exportin 5 (XPO5) - coding DNA reference sequence

(used for variant description)

(last modified June 29, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_020750.2 in the XPO5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_051658.1, covering XPO5 transcript NM_020750.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              acttccgcgggcgcgtgcgcagtggcgggcc       c.-181

 .         .         .         .         .         .                g.5091
 gggcgcgtgcgcagcgccggcttcttcccagcgcgagttgctgctaacgctcctcctcca       c.-121

 .         .         .         .         .         .                g.5151
 gcttcccacccccgccgcccgccgcggcccggtaccaacgggtggtctcgccgagggagc       c.-61

 .         .         .         .         .         .                g.5211
 tgtcgtgcctcgtggtcccgggactgcagtggtgtgcgctctcggcgcgtggcgctaggc       c.-1

          .         .         .         .         .         .       g.5271
 ATGGCGATGGATCAAGTAAACGCGCTGTGCGAGCAGCTGGTGAAAGCGGTGACGGTCATG       c.60
 M  A  M  D  Q  V  N  A  L  C  E  Q  L  V  K  A  V  T  V  M         p.20

          .         .         .         .      | 02  .         .    g.7489
 ATGGACCCCAACTCCACCCAGCGCTACCGGCTGGAAGCCCTCAAG | TTTTGTGAGGAGTTT    c.120
 M  D  P  N  S  T  Q  R  Y  R  L  E  A  L  K   | F  C  E  E  F      p.40

          .         .         .         .         .         .       g.7549
 AAAGAAAAGTGTCCTATCTGTGTCCCCTGTGGCTTGAGGTTGGCTGAGAAAACACAAGTT       c.180
 K  E  K  C  P  I  C  V  P  C  G  L  R  L  A  E  K  T  Q  V         p.60

          .         .         .         .        | 03.         .    g.8510
 GCCATCGTCAGACATTTTGGCCTTCAGATCCTGGAACACGTTGTCAA | GTTTCGGTGGAAC    c.240
 A  I  V  R  H  F  G  L  Q  I  L  E  H  V  V  K  |  F  R  W  N      p.80

          .         .         .         .         .         .       g.8570
 GGCATGTCTCGATTGGAGAAGGTGTATCTGAAGAACAGTGTCATGGAGCTGATTGCAAAT       c.300
 G  M  S  R  L  E  K  V  Y  L  K  N  S  V  M  E  L  I  A  N         p.100

  | 04       .         .         .         .         .         .    g.10141
  | GGAACATTGAACATTTTGGAAGAGGAGAACCATATTAAAGATGCTCTGTCTCGAATTGTA    c.360
  | G  T  L  N  I  L  E  E  E  N  H  I  K  D  A  L  S  R  I  V      p.120

          .         .         .         .         .         .       g.10201
 GTGGAAATGATCAAGCGAGAGTGGCCACAGCATTGGCCTGACATGCTAATAGAATTGGAC       c.420
 V  E  M  I  K  R  E  W  P  Q  H  W  P  D  M  L  I  E  L  D         p.140

          .         | 05         .         .         .         .    g.10433
 ACTCTTTCCAAACAAGGG | GAAACACAGACAGAATTGGTGATGTTTATCCTTTTGCGACTG    c.480
 T  L  S  K  Q  G   | E  T  Q  T  E  L  V  M  F  I  L  L  R  L      p.160

          .         .         .         .         .         .       g.10493
 GCAGAGGATGTAGTGACTTTTCAGACACTTCCCCCTCAAAGAAGAAGGGACATCCAGCAA       c.540
 A  E  D  V  V  T  F  Q  T  L  P  P  Q  R  R  R  D  I  Q  Q         p.180

          .         .         .         .         .         .       g.10553
 ACATTAACCCAGAACATGGAAAGGATCTTCAGTTTTCTGCTTAACACACTTCAAGAAAAT       c.600
 T  L  T  Q  N  M  E  R  I  F  S  F  L  L  N  T  L  Q  E  N         p.200

