zinc finger protein 408 (ZNF408) - coding DNA reference sequence

(used for variant description)

(last modified September 13, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_024741.2 in the ZNF408 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052967.1, covering ZNF408 transcript NM_024741.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5041
                    ataactgtccgactcgtcgctcccaaagagatggctggaac       c.-241

 .         .         .         .         .         .                g.5101
 aattagttccgctttcccagctagtcgaatcactggtgcacctccggaatccgaggttcg       c.-181

 .         .         .         .         .         .                g.5161
 cattgctctcggacagagttctgcctccccagtactcccaaactcccagtcctgtgcacc       c.-121

 .         .         .         .         .         .                g.5221
 aatgaggtccagctctgaggcttctttcctgagaaaaaaatttggaagtccgtgactgtt       c.-61

 .         .         .         .         .         .                g.5281
 tcctggaggagctgagaagaggaagctcacttccggcgtagggaggctttctgacccgga       c.-1

          .         .         .         .         .   | 02     .    g.5640
 ATGGAGGAGGCGGAGGAGCTGCTCTTGGAGGGGAAGAAGGCGCTGCAACTCG | CCCGCGAG    c.60
 M  E  E  A  E  E  L  L  L  E  G  K  K  A  L  Q  L  A |   R  E      p.20

          .         .         .         .         .         .       g.5700
 CCGCGCCTGGGCCTGGACTTAGGATGGAACCCTTCCGGAGAAGGCTGTACGCAGGGCCTC       c.120
 P  R  L  G  L  D  L  G  W  N  P  S  G  E  G  C  T  Q  G  L         p.40

          .         .         .         .         .         .       g.5760
 AAAGACGTCCCACCCGAGCCGACCCGAGACATCCTCGCTTTAAAGAGCCTTCCCCGGGGC       c.180
 K  D  V  P  P  E  P  T  R  D  I  L  A  L  K  S  L  P  R  G         p.60

          .         .         .         .         .         .       g.5820
 TTGGCCCTTGGCCCCTCACTCGCCAAGGAACAGCGCTTGGGGGTCTGGTGTGTCGGGGAC       c.240
 L  A  L  G  P  S  L  A  K  E  Q  R  L  G  V  W  C  V  G  D         p.80

          .         .         .         .         .         .       g.5880
 CCCCTGCAGCCCGGCCTGCTGTGGGGGCCGCTGGAAGAGGAGTCTGCCTCCAAGGAGAAG       c.300
 P  L  Q  P  G  L  L  W  G  P  L  E  E  E  S  A  S  K  E  K         p.100

          .         .         . | 03       .         .         .    g.6967
 GGCGAGGGAGTAAAGCCACGGCAGGAGGAG | AACCTGTCATTAGGCCCATGGGGAGACGTG    c.360
 G  E  G  V  K  P  R  Q  E  E   | N  L  S  L  G  P  W  G  D  V      p.120

          .         .         .   | 04     .         .         .    g.7245
 TGTGCCTGTGAGCAGAGTTCTGGCTGGACTAG | CTTGGTACAACGGGGCAGGCTGGAGAGT    c.420
 C  A  C  E  Q  S  S  G  W  T  S  |  L  V  Q  R  G  R  L  E  S      p.140

          .         .         .         .         .         .       g.7305
 GAGGGAAATGTGGCCCCAGTGCGGATCAGCGAGAGGCTTCATCTGCAAGTGTACCAGCTG       c.480
 E  G  N  V  A  P  V  R  I  S  E  R  L  H  L  Q  V  Y  Q  L         p.160

          .         .         .         .         .         .       g.7365
 GTGCTGCCAGGCTCTGAACTGCTGCTGTGGCCCCAGCCTTCCTCTGAGGGCCCAAGTCTC       c.540
 V  L  P  G  S  E  L  L  L  W  P  Q  P  S  S  E  G  P  S  L         p.180

          .         .         .         .         .         .       g.7425
 ACCCAGCCTGGGCTGGACAAAGAGGCAGCTGTAGCAGTGGTGACAGAAGTGGAGTCTGCT       c.600
 T  Q  P  G  L  D  K  E  A  A  V  A  V  V  T  E  V  E  S  A         p.200

