The CYP2D6 gene homepage

CYP2D6 reference haplotypes. Download the current CYP2D6 DRAFT reference haplotype list (ver.2015-07-24).
NOTE: the coding DNA reference sequence represents haplotype CYP2D6*1 which differs from the reference genome sequence (build hg19). For the coding region the differences include c.408C>G, c.886T>C and c.1457C>G.
General information
Gene symbol CYP2D6
Gene name cytochrome P450, family 2, subfamily D, polypeptide 6
Chromosome 22
Chromosomal band q13.1
Imprinted Not imprinted
Genomic reference LRG_303
Transcript reference NM_000106.4
Exon/intron information NM_000106.4 exon/intron table
Associated with diseases DMBCYP2D6, DMBp
Citation reference(s) -
Refseq URL Genomic reference sequence
Curators (2) Andrea Gaedigk and Lisa Kalman
Total number of public variants reported 2632
Unique public DNA variants reported 271
Individuals with public variants 509
Hidden variants 7
Download all this gene's data Download all data
Notes CYP2D6 reference haplotypes. Download the current CYP2D6 DRAFT reference haplotype list (ver.2015-07-24).
Date created May 03, 2013
Date last updated October 20, 2021
Version CYP2D6:211020

Graphical displays and utilities
Graphs Graphs displaying summary information of all variants in the database »
Reading frame checker The Reading-frame checker generates a prediction of the effect of whole-exon changes. Active for: NM_000106.4.
UCSC Genome Browser Show variants in the UCSC Genome Browser (full view, compact view)
Ensembl Genome Browser Show variants in the Ensembl Genome Browser (full view, compact view)
NCBI Sequence Viewer Show distribution histogram of variants in the NCBI Sequence Viewer

Links to other resources
Homepage URL
External URL Human Cytochrome P450 (CYP) Allele Nomenclature Committee
SuperCYP Cytochrome P450 database
HGNC 2625
Entrez Gene 1565
PubMed articles CYP2D6
OMIM - Gene 124030
OMIM - Diseases DMBCYP2D6 (metabolism, drug, poor/rapid)
GeneCards CYP2D6
GeneTests CYP2D6
Orphanet CYP2D6

Active transcripts




NCBI ID     

NCBI Protein ID     

00023855 22 transcript variant 1 NM_000106.4 NP_000097.2 2632

Copyright & disclaimer
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