          .         .  | 06      .         .         | 07         . g.13733
 GTAAACAAGTATCAGCAAGTG | AAGACAGATACTTCTCAGGAGTCAAAG | GCGCAAGCAAAC c.660
 V  N  K  Y  Q  Q  V   | K  T  D  T  S  Q  E  S  K   | A  Q  A  N   p.220

          .         .         .         .         .         .       g.13793
 TGTCGAGTAGGAGTTGCAGCACTGAATACTCTAGCAGGCTATATTGACTGGGTGTCTATG       c.720
 C  R  V  G  V  A  A  L  N  T  L  A  G  Y  I  D  W  V  S  M         p.240

          .         .         .         .         .         .       g.13853
 AGTCACATCACTGCTGAAAACTGTAAACTCCTGGAGATACTGTGTTTGCTGTTGAATGAA       c.780
 S  H  I  T  A  E  N  C  K  L  L  E  I  L  C  L  L  L  N  E         p.260

          .         .         .         .         .     | 08   .    g.15345
 CAGGAACTTCAGTTGGGAGCCGCTGAGTGTCTTCTCATTGCAGTCAGCAGAAAA | GGCAAG    c.840
 Q  E  L  Q  L  G  A  A  E  C  L  L  I  A  V  S  R  K   | G  K      p.280

          .         .         .         .         .         .       g.15405
 TTGGAAGACCGGAAGCCCTTGATGGTCTTATTTGGAGATGTTGCCATGCATTATATACTC       c.900
 L  E  D  R  K  P  L  M  V  L  F  G  D  V  A  M  H  Y  I  L         p.300

          .  | 09      .         .         .         .         .    g.18778
 TCCGCCGCACA | GACTGCTGATGGAGGAGGTTTGGTAGAAAAACACTACGTCTTTCTGAAG    c.960
 S  A  A  Q  |  T  A  D  G  G  G  L  V  E  K  H  Y  V  F  L  K      p.320

          .         .         .         .         .  | 10      .    g.20077
 AGGCTCTGTCAGGTGTTGTGTGCGCTGGGCAATCAGCTGTGTGCATTGCTG | GGTGCAGAT    c.1020
 R  L  C  Q  V  L  C  A  L  G  N  Q  L  C  A  L  L   | G  A  D      p.340

          .         .         .         .         .         .       g.20137
 TCTGATGTAGAAACACCATCAAACTTTGGAAAATACCTGGAATCTTTTCTTGCTTTCACA       c.1080
 S  D  V  E  T  P  S  N  F  G  K  Y  L  E  S  F  L  A  F  T         p.360

          .      | 11  .         .         .         .         .    g.20817
 ACCCATCCAAGTCAG | TTTCTACGCTCTTCAACTCAGATGACTTGGGGAGCCCTCTTCAGG    c.1140
 T  H  P  S  Q   | F  L  R  S  S  T  Q  M  T  W  G  A  L  F  R      p.380

          .         .         .         .         .         .       g.20877
 CATGAAATCCTGTCCCGTGATCCTTTGCTATTAGCAATAATACCAAAATATCTTCGTGCT       c.1200
 H  E  I  L  S  R  D  P  L  L  L  A  I  I  P  K  Y  L  R  A         p.400

          .         .  | 12      .         .         .         .    g.22523
 TCCATGACTAACTTGGTCAAG | ATGGGCTTTCCTTCTAAAACAGACAGCCCTAGCTGTGAA    c.1260
 S  M  T  N  L  V  K   | M  G  F  P  S  K  T  D  S  P  S  C  E      p.420

          .         .         .         .         .   | 13     .    g.25119
 TATTCTCGGTTTGATTTTGATAGCGATGAGGACTTCAATGCTTTCTTCAACT | CCTCCCGA    c.1320
 Y  S  R  F  D  F  D  S  D  E  D  F  N  A  F  F  N  S |   S  R      p.440

          .         .         .         .         .         .       g.25179
 GCACAACAAGGAGAGGTGATGAGGTTGGCATGTCGTTTGGATCCCAAAACTAGCTTCCAG       c.1380
 A  Q  Q  G  E  V  M  R  L  A  C  R  L  D  P  K  T  S  F  Q         p.460

