zinc finger protein 185 (LIM domain) (ZNF185) - coding DNA reference sequence

(used for variant description)

(last modified June 4, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001178106.1 in the ZNF185 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021255.1, covering ZNF185 transcript NM_001178106.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             cagaagccctgctgaatcaagtgagaggagagctgcggagcaatcacc       c.-1

          .         .         .     | 02   .         .         .    g.5294
 ATGAGTATCTCAGCTCTTGGAGGCCGCACCAAAG | GGAAGCCTCTGCCACCAGGCGAGGAG    c.60
 M  S  I  S  A  L  G  G  R  T  K  G |   K  P  L  P  P  G  E  E      p.20

          .         .         .         .         .         .       g.5354
 GAGCGCAATAACGTTCTCAAGCAGATGAAAGTGCGAACCACGCTGAAGGGGGACAAGAGC       c.120
 E  R  N  N  V  L  K  Q  M  K  V  R  T  T  L  K  G  D  K  S         p.40

          .         .         .         | 03         .         .    g.5718
 TGGATTACCAAGCAGGATGAATCGGAGGGTCGCACCAT | AGAGCTGCCCTCAGGCCGGAGT    c.180
 W  I  T  K  Q  D  E  S  E  G  R  T  I  |  E  L  P  S  G  R  S      p.60

          .         .         .         .     | 04   .         .    g.7705
 CGCGCCACATCCTTTTCATCAGCTGGGGAGGTTCCGAAGCCTAG | GCCTCCGAGCACAAGG    c.240
 R  A  T  S  F  S  S  A  G  E  V  P  K  P  R  |  P  P  S  T  R      p.80

          .         .    | 05    .         .         .         .    g.7880
 GCTCCCACTGGCTACATCATCCG | GGGAGTGTTCACCAAGCCCATAGACAGCTCTTCCCAG    c.300
 A  P  T  G  Y  I  I  R  |  G  V  F  T  K  P  I  D  S  S  S  Q      p.100

          .         .         .         .  | 06      .         .    g.8642
 CCCCAGCAGCAGTTCCCCAAGGCCAACGGGACTCCAAAAAG | TGCTGCCAGTCTGGTGAGA    c.360
 P  Q  Q  Q  F  P  K  A  N  G  T  P  K  S  |  A  A  S  L  V  R      p.120

          .         .         .         .         .         .       g.8702
 ACAGCTAACGCTGGTCCTCCCCGCCCCTCCTCCTCTGGCTACAAGATGACCACTGAGGAT       c.420
 T  A  N  A  G  P  P  R  P  S  S  S  G  Y  K  M  T  T  E  D         p.140

          .  | 07      .         .         .         .         .    g.9590
 TACAAGAAGCT | GGCACCCTACAATATCAGGCGCAGCTCTACATCAGGGGACACCGAGGAG    c.480
 Y  K  K  L  |  A  P  Y  N  I  R  R  S  S  T  S  G  D  T  E  E      p.160

          .         .         .         .         . | 08       .    g.10896
 GAGGAGGAGGAGGAGGTGGTGCCATTCTCCTCAGATGAACAGAAACGGAG | GTCAGAGGCT    c.540
 E  E  E  E  E  V  V  P  F  S  S  D  E  Q  K  R  R  |  S  E  A      p.180

          .         .         .         .         .         .       g.10956
 GCAAGCGGTGTTCTGAGGAGGACAGCTCCCCGGGAGCACTCCTACGTCCTGTCAGCGGCC       c.600
 A  S  G  V  L  R  R  T  A  P  R  E  H  S  Y  V  L  S  A  A         p.200

          .     | 09   .         .         .         .    | 10    . g.12738
 AAGAAGAGCACTGG | TCCTACCCAGGAGACACAGGCACCGTTTATCGCGAAGAG | GGTGGAG c.660
 K  K  S  T  G  |  P  T  Q  E  T  Q  A  P  F  I  A  K  R  |  V  E   p.220

          .         .         .         .         .         .       g.12798
 GTGGTGGAAGAGGACGGGCCTTCTGAGAAGAGCCAGGACCCACCTGCTCTGGCAAGATCC       c.720
 V  V  E  E  D  G  P  S  E  K  S  Q  D  P  P  A  L  A  R  S         p.240

          .        | 11.         .         .         .         .    g.13321
 ACTCCTGGCTCAAACAG | TGCGGATGGAGGCAGGACCAAAGCGTCTCGGGCAATTTGGATC    c.780
 T  P  G  S  N  S  |  A  D  G  G  R  T  K  A  S  R  A  I  W  I      p.260

