zona pellucida glycoprotein 1 (sperm receptor) (ZP1) - coding DNA reference sequence

(used for variant description)

(last modified July 9, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_207341.2 in the ZP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_034138.1, covering ZP1 transcript NM_207341.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         gggtgtgtctgtggcgtctc       c.-1

          .         .         .         .         .         .       g.5080
 ATGGCAGGAGGCTCAGCCACGACCTGGGGTTACCCTGTGGCCCTGCTACTGCTGGTTGCC       c.60
 M  A  G  G  S  A  T  T  W  G  Y  P  V  A  L  L  L  L  V  A         p.20

          .         .         .         .         .         .       g.5140
 ACCCTGGGGCTGGGTAGGTGGCTCCAGCCCGACCCTGGCCTCCCAGGCCTCCGGCACAGC       c.120
 T  L  G  L  G  R  W  L  Q  P  D  P  G  L  P  G  L  R  H  S         p.40

          .         .         .         .         .         .       g.5200
 TACGACTGTGGGATCAAGGGAATGCAGCTGCTGGTGTTCCCCAGGCCAGGCCAGACTCTC       c.180
 Y  D  C  G  I  K  G  M  Q  L  L  V  F  P  R  P  G  Q  T  L         p.60

          .       | 02 .         .         .         .         .    g.6647
 CGCTTCAAGGTGGTGG | ATGAATTTGGGAACCGATTTGATGTCAACAACTGCTCCATCTGC    c.240
 R  F  K  V  V  D |   E  F  G  N  R  F  D  V  N  N  C  S  I  C      p.80

          .         .         .         .         .         .       g.6707
 TACCACTGGGTCACCTCCAGGCCGCAGGAGCCTGCAGTCTTCTCGGCCGATTACAGAGGC       c.300
 Y  H  W  V  T  S  R  P  Q  E  P  A  V  F  S  A  D  Y  R  G         p.100

          .         | 03         .         .         .         .    g.7037
 TGCCACGTGCTGGAGAAG | GATGGGCGTTTCCACCTGAGGGTGTTCATGGAGGCTGTGCTG    c.360
 C  H  V  L  E  K   | D  G  R  F  H  L  R  V  F  M  E  A  V  L      p.120

          .         .         .         .         .         .       g.7097
 CCCAATGGTCGTGTGGATGTGGCACAAGACGCTACTCTGATCTGTCCCAAACCTGACCCC       c.420
 P  N  G  R  V  D  V  A  Q  D  A  T  L  I  C  P  K  P  D  P         p.140

          .         .         .         .         .         .       g.7157
 TCCCGGACTCTGGACTCCCAGCTGGCACCACCCGCCATGTTCTCTGTCTCAACCCCACAA       c.480
 S  R  T  L  D  S  Q  L  A  P  P  A  M  F  S  V  S  T  P  Q         p.160

          .         .         .         .         .         .       g.7217
 ACCCTTTCCTTCCTCCCCACCTCTGGCCATACCTCCCAAGGCTCTGGCCATGCCTTTCCC       c.540
 T  L  S  F  L  P  T  S  G  H  T  S  Q  G  S  G  H  A  F  P         p.180

          .         .         .         .         .         .       g.7277
 AGCCCACTGGACCCAGGGCACAGCTCTGTCCACCCAACCCCTGCTTTACCATCCCCTGGA       c.600
 S  P  L  D  P  G  H  S  S  V  H  P  T  P  A  L  P  S  P  G         p.200

          .         .         .         .         .         .       g.7337
 CCTGGACCTACCCTCGCCACCCTGGCTCAACCCCACTGGGGCACCTTGGAACACTGGGAT       c.660
 P  G  P  T  L  A  T  L  A  Q  P  H  W  G  T  L  E  H  W  D         p.220

          .         .   | 04     .         .         .         .    g.7828
 GTGAACAAACGAGATTACATAG | GTACCCACCTGAGCCAGGAGCAGTGCCAGGTGGCCTCA    c.720
 V  N  K  R  D  Y  I  G |   T  H  L  S  Q  E  Q  C  Q  V  A  S      p.240

          .         .         .         .         .         .       g.7888
 GGGCACCTCCCCTGCATCGTGAGAAGAACTTCAAAAGAAGCCTGTCAGCAGGCTGGCTGC       c.780
 G  H  L  P  C  I  V  R  R  T  S  K  E  A  C  Q  Q  A  G  C         p.260

          .         .         .         .       | 05 .         .    g.8429
 TGCTATGACAACACCAGAGAGGTTCCCTGTTACTATGGCAACACAG | CTACTGTCCAGTGC    c.840
 C  Y  D  N  T  R  E  V  P  C  Y  Y  G  N  T  A |   T  V  Q  C      p.280

          .         .         .         .         .         .       g.8489
 TTCAGAGATGGCTACTTCGTCCTCGTAGTGTCCCAAGAAATGGCCTTGACACACAGGATC       c.900
 F  R  D  G  Y  F  V  L  V  V  S  Q  E  M  A  L  T  H  R  I         p.300

          .         .         .         .         .         .       g.8549
 ACACTGGCCAACATCCACCTGGCCTATGCCCCCACCAGCTGCTCCCCAACACAGCACACG       c.960
 T  L  A  N  I  H  L  A  Y  A  P  T  S  C  S  P  T  Q  H  T         p.320

