zinc finger and AT hook domain containing (ZFAT) - coding DNA reference sequence

(used for variant description)

(last modified May 4, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_020863.3 in the ZFAT gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016356.1, covering ZFAT transcript NM_020863.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       gaggag       c.-181

 .         .         .         .         .         .                g.5066
 ggcgaagactccatccgccatgttggatgccgcagattcgccataacctcgccggctctt       c.-121

 .         .         .         .         .         .                g.5126
 ttcttaaaaaaataaaaataaaaagcgaagcgtcagcagggcgccccgccccctcggtcg       c.-61

 .         .         .         .         .         .                g.5186
 gcacgggagggggcccggaagagcccgaggcttttttttcctccgcggtggggcgttgcc       c.-1

          .          | 02        .         .         .         .    g.60353
 ATGGAGACGCGGGCGGCAG | AAAACACGGCCATCTTTATGTGTAAATGTTGTAACCTCTTC    c.60
 M  E  T  R  A  A  E |   N  T  A  I  F  M  C  K  C  C  N  L  F      p.20

          .         .         .         .         .         .       g.60413
 TCACCAAATCAGTCGGAACTCCTCTCCCACGTTTCAGAGAAGCACATGGAAGAAGGGGTT       c.120
 S  P  N  Q  S  E  L  L  S  H  V  S  E  K  H  M  E  E  G  V         p.40

          .         .         .         .         .         .       g.60473
 AATGTTGATGAGATTATTATTCCCCTTAGGCCTCTGAGTACACCTGAACCCCCCAACTCA       c.180
 N  V  D  E  I  I  I  P  L  R  P  L  S  T  P  E  P  P  N  S         p.60

          .       | 03 .         .         .         .         .    g.80381
 AGCAAAACCGGAGATG | AGTTTTTGGTCATGAAGAGGAAGAGAGGCAGGCCTAAGGGGTCC    c.240
 S  K  T  G  D  E |   F  L  V  M  K  R  K  R  G  R  P  K  G  S      p.80

          .         .         .         .         .         .       g.80441
 ACGAAGAAGTCCAGCACAGAAGAGGAGCTGGCAGAAAACATCGTGAGTCCGACTGAGGAC       c.300
 T  K  K  S  S  T  E  E  E  L  A  E  N  I  V  S  P  T  E  D         p.100

          .         .         .         .         .         .       g.80501
 AGCCCGCTGGCTCCGGAGGAAGGGAACAGCCTGCCTCCAAGCAGCTTGGAGTGTAGCAAG       c.360
 S  P  L  A  P  E  E  G  N  S  L  P  P  S  S  L  E  C  S  K         p.120

          .         .         .         .         .         .       g.80561
 TGCTGTCGGAAGTTCTCCAACACGCGCCAGCTGCGGAAGCACATCTGCATTATCGTGCTG       c.420
 C  C  R  K  F  S  N  T  R  Q  L  R  K  H  I  C  I  I  V  L         p.140

          .         .         | 04         .         .         .    g.107426
 AATTTGGGTGAGGAGGAAGGAGAAGCAG | GTAACGAGTCTGACCTTGAACTAGAAAAGAAG    c.480
 N  L  G  E  E  E  G  E  A  G |   N  E  S  D  L  E  L  E  K  K      p.160

          .         .         .         .         .         .       g.107486
 TGTAAGGAAGATGATCGGGAAAAAGCCTCGAAAAGACCACGGTCACAGAAAACAGAGAAA       c.540
 C  K  E  D  D  R  E  K  A  S  K  R  P  R  S  Q  K  T  E  K         p.180

          .         .         .         .         .         .       g.107546
 GTCCAGAAGATCTCAGGAAAGGAGGCCAGACAGCTTTCTGGGGCGAAGAAACCCATCATA       c.600
 V  Q  K  I  S  G  K  E  A  R  Q  L  S  G  A  K  K  P  I  I         p.200

          .         .         .     | 05   .         .         .    g.109196
 AGTGTGGTTTTAACTGCACACGAAGCAATTCCAG | GTGCTACCAAGATTGTGCCAGTGGAG    c.660
 S  V  V  L  T  A  H  E  A  I  P  G |   A  T  K  I  V  P  V  E      p.220

          .         .         .         .         .         .       g.109256
 GCTGGGCCCCCTGAAACAGGAGCTACAAATTCTGAGACCACTTCAGCAGACCTGGTGCCT       c.720
 A  G  P  P  E  T  G  A  T  N  S  E  T  T  S  A  D  L  V  P         p.240

