ADAM metallopeptidase with thrombospondin type 1 motif, 10 (ADAMTS10) - coding DNA reference sequence

(used for variant description)

(last modified November 11, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_030957.2 in the ADAMTS10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011840.2, covering ADAMTS10 transcript NM_030957.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           gcgcgcgcggggcggcgagacagcggcggcgacg       c.-241

 .         .         .      | 02  .         .         .             g.7492
 gcgcggaggccccgggcgcggcgcag | gctccaaagaagaagaaaccaaggcccagagagg    c.-181

 .         .         .         .         .         .                g.7552
 gaggcccaggtgcagggagcaggcgagggaaggatccgtacaggggcccaacactactcc       c.-121

 .         .         . | 03       .         .         .             g.9933
 accaaccgaagcccccaaaag | gagcccggtgatgctgcgaaggctgtgaacaggggaggc    c.-61

 .         .         .         .         .         .                g.9993
 ggcactgtgggggctgccggcagccggggctggggagagacatgtggacacgtggcctct       c.-1

          .         .         .         .         .         .       g.10053
 ATGGCTCCCGCCTGCCAGATCCTCCGCTGGGCCCTCGCCCTGGGGCTGGGCCTCATGTTC       c.60
 M  A  P  A  C  Q  I  L  R  W  A  L  A  L  G  L  G  L  M  F         p.20

          .         .         | 04         .         .         .    g.10377
 GAGGTCACGCACGCCTTCCGGTCTCAAG | ATGAGTTCCTGTCCAGTCTGGAGAGCTATGAG    c.120
 E  V  T  H  A  F  R  S  Q  D |   E  F  L  S  S  L  E  S  Y  E      p.40

          .         .         .         .         .         .       g.10437
 ATCGCCTTCCCCACCCGCGTGGACCACAACGGGGCACTGCTGGCCTTCTCGCCACCTCCT       c.180
 I  A  F  P  T  R  V  D  H  N  G  A  L  L  A  F  S  P  P  P         p.60

          .         .         .         .         .         .       g.10497
 CCCCGGAGGCAGCGCCGCGGCACGGGGGCCACAGCCGAGTCCCGCCTCTTCTACAAAGTG       c.240
 P  R  R  Q  R  R  G  T  G  A  T  A  E  S  R  L  F  Y  K  V         p.80

          .         .         .         .         .         .       g.10557
 GCCTCGCCCAGCACCCACTTCCTGCTGAACCTGACCCGCAGCTCCCGTCTACTGGCAGGG       c.300
 A  S  P  S  T  H  F  L  L  N  L  T  R  S  S  R  L  L  A  G         p.100

          .         .         .         .         .         .       g.10617
 CACGTCTCCGTGGAGTACTGGACACGGGAGGGCCTGGCCTGGCAGAGGGCGGCCCGGCCC       c.360
 H  V  S  V  E  Y  W  T  R  E  G  L  A  W  Q  R  A  A  R  P         p.120

          .         .         .         .         .         .       g.10677
 CACTGCCTCTACGCTGGTCACCTGCAGGGCCAGGCCAGCACCTCCCATGTGGCCATCAGC       c.420
 H  C  L  Y  A  G  H  L  Q  G  Q  A  S  T  S  H  V  A  I  S         p.140

          .      | 05  .         .         .         .         .    g.11865
 ACCTGTGGAGGCCTG | CACGGCCTGATCGTGGCAGACGAGGAAGAGTACCTGATTGAGCCC    c.480
 T  C  G  G  L   | H  G  L  I  V  A  D  E  E  E  Y  L  I  E  P      p.160

          .         .         .         .         .         .       g.11925
 CTGCACGGTGGGCCCAAGGGTTCTCGGAGCCCGGAGGAAAGTGGACCACATGTGGTGTAC       c.540
 L  H  G  G  P  K  G  S  R  S  P  E  E  S  G  P  H  V  V  Y         p.180

          .         .         .         .         .   | 06     .    g.14567
 AAGCGTTCCTCTCTGCGTCACCCCCACCTGGACACAGCCTGTGGAGTGAGAG | ATGAGAAA    c.600
 K  R  S  S  L  R  H  P  H  L  D  T  A  C  G  V  R  D |   E  K      p.200

          .         .         .         .         .         .       g.14627
 CCGTGGAAAGGGCGGCCATGGTGGCTGCGGACCTTGAAGCCACCGCCTGCCAGGCCCCTG       c.660
 P  W  K  G  R  P  W  W  L  R  T  L  K  P  P  P  A  R  P  L         p.220

          .         .         .         .         .         .       g.14687
 GGGAATGAAACAGAGCGTGGCCAGCCAGGCCTGAAGCGATCGGTCAGCCGAGAGCGCTAC       c.720
 G  N  E  T  E  R  G  Q  P  G  L  K  R  S  V  S  R  E  R  Y         p.240

          .         .         .         .         .         .       g.14747
 GTGGAGACCCTGGTGGTGGCTGACAAGATGATGGTGGCCTATCACGGGCGCCGGGATGTG       c.780
 V  E  T  L  V  V  A  D  K  M  M  V  A  Y  H  G  R  R  D  V         p.260

          .         .         . | 07       .         .         .    g.18417
 GAGCAGTATGTCCTGGCCATCATGAACATT | GTTGCCAAACTTTTCCAGGACTCGAGTCTG    c.840
 E  Q  Y  V  L  A  I  M  N  I   | V  A  K  L  F  Q  D  S  S  L      p.280

