zona pellucida glycoprotein 3 (sperm receptor) (ZP3) - coding DNA reference sequence

(used for variant description)

(last modified July 9, 2018)

This file was created to facilitate the description of sequence variants on transcript NM_001110354.1 in the ZP3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033938.1, covering ZP3 transcript NM_001110354.1.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.32441
                                                   tgcaggtacc       c.-1

          .         .         .         .         .         .       g.32501
 ATGGAGCTGAGCTATAGGCTCTTCATCTGCCTCCTGCTCTGGGGTAGTACTGAGCTGTGC       c.60
 M  E  L  S  Y  R  L  F  I  C  L  L  L  W  G  S  T  E  L  C         p.20

          .         .         .         .         .         .       g.32561
 TACCCCCAACCCCTCTGGCTCTTGCAGGGTGGAGCCAGCCATCCTGAGACGTCCGTACAG       c.120
 Y  P  Q  P  L  W  L  L  Q  G  G  A  S  H  P  E  T  S  V  Q         p.40

          .         .         .         .         .         .       g.32621
 CCCGTACTGGTGGAGTGTCAGGAGGCCACTCTGATGGTCATGGTCAGCAAAGACCTTTTT       c.180
 P  V  L  V  E  C  Q  E  A  T  L  M  V  M  V  S  K  D  L  F         p.60

          .         .         .         .         .         .       g.32681
 GGCACCGGGAAGCTCATCAGGGCTGCTGACCTCACCTTGGGCCCAGAGGCCTGTGAGCCT       c.240
 G  T  G  K  L  I  R  A  A  D  L  T  L  G  P  E  A  C  E  P         p.80

          .         .         .         .         .         .       g.32741
 CTGGTCTCCATGGACACAGAAGATGTGGTCAGGTTTGAGGTTGGACTCCACGAGTGTGGC       c.300
 L  V  S  M  D  T  E  D  V  V  R  F  E  V  G  L  H  E  C  G         p.100

          .   | 02     .         .         .         .         .    g.37039
 AACAGCATGCAG | GTAACTGACGATGCCCTGGTGTACAGCACCTTCCTGCTCCATGACCCC    c.360
 N  S  M  Q   | V  T  D  D  A  L  V  Y  S  T  F  L  L  H  D  P      p.120

          .         .         .         .         .         .       g.37099
 CGCCCCGTGGGAAACCTGTCCATCGTGAGGACTAACCGCGCAGAGATTCCCATCGAGTGC       c.420
 R  P  V  G  N  L  S  I  V  R  T  N  R  A  E  I  P  I  E  C         p.140

          .  | 03      .         .         .         .         .    g.40452
 CGCTACCCCAG | GCAGGGCAATGTGAGCAGCCAGGCCATCCTGCCCACCTGGTTGCCCTTC    c.480
 R  Y  P  R  |  Q  G  N  V  S  S  Q  A  I  L  P  T  W  L  P  F      p.160

          .         .         .         .         .      | 04  .    g.40951
 AGGACCACGGTGTTCTCAGAGGAGAAGCTGACTTTCTCTCTGCGTCTGATGGAGG | AGAAC    c.540
 R  T  T  V  F  S  E  E  K  L  T  F  S  L  R  L  M  E  E |   N      p.180

          .         .         .         .         .         .       g.41011
 TGGAACGCTGAGAAGAGGTCCCCCACCTTCCACCTGGGAGATGCAGCCCACCTCCAGGCA       c.600
 W  N  A  E  K  R  S  P  T  F  H  L  G  D  A  A  H  L  Q  A         p.200

          .         .         .         .         .         .       g.41071
 GAAATCCACACTGGCAGCCACGTGCCACTGCGGTTGTTTGTGGACCACTGCGTGGCCACA       c.660
 E  I  H  T  G  S  H  V  P  L  R  L  F  V  D  H  C  V  A  T         p.220

          .         .         .         .         .    | 05    .    g.41521
 CCGACACCAGACCAGAATGCCTCCCCTTATCACACCATCGTGGACTTCCATGG | CTGTCTT    c.720
 P  T  P  D  Q  N  A  S  P  Y  H  T  I  V  D  F  H  G  |  C  L      p.240

          .         .         .         .         .         .       g.41581
 GTCGACGGTCTCACTGATGCCTCTTCTGCATTCAAAGTTCCTCGACCCGGGCCAGATACA       c.780
 V  D  G  L  T  D  A  S  S  A  F  K  V  P  R  P  G  P  D  T         p.260

          .         .         .         .         .  | 06      .    g.47735
 CTCCAGTTCACAGTGGATGTCTTCCACTTTGCTAATGACTCCAGAAACATG | ATATACATC    c.840
 L  Q  F  T  V  D  V  F  H  F  A  N  D  S  R  N  M   | I  Y  I      p.280

          .         .         .         .         .         .       g.47795
 ACCTGCCACCTGAAGGTCACCCTAGCTGAGCAGGACCCAGATGAACTCAACAAGGCCTGT       c.900
 T  C  H  L  K  V  T  L  A  E  Q  D  P  D  E  L  N  K  A  C         p.300

          .         .    | 07    .         .         .         .    g.47988
 TCCTTCAGCAAGCCTTCCAACAG | CTGGTTCCCAGTGGAAGGCTCGGCTGACATCTGTCAA    c.960
 S  F  S  K  P  S  N  S  |  W  F  P  V  E  G  S  A  D  I  C  Q      p.320

          .         .         .         .         .         .       g.48048
 TGCTGTAACAAAGGTGACTGTGGCACTCCAAGCCATTCCAGGAGGCAGCCTCATGTCATG       c.1020
 C  C  N  K  G  D  C  G  T  P  S  H  S  R  R  Q  P  H  V  M         p.340

          .         .         .         . | 08       .         .    g.49338
 AGCCAGTGGTCCAGGTCTGCTTCCCGTAACCGCAGGCATG | TGACAGAAGAAGCAGATGTC    c.1080
 S  Q  W  S  R  S  A  S  R  N  R  R  H  V |   T  E  E  A  D  V      p.360

          .         .         .         .         .         .       g.49398
 ACCGTGGGGCCACTGATCTTCCTGGACAGGAGGGGTGACCATGAAGTAGAGCAGTGGGCT       c.1140
 T  V  G  P  L  I  F  L  D  R  R  G  D  H  E  V  E  Q  W  A         p.380

          .         .         .         .         .         .       g.49458
 TTGCCTTCTGACACCTCAGTGGTGCTGCTGGGCGTAGGCCTGGCTGTGGTGGTGTCCCTG       c.1200
 L  P  S  D  T  S  V  V  L  L  G  V  G  L  A  V  V  V  S  L         p.400

          .         .         .         .         .         .       g.49518
 ACTCTGACTGCTGTTATCCTGGTTCTCACCAGGAGGTGTCGCACTGCCTCCCACCCTGTG       c.1260
 T  L  T  A  V  I  L  V  L  T  R  R  C  R  T  A  S  H  P  V         p.420

          .                                                         g.49533
 TCTGCTTCCGAATAA                                                    c.1275
 S  A  S  E  X                                                      p.424

          .                                                         g.49548
 aagaagaaagcaata                                                    c.*15

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Zona pellucida glycoprotein 3 (sperm receptor) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.