zinc finger and BTB domain containing 18 (ZBTB18) - coding DNA reference sequence

(used for variant description)

(last modified August 3, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_205768.2 in the ZBTB18 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033841.1, covering ZBTB18 transcript NM_205768.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.7373
        attctaacacacagacagggagttagtgtgtgcggatctgtggtggagaaggt       c.-121

 .         .         .         .         .         .                g.7433
 atctcattcctctctaacatcatctccactttgcatctgtctctcttagtctgctttttt       c.-61

 .         .         .         .         .         .                g.7493
 tccaccgatgtaacagacctggagccagcaggactcagaggaaaggacttaatcaggttt       c.-1

          .    | 02    .         .         .         .         .    g.9896
 ATGTGTCCTAAAG | GTTATGAAGACAGTATGGAGTTTCCAGACCATAGTAGACATTTGCTA    c.60
 M  C  P  K  G |   Y  E  D  S  M  E  F  P  D  H  S  R  H  L  L      p.20

          .         .         .         .         .         .       g.9956
 CAGTGTCTGAGCGAGCAGAGACACCAGGGTTTTCTTTGTGACTGCACTGTTCTGGTGGGA       c.120
 Q  C  L  S  E  Q  R  H  Q  G  F  L  C  D  C  T  V  L  V  G         p.40

          .         .         .         .         .         .       g.10016
 GATGCCCAGTTCCGAGCGCACCGAGCTGTACTGGCTTCATGCAGCATGTATTTCCACCTC       c.180
 D  A  Q  F  R  A  H  R  A  V  L  A  S  C  S  M  Y  F  H  L         p.60

          .         .         .         .         .         .       g.10076
 TTTTACAAGGACCAGCTGGACAAAAGAGACATTGTTCATCTGAACAGCGACATTGTTACA       c.240
 F  Y  K  D  Q  L  D  K  R  D  I  V  H  L  N  S  D  I  V  T         p.80

          .         .         .         .         .         .       g.10136
 GCCCCCGCTTTCGCTCTCCTGCTTGAATTCATGTATGAAGGGAAACTCCAGTTCAAAGAC       c.300
 A  P  A  F  A  L  L  L  E  F  M  Y  E  G  K  L  Q  F  K  D         p.100

          .         .         .         .         .         .       g.10196
 TTGCCCATTGAAGACGTGCTAGCAGCTGCCAGTTATCTCCACATGTATGACATTGTCAAA       c.360
 L  P  I  E  D  V  L  A  A  A  S  Y  L  H  M  Y  D  I  V  K         p.120

          .         .         .         .         .         .       g.10256
 GTCTGCAAAAAGAAGCTGAAAGAGAAAGCCACCACGGAGGCAGACAGCACCAAAAAGGAA       c.420
 V  C  K  K  K  L  K  E  K  A  T  T  E  A  D  S  T  K  K  E         p.140

          .         .         .         .         .         .       g.10316
 GAAGATGCTTCAAGTTGTTCGGACAAAGTCGAGAGTCTCTCCGATGGCAGCAGCCACATA       c.480
 E  D  A  S  S  C  S  D  K  V  E  S  L  S  D  G  S  S  H  I         p.160

          .         .         .         .         .         .       g.10376
 GCAGGCGATTTGCCCAGTGATGAAGATGAAGGAGAAGATGAAAAATTGAACATCCTGCCC       c.540
 A  G  D  L  P  S  D  E  D  E  G  E  D  E  K  L  N  I  L  P         p.180

          .         .         .         .         .         .       g.10436
 AGCAAAAGGGACTTGGCGGCCGAGCCTGGGAACATGTGGATGCGATTGCCCTCAGACTCA       c.600
 S  K  R  D  L  A  A  E  P  G  N  M  W  M  R  L  P  S  D  S         p.200

          .         .         .         .         .         .       g.10496
 GCAGGCATCCCCCAGGCTGGCGGAGAGGCAGAGCCACACGCCACAGCAGCTGGAAAAACA       c.660
 A  G  I  P  Q  A  G  G  E  A  E  P  H  A  T  A  A  G  K  T         p.220

          .         .         .         .         .         .       g.10556
 GTAGCCAGCCCCTGCAGCTCAACAGAGTCTTTGTCCCAGAGGTCTGTCACCTCCGTGAGG       c.720
 V  A  S  P  C  S  S  T  E  S  L  S  Q  R  S  V  T  S  V  R         p.240

          .         .         .         .         .         .       g.10616
 GATTCGGCAGATGTTGACTGTGTGCTGGACCTGTCTGTCAAGTCCAGCCTTTCAGGAGTT       c.780
 D  S  A  D  V  D  C  V  L  D  L  S  V  K  S  S  L  S  G  V         p.260

          .         .         .         .         .         .       g.10676
 GAAAATCTGAACAGCTCTTATTTCTCTTCACAGGACGTGCTGAGAAGCAACCTGGTGCAG       c.840
 E  N  L  N  S  S  Y  F  S  S  Q  D  V  L  R  S  N  L  V  Q         p.280