          .         .         .         .         .   | 05     .    g.8594
 GTACAGCAGGAAGTGGCCTCCCCTGGGGAGGATGCAGCAGAACCTTGCATAG | ATCCTGGT    c.660
 V  Q  Q  E  V  A  S  P  G  E  D  A  A  E  P  C  I  D |   P  G      p.220

          .         .         .         .         .         .       g.8654
 TCCCAGTCACCCTCTGGCATCCAGGCAGAGAATATGGTGAGCCCTGGACTTAAGTTCCCA       c.720
 S  Q  S  P  S  G  I  Q  A  E  N  M  V  S  P  G  L  K  F  P         p.240

          .         .         .         .         .         .       g.8714
 ACCCAGGACCGAATTTCCAAGGATAGCCAGCCACTTGGCCCATTGCTTCAGGATGGCGAC       c.780
 T  Q  D  R  I  S  K  D  S  Q  P  L  G  P  L  L  Q  D  G  D         p.260

          .         .         .         .         .         .       g.8774
 GTGGATGAGGAATGCCCGGCCCAGGCACAGATGCCACCTGAACTTCAGAGCAATTCGGCT       c.840
 V  D  E  E  C  P  A  Q  A  Q  M  P  P  E  L  Q  S  N  S  A         p.280

          .         .         .         .         .         .       g.8834
 ACCCAGCAGGACCCAGATGGCAGTGGAGCCAGTTTCTCATCTTCTGCCAGGGGCACCCAG       c.900
 T  Q  Q  D  P  D  G  S  G  A  S  F  S  S  S  A  R  G  T  Q         p.300

          .         .         .         .         .         .       g.8894
 CCGCATGGCTACCTGGCCAAGAAGTTACACAGCCCCAGTGATCAGTGCCCACCCAGAGCA       c.960
 P  H  G  Y  L  A  K  K  L  H  S  P  S  D  Q  C  P  P  R  A         p.320

          .         .         .         .         .         .       g.8954
 AAGACCCCAGAGCCTGGAGCCCAGCAGTCTGGCTTCCCTACACTCTCGCGGAGCCCTCCT       c.1020
 K  T  P  E  P  G  A  Q  Q  S  G  F  P  T  L  S  R  S  P  P         p.340

          .         .         .         .         .         .       g.9014
 GGCCCAGCAGGAAGCTCCCCAAAGCAGGGGCGACGGTACCGGTGTGGAGAGTGTGGCAAG       c.1080
 G  P  A  G  S  S  P  K  Q  G  R  R  Y  R  C  G  E  C  G  K         p.360

          .         .         .         .         .         .       g.9074
 GCATTCCTACAGCTGTGCCACCTAAAGAAGCACGCATTTGTGCACACGGGCCACAAGCCC       c.1140
 A  F  L  Q  L  C  H  L  K  K  H  A  F  V  H  T  G  H  K  P         p.380

          .         .         .         .         .         .       g.9134
 TTTCTTTGCACTGAGTGTGGCAAGAGCTATAGCTCAGAGGAGAGCTTCAAAGCCCATATG       c.1200
 F  L  C  T  E  C  G  K  S  Y  S  S  E  E  S  F  K  A  H  M         p.400

          .         .         .         .         .         .       g.9194
 CTGGGCCACCGTGGGGTGCGGCCCTTCCCCTGTCCACAATGCGACAAGGCCTATGGCACC       c.1260
 L  G  H  R  G  V  R  P  F  P  C  P  Q  C  D  K  A  Y  G  T         p.420

          .         .         .         .         .         .       g.9254
 CAGCGAGACCTCAAAGAGCACCAGGTGGTACATTCAGGTGCCCGGCCCTTTGCTTGTGAC       c.1320
 Q  R  D  L  K  E  H  Q  V  V  H  S  G  A  R  P  F  A  C  D         p.440

          .         .         .         .         .         .       g.9314
 CAGTGTGGCAAGGCCTTTGCCCGCCGGCCCTCCCTGCGGCTGCATCGCAAGACCCACCAG       c.1380
 Q  C  G  K  A  F  A  R  R  P  S  L  R  L  H  R  K  T  H  Q         p.460

