X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (XPNPEP2) - coding DNA reference sequence

(used for variant description)

(last modified February 20, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_003399.5 in the XPNPEP2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000023.10, covering XPNPEP2 transcript NM_003399.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         ggaa       c.-241

 .         .         .         .         .         .                g.5064
 cttgcacagtccgcctcgggcagcccaaagctcctctgcccaccctggctcccagagccc       c.-181

 .         .         .         .         .         .                g.5124
 tccaaaacaaaagaccagagaagcactctccacccagcagccagacgcctccttcttgac       c.-121

 .         .         .         .         .         .                g.5184
 gccagcccccaccctctgtctgctcgagcccaggaaaggcctgaaggaagaggccgggga       c.-61

 .         .         .         .         .         .                g.5244
 aagagccctccctctctcccttgtccctccatccacccagcgccggcatctggagaccct       c.-1

          .         .         .         .          | 02        .    g.8149
 ATGGCCCGGGCTCACTGGGGCTGCTGCCCCTGGCTGGTCCTCCTCTGTG | CTTGTGCCTGG    c.60
 M  A  R  A  H  W  G  C  C  P  W  L  V  L  L  C  A |   C  A  W      p.20

          .         .         .         .         .         .       g.8209
 GGCCACACAAAGCCAGTGGACCTTGGAGGGCAGGATGTGAGAAACTGTTCCACCAACCCC       c.120
 G  H  T  K  P  V  D  L  G  G  Q  D  V  R  N  C  S  T  N  P         p.40

     | 03    .         .         .         .         .         .    g.10048
 CCT | TACCTTCCAGTTACTGTGGTCAATACCACAATGTCACTCACAGCCCTCCGCCAGCAG    c.180
 P   | Y  L  P  V  T  V  V  N  T  T  M  S  L  T  A  L  R  Q  Q      p.60

          .         .         .         .         .     | 04   .    g.11239
 ATGCAGACCCAGAATCTCTCAGCCTACATCATCCCAGGCACAGATGCTCACATG | AACGAG    c.240
 M  Q  T  Q  N  L  S  A  Y  I  I  P  G  T  D  A  H  M   | N  E      p.80

          .         .         .         .         .         | 05    g.12268
 TACATCGGCCAACATGACGAGAGGCGTGCGTGGATTACAGGCTTTACAGGGTCTGCAG | GA    c.300
 Y  I  G  Q  H  D  E  R  R  A  W  I  T  G  F  T  G  S  A  G |       p.100

          .         .         .         .         .         .       g.12328
 ACTGCAGTGGTGACTATGAAGAAAGCAGCTGTCTGGACCGACAGTCGCTACTGGACTCAG       c.360
 T  A  V  V  T  M  K  K  A  A  V  W  T  D  S  R  Y  W  T  Q         p.120

          .         .         .         .    | 06    .         .    g.12642
 GCTGAGCGGCAGATGGACTGCAACTGGGAGCTCCATAAGGAAG | TTGGCACCACTCCTATT    c.420
 A  E  R  Q  M  D  C  N  W  E  L  H  K  E  V |   G  T  T  P  I      p.140

          .         .         .         .         .         .       g.12702
 GTCACCTGGCTCCTCACCGAGATTCCTGCTGGAGGGCGTGTGGGTTTTGACCCCTTCCTC       c.480
 V  T  W  L  L  T  E  I  P  A  G  G  R  V  G  F  D  P  F  L         p.160

          . | 07       .         .         .         .         .    g.13687
 TTGTCCATTG | ACACCTGGGAGAGTTATGATCTGGCCCTCCAAGGCTCTAACAGACAGCTG    c.540
 L  S  I  D |   T  W  E  S  Y  D  L  A  L  Q  G  S  N  R  Q  L      p.180

          .         .         .         .         .         .       g.13747
 GTGTCCATCACAACCAATCTTGTGGACCTGGTATGGGGATCAGAGAGGCCACCGGTTCCA       c.600
 V  S  I  T  T  N  L  V  D  L  V  W  G  S  E  R  P  P  V  P         p.200

          .         .         .        | 08.         .         .    g.16521
 AATCAACCCATTTATGCCCTGCAGGAGGCATTCACAG | GGAGCACTTGGCAGGAGAAAGTA    c.660
 N  Q  P  I  Y  A  L  Q  E  A  F  T  G |   S  T  W  Q  E  K  V      p.220

          .         .         .         .         .         .       g.16581
 TCTGGCGTCCGAAGCCAGATGCAGAAGCATCAAAAGGTCCCGACTGCCGTCCTTCTGTCG       c.720
 S  G  V  R  S  Q  M  Q  K  H  Q  K  V  P  T  A  V  L  L  S         p.240

