zinc and ring finger 2 (ZNRF2) - coding DNA reference sequence

(used for variant description)

(last modified June 21, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_147128.3 in the ZNRF2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering ZNRF2 transcript NM_147128.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              gcgggccacgtgcgggaggaggggccgcctt       c.-1021

 .         .         .         .         .         .                g.5091
 ctggttggcgcccggtgtccgttcctcctatcggcgtaggccccgcgaggaagacaaggg       c.-961

 .         .         .         .         .         .                g.5151
 cgcgccctggctgggagggcgtggccagagacctgtccatcaccgagtccacgagtggca       c.-901

 .         .         .         .         .         .                g.5211
 gcacctaccacaccgcagtaccttggcgaggcggagcaggggcaggcaggtcgcggaagg       c.-841

 .         .         .         .         .         .                g.5271
 gggaggcggagcaaggccggcgggagccaatcggcctggcggcacgagggggcgggggcg       c.-781

 .         .         .         .         .         .                g.5331
 gggtcaacgcgcgcgacccaaacacacgggccgggcgcaccctgcagccgcgccgctccg       c.-721

 .         .         .         .         .         .                g.5391
 cggccttccggcgcggggccggggaacctcctccccatctgcgcaccccccgccttcgcg       c.-661

 .         .         .         .         .         .                g.5451
 gcccagatcctcccgccagcccggcccctccttcgcagggggagcgaggcgacggttgcc       c.-601

 .         .         .         .         .         .                g.5511
 gggaagcgcgcgccacctctccctcccatttttcgttctcccctcgcgcgccacccgttt       c.-541

 .         .         .         .         .         .                g.5571
 ttcctctttctccgttaataacagctgggtggctgggggaggagggaaggtggccccggc       c.-481

 .         .         .         .         .         .                g.5631
 ggagtctgggcgggcgcctcccactcagccgccagccgccgtgggagccggaggatggcg       c.-421

 .         .         .         .         .         .                g.5691
 gcggtagcagcggccgcccgagaggaggcggtgccgagatcgggggcgccgagcgcggca       c.-361

 .         .         .         .         .         .                g.5751
 gcagagagcggtagcggcccgtcgtggcgcaccagaaccgaaaccagcggcagccgcacg       c.-301

 .         .         .         .         .         .                g.5811
 gccacttgagccgccccttcctgctggagccagcgaggggtgcctgcagccgggacccct       c.-241

 .         .         .         .         .         .                g.5871
 tcctctccgcgtctcctcgtctcccgcgcccgcgtcaggccgtcggcctcgcccgccgcc       c.-181

 .         .         .         .         .         .                g.5931
 ccaagaagagcgcgccgggcgccgactgcccctctggacgccgggcggcggccctggacg       c.-121

 .         .         .         .         .         .                g.5991
 tgcgggggcctctctgggccggccgcggcgcctgggccctgccctctagctcccgcgctc       c.-61

 .         .         .         .         .         .                g.6051
 gctcccgccctcccggctctcggggcgcagcgcgcgggcccggcccggggcagggcggac       c.-1

          .         .         .         .         .         .       g.6111
 ATGGGCGCCAAACAGAGCGGCCCGGCCGCCGCTAACGGCCGCACGCGCGCGTACTCGGGC       c.60
 M  G  A  K  Q  S  G  P  A  A  A  N  G  R  T  R  A  Y  S  G         p.20

          .         .         .         .         .         .       g.6171
 TCGGATCTACCTTCCAGTAGCAGCGGAGGCGCCAATGGGACCGCGGGCGGCGGCGGGGGC       c.120
 S  D  L  P  S  S  S  S  G  G  A  N  G  T  A  G  G  G  G  G         p.40

          .         .         .         .         .         .       g.6231
 GCTCGGGCCGCCGCCGCGGGGAGGTTCCCGGCTCAGGTGCCCAGCGCGCACCAGCCCAGC       c.180
 A  R  A  A  A  A  G  R  F  P  A  Q  V  P  S  A  H  Q  P  S         p.60

          .         .         .         .         .         .       g.6291
 GCCTCCGGCGGCGCCGCGGCGGCCGCGGCGGCCCCGGCAGCCCCGGCGGCCCCGCGCAGC       c.240
 A  S  G  G  A  A  A  A  A  A  A  P  A  A  P  A  A  P  R  S         p.80

          .         .         .         .         .         .       g.6351
 CGCTCCCTCGGCGGGGCCGTGGGGAGCGTGGCGTCGGGGGCCCGCGCGGCGCAGTCCCCC       c.300
 R  S  L  G  G  A  V  G  S  V  A  S  G  A  R  A  A  Q  S  P         p.100

          .         .         .         .         .         .       g.6411
 TTCAGCATCCCGAACAGCAGCAGCGGCCCGTACGGCTCGCAGGACTCGGTGCACAGCAGC       c.360
 F  S  I  P  N  S  S  S  G  P  Y  G  S  Q  D  S  V  H  S  S         p.120

          .         .         .         .         .         .       g.6471
 CCTGAGGACGGCGGCGGCGGCCGGGACCGGCCGGTGGGCGGGAGCCCCGGCGGGCCGCGC       c.420
 P  E  D  G  G  G  G  R  D  R  P  V  G  G  S  P  G  G  P  R         p.140

          .         .         .         .          | 02        .    g.44346
 CTGGTGATCGGCTCCTTACCAGCTCACCTCTCGCCGCACATGTTTGGAG | GATTTAAGTGC    c.480
 L  V  I  G  S  L  P  A  H  L  S  P  H  M  F  G  G |   F  K  C      p.160

