tyrosyl-tRNA synthetase (YARS) - coding DNA reference sequence

(used for variant description)

(last modified December 2, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_003680.3 in the YARS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008408.1, covering YARS transcript NM_003680.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5008
                                                     gcaacagc       c.-781

 .         .         .         .         .         .                g.5068
 ctcccgccgagccggccgggacagaggcggcccccacccccactgggcaggggactgcag       c.-721

 .         .         .         .         .         .                g.5128
 acggcgctccccgactctcaagacgaccagggagcttcccttttcctcagcggggtgagg       c.-661

 .         .         .         .         .         .                g.5188
 ggcatctgtcgcccgccgacttggaggtggaggggcagggacattccctcgccatcacct       c.-601

 .         .         .         .         .         .                g.5248
 caggagctagaacgcgcccttctcgcagcagggcgtgggcctcccaatccctccaagggg       c.-541

 .         .         .         .         .         .                g.5308
 cggacggcgtgcgcaaccccctggagaagcaacaggcgcccccatccccctccaagccgg       c.-481

 .         .         .         .         .         .                g.5368
 gtaacgccgaccccctcgtccctcccgctcttcacctccggaagccgggccaaagcctgg       c.-421

 .         .         .         .         .         .                g.5428
 gcgaacgactgcgcctcactccgccccctgcgccattttatcgccccctccccgacctcc       c.-361

 .         .         .         .         .         .                g.5488
 cctaccccgagtcagccgggccaacaccagggggagggcaaaccagcagtgattggcagg       c.-301

 .         .         .         .         .         .                g.5548
 aaaccgtcccgcctctaggagggttgtgccccgctcaggcgcctcagccccgccctccgc       c.-241

 .         .         .         .         .         .                g.5608
 accgcccaccgtgcccactggctccaccttttcccgtctcatcgacctgctcgactctct       c.-181

 .         .         .         .         .         .                g.5668
 gctgctcctcactttttccggccgctgccggaggggtccaggccgagtaagcggagcgcc       c.-121

 .         .         .         .         .         .                g.5728
 gagcccagctgatgcaacctggctggactcgcgtgacagttcccggcacgcggcggcgac       c.-61

 .         .         .         .         .         .                g.5788
 ggtgacccaggaaggggctctggtgccgggctgagcgggggaagcaggggtagcggagcc       c.-1

          .         .         .         .         .        | 02.    g.11978
 ATGGGGGACGCTCCCAGCCCTGAAGAGAAACTGCACCTTATCACCCGGAACCTGCAG | GAG    c.60
 M  G  D  A  P  S  P  E  E  K  L  H  L  I  T  R  N  L  Q   | E      p.20

          .         .         .         .         .         .       g.12038
 GTTCTGGGGGAAGAGAAGCTGAAGGAGATACTGAAGGAGCGGGAACTTAAAATTTACTGG       c.120
 V  L  G  E  E  K  L  K  E  I  L  K  E  R  E  L  K  I  Y  W         p.40

          .         .         .         .         .         .       g.12098
 GGAACGGCAACCACGGGCAAACCACATGTGGCTTACTTTGTGCCCATGTCAAAGATTGCA       c.180
 G  T  A  T  T  G  K  P  H  V  A  Y  F  V  P  M  S  K  I  A         p.60

          .         .     | 03   .         .         .         .    g.12302
 GACTTCTTAAAGGCAGGGTGTGAG | GTAACAATTCTGTTTGCGGACCTCCACGCATACCTG    c.240
 D  F  L  K  A  G  C  E   | V  T  I  L  F  A  D  L  H  A  Y  L      p.80

          .         .         .         .         .         .       g.12362
 GATAACATGAAAGCCCCATGGGAACTTCTAGAACTCCGAGTCAGTTACTATGAGAATGTG       c.300
 D  N  M  K  A  P  W  E  L  L  E  L  R  V  S  Y  Y  E  N  V         p.100

          .         .         .         .         .         .       g.12422
 ATCAAAGCAATGCTGGAGAGCATTGGTGTGCCCTTGGAGAAGCTCAAGTTCATCAAAGGC       c.360
 I  K  A  M  L  E  S  I  G  V  P  L  E  K  L  K  F  I  K  G         p.120