          .          | 09        .         .         .         .    g.17816
 GCGCTTGAGGAGACGGCCT | GGCTCTTCAACCTTCGAGCCAGTGACATCCCCTATAACCCC    c.780
 A  L  E  E  T  A  W |   L  F  N  L  R  A  S  D  I  P  Y  N  P      p.260

          .         .         .         .  | 10      .         .    g.18199
 TTCTTCTATTCCTACACGCTGCTCACAGACTCTTCTATTAG | GTTGTTTGCAAACAAGAGT    c.840
 F  F  Y  S  Y  T  L  L  T  D  S  S  I  R  |  L  F  A  N  K  S      p.280

          .         .         .         .         .         .       g.18259
 CGCTTTAGCTCCGAAACCTTGAGCTATCTGAACTCCAGTTGCACAGGCCCCATGTGTGTG       c.900
 R  F  S  S  E  T  L  S  Y  L  N  S  S  C  T  G  P  M  C  V         p.300

          .         .         .         .         .         .       g.18319
 CAAATCGAGGATTACAGCCAAGTTCGTGACAGCATCCAGGCCTACTCATTGGGAGATGTG       c.960
 Q  I  E  D  Y  S  Q  V  R  D  S  I  Q  A  Y  S  L  G  D  V         p.320

          .         .         .         .         .        | 11.    g.19192
 AGGATCTGGATTGGGACCAGCTATACCATGTATGGGATCTATGAAATGATACCCAAG | GAG    c.1020
 R  I  W  I  G  T  S  Y  T  M  Y  G  I  Y  E  M  I  P  K   | E      p.340

          .         .         .         .         .         .       g.19252
 AAACTCGTGACAGACACCTACTCCCCAGTGATGATGACCAAGGCAGTGAAGAACAGCAAG       c.1080
 K  L  V  T  D  T  Y  S  P  V  M  M  T  K  A  V  K  N  S  K         p.360

          .         .        | 12.         .         .         .    g.20535
 GAGCAGGCCCTCCTCAAGGCCAGCCAC | GTGCGGGACGCTGTGGCTGTGATCCGGTACTTG    c.1140
 E  Q  A  L  L  K  A  S  H   | V  R  D  A  V  A  V  I  R  Y  L      p.380

          .         .         .         .         .         .       g.20595
 GTCTGGCTGGAGAAGAACGTGCCCAAAGGCACAGTGGATGAGTTCTCGGGGGCAGAGATC       c.1200
 V  W  L  E  K  N  V  P  K  G  T  V  D  E  F  S  G  A  E  I         p.400

          .        | 13.         .         .         .         .    g.21367
 GTGGACAAGTTCCGAGG | AGAAGAACAGTTCTCCTCCGGACCCAGTTTTGAAACCATCTCT    c.1260
 V  D  K  F  R  G  |  E  E  Q  F  S  S  G  P  S  F  E  T  I  S      p.420

          .         .         .      | 14  .         .         .    g.22539
 GCTAGTGGTCTGAATGCTGCCCTGGCCCACTACAG | CCCGACCAAGGAGCTGAACCGCAAG    c.1320
 A  S  G  L  N  A  A  L  A  H  Y  S  |  P  T  K  E  L  N  R  K      p.440

          .         .         .         .        | 15.         .    g.25223
 CTGTCCTCAGATGAGATGTACCTGCTGGACTCTGGGGGGCAGTACTG | GGACGGGACCACA    c.1380
 L  S  S  D  E  M  Y  L  L  D  S  G  G  Q  Y  W  |  D  G  T  T      p.460

          .         .         .         .         | 16         .    g.26554
 GACATCACCAGAACAGTCCACTGGGGCACCCCCTCTGCCTTCCAGAAG | GAGGCATACACC    c.1440
 D  I  T  R  T  V  H  W  G  T  P  S  A  F  Q  K   | E  A  Y  T      p.480

          .         .         .         .         .         | 17    g.27204
 CGTGTGCTGATAGGAAATATTGACCTGTCCAGGCTCATCTTTCCCGCTGCTACATCAG | GG    c.1500
 R  V  L  I  G  N  I  D  L  S  R  L  I  F  P  A  A  T  S  G |       p.500

          .         .         .         .         .         .       g.27264
 CGAATGGTGGAGGCCTTTGCCCGCAGAGCCTTGTGGGATGCTGGTCTCAATTATGGTCAT       c.1560
 R  M  V  E  A  F  A  R  R  A  L  W  D  A  G  L  N  Y  G  H         p.520

          .         .         .         .    | 18    .         .    g.28053
 GGGACAGGCCACGGCATTGGCAACTTCCTGTGTGTGCATGAGT | GGCCAGTGGGATTCCAG    c.1620
 G  T  G  H  G  I  G  N  F  L  C  V  H  E  W |   P  V  G  F  Q      p.540

