zinc finger with KRAB and SCAN domains 4 (ZKSCAN4) - coding DNA reference sequence

(used for variant description)

(last modified May 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_019110.3 in the ZKSCAN4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering ZKSCAN4 transcript NM_019110.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         ccaa       c.-241

 .         .         .         .         .         .                g.5064
 agacatcctttggtgatacttactgtgggattcagagtggggtgcagaggacgaccctgc       c.-181

 .         .         .         .         .         .                g.5124
 aaaggcacggactataagagagatctgtgcagctgcgcctcagggggtgtcctgggcccc       c.-121

 .         .         .         .         .         .                g.5184
 tgggcatgacaggagggggaccacttgcagttctactggaaaatttaccacccttccaga       c.-61

 .         .         .         .         .         .                g.5244
 atcctctgaagatatacaggtcgcaactagagtgagacccgagtactgccttgggtcaga       c.-1

          .         .         .         .         .         .       g.5304
 ATGGCTAGAGAACCGAGAAAAAACGCAGCCCTGGACGCCCAGTCTGCAGAAGACCAGACG       c.60
 M  A  R  E  P  R  K  N  A  A  L  D  A  Q  S  A  E  D  Q  T         p.20

          .         .         .         .         .         .       g.5364
 GGGCTCCTGACCGTGAAGGTGGAGAAGGAGGAAGCCTCCGCCTTGACGGCGGAGGTGAGA       c.120
 G  L  L  T  V  K  V  E  K  E  E  A  S  A  L  T  A  E  V  R         p.40

          .         .         .         .         .         .       g.5424
 GCACCCTGCAGCCCTGCTCGGGGCCCCGAACGCTCCCGCCAGCGCTTCCGAGGCTTCCGC       c.180
 A  P  C  S  P  A  R  G  P  E  R  S  R  Q  R  F  R  G  F  R         p.60

          .         .         .         .         .         .       g.5484
 TACCCGGAGGCTGCGGGCCCCCGCGAGGCGTTGAGCCGGCTCCGAGAACTCTGCGGACAA       c.240
 Y  P  E  A  A  G  P  R  E  A  L  S  R  L  R  E  L  C  G  Q         p.80

          .         .         .         .         .         .       g.5544
 TGGCTGCAGCCTGAGATGCACAGCAAGGAGCAGATCCTGGAGCTGCTGGTGCTGGAGCAG       c.300
 W  L  Q  P  E  M  H  S  K  E  Q  I  L  E  L  L  V  L  E  Q         p.100

          .         .         .         .         .         .       g.5604
 TTCCTGACCATCCTGCCGGGGAATCTGCAGAGCTGGGTGCGGGAGCAGCATCCAGAGAGC       c.360
 F  L  T  I  L  P  G  N  L  Q  S  W  V  R  E  Q  H  P  E  S         p.120

          .         .         .         .         .         .       g.5664
 GGGGAGGAGGTGGTGGTGCTATTGGAGTATTTGGAGAGGCAGCTGGATGAGCCGGCGCCG       c.420
 G  E  E  V  V  V  L  L  E  Y  L  E  R  Q  L  D  E  P  A  P         p.140

     | 02    .         .         .         .         .         .    g.7447
 CAG | GTTCCCGTTGGTGACCAGGGGCAAGAACTGCTCTGTTGCAAGATGGCACTATTGACA    c.480
 Q   | V  P  V  G  D  Q  G  Q  E  L  L  C  C  K  M  A  L  L  T      p.160

          .         .         .         .         .         .       g.7507
 CAAACTCAAGGGTCTCAAAGTAGCCAGTGCCAGCCAATGAAGGCTCTGTTCAAGCATGAA       c.540
 Q  T  Q  G  S  Q  S  S  Q  C  Q  P  M  K  A  L  F  K  H  E         p.180

          .         .         .  | 03      .         .         .    g.9104
 TCTCTGGGATCCCAGCCCTTACACGATAGAG | TTCTCCAGGTTCCTGGGCTTGCCCAGGGA    c.600
 S  L  G  S  Q  P  L  H  D  R  V |   L  Q  V  P  G  L  A  Q  G      p.200

          .         .         .         .         .     | 04   .    g.10138
 GGGTGCTGCAGAGAAGATGCAATGGTAGCTTCCAGGCTCACTCCAGGGTCCCAG | GGTTTG    c.660
 G  C  C  R  E  D  A  M  V  A  S  R  L  T  P  G  S  Q   | G  L      p.220

          .         .         .         .         .         .       g.10198
 CTGAAAATGGAAGATGTGGCCCTGACCCTCACTCCTGGGTGGACACAGCTGGATTCATCT       c.720
 L  K  M  E  D  V  A  L  T  L  T  P  G  W  T  Q  L  D  S  S         p.240

          .         .         .         .         .         | 05    g.11251
 CAGGTGAACCTCTACAGAGATGAAAAGCAGGAGAACCATAGCAGCCTGGTCTCCCTTG | GT    c.780
 Q  V  N  L  Y  R  D  E  K  Q  E  N  H  S  S  L  V  S  L  G |       p.260

          .         .         .         .         .         .       g.11311
 GGTGAAATACAGACTAAGAGCAGGGACTTGCCTCCAGTCAAGAAGCTTCCAGAAAAGGAG       c.840
 G  E  I  Q  T  K  S  R  D  L  P  P  V  K  K  L  P  E  K  E         p.280