          .         .         .         .        | 12.         .    g.19146
 GAGTGCCTGCCAAGTATGCCTAGCCCCGCTGGGAGCCAGGAGCTCAG | CTCAAGAGGTGAG    c.840
 E  C  L  P  S  M  P  S  P  A  G  S  Q  E  L  S  |  S  R  G  E      p.280

          .         .         .         .         .         .       g.19206
 GAAATTGTCCGCCTGCAGATCCTGACACCCAGGGCAGGACTCCGCCTGGTGGCCCCAGAC       c.900
 E  I  V  R  L  Q  I  L  T  P  R  A  G  L  R  L  V  A  P  D         p.300

          .     | 13   .         .         .         .         .    g.22276
 GTGGAAGGCATGAG | GTCTTCCCCAGGCAACAAAGACAAGGAGGCCCCCTGCTCCAGAGAG    c.960
 V  E  G  M  R  |  S  S  P  G  N  K  D  K  E  A  P  C  S  R  E      p.320

          .         .         .         .         .          | 14    g.23432
 CTCCAGAGGGACTTGGCTGGTGAGGAGGCTTTCAGGGCCCCCAACACAGATGCTGCAAG | G    c.1020
 L  Q  R  D  L  A  G  E  E  A  F  R  A  P  N  T  D  A  A  R  |      p.340

          .         .         .         .         .         .       g.23492
 TCAAGTGCACAGTTGAGTGATGGCAATGTGGGATCCGGAGCCACGGGCTCCCGGCCTGAA       c.1080
 S  S  A  Q  L  S  D  G  N  V  G  S  G  A  T  G  S  R  P  E         p.360

          .         .         .         | 15         .         .    g.26998
 GGCTTGGCTGCAGTAGACATCGGCTCCGAGAGAGGAAG | GCTGTGTGCAGCTGCTAGCTTT    c.1140
 G  L  A  A  V  D  I  G  S  E  R  G  R  |  L  C  A  A  A  S  F      p.380

          .         .         .         .         .         .       g.27058
 GCCTCTTTCCTGGAAGACCAGGATGGGCACAGTGCCAACTCTCAGTCCTGCAAGCCTAGA       c.1200
 A  S  F  L  E  D  Q  D  G  H  S  A  N  S  Q  S  C  K  P  R         p.400

          .     | 16   .         .         .         .         .    g.28678
 CCAGCAGCCATCAG | CTCCAGTGCCACTTCAGTCTCTGCTGTCCCTGCTGATAGGAAGAGC    c.1260
 P  A  A  I  S  |  S  S  A  T  S  V  S  A  V  P  A  D  R  K  S      p.420

          .         .         .         .     | 17   .         .    g.35841
 AACAGCACAGCAGCCCAGGAGGATGCAAAGGCAGACCCAAAGGG | GGCCTTGGCTGATTAT    c.1320
 N  S  T  A  A  Q  E  D  A  K  A  D  P  K  G  |  A  L  A  D  Y      p.440

          .         .         .         .         .         .       g.35901
 GAGGGGAAGGATGTGGCCACCAGGGTCGGAGAGGCCTGGCAGGAGAGGCCTGGAGCTCCA       c.1380
 E  G  K  D  V  A  T  R  V  G  E  A  W  Q  E  R  P  G  A  P         p.460

          .         .         .         .         .         .       g.35961
 AGAGGTGGCCAAGGAGACCCAGCTGTACCCGCTCAGCAACCTGCAGATCCCAGCACCCCA       c.1440
 R  G  G  Q  G  D  P  A  V  P  A  Q  Q  P  A  D  P  S  T  P         p.480

          .         .         .         .         .         .       g.36021
 GAGCGGCAGAGCAGCCCCAGCGGATCTGAGCAACTTGTCAGACGAGAGAGTTGTGGCAGC       c.1500
 E  R  Q  S  S  P  S  G  S  E  Q  L  V  R  R  E  S  C  G  S         p.500

    | 18     .         .         .         .         .         .    g.50315
 AG | CGTGTTGACTGATTTTGAGGGGAAGGATGTGGCCACCAAGGTCGGAGAGGCCTGGCAG    c.1560
 S  |  V  L  T  D  F  E  G  K  D  V  A  T  K  V  G  E  A  W  Q      p.520

          .         .         .         .         .         .       g.50375
 GACAGGCCTGGAGCCCCAAGAGGTGGCCAAGGAGACCCAGCTGTACCCACTCAGCAACCT       c.1620
 D  R  P  G  A  P  R  G  G  Q  G  D  P  A  V  P  T  Q  Q  P         p.540