          .         .         .         .         .         .       g.10736
 GTGAAGGTGGAGAAAGAGGCTTCCTGTGATGAGAGTGATGTTGGCACTAATGACTATGAC       c.900
 V  K  V  E  K  E  A  S  C  D  E  S  D  V  G  T  N  D  Y  D         p.300

          .         .         .         .         .         .       g.10796
 ATGGAACATAGCACTGTGAAAGAAAGTGTGAGCACTAATAACAGGGTACAGTATGAGCCG       c.960
 M  E  H  S  T  V  K  E  S  V  S  T  N  N  R  V  Q  Y  E  P         p.320

          .         .         .         .         .         .       g.10856
 GCCCATCTGGCTCCCCTGAGGGAGGACTCGGTCTTGAGGGAGCTGGACCGGGAGGACAAA       c.1020
 A  H  L  A  P  L  R  E  D  S  V  L  R  E  L  D  R  E  D  K         p.340

          .         .         .         .         .         .       g.10916
 GCCAGTGATGATGAGATGATGACCCCAGAGAGCGAGCGTGTCCAGGTGGAGGGAGGCATG       c.1080
 A  S  D  D  E  M  M  T  P  E  S  E  R  V  Q  V  E  G  G  M         p.360

          .         .         .         .         .         .       g.10976
 GAGAGCAGTCTGCTCCCCTACGTCTCCAACATCCTGAGCCCCGCGGGCCAGATCTTCATG       c.1140
 E  S  S  L  L  P  Y  V  S  N  I  L  S  P  A  G  Q  I  F  M         p.380

          .         .         .         .         .         .       g.11036
 TGCCCCCTGTGCAACAAGGTCTTCCCCAGCCCCCACATCCTGCAGATCCACCTGAGCACG       c.1200
 C  P  L  C  N  K  V  F  P  S  P  H  I  L  Q  I  H  L  S  T         p.400

          .         .         .         .         .         .       g.11096
 CACTTCCGCGAGCAGGACGGCATCCGCAGCAAGCCCGCCGCCGATGTCAACGTGCCCACG       c.1260
 H  F  R  E  Q  D  G  I  R  S  K  P  A  A  D  V  N  V  P  T         p.420

          .         .         .         .         .         .       g.11156
 TGCTCGCTGTGTGGGAAGACTTTCTCTTGCATGTACACCCTCAAGCGCCACGAGAGGACT       c.1320
 C  S  L  C  G  K  T  F  S  C  M  Y  T  L  K  R  H  E  R  T         p.440

          .         .         .         .         .         .       g.11216
 CACTCGGGGGAGAAGCCCTACACATGCACCCAGTGCGGCAAGAGCTTCCAGTACTCGCAC       c.1380
 H  S  G  E  K  P  Y  T  C  T  Q  C  G  K  S  F  Q  Y  S  H         p.460

          .         .         .         .         .         .       g.11276
 AACCTGAGCCGCCATGCCGTGGTGCACACCCGCGAGAAGCCGCACGCCTGCAAGTGGTGC       c.1440
 N  L  S  R  H  A  V  V  H  T  R  E  K  P  H  A  C  K  W  C         p.480

          .         .         .         .         .         .       g.11336
 GAGCGCAGGTTCACGCAGTCCGGGGACCTGTACAGACACATTCGCAAGTTCCACTGTGAG       c.1500
 E  R  R  F  T  Q  S  G  D  L  Y  R  H  I  R  K  F  H  C  E         p.500

          .         .         .         .         .         .       g.11396
 TTGGTGAACTCCTTGTCGGTCAAAAGCGAAGCACTGAGCTTGCCTACTGTCAGAGACTGG       c.1560
 L  V  N  S  L  S  V  K  S  E  A  L  S  L  P  T  V  R  D  W         p.520

          .         .         .                                     g.11432
 ACCTTAGAAGATAGCTCTCAAGAACTTTGGAAATAA                               c.1596
 T  L  E  D  S  S  Q  E  L  W  K  X                                 p.531

          .         .         .         .         .         .       g.11492
 ttttatatatatataaataatatatatatatatacatatatataaatagatctctatata       c.*60

          .         .         .         .         .         .       g.11552
 gttgtggtacggtctaaaagcagtcttgtttcctggaaataaaaagttgggatattaact       c.*120

          .         .         .         .         .         .       g.11612
 tgtttttgcactttagaatagcatgagaatctcactaatttagcattctgataaaagaaa       c.*180

          .         .         .         .         .         .       g.11672
 ctttagagcaagtcagaatagagaggtgtttttcctttgaggggataggggaagtaagcc       c.*240

          .         .         .         .         .         .       g.11732
 aataagaaccttttaaacaaatcgtcctgtcacaaaatgctttcatatggcttaattttg       c.*300

