The GCK gene homepage

General information
Gene symbol GCK
Gene name glucokinase (hexokinase 4)
Chromosome 7
Chromosomal band p15.3-p15.1
Imprinted Not imprinted
Genomic reference NG_008847.2
Transcript reference NM_000162.3
Exon/intron information NM_000162.3 exon/intron table
Associated with diseases HHF-3, MODY-2, NIDDM, PNDM1
Citation reference(s) -
Refseq URL Genomic reference sequence
Curators (2) Monique Losekoot and Kevin Colclough
Total number of public variants reported 1412
Unique public DNA variants reported 180
Individuals with public variants 829
Hidden variants 58
Download all this gene's data Download all data
Notes Establishment of this gene variant database (LSDB) was supported by the Leiden University Medical Center (LUMC), Leiden, Nederland.
Date created September 05, 2008
Date last updated February 08, 2021
Version GCK:210208

Graphical displays and utilities
Graphs Graphs displaying summary information of all variants in the database »
Reading frame checker The Reading-frame checker generates a prediction of the effect of whole-exon changes. Active for: NM_000162.3.
UCSC Genome Browser Show variants in the UCSC Genome Browser (full view, compact view)
Ensembl Genome Browser Show variants in the Ensembl Genome Browser (full view, compact view)
NCBI Sequence Viewer Show distribution histogram of variants in the NCBI Sequence Viewer

Links to other resources
Homepage URL
External URL Diabetes genes
HGNC 4195
Entrez Gene 2645
PubMed articles GCK
OMIM - Gene 138079
OMIM - Diseases HHF-3 (hypoglycemia, hyperinsulinemic, familial, type 3 (HHF-3))
MODY-2 (diabetes of the young, maturity-onset, type 2 (MODY-2))
NIDDM (diabetes mellitus, noninsulin-dependent (NIDDM))
PNDM1 (diabetes mellitus, permanent neonatal, type 1 (PNDM1))
GeneCards GCK
GeneTests GCK
Orphanet GCK

Active transcripts




NCBI ID     

NCBI Protein ID     

00008409 7 transcript variant 1 NM_000162.3 NP_000153.1 1412

Copyright & disclaimer
The contents of this LOVD database are the intellectual property of the respective submitter(s) and curator(s) of the individual records. Individual data entries may indicate which data license applies to that specific record. When no license is listed, no permissions are granted. Any unauthorized use, copying, storage, or distribution of this material without written permission from the curator(s) will lead to copyright infringement with possible ensuing litigation. Copyright © 2008-2021. All Rights Reserved. For further details, refer to Directive 96/9/EC of the European Parliament and the Council of March 11 (1996) on the legal protection of databases.

We have used all reasonable efforts to ensure that the information displayed on these pages and contained in the databases is of high quality. We make no warranty, express or implied, as to its accuracy or that the information is fit for a particular purpose, and will not be held responsible for any consequences arising from any inaccuracies or omissions. Individuals, organizations, and companies that use this database do so on the understanding that no liability whatsoever, either direct or indirect, shall rest upon the data submitter(s), curator(s), or any of their employees or agents for the effects of any product, process, or method that may be produced or adopted by any part, notwithstanding that the formulation of such product, process or method may be based upon information here provided.