          .         .         .         .    | 19    .         .    g.28741
 TCCAACAACATCGCTATGGCCAAGGGCATGTTCACTTCCATTG | AACCTGGTTACTATAAG    c.1680
 S  N  N  I  A  M  A  K  G  M  F  T  S  I  E |   P  G  Y  Y  K      p.560

          .         .         .         .         .         .       g.28801
 GATGGAGAATTTGGGATCCGTCTCGAAGATGTGGCTCTCGTGGTAGAAGCAAAGACCAAG       c.1740
 D  G  E  F  G  I  R  L  E  D  V  A  L  V  V  E  A  K  T  K         p.580

  | 20       .         .         .         .         .         .    g.33693
  | TACCCAGGGAGCTACCTGACCTTTGAAGTGGTATCATTTGTGCCCTATGACCGGAACCTC    c.1800
  | Y  P  G  S  Y  L  T  F  E  V  V  S  F  V  P  Y  D  R  N  L      p.600

          .         .         . | 21       .         .         .    g.34351
 ATCGATGTCAGCCTGCTGTCTCCCGAGCAT | CTCCAGTACCTGAATCGCTACTACCAGACC    c.1860
 I  D  V  S  L  L  S  P  E  H   | L  Q  Y  L  N  R  Y  Y  Q  T      p.620

          .         .         .         .         .         .       g.34411
 ATCCGGGAGAAGGTGGGTCCAGAGCTGCAGAGGCGCCAGCTACTAGAGGAGTTCGAGTGG       c.1920
 I  R  E  K  V  G  P  E  L  Q  R  R  Q  L  L  E  E  F  E  W         p.640

          .         .         .         .         .         .       g.34471
 CTTCAACAGCACACAGAGCCCCTGGCCGCCAGGGCCCCAGACACCGCCTCCTGGGCCTCT       c.1980
 L  Q  Q  H  T  E  P  L  A  A  R  A  P  D  T  A  S  W  A  S         p.660

          .         .         .         .                           g.34516
 GTGTTAGTGGTCTCCACCCTTGCCATCCTTGGCTGGAGTGTCTAG                      c.2025
 V  L  V  V  S  T  L  A  I  L  G  W  S  V  X                        p.674

          .         .         .         .         .         .       g.34576
 aggctccagactctcctgttaaccctccatctagatggggggctcccttgcttagctccc       c.*60

          .         .         .         .         .         .       g.34636
 ctcaccctgcactgaacataccccaagagcccctgctggcccattgcctagaaacctttg       c.*120

          .         .         .         .         .         .       g.34696
 cattcatcctccttctccaagacctatggagaaggtcccaggccccaggaacacagggct       c.*180

          .         .         .         .         .         .       g.34756
 tcttggccccagatggcacctccctgcaccccggggttgtataccacaccctgggcccct       c.*240

          .         .         .         .         .         .       g.34816
 aatcccaggccccgagataggaaagccagctagtctcttctcttctgtgatctcagtagg       c.*300

          .         .         .         .         .         .       g.34876
 cctaacctataacctagcacagactgctacagctgctcccctcccgccaaacaaaacccc       c.*360

          .         .         .         .         .         .       g.34936
 aagagagcaatgcccctaccacccaagggtgccatggtcccgggagagcccaaacctatc       c.*420

          .         .         .         .         .         .       g.34996
 accacctgttgggcatagccagagctgttcccacccagccagggcatgaaacatcaaccc       c.*480

          .         .         .         .         .         .       g.35056
 cccacatgtgaacccatcattcctaaaccctgggtaggctccatgccaagtaacagcaga       c.*540

          .         .         .         .         .         .       g.35116
 gggagttaagccataggaatttggctgtggagtaagagggaatgcggtgaggcactctgg       c.*600

          .         .         .         .         .         .       g.35176
 aatatgaccctaccagaggttggagaacaaacttgggcagccggaacccgtcactattct       c.*660

          .         .         .         .         .         .       g.35236
 agacttccctggcattcgaggagccctttgaactttccaaagtgcagccacagctacaat       c.*720

          .         .         .         .         .         .       g.35296
 gctgttaaatcctcccacattcttggatgccccttcaccttgtgtggacagtgtctggtt       c.*780

          .         .         .         .         .         .       g.35356
 tctccattttacagacaggaaaactgagcttcagacagggggtgggctttgcctaaggac       c.*840

          .         .         .         .         .         .       g.35416
 acacaaatttggttgggagttgatggggccagatgagccagcattccagctctttcaccc       c.*900

          .         .         .         .         .         .       g.35476
 ttcagcaacatgcagagtccctgagcccacctcccagccctctcctcattctctgaaccc       c.*960

          .         .         .         .         .         .       g.35536
 actgtggtgagaagaatttgctccggccaaattggccgttagccacctgggtccacatcc       c.*1020

          .         .         .         .                           g.35580
 tgctaagacgtttaaaacagcctaacaaagacacttgcctctgg                       c.*1064

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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