The XRCC3 gene homepage

General information
Gene symbol	XRCC3
Gene name	X-ray repair complementing defective repair in Chinese hamster cells 3
Chromosome	14
Chromosomal band	q32.3
Imprinted	Unknown
Genomic reference	NG_011516.1
Transcript reference	NM_001100118.1, NM_001100119.1, NM_005432.3, XM_005268045.1, XM_005268046.1, XM_005268047.1, XM_005268048.1
Associated with diseases	CMM-6, cancer, breast, familial
Citation reference(s)	-
Curators (1)	Johan T. den Dunnen
Total number of public variants reported	34
Unique public DNA variants reported	5
Individuals with public variants	27
Hidden variants	64
Date created	January 21, 2014
Date last updated	September 23, 2016
Version	XRCC3:160923

Graphical displays and utilities
Graphs	Graphs displaying summary information of all variants in the database »
UCSC Genome Browser	Show variants in the UCSC Genome Browser (full view, compact view)
Ensembl Genome Browser	Show variants in the Ensembl Genome Browser (full view, compact view)
NCBI Sequence Viewer	Show distribution histogram of variants in the NCBI Sequence Viewer

Links to other resources
External URL	List of LSDBs for this gene The reference LOVD for this gene, if available
HGNC	HGNC:12830
Entrez Gene	7517
PubMed articles	XRCC3
OMIM - Gene	600675
OMIM - Diseases	CMM-6 (melanoma, cutaneous, malignant, susceptibility to, type 6 (CMM-6)) cancer, breast, familial
HGMD	XRCC3
GeneCards	XRCC3
GeneTests	XRCC3

Active transcripts

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Operator	Column type	Example	Matches
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space	Text	Arg Ser	all entries containing 'Arg' and 'Ser'
\|	Text	Arg\|Ser	all entries containing 'Arg' or 'Ser'
!	Text	!fs	all entries not containing 'fs'
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$	Text	Ser)$	all entries ending with 'Ser)'
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combination	Text	*\|Ter !fs	all entries containing '*' or 'Ter' but not containing 'fs'
	Date	2020	all entries matching the year 2020
\|	Date	2020-03\|2020-04	all entries matching March or April, 2020
!	Date	!2020-03	all entries not matching March, 2020
<	Date	<2020	all entries before the year 2020
<=	Date	<=2020-06	all entries in or before June, 2020
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>=	Date	>=2020-06-15	all entries on or after June 15th, 2020
combination	Date	2019\|2020 <2020-03	all entries in 2019 or 2020, and before March, 2020
	Numeric	23	all entries exactly matching 23
\|	Numeric	23\|24	all entries exactly matching 23 or 24
!	Numeric	!23	all entries not exactly matching 23
<	Numeric	<23	all entries lower than 23
<=	Numeric	<=23	all entries lower than, or equal to, 23
>	Numeric	>23	all entries higher than 23
>=	Numeric	>=23	all entries higher than, or equal to, 23
combination	Numeric	>=20 <30 !23	all entries with values from 20 to 29, but not equal to 23

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Example	Matches
Asian	all entries containing 'Asian', 'asian', including 'Caucasian', 'caucasian', etc.
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"South Asian"	all entries containing 'South Asian', but not containing 'South East Asian'

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ID	Chr	Name	NCBI ID	NCBI Protein ID	Variants
00009495	14	transcript variant 3	NM_001100118.1	NP_001093588.1	34
00023546	14	Manually created transcript	NM_001100119.1	-	34
00024156	14	Manually created transcript	NM_005432.3	-	34
00036717	14	transcript variant X3	XM_005268047.1	-	-
00036718	14	transcript variant X1	XM_005268045.1	-	-
00036719	14	transcript variant X2	XM_005268046.1	XP_005268103.1	-
00036720	14	transcript variant X4	XM_005268048.1	XP_005268105.1	-

Copyright & disclaimer
The contents of this LOVD database are the intellectual property of the respective submitter(s) and curator(s) of the individual records. Individual data entries may indicate which data license applies to that specific record. When no license is listed, no permissions are granted. Any unauthorized use, copying, storage, or distribution of this material without written permission from the curator(s) will lead to copyright infringement with possible ensuing litigation. Copyright © 2014-2025. All Rights Reserved. For further details, refer to Directive 96/9/EC of the European Parliament and the Council of March 11 (1996) on the legal protection of databases. We have used all reasonable efforts to ensure that the information displayed on these pages and contained in the databases is of high quality. We make no warranty, express or implied, as to its accuracy or that the information is fit for a particular purpose, and will not be held responsible for any consequences arising from any inaccuracies or omissions. Individuals, organizations, and companies that use this database do so on the understanding that no liability whatsoever, either direct or indirect, shall rest upon the data submitter(s), curator(s), or any of their employees or agents for the effects of any product, process, or method that may be produced or adopted by any part, notwithstanding that the formulation of such product, process or method may be based upon information here provided.

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XRCC3 (X-ray repair complementing defective repair ...)