          .         .         .         .         .         .       g.109316
 CGGAGAGGCTACCAGGAATACGCCATTCAGCAGACACCTTATGAGCAACCAATGAAGTCA       c.780
 R  R  G  Y  Q  E  Y  A  I  Q  Q  T  P  Y  E  Q  P  M  K  S         p.260

       | 06  .         .         .         .         .         .    g.115171
 AGCAG | GCTAGGTCCCACTCAGCTCAAAATCTTCACTTGTGAATACTGCAACAAGGTCTTC    c.840
 S  R  |  L  G  P  T  Q  L  K  I  F  T  C  E  Y  C  N  K  V  F      p.280

          .         .         .         .         .         .       g.115231
 AAGTTCAAGCACTCGCTGCAGGCCCACCTGAGGATCCACACCAATGAAAAGCCATACAAG       c.900
 K  F  K  H  S  L  Q  A  H  L  R  I  H  T  N  E  K  P  Y  K         p.300

          .         .         .         .         .         .       g.115291
 TGCCCCCAGTGCAGCTATGCCAGTGCCATCAAGGCCAACCTCAATGTGCACCTGCGCAAG       c.960
 C  P  Q  C  S  Y  A  S  A  I  K  A  N  L  N  V  H  L  R  K         p.320

          .         .         .         .         .         .       g.115351
 CACACTGGAGAGAAGTTCGCCTGCGACTATTGCTCGTTCACCTGCCTGAGCAAGGGCCAC       c.1020
 H  T  G  E  K  F  A  C  D  Y  C  S  F  T  C  L  S  K  G  H         p.340

          .         .         .         .         .         .       g.115411
 CTCAAGGTGCACATCGAGCGAGTGCACAAGAAGATCAAGCAGCACTGCCGCTTCTGCAAG       c.1080
 L  K  V  H  I  E  R  V  H  K  K  I  K  Q  H  C  R  F  C  K         p.360

          .         .         .         .         .         .       g.115471
 AAGAAGTACTCTGACGTCAAGAACCTCATCAAGCACATCCGAGACGCGCATGACCCACAG       c.1140
 K  K  Y  S  D  V  K  N  L  I  K  H  I  R  D  A  H  D  P  Q         p.380

          .         .         .         .         .         .       g.115531
 GACAAGAAGGTCAAAGAGGCCTTGGACGAGCTCTGCCTGATGACGAGGGAGGGCAAGCGG       c.1200
 D  K  K  V  K  E  A  L  D  E  L  C  L  M  T  R  E  G  K  R         p.400

          .         .         .         .         .         .       g.115591
 CAGCTGCTCTATGACTGCCACATCTGTGAGCGCAAGTTCAAGAACGAGCTGGACCGTGAC       c.1260
 Q  L  L  Y  D  C  H  I  C  E  R  K  F  K  N  E  L  D  R  D         p.420

          .         .         .         .         .         .       g.115651
 CGCCATATGCTGGTCCACGGAGACAAGTGGCCTTTTGCCTGTGAGCTCTGTGGCCATGGG       c.1320
 R  H  M  L  V  H  G  D  K  W  P  F  A  C  E  L  C  G  H  G         p.440

          .         .         .         .         .         .       g.115711
 GCCACCAAGTACCAGGCGCTGGAACTGCATGTCAGGAAGCACCCCTTCGTGTACGTCTGT       c.1380
 A  T  K  Y  Q  A  L  E  L  H  V  R  K  H  P  F  V  Y  V  C         p.460

          .         .         .         .         .         .       g.115771
 GCCGTCTGCCGCAAGAAGTTCGTCAGCTCCATCAGGCTGCGCACCCACATCAAAGAGGTG       c.1440
 A  V  C  R  K  K  F  V  S  S  I  R  L  R  T  H  I  K  E  V         p.480

          .         .         .         .         .         .       g.115831
 CACGGGGCTGCCCAGGAGGCCTTGGTCTTCACCAGTTCCATCAACCAGAGCTTCTGCCTC       c.1500
 H  G  A  A  Q  E  A  L  V  F  T  S  S  I  N  Q  S  F  C  L         p.500

          .         .         .         .         .         .       g.115891
 CTGGAACCTGGTGGGGACATCCAGCAAGAAGCTCTGGGGGACCAGCTACAGCTGGTGGAA       c.1560
 L  E  P  G  G  D  I  Q  Q  E  A  L  G  D  Q  L  Q  L  V  E         p.520