          .         .         .         .         .         .       g.9374
 GTGCCAGCTGCCCCTGCCCCTTGCCCATGCCCTGTGTGTGGGCGGCCCCTGGCCAACCAG       c.1440
 V  P  A  A  P  A  P  C  P  C  P  V  C  G  R  P  L  A  N  Q         p.480

          .         .         .         .         .         .       g.9434
 GGCTCCCTGCGGAACCATATGAGGCTCCATACAGGAGAAAAGCCTTTCCTGTGCCCGCAC       c.1500
 G  S  L  R  N  H  M  R  L  H  T  G  E  K  P  F  L  C  P  H         p.500

          .         .         .         .         .         .       g.9494
 TGTGGCCGGGCGTTTCGTCAGCGGGGCAACCTGCGTGGGCATTTGCGGCTCCACACCGGG       c.1560
 C  G  R  A  F  R  Q  R  G  N  L  R  G  H  L  R  L  H  T  G         p.520

          .         .         .         .         .         .       g.9554
 GAGCGTCCTTACCGCTGCCCACACTGTGCCGATGCCTTCCCCCAGCTGCCTGAACTGCGG       c.1620
 E  R  P  Y  R  C  P  H  C  A  D  A  F  P  Q  L  P  E  L  R         p.540

          .         .         .         .         .         .       g.9614
 CGCCATCTCATCTCACACACCGGGGAGGCCCACTTGTGCCCGGTGTGTGGCAAGGCCCTC       c.1680
 R  H  L  I  S  H  T  G  E  A  H  L  C  P  V  C  G  K  A  L         p.560

          .         .         .         .         .         .       g.9674
 CGAGACCCACACACGCTCCGAGCTCACGAGCGCCTGCACTCCGGAGAGAGGCCCTTTCCC       c.1740
 R  D  P  H  T  L  R  A  H  E  R  L  H  S  G  E  R  P  F  P         p.580

          .         .         .         .         .         .       g.9734
 TGTCCCCAGTGTGGCCGTGCTTACACGCTGGCCACCAAGCTGCGGCGCCACCTCAAATCT       c.1800
 C  P  Q  C  G  R  A  Y  T  L  A  T  K  L  R  R  H  L  K  S         p.600

          .         .         .         .         .         .       g.9794
 CACTTGGAGGACAAGCCCTACCGCTGCCCCACCTGTGGCATGGGCTACACCCTCCCGCAG       c.1860
 H  L  E  D  K  P  Y  R  C  P  T  C  G  M  G  Y  T  L  P  Q         p.620

          .         .         .         .         .         .       g.9854
 AGCCTCAGGCGGCATCAGCTCAGTCACCGGCCTGAGGCACCCTGCAGCCCACCCTCTGTG       c.1920
 S  L  R  R  H  Q  L  S  H  R  P  E  A  P  C  S  P  P  S  V         p.640

          .         .         .         .         .         .       g.9914
 CCTTCTGCTGCTTCTGAGCCCACTGTGGTGCTCCTGCAGGCTGAGCCACAACTGCTGGAC       c.1980
 P  S  A  A  S  E  P  T  V  V  L  L  Q  A  E  P  Q  L  L  D         p.660

          .         .         .         .         .         .       g.9974
 ACACACAGAGAGGAGGAAGTCTCCCCCGCCAGGGATGTTGTTGAGGTCACCATTTCAGAA       c.2040
 T  H  R  E  E  E  V  S  P  A  R  D  V  V  E  V  T  I  S  E         p.680

          .         .         .         .         .         .       g.10034
 AGCCAGGAGAAGTGCTTTGTGGTGCCAGAGGAGCCAGATGCCGCCCCCAGCCTGGTGCTA       c.2100
 S  Q  E  K  C  F  V  V  P  E  E  P  D  A  A  P  S  L  V  L         p.700

          .         .         .         .         .         .       g.10094
 ATCCATAAGGACATGGGCCTCGGCGCCTGGGCAGAGGTGGTGGAGGTGGAGATGGGCACC       c.2160
 I  H  K  D  M  G  L  G  A  W  A  E  V  V  E  V  E  M  G  T         p.720

                                                                    g.10097
 TGA                                                                c.2163
 X                                                                  p.720

          .         .         .         .         .                 g.10150
 cagctttgccttttgctgacacagctccataaagactcgtgctttctcactgc              c.*53

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Zinc finger protein 408 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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