          .         . | 04       .         .         .         .    g.16461
 ACTGATTACCAGCTCAGCAA | AGAGTACACACTAGATGTGTACAGACTCTCCTCCGTGGTC    c.420
 T  D  Y  Q  L  S  K  |  E  Y  T  L  D  V  Y  R  L  S  S  V  V      p.140

          .         .         .         .         .         .       g.16521
 ACACAGCACGATTCCAAGAAGGCTGGAGCTGAGGTGGTAAAGCAGGTGGAGCACCCTTTG       c.480
 T  Q  H  D  S  K  K  A  G  A  E  V  V  K  Q  V  E  H  P  L         p.160

          .         .         . | 05       .         .         .    g.25219
 CTGAGTGGCCTCTTATACCCCGGACTGCAG | GCTTTGGATGAAGAGTATTTAAAAGTAGAT    c.540
 L  S  G  L  L  Y  P  G  L  Q   | A  L  D  E  E  Y  L  K  V  D      p.180

          .         .         .         .         .  | 06      .    g.31787
 GCCCAATTTGGAGGCATTGATCAGAGAAAGATTTTCACCTTTGCAGAGAAG | TACCTCCCT    c.600
 A  Q  F  G  G  I  D  Q  R  K  I  F  T  F  A  E  K   | Y  L  P      p.200

          .         .         .         .         .         .       g.31847
 GCACTTGGCTATTCAAAACGGGTCCATCTGATGAATCCTATGGTTCCAGGATTAACAGGC       c.660
 A  L  G  Y  S  K  R  V  H  L  M  N  P  M  V  P  G  L  T  G         p.220

          .         .     | 07   .         .         .         .    g.35993
 AGCAAAATGAGCTCTTCAGAAGAG | GAGTCCAAGATTGATCTCCTTGATCGGAAGGAGGAT    c.720
 S  K  M  S  S  S  E  E   | E  S  K  I  D  L  L  D  R  K  E  D      p.240

          .         .         .         .         .         .       g.36053
 GTGAAGAAAAAACTGAAGAAGGCCTTCTGTGAGCCAGGAAATGTGGAGAACAATGGGGTT       c.780
 V  K  K  K  L  K  K  A  F  C  E  P  G  N  V  E  N  N  G  V         p.260

          .         .         .         . | 08       .         .    g.36605
 CTGTCCTTCATCAAGCATGTCCTTTTTCCCCTTAAGTCCG | AGTTTGTGATCCTACGAGAT    c.840
 L  S  F  I  K  H  V  L  F  P  L  K  S  E |   F  V  I  L  R  D      p.280

          .         .         .         .         .         .       g.36665
 GAGAAATGGGGTGGAAACAAAACCTACACAGCTTACGTGGACCTGGAAAAGGACTTTGCT       c.900
 E  K  W  G  G  N  K  T  Y  T  A  Y  V  D  L  E  K  D  F  A         p.300

        | 09 .         .         .         .         .         .    g.40547
 GCTGAG | GTTGTACATCCTGGAGACCTGAAGAATTCTGTTGAAGTCGCACTGAACAAGTTG    c.960
 A  E   | V  V  H  P  G  D  L  K  N  S  V  E  V  A  L  N  K  L      p.320

          .         .         .         .         .         .       g.40607
 CTGGATCCAATCCGGGAAAAGTTTAATACCCCTGCCCTGAAAAAACTGGCCAGCGCTGCC       c.1020
 L  D  P  I  R  E  K  F  N  T  P  A  L  K  K  L  A  S  A  A         p.340

          .         .   | 10     .         .         .         .    g.41925
 TACCCAGATCCCTCAAAGCAGA | AGCCAATGGCCAAAGGCCCTGCCAAGAATTCAGAACCA    c.1080
 Y  P  D  P  S  K  Q  K |   P  M  A  K  G  P  A  K  N  S  E  P      p.360

          .         .         .         .         .         .       g.41985
 GAGGAGGTCATCCCATCCCGGCTGGATATCCGTGTGGGGAAAATCATCACTGTGGAGAAG       c.1140
 E  E  V  I  P  S  R  L  D  I  R  V  G  K  I  I  T  V  E  K         p.380

  | 11       .         .         .         .         .         .    g.42814
  | CACCCAGATGCAGACAGCCTGTATGTAGAGAAGATTGACGTGGGGGAAGCTGAACCACGG    c.1200
  | H  P  D  A  D  S  L  Y  V  E  K  I  D  V  G  E  A  E  P  R      p.400