          .         .         .         .         .         .       g.115951
 GAGGAGTTTGCCCTCCAGGGCGTGAATGCACTCAAGGAAGAGGCCTGTCCTGGGGACACT       c.1620
 E  E  F  A  L  Q  G  V  N  A  L  K  E  E  A  C  P  G  D  T         p.540

          .         .         .         .         .         .       g.116011
 CAGCTGGAGGAGGGCCGGAAGGAGCCGGAGGCCCCTGGGGAAATGCCTGCCCCAGCTGTG       c.1680
 Q  L  E  E  G  R  K  E  P  E  A  P  G  E  M  P  A  P  A  V         p.560

          .         .         .         .         .         .       g.116071
 CACCTGGCCTCCCCGCAGGCCGAAAGCACAGCCCTGCCACCCTGTGAGCTGGAAACCACC       c.1740
 H  L  A  S  P  Q  A  E  S  T  A  L  P  P  C  E  L  E  T  T         p.580

          .         .         .         .         .         .       g.116131
 GTGGTCTCCTCCTCAGACCTGCATTCTCAAGAGGTGGTTTCAGATGATTTTTTGTTGAAA       c.1800
 V  V  S  S  S  D  L  H  S  Q  E  V  V  S  D  D  F  L  L  K         p.600

          .         .         .         .         .         .       g.116191
 AATGATACCTCCTCCGCAGAGGCTCATGCTGCTCCTGAGAAGCCCCCAGACATGCAGCAC       c.1860
 N  D  T  S  S  A  E  A  H  A  A  P  E  K  P  P  D  M  Q  H         p.620

          .         .         .         .         .         .       g.116251
 AGAAGCTCAGTCCAGACGCAAGGTGAAGTGATCACACTACTGCTGTCCAAGGCCCAGAGT       c.1920
 R  S  S  V  Q  T  Q  G  E  V  I  T  L  L  L  S  K  A  Q  S         p.640

          .         .         .         .         .         .       g.116311
 GCTGGGTCAGATCAGGAAAGCCATGGCGCCCAGAGCCCCCTAGGGGAAGGGCAGAACATG       c.1980
 A  G  S  D  Q  E  S  H  G  A  Q  S  P  L  G  E  G  Q  N  M         p.660

          .         .         .         .         .         .       g.116371
 GCTGTGCTTTCAGCTGGTGACCCAGATCCCAGCAGGTGTCTCAGGTCAAACCCAGCTGAG       c.2040
 A  V  L  S  A  G  D  P  D  P  S  R  C  L  R  S  N  P  A  E         p.680

          .         .         .         .         .         .       g.116431
 GCCTCAGACCTCCTCCCTCCAGTAGCTGGTGGTGGGGACACCATCACACATCAGCCTGAC       c.2100
 A  S  D  L  L  P  P  V  A  G  G  G  D  T  I  T  H  Q  P  D         p.700

          .         .         .         .         .         .       g.116491
 TCTTGCAAAGCTGCCCCTGAGCACCGGTCAGGCATCACCGCTTTCATGAAGGTCCTGAAC       c.2160
 S  C  K  A  A  P  E  H  R  S  G  I  T  A  F  M  K  V  L  N         p.720

          .         .         .         .         .         .       g.116551
 AGTTTACAGAAGAAGCAAATGAACACCAGCTTGTGTGAGCGGATCCGGAAGGTTTATGGA       c.2220
 S  L  Q  K  K  Q  M  N  T  S  L  C  E  R  I  R  K  V  Y  G         p.740

          .         .   | 07     .         .         .         .    g.117419
 GACCTGGAGTGTGAATACTGTG | GCAAACTTTTTTGGTACCAAGTGCATTTTGATATGCAT    c.2280
 D  L  E  C  E  Y  C  G |   K  L  F  W  Y  Q  V  H  F  D  M  H      p.760

          .         .         .         .         .         .       g.117479
 GTCCGCACCCACACCCGGGAACATCTGTATTATTGCTCTCAGTGTCATTATTCTTCCATC       c.2340
 V  R  T  H  T  R  E  H  L  Y  Y  C  S  Q  C  H  Y  S  S  I         p.780

          .         .         .         .         .         .       g.117539
 ACCAAAAACTGCCTTAAACGCCACGTAATTCAGAAACACAGTAACATCTTGCTGAAGTGT       c.2400
 T  K  N  C  L  K  R  H  V  I  Q  K  H  S  N  I  L  L  K  C         p.800