          .         .         .         .         .         .       g.50435
 GCAGATCCCAGTACCCCAGAACAGCAGAACAGCCCCAGCGGATCTGAGCAATTCGTCAGA       c.1680
 A  D  P  S  T  P  E  Q  Q  N  S  P  S  G  S  E  Q  F  V  R         p.560

          .         . | 19       .         .         .         .    g.54437
 CGAGAGAGCTGCACCAGCAG | GGTGAGGAGCCCCTCGAGCTGCATGGTCACTGTTACTGTC    c.1740
 R  E  S  C  T  S  R  |  V  R  S  P  S  S  C  M  V  T  V  T  V      p.580

          .         .         .         .         .         .       g.54497
 ACTGCCACATCTGAGCAGCCTCACATTTATATTCCAGCCCCCGCAAGTGAATTGGACTCC       c.1800
 T  A  T  S  E  Q  P  H  I  Y  I  P  A  P  A  S  E  L  D  S         p.600

          .  | 20      .         .         .         .         .    g.56054
 AGCTCTACCAC | CAAAGGGATTCTCTTCGTGAAGGAGTACGTGAATGCTAGTGAAGTGTCT    c.1860
 S  S  T  T  |  K  G  I  L  F  V  K  E  Y  V  N  A  S  E  V  S      p.620

          .         .         .   | 21     .         .         .    g.57753
 TCTGGGAAGCCAGTATCTGCACGCTATAGCAA | CGTCAGCAGCATTGAGGACTCATTCGCC    c.1920
 S  G  K  P  V  S  A  R  Y  S  N  |  V  S  S  I  E  D  S  F  A      p.640

          .         .         .         .     | 22   .         .    g.59956
 ATGGAGAAGAAGCCTCCATGTGGCAGCACTCCATACTCTGAGAG | GACAACTGGAGGGATC    c.1980
 M  E  K  K  P  P  C  G  S  T  P  Y  S  E  R  |  T  T  G  G  I      p.660

          .         .         .         .         .         .       g.60016
 TGTACTTACTGCAACCGTGAGATCCGAGACTGTCCAAAGATTACCCTAGAACATCTTGGT       c.2040
 C  T  Y  C  N  R  E  I  R  D  C  P  K  I  T  L  E  H  L  G         p.680

          .         .        | 23.         .         .         .    g.61034
 ATCTGCTGCCATGAATATTGCTTTAAG | TGTGGGATTTGCAGTAAACCGATGGGCGATCTC    c.2100
 I  C  C  H  E  Y  C  F  K   | C  G  I  C  S  K  P  M  G  D  L      p.700

          .         .         .         .         .         .       g.61094
 CTGGATCAGATCTTCATTCACCGTGACACCATTCACTGTGGGAAATGCTATGAGAAGCTC       c.2160
 L  D  Q  I  F  I  H  R  D  T  I  H  C  G  K  C  Y  E  K  L         p.720

                                                                g.61100
 TTCTAG |                                                          c.2167
 F  X                                                            p.721

  | 24       .         .         .         .         .         .    g.61892
  | cgaccccccaccgccaggctgatcagaagctgatgactcgtggacaaatttggctgtccc    c.*60

          .         .         .         .         .         .       g.61952
 cagttttgccccaagttgctgtctccccttccctcacctcctccctccctgtttgatttc       c.*120

          .         .         .         .         .         .       g.62012
 ttcatgcttttgcccttctcaagttgaagttgcatacatccaatatcgtatcttaatgat       c.*180

          .         .         .         .         .         .       g.62072
 gctatgataattgcttgtgtgtgtagcttcttgtagcttagaaagcgctttatgcccatg       c.*240

          .         .         .         .         .         .       g.62132
 atgtcatttcaggctcaaccaaagaggatcaaacaggaattccatcttggcttccctaag       c.*300

          .         .         .         .         .         .       g.62192
 acagattggctttctaatgagtttaagtgggcagaagtgtagggttcagtgtgtcctgac       c.*360

          .         .         .         .         .         .       g.62252
 tcccttgaggcttataatgggccaagttgaagactgttgatgatccctggtgggtaaatt       c.*420

          .         .         .         .         .         .       g.62312
 gcagacatcaaatgctagggattggcataggctagtgtttagcttgtctatttgccatat       c.*480

          .         .         .         .         .         .       g.62372
 ctattttttttaaatttccatacacttgtaaaagtagttagttgcttttgattgagttat       c.*540