          .         .         .         .         .         .       g.25239
 ATGGCTGGGGAGTGGCTAAAGTATCAACTATCAACTTTTCTTGATGCTGGTTCTGTGAAT       c.1440
 M  A  G  E  W  L  K  Y  Q  L  S  T  F  L  D  A  G  S  V  N         p.480

   | 14      .         .         .         .         .         .    g.27631
 T | CTTGTTCTGCAGTTGGAACTGGAGAAGGAAGCCTCTGTTCCGTCTTCTCACCTTCATTC    c.1500
 S |   C  S  A  V  G  T  G  E  G  S  L  C  S  V  F  S  P  S  F      p.500

          .         .         .         .         .         .       g.27691
 GTGCAGTGGGAAGCCATGACTCTTTTTTTGGAAAGTGTTATCACCCAGATGTTTCGAACA       c.1560
 V  Q  W  E  A  M  T  L  F  L  E  S  V  I  T  Q  M  F  R  T         p.520

          .   | 15     .         .         .         .         .    g.29670
 CTAAATAGAGAA | GAAATTCCTGTTAATGATGGAATAGAGCTATTGCAGATGGTTCTGAAC    c.1620
 L  N  R  E   | E  I  P  V  N  D  G  I  E  L  L  Q  M  V  L  N      p.540

          .         .         .         .         .         .       g.29730
 TTTGATACCAAGGATCCCCTCATCCTGTCCTGCGTCCTTACTAATGTCTCTGCACTCTTT       c.1680
 F  D  T  K  D  P  L  I  L  S  C  V  L  T  N  V  S  A  L  F         p.560

          .         .         .         .         | 16         .    g.31153
 CCATTTGTCACCTACAGACCAGAGTTCCTGCCCCAGGTCTTCTCTAAG | CTATTTTCATCT    c.1740
 P  F  V  T  Y  R  P  E  F  L  P  Q  V  F  S  K   | L  F  S  S      p.580

          .         .         . | 17       .         .         .    g.31527
 GTCACTTTTGAAACTGTTGAAGAAAGTAAG | GCCCCCAGAACCCGGGCAGTGAGGAATGTG    c.1800
 V  T  F  E  T  V  E  E  S  K   | A  P  R  T  R  A  V  R  N  V      p.600

          .         .         .         .         .         .       g.31587
 AGGAGGCATGCTTGTTCCTCCATCATCAAGATGTGTCGTGACTACCCCCAGCTTGTGCTG       c.1860
 R  R  H  A  C  S  S  I  I  K  M  C  R  D  Y  P  Q  L  V  L         p.620

  | 18       .         .         .         .         .         .    g.32675
  | CCCAATTTTGACATGCTTTATAACCATGTGAAGCAACTCCTCTCCAATGAGCTACTCCTG    c.1920
  | P  N  F  D  M  L  Y  N  H  V  K  Q  L  L  S  N  E  L  L  L      p.640

          .         .         .         .         .         .       g.32735
 ACACAAATGGAGAAGTGTGCCCTCATGGAAGCCCTGGTTCTCATTAGCAACCAATTTAAG       c.1980
 T  Q  M  E  K  C  A  L  M  E  A  L  V  L  I  S  N  Q  F  K         p.660

          .         .         .         .         .         .       g.32795
 AACTACGAGCGTCAGAAGGTGTTCCTAGAGGAGCTGATGGCACCAGTGGCCAGCATCTGG       c.2040
 N  Y  E  R  Q  K  V  F  L  E  E  L  M  A  P  V  A  S  I  W         p.680

          .         . | 19       .         .         .         .    g.33408
 CTTTCTCAAGACATGCACAG | AGTGCTGTCAGATGTTGATGCTTTCATTGCGTATGTGGGT    c.2100
 L  S  Q  D  M  H  R  |  V  L  S  D  V  D  A  F  I  A  Y  V  G      p.700