          .         .         .         .         .         .       g.117599
 CCCACCGATGGCTGTGACTACTCAACTCCAGATAAATATAAGCTACAGGCACATCTTAAA       c.2460
 P  T  D  G  C  D  Y  S  T  P  D  K  Y  K  L  Q  A  H  L  K         p.820

          .      | 08  .         .         .         .         .    g.127739
 GTTCACACAGCACTG | GACAAAAGGAGTTATTCTTGTCCTGTTTGTGAAAAGTCTTTTTCA    c.2520
 V  H  T  A  L   | D  K  R  S  Y  S  C  P  V  C  E  K  S  F  S      p.840

          .         .         .         .    | 09    .         .    g.129671
 GAGGATCGATTGATAAAGTCACATATCAAGACCAACCATCCTG | AGGTCTCCATGAGCACC    c.2580
 E  D  R  L  I  K  S  H  I  K  T  N  H  P  E |   V  S  M  S  T      p.860

          .         .         .         .         .         .       g.129731
 ATTTCTGAGGTTCTCGGGAGGAGGGTTCAGCTGAAAGGGCTAATTGGAAAGAGAGCCATG       c.2640
 I  S  E  V  L  G  R  R  V  Q  L  K  G  L  I  G  K  R  A  M         p.880

          .         .         .         .         .         .       g.129791
 AAATGCCCATATTGTGACTTTTATTTCATGAAGAATGGCTCAGACCTTCAGCGTCATATT       c.2700
 K  C  P  Y  C  D  F  Y  F  M  K  N  G  S  D  L  Q  R  H  I         p.900

          .    | 10    .         .         .         .         .    g.134091
 TGGGCTCATGAAG | GTGTGAAGCCCTTCAAGTGTTCTTTGTGTGAGTATGCAACTCGTAGC    c.2760
 W  A  H  E  G |   V  K  P  F  K  C  S  L  C  E  Y  A  T  R  S      p.920

          .         .         .         .         .         .       g.134151
 AAGAGTAACCTCAAGGCTCATATGAATCGTCACAGCACTGAGAAAACCCACCTATGTGAC       c.2820
 K  S  N  L  K  A  H  M  N  R  H  S  T  E  K  T  H  L  C  D         p.940

          .         .         .         .         .         .       g.134211
 ATGTGTGGCAAGAAATTCAAATCAAAAGGGACACTGAAAAGTCACAAACTCCTTCACACT       c.2880
 M  C  G  K  K  F  K  S  K  G  T  L  K  S  H  K  L  L  H  T         p.960

         | 11.         .         .         .         .         .    g.152681
 GCAGATG | GGAAGCAGTTTAAGTGCACGGTGTGTGACTACACAGCGGCCCAGAAGCCACAG    c.2940
 A  D  G |   K  Q  F  K  C  T  V  C  D  Y  T  A  A  Q  K  P  Q      p.980

          .         .         .       | 12 .         .         .    g.185101
 CTGCTGCGGCACATGGAACAGCATGTCTCCTTCAAG | CCTTTCCGCTGTGCCCATTGCCAT    c.3000
 L  L  R  H  M  E  Q  H  V  S  F  K   | P  F  R  C  A  H  C  H      p.1000

          .         .         .         .         .         .       g.185161
 TACTCCTGCAACATATCTGGCTCTCTGAAGCGGCACTACAACAGGAAGCACCCTAATGAG       c.3060
 Y  S  C  N  I  S  G  S  L  K  R  H  Y  N  R  K  H  P  N  E         p.1020

          .         .         .         .         .      | 13  .    g.197053
 GAGTATGCCAACGTGGGCACCGGGGAGCTGGCAGCGGAGGTGCTCATCCAGCAAG | GTGGT    c.3120
 E  Y  A  N  V  G  T  G  E  L  A  A  E  V  L  I  Q  Q  G |   G      p.1040

          .         .         .         .         .         .       g.197113
 TTGAAGTGTCCTGTTTGCAGCTTTGTATATGGCACCAAATGGGAGTTCAATAGGCACTTG       c.3180
 L  K  C  P  V  C  S  F  V  Y  G  T  K  W  E  F  N  R  H  L         p.1060

          .         .         .         .         .     | 14   .    g.205454
 AAGAACAAACATGGCTTGAAGGTGGTGGAAATTGATGGAGACCCCAAGTGGGAG | ACAGCA    c.3240
 K  N  K  H  G  L  K  V  V  E  I  D  G  D  P  K  W  E   | T  A      p.1080

