zona pellucida binding protein (ZPBP) - coding DNA reference sequence

(used for variant description)

(last modified April 9, 2022)

This file was created to facilitate the description of sequence variants on transcript NM_007009.2 in the ZPBP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering ZPBP transcript NM_007009.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.5010
                                                   ggctgcaggt       c.-61

 .         .         .         .         .         .                g.5070
 gggcgcgcgttgcctaacgaccttccgcgcggacggtgggcaggcgacggcggcgtgtgg       c.-1

          .         .         .         .         .         .       g.5130
 ATGGAGGCCTTCGCCCTTGGCCCAGCGCGGCGGGGCAGGCGGCGGACCCGGGCCGCCGGC       c.60
 M  E  A  F  A  L  G  P  A  R  R  G  R  R  R  T  R  A  A  G         p.20

          .         .         .         .         .         .       g.5190
 TCCCTGCTCTCTCGGGCCGCCATCCTCCTCTTTATCTCCGCCTTCCTGGTGCGGGTGCCC       c.120
 S  L  L  S  R  A  A  I  L  L  F  I  S  A  F  L  V  R  V  P         p.40

         | 02.         .         .         .         .         .    g.8608
 TCATCAG | TTGGACACTTGGTTCGATTACCAAGAGCTTTTCGCTTGACCAAAGATTCAGTG    c.180
 S  S  V |   G  H  L  V  R  L  P  R  A  F  R  L  T  K  D  S  V      p.60

          .         .         | 03         .         .         .    g.16397
 AAAATAGTGGGATCAACAAGTTTTCCAG | TGAAAGCGTATGTCATGCTCCATCAAAAGAGT    c.240
 K  I  V  G  S  T  S  F  P  V |   K  A  Y  V  M  L  H  Q  K  S      p.80

          .         .         .         .         .         .       g.16457
 CCACACGTGTTATGTGTAACGCAACAACTGCGAAATGCTGAACTGATAGACCCATCATTC       c.300
 P  H  V  L  C  V  T  Q  Q  L  R  N  A  E  L  I  D  P  S  F         p.100

          .         .         .     | 04   .         .         .    g.40149
 CAATGGTATGGGCCTAAAGGAAAAGTTGTTTCAG | TAGAAAACCGCACTGCACAAATAACA    c.360
 Q  W  Y  G  P  K  G  K  V  V  S  V |   E  N  R  T  A  Q  I  T      p.120

          .         .         .         .         .         .       g.40209
 TCCACAGGAAGCCTTGTATTCCAAAATTTTGAGGAGAGTATGAGTGGAATTTATACATGT       c.420
 S  T  G  S  L  V  F  Q  N  F  E  E  S  M  S  G  I  Y  T  C         p.140

          .         .         .         .         .         .       g.40269
 TTCCTCGAATATAAACCTACTGTGGAAGAAATTGTTAAACGTCTTCAACTAAAATATGCT       c.480
 F  L  E  Y  K  P  T  V  E  E  I  V  K  R  L  Q  L  K  Y  A         p.160

         | 05.         .         .         .         .         .    g.67007
 ATATATG | CTTATCGTGAGCCTCATTATTATTATCAGTTCACAGCTCGATATCATGCAGCT    c.540
 I  Y  A |   Y  R  E  P  H  Y  Y  Y  Q  F  T  A  R  Y  H  A  A      p.180

          .         .         .         .         .         .       g.67067
 CCCTGCAATAGCATTTATAATATTTCTTTTGAGAAGAAACTTCTTCAGATTTTAAGCAAA       c.600
 P  C  N  S  I  Y  N  I  S  F  E  K  K  L  L  Q  I  L  S  K         p.200

          .         .         .         .         .         .       g.67127
 CTGCTTCTTGACCTTTCATGTGAAATTTCCTTACTTAAGTCTGAATGCCATCGCGTTAAA       c.660
 L  L  L  D  L  S  C  E  I  S  L  L  K  S  E  C  H  R  V  K         p.220

          .         .         .         .       | 06 .         .    g.79962
 ATGCAAAGAGCTGGTTTGCAAAATGAATTGTTCTTTGCATTTTCAG | TTTCATCTCTAGAC    c.720
 M  Q  R  A  G  L  Q  N  E  L  F  F  A  F  S  V |   S  S  L  D      p.240

          .         .         .         .         .         .       g.80022
 ACTGAAAAAGGACCCAAGCGATGTACAGACCATAACTGTGAACCTTACAAAAGACTTTTT       c.780
 T  E  K  G  P  K  R  C  T  D  H  N  C  E  P  Y  K  R  L  F         p.260

     | 07    .         .         .         .         .         .    g.114802
 AAG | GCTAAAAATCTCATAGAGAGATTTTTTAATCAACAAGTAGAAATTCTTGGCAGACGT    c.840
 K   | A  K  N  L  I  E  R  F  F  N  Q  Q  V  E  I  L  G  R  R      p.280

          .         .         .         .         .         .       g.114862
 GCAGAACAATTACCTCAAATATACTATATTGAAGGTACTCTCCAAATGGTTTGGATTAAT       c.900
 A  E  Q  L  P  Q  I  Y  Y  I  E  G  T  L  Q  M  V  W  I  N         p.300

          .         .         .         .         .         .       g.114922
 CGCTGCTTTCCAGGATATGGAATGAATGTCCAGCAACATCCAAAATGTCCTGAGTGCTGT       c.960
 R  C  F  P  G  Y  G  M  N  V  Q  Q  H  P  K  C  P  E  C  C         p.320

   | 08      .         .         .         .         .         .    g.160701
 G | TGATCTGCAGCCCTGGATCATATAACCCCCGTGATGGAATTCATTGCCTTCAATGCAAT    c.1020
 V |   I  C  S  P  G  S  Y  N  P  R  D  G  I  H  C  L  Q  C  N      p.340

          .         .         .                                     g.160737
 AGCAGCCTGGTGTATGGAGCAAAAACGTGCTTATAA                               c.1056
 S  S  L  V  Y  G  A  K  T  C  L  X                                 p.351

          .         .         .         .         .         .       g.160797
 gccattatcttcagttattcagtggtttattaaatgcaaagtatatatttgaaatattaa       c.*60

          .         .         .         .                           g.160838
 cataataaattattatgccaaaattaatcatattttacaaa                          c.*101

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Zona pellucida binding protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.