          .         .         .         .         .         .       g.44406
 CCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTA       c.540
 P  V  C  S  K  F  V  S  S  D  E  M  D  L  H  L  V  M  C  L         p.180

          .         .      | 03  .         .         .         .    g.76456
 ACAAAGCCACGAATAACCTATAATG | AGGATGTACTGAGTAAAGATGCTGGGGAATGTGCA    c.600
 T  K  P  R  I  T  Y  N  E |   D  V  L  S  K  D  A  G  E  C  A      p.200

          .         .         .         .         .         .       g.76516
 ATATGCCTTGAAGAATTGCAGCAGGGAGATACTATAGCACGACTGCCTTGTCTATGCATA       c.660
 I  C  L  E  E  L  Q  Q  G  D  T  I  A  R  L  P  C  L  C  I         p.220

          .  | 04      .         .         .         .         .    g.83119
 TATCATAAAGG | CTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCCCTGAGCACCCT    c.720
 Y  H  K  G  |  C  I  D  E  W  F  E  V  N  R  S  C  P  E  H  P      p.240

                                                                g.83128
 TCAGATTAA |                                                       c.730
 S  D  X                                                         p.242

          .         .   | 05     .         .         .         .    g.86766
 gcgtcagcttcctgttttatag | gttttcttgtcttgacaagatgcttgaaaaaccaagag    c.*60

          .         .         .         .         .         .       g.86826
 gatatgaaaatctgtctctggagaaacaaagacgcaggcatactcagccagaaatctgag       c.*120

          .         .         .         .         .         .       g.86886
 ttttgtgagacttggtaatacagagatggacaatcgtactggggtaaaaaaaccctgctg       c.*180

          .         .         .         .         .         .       g.86946
 aagagaggacagtgaccacagaactcagtgtaccaaacatgcatacaaaggacacacagg       c.*240

          .         .         .         .         .         .       g.87006
 gattttgaaaatgctgcacatcccttaatagtcatctacataggtaatactgataaacat       c.*300

          .         .         .         .         .         .       g.87066
 tttgtattcagacgccaaagttaactgatttaaaagttgatttactttttattaagttct       c.*360

          .         .         .         .         .         .       g.87126
 ccagagctgcacaactagttatgttttgatttgttttgttttttaatttggggtctcttt       c.*420

          .         .         .         .         .         .       g.87186
 gttttccccaacataatgttcataatgtttctgcattcatctgttcttaaattgaaaaac       c.*480

          .         .         .         .         .         .       g.87246
 atataatttacttcttataaattgaagtcttaaatgtgaaaccaagaaatgtaatcaagc       c.*540

          .         .         .         .         .         .       g.87306
 agtaaaaacatctgaatgtagaccatgatctcaagttcttccattttctcccccacgagt       c.*600

          .         .         .         .         .         .       g.87366
 ggaaaatagacttctacataggaaagctaaaatatgttaatatttttaaattaaaggttt       c.*660

          .         .         .         .         .         .       g.87426
 aatatcagaatgcagtccaaagagcaaatcatattacataattacattttaattaaatat       c.*720

          .         .         .         .         .         .       g.87486
 agaatattctactgaattgcaatttattaaatattcttatcctcttaaataaaactgctc       c.*780

          .         .         .         .         .         .       g.87546
 aacagttaatcagcagtgaatcatcttgcagctatgcaatttaaaaaaaatacagattac       c.*840

          .         .         .         .         .         .       g.87606
 caatttcaagtgctgccagctaaaataactgttttaacgggtatcttttgtttgttcttt       c.*900

          .         .         .         .         .         .       g.87666
 tcacttaattattttattgtgctttgcatctccaggcagttctctcacatttgggtaaaa       c.*960

          .         .         .         .         .         .       g.87726
 tgtttagcaggctgtaaacttaagaaaagggtaaaataaaattttctggagaggaacttg       c.*1020

          .         .         .         .         .         .       g.87786
 gaatttgagggagattttatatacctttaaaaactgtaatttaattgggatgccaggttt       c.*1080

          .         .         .         .         .         .       g.87846
 atagcaatttgcaactttaattttccagataatctggaggttagcatttgataaatgatt       c.*1140

          .         .         .         .         .         .       g.87906
 ttttaaagtagatatgaagattttgttaatttataatttattcatgtgttattactgtaa       c.*1200

          .         .         .         .         .         .       g.87966
 ttgaaaatgttatagacacttttaaattcagtttgtgtagaaagaaatgtgttaaacaaa       c.*1260

          .         .         .         .         .         .       g.88026
 attatgttaataaatattcccacataatacatctgaatggttaaaaatactggaagagtt       c.*1320

          .         .         .         .         .         .       g.88086
 gtcagggctacaatagtgaatgtccttttttttaatatcaaaaatatcgataagtaggtt       c.*1380

          .         .         .         .         .         .       g.88146
 ttgtgttttcaacgtagggaaaatgttatcagtgaataggtggtgtactttacttggtat       c.*1440

          .         .         .         .         .         .       g.88206
 aatttaaagttgcacagtaagtactgtttccttattttaatctttctttactcataatgt       c.*1500

          .         .         .         .         .         .       g.88266
 atttaagaatttgctgttttatttaacgctgctactcttaatcttctctaaatttttccc       c.*1560

          .         .         .         .         .         .       g.88326
 cctactttcttgcttctgtttcacattttttaaaagggcaagtacaggagcaactgctgc       c.*1620

          .         .         .         .         .         .       g.88386
 tacccagaaaaatgtgtgtattataaataattaaagagtttttaattgctttctgtatga       c.*1680

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Zinc and ring finger 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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