          .         .         .         .         .         .       g.33468
 ACAGATCAGAAGAGCTGTGACCCAGGCCTGGAGGATCCGTGTGGCTTAAACCGTGCACGA       c.2160
 T  D  Q  K  S  C  D  P  G  L  E  D  P  C  G  L  N  R  A  R         p.720

  | 20       .         .         .         .         .         .    g.34383
  | ATGAGCTTTTGTGTATACAGCATTCTGGGTGTGGTGAAACGAACTTGCTGGCCCACTGAC    c.2220
  | M  S  F  C  V  Y  S  I  L  G  V  V  K  R  T  C  W  P  T  D      p.740

          .         .         .         .         .         .       g.34443
 CTAGAAGAGGCCAAAGCTGGGGGATTTGTGGTGGGTTATACATCCAGTGGAAATCCAATC       c.2280
 L  E  E  A  K  A  G  G  F  V  V  G  Y  T  S  S  G  N  P  I         p.760

          .         .         .         .         .         .       g.34503
 TTCCGTAACCCCTGCACAGAGCAGATTCTGAAACTTCTTGACAATTTGCTTGCGCTTATA       c.2340
 F  R  N  P  C  T  E  Q  I  L  K  L  L  D  N  L  L  A  L  I         p.780

    | 21     .         .         .         .         .         .    g.47126
 AG | AACCCACAATACATTATATGCACCAGAAATGCTAGCCAAAATGGCAGAGCCTTTCACC    c.2400
 R  |  T  H  N  T  L  Y  A  P  E  M  L  A  K  M  A  E  P  F  T      p.800

          .         .         .         .    | 22    .         .    g.49517
 AAGGCTCTGGATATGCTTGACGCGGAAAAATCTGCTATATTAG | GATTACCTCAACCTCTC    c.2460
 K  A  L  D  M  L  D  A  E  K  S  A  I  L  G |   L  P  Q  P  L      p.820

          .         .         .         .         .         .       g.49577
 TTGGAACTCAATGACTCTCCTGTCTTCAAAACCGTCTTGGAAAGAATGCAGCGTTTCTTC       c.2520
 L  E  L  N  D  S  P  V  F  K  T  V  L  E  R  M  Q  R  F  F         p.840

          .         . | 23       .         .         .         .    g.50291
 TCTACCCTCTATGAAAACTG | TTTTCATATCCTAGGGAAGGCAGGCCCTTCCATGCAGCAA    c.2580
 S  T  L  Y  E  N  C  |  F  H  I  L  G  K  A  G  P  S  M  Q  Q      p.860

          .         .         .         .         .         .       g.50351
 GACTTCTATACTGTGGAGGACCTTGCTACCCAGCTTCTCAGCTCAGCCTTTGTCAACTTG       c.2640
 D  F  Y  T  V  E  D  L  A  T  Q  L  L  S  S  A  F  V  N  L         p.880

          .         .         .        | 24.         .         .    g.52173
 AACAATATTCCTGACTACCGACTCAGACCCATGCTTC | GTGTCTTTGTAAAGCCTCTGGTG    c.2700
 N  N  I  P  D  Y  R  L  R  P  M  L  R |   V  F  V  K  P  L  V      p.900

          .         .         .         .         .         .       g.52233
 CTCTTCTGTCCCCCAGAGCACTATGAAGCCCTGGTATCCCCCATCCTCGGACCTCTTTTC       c.2760
 L  F  C  P  P  E  H  Y  E  A  L  V  S  P  I  L  G  P  L  F         p.920

          .      | 25  .         .         .         .         .    g.52915
 ACCTACCTCCATATG | AGGCTTTCTCAGAAATGGCAAGTTATCAACCAAAGGAGCCTGCTG    c.2820
 T  Y  L  H  M   | R  L  S  Q  K  W  Q  V  I  N  Q  R  S  L  L      p.940

    | 26     .         .         .         .         .         .    g.53402
 TG | TGGAGAAGATGAGGCTGCAGATGAAAACCCAGAGTCTCAAGAGATGCTGGAGGAGCAA    c.2880
 C  |  G  E  D  E  A  A  D  E  N  P  E  S  Q  E  M  L  E  E  Q      p.960

