tyrosyl-tRNA synthetase 2, mitochondrial (YARS2) - coding DNA reference sequence

(used for variant description)

(last modified September 23, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_001040436.2 in the YARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering YARS2 transcript NM_001040436.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          accttccctaggagctgta       c.-61

 .         .         .         .         .         .                g.5079
 agtaggtgggtgtggtgggagcctctgcaatcccagcattcccttcgtgccgctaccaag       c.-1

          .         .         .         .         .         .       g.5139
 ATGGCGGCGCCCATCTTGCGGTCCTTTTCCTGGGGCCGGTGGTCTGGTACCCTAAATCTC       c.60
 M  A  A  P  I  L  R  S  F  S  W  G  R  W  S  G  T  L  N  L         p.20

          .         .         .         .         .         .       g.5199
 TCAGTATTGTTGCCCTTGGGGCTGCGTAAGGCCCACTCGGGCGCTCAGGGGTTACTGGCA       c.120
 S  V  L  L  P  L  G  L  R  K  A  H  S  G  A  Q  G  L  L  A         p.40

          .         .         .         .         .         .       g.5259
 GCGCAGAAGGCTCGAGGTCTGTTCAAGGACTTCTTCCCGGAGACGGGGACGAAAATAGAG       c.180
 A  Q  K  A  R  G  L  F  K  D  F  F  P  E  T  G  T  K  I  E         p.60

          .         .         .         .         .         .       g.5319
 CTCCCAGAGCTCTTCGACCGTGGCACGGCGAGTTTTCCCCAAACCATTTACTGTGGCTTC       c.240
 L  P  E  L  F  D  R  G  T  A  S  F  P  Q  T  I  Y  C  G  F         p.80

          .         .         .         .         .         .       g.5379
 GACCCCACGGCAGACTCGCTTCATGTGGGTCATCTACTTGCGCTGCTGGGCCTGTTTCAT       c.300
 D  P  T  A  D  S  L  H  V  G  H  L  L  A  L  L  G  L  F  H         p.100

          .         .         .         .         .         .       g.5439
 TTGCAGCGAGCGGGCCACAACGTGATCGCGCTGGTGGGAGGCGCCACGGCGCGCCTGGGA       c.360
 L  Q  R  A  G  H  N  V  I  A  L  V  G  G  A  T  A  R  L  G         p.120

          .         .         .         .         .         .       g.5499
 GACCCGAGCGGCCGTACCAAGGAACGCGAGGCGCTGGAGACAGAGCGCGTGCGAGCCAAC       c.420
 D  P  S  G  R  T  K  E  R  E  A  L  E  T  E  R  V  R  A  N         p.140

          .         .         .         .         .         .       g.5559
 GCGCGAGCTCTGCGCCTAGGGCTTGAGGCCCTGGCGGCTAATCACCAGCAGCTTTTCACT       c.480
 A  R  A  L  R  L  G  L  E  A  L  A  A  N  H  Q  Q  L  F  T         p.160

          .         .         .         .         .         .       g.5619
 GATGGGCGCTCCTGGGGCAGCTTCACTGTGCTGGACAACTCGGCCTGGTACCAGAAGCAG       c.540
 D  G  R  S  W  G  S  F  T  V  L  D  N  S  A  W  Y  Q  K  Q         p.180

          .         .         .         .         .         .       g.5679
 CACCTGGTGGACTTCCTGGCGGCAGTGGGGGGTCACTTCCGCATGGGGACGCTGCTGAGC       c.600
 H  L  V  D  F  L  A  A  V  G  G  H  F  R  M  G  T  L  L  S         p.200

          .         .         .         .         .         .       g.5739
 CGGCAGAGCGTGCAGCTGCGGCTCAAGAGCCCCGAGGGCATGAGCTTGGCCGAGTTCTTT       c.660
 R  Q  S  V  Q  L  R  L  K  S  P  E  G  M  S  L  A  E  F  F         p.220

          .         .         .         .         .         .       g.5799
 TACCAGGTGCTCCAGGCCTATGACTTCTATTACCTCTTCCAGCGTTATGGATGCAGGGTC       c.720
 Y  Q  V  L  Q  A  Y  D  F  Y  Y  L  F  Q  R  Y  G  C  R  V         p.240

          .         .         .         .         .          | 02    g.6869
 CAGCTGGGCGGATCTGATCAACTAGGCAACATCATGTCCGGATATGAGTTCATCAACAA | G    c.780
 Q  L  G  G  S  D  Q  L  G  N  I  M  S  G  Y  E  F  I  N  K  |      p.260

          .         .         .         .         .         .       g.6929
 TTGACTGGAGAAGATGTATTTGGAATCACCGTTCCTCTAATTACAAGTACAACTGGAGCA       c.840
 L  T  G  E  D  V  F  G  I  T  V  P  L  I  T  S  T  T  G  A         p.280