          .         .         .         .         .         .       g.11371
 CATGGGAAGATATGCCACCTGAGGGAAGACATTGCCCAGATTCCTACACATGCAGAAGCT       c.900
 H  G  K  I  C  H  L  R  E  D  I  A  Q  I  P  T  H  A  E  A         p.300

          .         .         .         .         .         .       g.11431
 GGTGAACAGGAGGGCAGGTTACAAAGAAAGCAGAAAAATGCCATAGGGAGTAGGCGACAT       c.960
 G  E  Q  E  G  R  L  Q  R  K  Q  K  N  A  I  G  S  R  R  H         p.320

          .         .         .         .         .         .       g.11491
 TATTGCCATGAATGTGGAAAGAGTTTTGCTCAAAGTTCAGGCCTGACTAAACACAGGAGA       c.1020
 Y  C  H  E  C  G  K  S  F  A  Q  S  S  G  L  T  K  H  R  R         p.340

          .         .         .         .         .         .       g.11551
 ATCCACACTGGTGAGAAACCCTATGAATGTGAAGACTGTGGAAAGACCTTCATTGGGAGC       c.1080
 I  H  T  G  E  K  P  Y  E  C  E  D  C  G  K  T  F  I  G  S         p.360

          .         .         .         .         .         .       g.11611
 TCTGCCCTTGTCATTCATCAGAGAGTCCACACTGGTGAGAAGCCATATGAGTGTGAAGAA       c.1140
 S  A  L  V  I  H  Q  R  V  H  T  G  E  K  P  Y  E  C  E  E         p.380

          .         .         .         .         .         .       g.11671
 TGTGGTAAGGTCTTCAGTCACAGCTCAAACCTTATCAAACACCAGAGAACCCACACTGGG       c.1200
 C  G  K  V  F  S  H  S  S  N  L  I  K  H  Q  R  T  H  T  G         p.400

          .         .         .         .         .         .       g.11731
 GAGAAGCCCTATGAGTGTGATGACTGTGGGAAGACCTTCAGCCAGAGCTGCAGCCTCCTT       c.1260
 E  K  P  Y  E  C  D  D  C  G  K  T  F  S  Q  S  C  S  L  L         p.420

          .         .         .         .         .         .       g.11791
 GAACATCACAAAATTCATACTGGGGAGAAGCCATACCAGTGCAATATGTGTGGCAAAGCC       c.1320
 E  H  H  K  I  H  T  G  E  K  P  Y  Q  C  N  M  C  G  K  A         p.440

          .         .         .         .         .         .       g.11851
 TTTAGGCGGAATTCACATCTCCTGAGACATCAGAGGATTCATGGTGATAAAAATGTTCAG       c.1380
 F  R  R  N  S  H  L  L  R  H  Q  R  I  H  G  D  K  N  V  Q         p.460

          .         .         .         .         .         .       g.11911
 AATCCTGAGCACGGGGAGTCCTGGGAAAGTCAGGGTAGGACGGAAAGCCAGTGGGAAAAT       c.1440
 N  P  E  H  G  E  S  W  E  S  Q  G  R  T  E  S  Q  W  E  N         p.480

          .         .         .         .         .         .       g.11971
 ACTGAGGCTCCCGTGTCTTATAAATGTAATGAGTGTGAGAGAAGTTTCACACGGAATAGA       c.1500
 T  E  A  P  V  S  Y  K  C  N  E  C  E  R  S  F  T  R  N  R         p.500

          .         .         .         .         .         .       g.12031
 AGTCTTATTGAACATCAGAAAATCCACACTGGTGAGAAACCCTATCAGTGTGACACATGT       c.1560
 S  L  I  E  H  Q  K  I  H  T  G  E  K  P  Y  Q  C  D  T  C         p.520

          .         .         .         .         .         .       g.12091
 GGAAAAGGTTTCACTCGAACTTCATACCTTGTTCAACATCAGAGAAGCCATGTAGGGAAA       c.1620
 G  K  G  F  T  R  T  S  Y  L  V  Q  H  Q  R  S  H  V  G  K         p.540

          .                                                         g.12109
 AAAACTCTTTCACAGTGA                                                 c.1638
 K  T  L  S  Q  X                                                   p.545

          .         .         .         .         .         .       g.12169
 cccatggtattcatgccaacattggtgctcatttgtcactgaactgaagccaccctggag       c.*60

          .         .         .         .         .         .       g.12229
 cccttaatggttacagaaattgtggaccagggctttatttaccactatacatcatcgggt       c.*120

          .         .         .         .         .         .       g.12289
 attagaaaatgtagtctggctgagacgatgagttatcttctacattctagaaagtgattg       c.*180

          .         .         .         .         .         .       g.12349
 gaagaagtcatttgataagaggccatgggagagtggtctggaagttgtaggacctaaaat       c.*240

          .         .         .         .         .         .       g.12409
 agtttgttctcacccagtgtatttaaatggccttctggacttgttaattgccctcagcca       c.*300

          .         .         .         .         .         .       g.12469
 gcactttaggacatctggttggatggctctgatgtggggggctgctgctctgaccattca       c.*360

          .         .         .         .                           g.12513
 ttttgcctctaatgaatctttcacaaattggtcagatccatgag                       c.*404

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Zinc finger with KRAB and SCAN domains 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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