .         .       g.49223
 ttatagagttcatagaaatacatcaataagctcctaaattatagagcctcaattttggtt       c.*1620

          .         .         .         .         .         .       g.49283
 tttctcatttgaaatgtttttgatttatcaatatttgtggtttaactttgtgggggtgtc       c.*1680

          .         .         .         .         .         .       g.49343
 caggcagtagatcattttttgtctatttttaaccaaataagaataacactcaagactatg       c.*1740

          .         .         .         .         .         .       g.49403
 ttctccatcccaacacatcacttaccacttgcactattcttaataggcctaaaatagtga       c.*1800

          .         .         .         .         .         .       g.49463
 gcatatataatcaaaataatacttcatacaacatatacttccatgcactcttcatgtaat       c.*1860

          .         .         .         .         .         .       g.49523
 cacatatgtgcatagatacacaatcgtattacataaaacacccttgaaaatatatgactt       c.*1920

          .         .         .         .         .         .       g.49583
 tgaataaaataaagctaccatgttaatacatcattttttgtttcttcctaattaacaaaa       c.*1980

          .         .         .         .         .         .       g.49643
 gggctctataatgattaggagagctgtaaggccattctttagtcattccaagtgtatatt       c.*2040

          .         .         .         .         .         .       g.49703
 tgtatcacaccagttacttgtgttcattgacaccaaatattttcaagctttttgtgagaa       c.*2100

          .         .         .         .         .         .       g.49763
 agagattcttgccttgaggctctgcagtggcaaatggtaggggcaatagcgctccctttt       c.*2160

          .         .         .         .         .         .       g.49823
 cacctgaaatgccttcagctcaggccttgggagtgaggtgtgggagtagccaccagcctc       c.*2220

          .         .         .         .         .         .       g.49883
 ccactgactaggcatgttaggaattagacaaggatggagagactggttttttccagcctt       c.*2280

          .         .         .         .         .         .       g.49943
 ggtttggaagcttgtctcaaaaaccattacaaaatcttaaccttcaaatacattctaaat       c.*2340

          .         .         .         .         .         .       g.50003
 cactttaatttagaagataggtgagcaacttgagtgatcccaaaccaaactaacagtgct       c.*2400

          .         .         .         .         .         .       g.50063
 ggtttgtccgacacccaaagcccacttcacacatttataaggacagagatttggtaactc       c.*2460

          .         .         .         .         .         .       g.50123
 atttgggtattttgtcagttttaacccttaatatacaggtatcccagctttgggcacatg       c.*2520

          .         .         .         .         .         .       g.50183
 tatgtccattcactttcaggaaggggtgtcagtactttctttctgtgtggtgaaaacata       c.*2580

          .         .         .         .         .         .       g.50243
 agccatggtgaactgataatttttgtttttaaattatttatattactgaattggcaaaat       c.*2640

          .         .         .         .         .         .       g.50303
 tacagttcacactgcagagctaggttgtcctattggcataaaacaaaccagcaacttttc       c.*2700

          .         .         .         .         .         .       g.50363
 tcatgtgtttggagttaaaatgtgtttttcagttataatttcaatttttaaatttcttgg       c.*2760

          .         .         .         .         .         .       g.50423
 tgctttgtctaattaattacatcccataacttgtcaggatagttgctccaactgaattgc       c.*2820

          .         .         .         .         .         .       g.50483
 tatcatttggctggatgggggtgaagtatgtcttcaaaatatattgaagtaagttcatca       c.*2880

          .         .         .         .         .         .       g.50543
 aacatgtttagacttcctctcattgctggagacagcccagtgtagagattggcacttccc       c.*2940

          .         .         .         .         .         .       g.50603
 tgtccagcactacaacttaattgctctatgcctcagtttccccataatacccttttccaa       c.*3000

          .         .         .         .         .         .       g.50663
 cctacctcacaaggttatcagaaagatcaaattaaataatagatgtgaaaatgctttgaa       c.*3060

          .         .         .         .         .         .       g.50723
 aatgtttttaagtgctatgcatatttatagagttattatagttattcaaatccataagca       c.*3120

          .         .         .         .         .         .       g.50783
 ggttatttttatttttttactgtttgaaaagaaataagtagtgtcattcatatgagttcc       c.*3180

          .         .         .         .         .         .       g.50843
 tgagtggatatgcgaatctttggtcttctcgacaggtgccctttctcttaccactagttg       c.*3240

          .         .         .         .         .         .       g.50903
 cttacaaaaatagcacccaaacacatggcacttggaagaaaaagacccactgaatctgag       c.*3300

          .         .         .         .         .         .       g.50963
 aaagtactttctggtggcaaatgaatttatcattttagtatagttttcgataaaggatat       c.*3360

          .         .         .         .         .         .       g.51023
 agcaacatcttttgataattgtgctttacaacttgaatgctgattcaaggcattatttgg       c.*3420

          .         .         .         .         .         .       g.51083
 atgtgagtttaatcttttcagccttgtaaatgggaaaatatatattaaaattgattgtca       c.*3480

          .         .         .         .         .         .       g.51143
 aatacagcatttctttggaaaccaccttaaaacattagtgctatggttatgagtgtatgt       c.*3540

          .         .         .         .         .         .       g.51203
 gccagtacttaccagtcaatgcattgtggatatgagctttcgttgactgcttctctgcag       c.*3600

          .         .         .         .         .         .       g.51263
 tcgttgatgctaataaatattgtcctgtttcttcatataataaattaatttttcaatttc       c.*3660

                                                                    g.51271
 tccttgta                                                           c.*3668

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The X-linked Kx blood group (McLeod syndrome) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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