          .         .         .         .         .         .       g.62432
 atagcagtttttcatttggtcttccactcacctttcactatatttgagtgttcccttaca       c.*600

          .         .         .         .         .         .       g.62492
 ggtatgttggcatgtgttggaaaatttacacaattaggtttaaattcagtaggatgtgat       c.*660

          .         .         .         .         .         .       g.62552
 tttaggatgctactgatcaaagtgatatctgtgtctgttggaatcttgatagctgattaa       c.*720

          .         .         .         .         .         .       g.62612
 tttgccctcaattctgctccctgaacttcacacataaatcttcccaagtgggttttaggg       c.*780

          .         .         .         .         .         .       g.62672
 tgtatagatcccagcaggattaaggaggtggaaaagcagctaacatttcttgaggctcta       c.*840

          .         .         .         .         .         .       g.62732
 ccacatagcaggcactgtcacagagtaatggcattaatccccataataatcctgtgaagg       c.*900

          .         .         .         .         .         .       g.62792
 tgatattctcatcccatcttagacatgaggatattggaactcagagaggtggctattgca       c.*960

          .         .         .         .         .         .       g.62852
 ttgcgcagaacgctacagagcccatgctcttcccagagcagcacccacaaaagcaagcat       c.*1020

          .         .         .         .         .         .       g.62912
 tgattttgtgctcagtgtgtgccaagcactgtgcagagggtacacagttcctgccaggtt       c.*1080

          .         .         .         .         .         .       g.62972
 aacaccctcccttcaggcctcccaaaggcataggcttgcaaagagcagaaggtgtgaaat       c.*1140

          .         .         .         .         .         .       g.63032
 cacactcttcctctgggcatcctggatccctgaattatccccccccccatgaagtacttc       c.*1200

          .         .         .         .         .         .       g.63092
 aagggccaagctgcccctttccctcctctccgcccatgaaaatgcctccaaactgagatg       c.*1260

          .         .         .         .         .         .       g.63152
 ctttcagctgagaacagatttgactcacagacattaccaaagaggagcttgtgaatccag       c.*1320

          .         .         .         .         .         .       g.63212
 gaaaagctccagggggctagctgatctgagcagagagctttcagtgacccattttcctgt       c.*1380

          .         .         .         .         .         .       g.63272
 ctagactctgccttaagctagtggcaactgctggggccccaggtacttgggacatggaaa       c.*1440

          .         .         .         .         .         .       g.63332
 ctcgttggatggctgggcagatgtaagcctgtccatgcagtcagccgatcctctgctcag       c.*1500

          .         .         .         .         .         .       g.63392
 gttcagctggactctgccatctgtgggcccagcatcactctgtaagttccttgaaaggaa       c.*1560

          .         .         .         .         .         .       g.63452
 gaacaaccttagagtatttctgatacaaaatgagggcctctgctcttgatttaattataa       c.*1620

          .         .         .         .         .         .       g.63512
 aatgtctacgtctttctccagtttctgagccctatgcacattggcttgtgggcttgttct       c.*1680

          .         .         .         .         .         .       g.63572
 tcctgccaaatgatcagagaggaacattccatttatttgtagtggatttcctctggaggg       c.*1740

          .         .         .         .         .         .       g.63632
 catgtacccacactaaataccaactgctcttcctcagctgtagtccccaacatcagactt       c.*1800

          .         .         .         .         .         .       g.63692
 ggcacgtggtggacactaacacacaggcactcaatgaatgagtgaaggaaataaaagtca       c.*1860

          .         .         .         .         .         .       g.63752
 ccccgttggtgagaggtgctatccctgagtctcagtgcaggaccagtggatgaaaggcaa       c.*1920

          .         .         .         .         .         .       g.63812
 ggtaaagaggcccaagataggctggcttcccccgttcaaggtatagtctgcctttaaggg       c.*1980

          .         .         .         .         .         .       g.63872
 agttttagaaccaacatgcaagacattgaaagaaatcttgcaagagccattattgactta       c.*2040

          .         .         .         .         .         .       g.63932
 gatccaaaacagcctctctcatgtctaaaaaggcacagaattttgcagatctgaggaaga       c.*2100

          .         .         .         .         .         .       g.63992
 gggatgcattacctttttgcttcttttcaattgcttagtgtttctaatcatacttaatcc       c.*2160

          .         .         .         .                           g.64040
 acactaatgtgcgcaattataataaatggtaagatatcacatgtgtca                   c.*2208

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Zinc finger protein 185 (LIM domain) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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