TP53 gene homepage

General information
Gene symbol TP53
Gene name tumor protein p53
Chromosome 17
Chromosomal band p13.1
Imprinted Unknown
Genomic reference NG_017013.2
Transcript reference NM_000546.5
Exon/intron information NM_000546.5 exon/intron table
Associated with diseases cancer, liver, CRC, GLM-1, LFS-1, Adrenocortical carcinoma, hereditary, Basal cell carcinoma, susceptibility to, 7, cancer, breast, familial, cancer, pancreatic, Choroid plexus papilloma, Nasopharyngeal carcinoma, osteosarcoma
Citation reference(s) -
Refseq URL Genomic reference sequence
Curators (1) Magali Olivier
Total number of public variants reported 336
Unique public DNA variants reported 189
Individuals with public variants 23194
Hidden variants 2
Download all this gene's data Download all data
Notes Establishment of this gene variant database (LSDB) was supported by the Leiden University Medical Center (LUMC), Leiden, Nederland.
Date created May 03, 2013
Date last updated July 27, 2019
Version TP53:190727

Graphical displays and utilities
Graphs Graphs displaying summary information of all variants in the database »
Reading frame checker The Reading-frame checker generates a prediction of the effect of whole-exon changes. Active for: NM_000546.5.
UCSC Genome Browser Show variants in the UCSC Genome Browser (full view, compact view)
Ensembl Genome Browser Show variants in the Ensembl Genome Browser (full view, compact view)
NCBI Sequence Viewer Show distribution histogram of variants in the NCBI Sequence Viewer

Links to other resources
Homepage URL https://www.LOVD.nl/TP53
External URL http://p53.iarc.fr
HGNC 11998
Entrez Gene 7157
PubMed articles TP53
OMIM - Gene 191170
OMIM - Diseases cancer, liver (cancer, hepatocellular)
CRC (cancer, colorectal (CRC))
GLM-1 (glioma, susceptibility, type 1 (GLM-1))
LFS-1 (Li-Fraumeni syndrome, type 1 (LFS-1))
Adrenocortical carcinoma, hereditary
Basal cell carcinoma, susceptibility to, 7
cancer, breast, familial
cancer, pancreatic
Choroid plexus papilloma
Nasopharyngeal carcinoma
osteosarcoma
HGMD TP53
GeneCards TP53
GeneTests TP53


Active transcripts


ID     

Chr     

Name     

NCBI ID     

NCBI Protein ID     

DescendingVariants     
00021656 17 transcript variant 1 NM_000546.5 NP_000537.3 336


Copyright & disclaimer
The contents of this LOVD database are the intellectual property of the respective curator(s). Any unauthorised use, copying, storage or distribution of this material without written permission from the curator(s) will lead to copyright infringement with possible ensuing litigation. Copyright © 2013-2019. All Rights Reserved. For further details, refer to Directive 96/9/EC of the European Parliament and the Council of March 11 (1996) on the legal protection of databases.

We have used all reasonable efforts to ensure that the information displayed on these pages and contained in the databases is of high quality. We make no warranty, express or implied, as to its accuracy or that the information is fit for a particular purpose, and will not be held responsible for any consequences arising out of any inaccuracies or omissions. Individuals, organisations and companies which use this database do so on the understanding that no liability whatsoever either direct or indirect shall rest upon the curator(s) or any of their employees or agents for the effects of any product, process or method that may be produced or adopted by any part, notwithstanding that the formulation of such product, process or method may be based upon information here provided.