          .         .         .         .         .         .       g.11792
 tcaacactgcattgtcttttgagctcttttttcccccccaacaaagtttttttgtttttt       c.*360

          .         .         .         .         .         .       g.11852
 gtttttttttttaagtagaaattccctccagttttattagcctctttatatgtctcaaat       c.*420

          .         .         .         .         .         .       g.11912
 tgcatgaattttttctggctgttggaaacctgaatgcttttagacccaaatggaaaattt       c.*480

          .         .         .         .         .         .       g.11972
 ctgaaatgctggattatctatttttaaacaagcagttgacttaaaactttctgtggcaac       c.*540

          .         .         .         .         .         .       g.12032
 ttctggttttctgacagttcccagtgagagaaatgctgaaagtacactgggatcactggg       c.*600

          .         .         .         .         .         .       g.12092
 acactgtcttatgaaggtttgcttgggatgaaaaaggatattgcagcttcagcagtgttg       c.*660

          .         .         .         .         .         .       g.12152
 aactgtgtgtttaaaaatgtgaattactgttattgtatactgtaattgattacatgggct       c.*720

          .         .         .         .         .         .       g.12212
 gggggggtgtcaaagaacttgacaggttgtgttgatgctcttagttgagtcttgaaaagt       c.*780

          .         .         .         .         .         .       g.12272
 aaatattaacgctacagaaatgcatgagtttcaatatattttttgtctttgtttgcattg       c.*840

          .         .         .         .         .         .       g.12332
 tataactttaacgagtgagtttaaaattatttaatttccttagaaaaatagcaccatttg       c.*900

          .         .         .         .         .         .       g.12392
 gaaaaaaaaactggtgttatgaagaacgtaaatgcactgtttttatttttattttatata       c.*960

          .         .         .         .         .         .       g.12452
 atttaaattgactttcccactgtctttaagttgaaactgttaagctgaataaaaacttaa       c.*1020

          .         .         .         .         .         .       g.12512
 gctgcaaattgataacttcgctacataacaaggaaaatataaatgtttacaaacagctta       c.*1080

          .         .         .         .         .         .       g.12572
 aagatttgcatgtgcagtgtgcatttataacaaacttctaattgcacaaaacccatgcca       c.*1140

          .         .         .         .         .         .       g.12632
 gctcagagtttaggtgtacacatttacccagttgagcgttcttagaataactactgcaca       c.*1200

          .         .         .         .         .         .       g.12692
 agttgacaataggtcgttctctctttttttttgtttgctccctttttctttttctcccct       c.*1260

          .         .         .         .         .         .       g.12752
 tcctccttaccctccctcccttactctccccccccaccaccaccctccacccccaactca       c.*1320

          .         .         .         .         .         .       g.12812
 tgaaaagattctatggactgaaaaagccccaggctgaaaggactggactgccttgattga       c.*1380

          .         .         .         .         .         .       g.12872
 catggggaagggggttagtagactatgtggattgcggcagcagaggctgcagcctaacgt       c.*1440

          .         .         .         .         .         .       g.12932
 gtggttttaatgaccagcacgcaaggcaaaagcattttgcacagtgtttgttttcctgtc       c.*1500

          .         .         .         .         .         .       g.12992
 ttgcacttacaaataaggtctatgggagtagcatggaaaacgtttgctgtttttcccttt       c.*1560

          .         .         .         .         .         .       g.13052
 tttttttaattgcttttgtttaaaatttgatcgccttaactactgtaaacatagcctatt       c.*1620

          .         .         .         .         .         .       g.13112
 tttgtgcttaagatactgaatggaaaactccattgtgtgttgctggactgttttggaaat       c.*1680

          .         .         .         .         .         .       g.13172
 atttggttaaatgtgtgttaatttggctgtaatggcatttaaagcaaacaaacaaacaaa       c.*1740

          .         .         .         .         .         .       g.13232
 aaaagctgtgaaaatggccttggagcattatctttagttacttgaagagtttctagtttt       c.*1800

          .         .         .         .         .         .       g.13292
 tttaaaatacagtttatgttaaaataatttttattaatttagagaagacaatcaatgtct       c.*1860

          .         .         .         .         .         .       g.13352
 gtgagaaaacggactttcttttggattttctttttgtggtcattgtgagtgattgctttt       c.*1920

          .         .         .         .         .         .       g.13412
 tccttttcttagtttcacattcttcctttgttctaaaacttagactgacatctagctttg       c.*1980

          .         .         .         .         .         .       g.13472
 acaatcatagtatgttttattttcctgagggggaataacttataatgctgtttagttttg       c.*2040

          .         .         .         .         .         .       g.13532
 tactattggtgtgttggtgaatttttaaactgtgtgctaactgcaataaattatatgaac       c.*2100

                                                                    g.13538
 tgagaa                                                             c.*2106

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Zinc finger and BTB domain containing 18 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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