          .         .         .         . | 27       .         .    g.54348
 CTGGTGAGGATGTTAACCCGAGAAGTCATGGACCTAATCA | CGGTTTGCTGTGTTTCAAAG    c.2940
 L  V  R  M  L  T  R  E  V  M  D  L  I  T |   V  C  C  V  S  K      p.980

          .         .         .         .    | 28    .         .    g.55171
 AAGGGTGCTGACCACAGTAGTGCTCCCCCAGCAGATGGAGACG | ATGAAGAAATGATGGCC    c.3000
 K  G  A  D  H  S  S  A  P  P  A  D  G  D  D |   E  E  M  M  A      p.1000

          .         .         .         .         .         .       g.55231
 ACAGAGGTCACCCCCTCAGCTATGGCAGAGCTTACAGACCTGGGCAAATGTCTGATGAAG       c.3060
 T  E  V  T  P  S  A  M  A  E  L  T  D  L  G  K  C  L  M  K         p.1020

        | 29 .         .         .         .         .         .    g.55915
 CATGAG | GATGTTTGTACAGCGCTATTAATTACAGCCTTCAATTCCCTGGCCTGGAAAGAT    c.3120
 H  E   | D  V  C  T  A  L  L  I  T  A  F  N  S  L  A  W  K  D      p.1040

          .         .         .         .         .     | 30   .    g.56113
 ACTCTGTCCTGCCAGAGGACAACCTCACAGCTCTGCTGGCCTCTCCTCAAACAA | GTGCTG    c.3180
 T  L  S  C  Q  R  T  T  S  Q  L  C  W  P  L  L  K  Q   | V  L      p.1060

          .         .         .         .         .         .       g.56173
 TCAGGGACACTGCTCGCAGATGCAGTTACGTGGCTTTTCACCAGTGTGCTGAAAGGCTTA       c.3240
 S  G  T  L  L  A  D  A  V  T  W  L  F  T  S  V  L  K  G  L         p.1080

          .         .         .         .         .         .       g.56233
 CAGATGCACGGGCAGCACGACGGGTGCATGGCTTCCCTGGTCCATCTGGCCTTCCAGATA       c.3300
 Q  M  H  G  Q  H  D  G  C  M  A  S  L  V  H  L  A  F  Q  I         p.1100

          .   | 31     .         .         .         .         .    g.56488
 TACGAGGCACTG | CGCCCCAGGTACCTGGAGATAAGAGCTGTAATGGAGCAAATCCCTGAA    c.3360
 Y  E  A  L   | R  P  R  Y  L  E  I  R  A  V  M  E  Q  I  P  E      p.1120

          .         .         .         .         .         .       g.56548
 ATACAGAAGGACTCACTGGACCAGTTTGACTGCAAGCTTTTAAACCCCTCCCTGCAGAAA       c.3420
 I  Q  K  D  S  L  D  Q  F  D  C  K  L  L  N  P  S  L  Q  K         p.1140

          .         .         .         .         .        | 32.    g.57073
 GTGGCTGACAAGCGCCGAAAGGACCAATTCAAACGCCTCATTGCTGGTTGCATTGGG | AAA    c.3480
 V  A  D  K  R  R  K  D  Q  F  K  R  L  I  A  G  C  I  G   | K      p.1160

          .         .         .         .         .         .       g.57133
 CCCTTGGGAGAGCAGTTCCGAAAAGAAGTTCACATTAAGAATCTTCCCTCACTTTTCAAA       c.3540
 P  L  G  E  Q  F  R  K  E  V  H  I  K  N  L  P  S  L  F  K         p.1180

          .         .         .         .         .         .       g.57193
 AAAACAAAGCCAATGCTGGAGACGGAGGTGCTGGACAATGATGGGGGTGGCCTGGCCACC       c.3600
 K  T  K  P  M  L  E  T  E  V  L  D  N  D  G  G  G  L  A  T         p.1200

          .                                                         g.57208
 ATCTTTGAACCCTGA                                                    c.3615
 I  F  E  P  X                                                      p.1204