          .         .         .         .         .         .       g.42874
 ACTGTGGTGAGCGGCCTGGTACAGTTCGTGCCCAAGGAGGAACTGCAGGACAGGCTGGTA       c.1260
 T  V  V  S  G  L  V  Q  F  V  P  K  E  E  L  Q  D  R  L  V         p.420

          .         .         .         .         .         .       g.42934
 GTGGTGCTGTGCAACCTGAAACCCCAGAAGATGAGAGGAGTCGAGTCCCAAGGCATGCTT       c.1320
 V  V  L  C  N  L  K  P  Q  K  M  R  G  V  E  S  Q  G  M  L         p.440

          .     | 12   .         .         .         .         .    g.43555
 CTGTGTGCTTCTAT | AGAAGGGATAAACCGCCAGGTTGAACCTCTGGACCCTCCGGCAGGC    c.1380
 L  C  A  S  I  |  E  G  I  N  R  Q  V  E  P  L  D  P  P  A  G      p.460

          .         .         .         .         .         .       g.43615
 TCTGCTCCTGGTGAGCACGTGTTTGTGAAGGGCTATGAAAAGGGCCAACCAGATGAGGAG       c.1440
 S  A  P  G  E  H  V  F  V  K  G  Y  E  K  G  Q  P  D  E  E         p.480

          .         .         .       | 13 .         .         .    g.46965
 CTCAAGCCCAAGAAGAAAGTCTTCGAGAAGTTGCAG | GCTGACTTCAAAATTTCTGAGGAG    c.1500
 L  K  P  K  K  K  V  F  E  K  L  Q   | A  D  F  K  I  S  E  E      p.500

          .         .         .         .         .         .       g.47025
 TGCATCGCACAGTGGAAGCAAACCAACTTCATGACCAAGCTGGGCTCCATTTCCTGTAAA       c.1560
 C  I  A  Q  W  K  Q  T  N  F  M  T  K  L  G  S  I  S  C  K         p.520

          .         .                                               g.47052
 TCGCTGAAAGGGGGGAACATTAGCTAG                                        c.1587
 S  L  K  G  G  N  I  S  X                                          p.528

          .         .         .         .         .         .       g.47112
 ccagcccagcatcttccccccttcttccaccactgagtcatctgctgtctcttcagtctg       c.*60

          .         .         .         .         .         .       g.47172
 ctccatccatcacccatttacccatctctcaggacacggaagcagcgggtttggactctt       c.*120

          .         .         .         .         .         .       g.47232
 tattcggtgcagaactcggcaaggggcagcttaccctccccagaacccaggatcatcctg       c.*180

          .         .         .         .         .         .       g.47292
 tctggctgcagtgagagaccaacccctaacaagggctgggccacagcagggagtccagcc       c.*240

          .         .         .         .         .         .       g.47352
 ctaccttcttcccttggcagctggagaaatctggtttcaatataactcatttaaaaattt       c.*300

          .         .         .         .         .         .       g.47412
 atgccacagtccttataattggaaaaatactggtgcccaggttttcttggagttatccaa       c.*360

          .         .         .         .         .         .       g.47472
 gcagctgcgcccctagctgggatctggtacctggactaggctaattacagcttctcccca       c.*420

          .         .         .         .         .         .       g.47532
 acaggaaactgtgggatttgaaaaggaaagggaagggaaaacagagaacctagtggtcta       c.*480

          .         .         .         .         .         .       g.47592
 ccaagtggttggcaactttcccaatgtctgcttactctgaggcttggcactgggggccag       c.*540

          .         .         .         .         .         .       g.47652
 ggcctgccccagggctcctggaatttcccttgatccagctaggctgggacactccctaaa       c.*600

          .         .         .         .         .         .       g.47712
 tcagctgcgtgttgttagcatcaggcagaatgaatggcagagagtgattctgtcttcata       c.*660

          .         .         .         .         .         .       g.47772
 gagggtggggtacttctccataaggcatctcagtcaaatccccatcactgtcataaattc       c.*720

          .         .                                               g.47794
 aaataaaatgtctgaacaaggg                                             c.*742

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tyrosyl-tRNA synthetase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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