          .         .         .         .         .         .       g.6989
 AAGCTGGGAAAGTCTGCTGGCAACGCTGTTTGGCTAAACAGAGATAAGACATCTCCATTT       c.900
 K  L  G  K  S  A  G  N  A  V  W  L  N  R  D  K  T  S  P  F         p.300

          .         .         .         .        | 03.         .    g.10092
 GAATTGTATCAATTCTTTGTCAGGCAACCGGACGATTCAGTGGAAAG | GTACCTGAAGCTG    c.960
 E  L  Y  Q  F  F  V  R  Q  P  D  D  S  V  E  R  |  Y  L  K  L      p.320

          .         .         .         .         .         .       g.10152
 TTCACTTTCCTGCCCCTTCCAGAGATTGATCATATCATGCAGCTGCATGTCAAAGAGCCA       c.1020
 F  T  F  L  P  L  P  E  I  D  H  I  M  Q  L  H  V  K  E  P         p.340

          .         .         .         .         .         .       g.10212
 GAAAGGCGGGGTCCTCAGAAACGACTGGCAGCAGAAGTAACAAAGCTTGTTCATGGACGA       c.1080
 E  R  R  G  P  Q  K  R  L  A  A  E  V  T  K  L  V  H  G  R         p.360

          .         .    | 04    .         .         .         .    g.10883
 GAAGGATTGGATTCTGCTAAAAG | GTGTACACAAGCCCTTTATCACAGTAGCATAGATGCA    c.1140
 E  G  L  D  S  A  K  R  |  C  T  Q  A  L  Y  H  S  S  I  D  A      p.380

          .         .         .         .         .         .       g.10943
 CTGGAGGTCATGTCTGATCAGGAGTTAAAAGAGTTGTTTAAAGAAGCTCCATTTTCTGAA       c.1200
 L  E  V  M  S  D  Q  E  L  K  E  L  F  K  E  A  P  F  S  E         p.400

          .         .         .         .         .         .       g.11003
 TTTTTTCTCGATCCTGGAACAAGTGTCCTAGATACTTGCCGCAAAGCAAATGCCATTCCA       c.1260
 F  F  L  D  P  G  T  S  V  L  D  T  C  R  K  A  N  A  I  P         p.420

          .     | 05   .         .         .         .         .    g.13636
 GATGGTCCCCGAGG | GTATCGAATGATAACAGAAGGCGGAGTCAGCATAAATCACCAACAA    c.1320
 D  G  P  R  G  |  Y  R  M  I  T  E  G  G  V  S  I  N  H  Q  Q      p.440

          .         .         .         .         .         .       g.13696
 GTAACAAATCCTGAGAGTGTTTTAATTGTTGGACAACATATTCTCAAGAATGGACTTTCC       c.1380
 V  T  N  P  E  S  V  L  I  V  G  Q  H  I  L  K  N  G  L  S         p.460

          .         .         .         .         .                 g.13750
 TTACTTAAAATAGGAAAAAGAAATTTCTACATTATAAAATGGCTTCAGTTGTGA             c.1434
 L  L  K  I  G  K  R  N  F  Y  I  I  K  W  L  Q  L  X               p.477

          .         .         .         .         .         .       g.13810
 tgaaaagtccttctggttgtccaaataaacttacccatcattcattctcaagacctctga       c.*60

          .         .         .         .         .         .       g.13870
 agggttggctccagaacttagacctttgcttatgcaaatcagaaaaacagaatggactag       c.*120

          .         .         .         .         .         .       g.13930
 gactcagtgtgagtaacttcattatttttatgggccggttaataaatatttgtttaataa       c.*180

          .         .         .         .         .         .       g.13990
 tgggatgttttattttctgatgtacaaagcttgattaccatagaaaaccatgattttcag       c.*240

          .         .         .         .         .         .       g.14050
 ggttaatctctttttaaaattatacttcagaagagaaagaaatgctgctttcctatctta       c.*300

          .         .         .         .         .         .       g.14110
 cccttcctgctctcctttttgtagtgatgaggaacaatgaaaaagaggtagtgtaaggaa       c.*360

          .         .         .         .         .         .       g.14170
 ttgtgaggctgggcatggtggctcacacctgtaatcccagcacttcgggaggccaaggtg       c.*420

          .         .         .         .         .         .       g.14230
 ggcaaatcgcttgaggccaggagtttgagaccagcctggccaacagggcgaaaccccgtc       c.*480

          .         .         .         .         .         .       g.14290
 tctactgaaaatataaaaattagccagatgtggttgcaggcacctgtaaccccagctact       c.*540

          .         .         .         .         .         .       g.14350
 caagaggctgagctgcgagaatcacttgaacccaggagatggaggttgcagtgagctgag       c.*600

          .         .         .         .         .         .       g.14410
 atcacgccactgcactccagcctgggagacagcatgagtagtgagtgaaactctgtctca       c.*660

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tyrosyl-tRNA synthetase 2, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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