          .         .         .         .         .         .       g.57268
 atcaagcttttgggcatccttcctcggcctttcttgtcatctcttctttccctttgtagc       c.*60

          .         .         .         .         .         .       g.57328
 cgatctctaggcccttcttgcactgccacctcactttccaccactgtcagcctggaaaga       c.*120

          .         .         .         .         .         .       g.57388
 gatccaggtctggagctggagagaacaggccctgtgcaggaccagaagtaattatactaa       c.*180

          .         .         .         .         .         .       g.57448
 agtatcaagaaagggagttagggcttaaactattctgtctagatgtcccagatagttccc       c.*240

          .         .         .         .         .         .       g.57508
 attctacttggagatttggcttttccaagaaaagctagagcagagcagcccttctcccac       c.*300

          .         .         .         .         .         .       g.57568
 aagccctcccacccccgtgcagccacatacctgtacagaatggtaactaagggtgctgtg       c.*360

          .         .         .         .         .         .       g.57628
 cccaaccctgcgactagcaaggctcgcagcaagagcacagccctcaactacttgtgccag       c.*420

          .         .         .         .         .         .       g.57688
 agtttctcttggaccactccaactcccactgagcccttttgctgctgggctggcaggaaa       c.*480

          .         .         .         .         .         .       g.57748
 ctttccccactccctaaggggcatgtctgggttaggtgctaagtgctgaagagaacttgg       c.*540

          .         .         .         .         .         .       g.57808
 tcagttctctcaactttgctttgggcaagaatctggtcacctgatgggatccatggtaca       c.*600

          .         .         .         .         .         .       g.57868
 ggctactgctaaacttggcacagtatcaagtatagtacctccaaggaccagggctgggaa       c.*660

          .         .         .         .         .         .       g.57928
 gtctttagtgctaacatcccctttagagttcacacatcttgcccttccatgaatgacccc       c.*720

          .         .         .         .         .         .       g.57988
 tcagtctggcctccccagcctcaaggtccactcaggcacaagagccacagtaccctagat       c.*780

          .         .         .         .         .         .       g.58048
 agtgtcacatgacaccgttgtcatccaaggataatacagaccaactaggctacatctgtg       c.*840

          .         .         .         .         .         .       g.58108
 atgagcagctagcaaagccgctggtcttctcctaggactaagtccaggtgccttccacaa       c.*900

          .         .         .         .         .         .       g.58168
 tctcatggtctttcaggtccctggttacttttctcaaaggccatttccaaaagaatacat       c.*960

          .         .         .         .         .         .       g.58228
 gccttcacatcacaacctgtactgtgagtccattctagaggtcactgaaaggccctgtaa       c.*1020

          .         .         .         .         .         .       g.58288
 agagaggacatggatacgggacctggccctgaggttattactggccgtaaggcagagtta       c.*1080

          .         .         .         .         .         .       g.58348
 atccatacagaaaccagtgtgtccatgtgctctgcacaaaaacagacctgttgtccatcc       c.*1140

          .         .         .         .         .         .       g.58408
 agtccactgacaagagggtttccccgagagccgaagtggactgaagctacagtttttagc       c.*1200

          .         .         .         .         .         .       g.58468
 tggtgcgggccacaggcagggtcagattgagaagaagcaaagctggggaagcagaagttg       c.*1260

          .         .         .         .         .         .       g.58528
 ggagtcttgtgttgctccctcttcctgtgtggtgctctgggtttctgtggatcgtgaagg       c.*1320

          .         .         .         .         .         .       g.58588
 cgatctcaagagtgtttccctccaaacctgatagctgcctattcctgtctggttggggct       c.*1380

          .         .         .         .         .         .       g.58648
 gtggaggatgtagttgtatttattgcattgtaatatttttaacatcctgtgacttcatgc       c.*1440

          .         .         .         .         .         .       g.58708
 tagaaattttctattgtttatagaaactttttgtagaaacattaactctaaagcacatct       c.*1500

          .         .         .                                     g.58746
 gcatgtcagtaaaaatctcagtttcgtacagaaaggga                             c.*1538

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Exportin 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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