          .         .         .         .         .     | 06   .    g.8681
 GAAGCTTTCGTGGTCTTCTACTTCCCTCTCACCCACTGTGGAACCACAATGCAG | GTGGCT    c.1020
 E  A  F  V  V  F  Y  F  P  L  T  H  C  G  T  T  M  Q   | V  A      p.340

          .         .         .         .         .         .       g.8741
 GGCGACCAGCTCATCTATGAGAACTGGCTGGTGTCTGGCATCCACATCCAAAAGGGGCCA       c.1080
 G  D  Q  L  I  Y  E  N  W  L  V  S  G  I  H  I  Q  K  G  P         p.360

          .         .         .   | 07     .         .         .    g.10648
 CAGGGTTCCATCACGCGGGACAGCACCTTCCA | GCTTCATGTGCGCTGTGTCTTCAACGCC    c.1140
 Q  G  S  I  T  R  D  S  T  F  Q  |  L  H  V  R  C  V  F  N  A      p.380

          .         .         .         .         .         .       g.10708
 AGTGACTTCCTGCCCATTCAGGCATCCATTTTCCCACCCCCATCGCCTGCTCCTATGACC       c.1200
 S  D  F  L  P  I  Q  A  S  I  F  P  P  P  S  P  A  P  M  T         p.400

          .         .         .         . | 08       .         .    g.10853
 CAGCCCGGCCCCCTGCGGCTTGAGCTGCGGATTGCCAAAG | ACGAGACCTTCAGCTCGTAC    c.1260
 Q  P  G  P  L  R  L  E  L  R  I  A  K  D |   E  T  F  S  S  Y      p.420

          .         .         .         .         .         .       g.10913
 TATGGGGAGGATGACTATCCCATCGTGAGGCTGCTCCGAGAACCAGTCCATGTGGAGGTC       c.1320
 Y  G  E  D  D  Y  P  I  V  R  L  L  R  E  P  V  H  V  E  V         p.440

          .         .         .         .         .         .       g.10973
 CGGCTTCTGCAGAGGACAGACCCCAACCTGGTCCTGCTGCTGCACCAGTGCTGGGGCGCT       c.1380
 R  L  L  Q  R  T  D  P  N  L  V  L  L  L  H  Q  C  W  G  A         p.460

          .         .         .         .         . | 09       .    g.11102
 CCCAGTGCCAACCCCTTCCAGCAGCCCCAGTGGCCCATCCTGTCAGACGG | ATGCCCTTTC    c.1440
 P  S  A  N  P  F  Q  Q  P  Q  W  P  I  L  S  D  G  |  C  P  F      p.480

          .         .         .         .         .         .       g.11162
 AAGGGCGACAGCTACAGAACCCAAATGGTAGCCTTGGACGGGGCCACACCTTTCCAGTCG       c.1500
 K  G  D  S  Y  R  T  Q  M  V  A  L  D  G  A  T  P  F  Q  S         p.500

          .         .         .         .         .         .       g.11222
 CACTACCAGCGATTCACTGTTGCTACCTTCGCCCTCCTGGACTCAGGCTCCCAGAGAGCC       c.1560
 H  Y  Q  R  F  T  V  A  T  F  A  L  L  D  S  G  S  Q  R  A         p.520

          .   | 10     .         .         .         .         .    g.12439
 CTCAGAGGACTG | GTTTACTTGTTCTGCAGCACCTCTGCCTGCCACACCTCAGGGCTGGAG    c.1620
 L  R  G  L   | V  Y  L  F  C  S  T  S  A  C  H  T  S  G  L  E      p.540

          .         .         .     | 11   .         .         .    g.12613
 ACTTGCTCCACTGCATGTAGCACTGGCACTACAA | GACAGCGACGATCCTCAGGTCACCGT    c.1680
 T  C  S  T  A  C  S  T  G  T  T  R |   Q  R  R  S  S  G  H  R      p.560

          .         .         .         .         .         .       g.12673
 AATGACACTGCCAGGCCCCAGGACATCGTGAGCTCTCCGGGGCCAGTGGGCTTTGAGGAT       c.1740
 N  D  T  A  R  P  Q  D  I  V  S  S  P  G  P  V  G  F  E  D         p.580

          .         .         .     | 12   .         .         .    g.12998
 TCTTATGGGCAGGAGCCCACACTTGGGCCCACAG | ACTCCAATGGGAACTCCAGCCTGAGA    c.1800
 S  Y  G  Q  E  P  T  L  G  P  T  D |   S  N  G  N  S  S  L  R      p.600

          .         .         .         .         .         .       g.13058
 CCTCTCCTTTGGGCGGTCCTTTTGCTGCCAGCTGTTGCCCTGGTCCTTGGGTTTGGTGTC       c.1860
 P  L  L  W  A  V  L  L  L  P  A  V  A  L  V  L  G  F  G  V         p.620

          .         .         .         .         .                 g.13115
 TTTGTGGGCCTGAGCCAGACCTGGGCCCAGAAGCTCTGGGAAAGCAACAGACAGTGA          c.1917
 F  V  G  L  S  Q  T  W  A  Q  K  L  W  E  S  N  R  Q  X            p.638

          .         .         .                                     g.13150
 atgggcccaataaacaatcatttcaaacctactga                                c.*35

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Zona pellucida glycoprotein 1 (sperm receptor) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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