          .         .         .         .         .         .       g.205514
 ACAGAAGCTCCTGAGGAGCCCTCCACCCAGTATCTCCACATCACAGAGGCCGAAGAAGAC       c.3300
 T  E  A  P  E  E  P  S  T  Q  Y  L  H  I  T  E  A  E  E  D         p.1100

          .         .         .         .         .         .       g.205574
 GTTCAAGGGACACAGGCAGCGGTGGCCGCGCTCCAGGACCTGAGATACACCTCTGAGAGT       c.3360
 V  Q  G  T  Q  A  A  V  A  A  L  Q  D  L  R  Y  T  S  E  S         p.1120

   | 15      .         .         .         .         .         .    g.208359
 G | GCGACCGACTGGACCCCACGGCCGTGAACATCCTGCAGCAGATCATTGAGCTGGGCGCC    c.3420
 G |   D  R  L  D  P  T  A  V  N  I  L  Q  Q  I  I  E  L  G  A      p.1140

          .         .         .         .         .         .       g.208419
 GAGACCCATGACGCCACTGCCCTTGCCTCGGTGGTTGCCATGGCACCAGGGACGGTGACT       c.3480
 E  T  H  D  A  T  A  L  A  S  V  V  A  M  A  P  G  T  V  T         p.1160

          .   | 16     .         .         .         .         .    g.239376
 GTGGTTAAGCAG | GTCACCGAGGAGGAGCCCAGCTCCAACCACACGGTCATGATCCAGGAG    c.3540
 V  V  K  Q   | V  T  E  E  E  P  S  S  N  H  T  V  M  I  Q  E      p.1180

          .         .         .         .         .         .       g.239436
 ACGGTCCAGCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTGTCCTCCGAC       c.3600
 T  V  Q  Q  A  S  V  E  L  A  E  Q  H  H  L  V  V  S  S  D         p.1200

          .         .         .         .         .         .       g.239496
 GACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCAGGGCGGGGAGGCCTCGGAGTTC       c.3660
 D  V  E  G  I  E  T  V  T  V  Y  T  Q  G  G  E  A  S  E  F         p.1220

          .         .         .         .         .         .       g.239556
 ATCGTCTACGTGCAGGAGGCCATGCAGCCTGTGGAGGAGCAGGCTGTGGAGCAGCCGGCC       c.3720
 I  V  Y  V  Q  E  A  M  Q  P  V  E  E  Q  A  V  E  Q  P  A         p.1240

          .                                                         g.239568
 CAGGAACTCTAG                                                       c.3732
 Q  E  L  X                                                         p.1243

          .         .         .         .         .         .       g.239628
 aggacatgtggcatcggatggccacagggcggggctgccaggctctgcaggcacccaggg       c.*60

          .         .         .         .         .         .       g.239688
 tggggaggccacccttcctgccctacccgcagaatggtgctctcctttgccctccctgcc       c.*120

          .         .         .         .         .         .       g.239748
 cagcagcctgataggactctcctagtccaacttggggtgggcaaggcagtcagcatcacc       c.*180

          .         .         .         .         .         .       g.239808
 agcaataccacaggaccctcaccccagcatagacacacaccccctgacccttaccatctg       c.*240

          .         .         .         .         .         .       g.239868
 cttcctgaaagacttcagtgtcagctcccctacacacaccccacaccttcaccccttgct       c.*300

          .         .         .         .         .         .       g.239928
 tcaagattcaaacagagactcccagtccccctcagcatcttccctgaatcacagccccag       c.*360

          .         .         .         .         .         .       g.239988
 ctccttgacccccatctaggtgccaaatgttcatctgcaaccgctatgcagtctggtgag       c.*420

          .         .         .         .         .         .       g.240048
 agggagacagccatcacatagaaagtgaccgtacgggtttttaatcactgctgggtgggg       c.*480

          .         .         .         .         .         .       g.240108
 tgggggtagggggattgtcctggctttgtcgacaaagtcccacttccccgagtattaagg       c.*540

          .         .         .         .         .         .       g.240168
 gcccttggtatcaagtgaggtaaattcacccatcacagggtctcgccctaccatcctgga       c.*600

          .         .         .         .         .         .       g.240228
 attatttcacttttaagataaatgcactatttcactgttcgcctcccattctaaggaggt       c.*660

          .         .         .                                     g.240262
 gaggtggttggaataaaaacagttcctgtctgaa                                 c.*694

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Zinc finger and AT hook domain containing protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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