          .         .         .         .         .     | 08   .    g.18578
 GGAAGCACCGTTAACATCCTCGTAACTCGCCTCATCCTGCTCACGGAGGACCAG | CCCACT    c.900
 G  S  T  V  N  I  L  V  T  R  L  I  L  L  T  E  D  Q   | P  T      p.300

          .         .         .         .         .         .       g.18638
 CTGGAGATCACCCACCATGCCGGGAAGTCCCTGGACAGCTTCTGTAAGTGGCAGAAATCC       c.960
 L  E  I  T  H  H  A  G  K  S  L  D  S  F  C  K  W  Q  K  S         p.320

          .         .         .         .         .         .       g.18698
 ATCGTGAACCACAGCGGCCATGGCAATGCCATTCCAGAGAACGGTGTGGCTAACCATGAC       c.1020
 I  V  N  H  S  G  H  G  N  A  I  P  E  N  G  V  A  N  H  D         p.340

          .         . | 09       .         .         .         .    g.19159
 ACAGCAGTGCTCATCACACG | CTATGACATCTGCATCTACAAGAACAAACCCTGCGGCACA    c.1080
 T  A  V  L  I  T  R  |  Y  D  I  C  I  Y  K  N  K  P  C  G  T      p.360

      | 10   .         .         .         .         .         .    g.19348
 CTAG | GCCTGGCCCCGGTGGGCGGAATGTGTGAGCGCGAGAGAAGCTGCAGCGTCAATGAG    c.1140
 L  G |   L  A  P  V  G  G  M  C  E  R  E  R  S  C  S  V  N  E      p.380

          .         .         .         .         . | 11       .    g.19495
 GACATTGGCCTGGCCACAGCGTTCACCATTGCCCACGAGATCGGGCACAC | ATTCGGCATG    c.1200
 D  I  G  L  A  T  A  F  T  I  A  H  E  I  G  H  T  |  F  G  M      p.400

          .         .         .         .         .         .       g.19555
 AACCATGACGGCGTGGGAAACAGCTGTGGGGCCCGTGGTCAGGACCCAGCCAAGCTCATG       c.1260
 N  H  D  G  V  G  N  S  C  G  A  R  G  Q  D  P  A  K  L  M         p.420

          .         .         .         .         .         .       g.19615
 GCTGCCCACATTACCATGAAGACCAACCCATTCGTGTGGTCATCCTGCAGCCGTGACTAC       c.1320
 A  A  H  I  T  M  K  T  N  P  F  V  W  S  S  C  S  R  D  Y         p.440

          .        | 12.         .         .         .         .    g.19844
 ATCACCAGCTTTCTAGA | CTCGGGCCTGGGGCTCTGCCTGAACAACCGGCCCCCCAGACAG    c.1380
 I  T  S  F  L  D  |  S  G  L  G  L  C  L  N  N  R  P  P  R  Q      p.460

          .         .         .         .         .         .       g.19904
 GACTTTGTGTACCCGACAGTGGCACCGGGCCAAGCCTACGATGCAGATGAGCAATGCCGC       c.1440
 D  F  V  Y  P  T  V  A  P  G  Q  A  Y  D  A  D  E  Q  C  R         p.480

          .         .         .          | 13        .         .    g.22855
 TTTCAGCATGGAGTCAAATCGCGTCAGTGTAAATACGGG | GAGGTCTGCAGCGAGCTGTGG    c.1500
 F  Q  H  G  V  K  S  R  Q  C  K  Y  G   | E  V  C  S  E  L  W      p.500

          .         .         .         .         .         .       g.22915
 TGTCTGAGCAAGAGCAACCGGTGCATCACCAACAGCATCCCGGCCGCCGAGGGCACGCTG       c.1560
 C  L  S  K  S  N  R  C  I  T  N  S  I  P  A  A  E  G  T  L         p.520

          .         .        | 14.         .         .         .    g.23634
 TGCCAGACGCACACCATCGACAAGGGG | TGGTGCTACAAACGGGTCTGTGTCCCCTTTGGG    c.1620
 C  Q  T  H  T  I  D  K  G   | W  C  Y  K  R  V  C  V  P  F  G      p.540

          .         .         .         .         .         .       g.23694
 TCGCGCCCAGAGGGTGTGGACGGAGCCTGGGGGCCGTGGACTCCATGGGGCGACTGCAGC       c.1680
 S  R  P  E  G  V  D  G  A  W  G  P  W  T  P  W  G  D  C  S         p.560

          .         .         .         .         .    | 15    .    g.23848
 CGGACCTGTGGCGGCGGCGTGTCCTCTTCTAGCCGTCACTGCGACAGCCCCAG | GCCAACC    c.1740
 R  T  C  G  G  G  V  S  S  S  S  R  H  C  D  S  P  R  |  P  T      p.580

          .         .         .         .         .        | 16.    g.25716
 ATCGGGGGCAAGTACTGTCTGGGTGAGAGAAGGCGGCACCGCTCCTGCAACACGGAT | GAC    c.1800
 I  G  G  K  Y  C  L  G  E  R  R  R  H  R  S  C  N  T  D   | D      p.600

          .         .         .         .         .         .       g.25776
 TGTCCCCCTGGCTCCCAGGACTTCAGAGAAGTGCAGTGTTCTGAATTTGACAGCATCCCT       c.1860
 C  P  P  G  S  Q  D  F  R  E  V  Q  C  S  E  F  D  S  I  P         p.620

          .         .         .         . | 17       .         .    g.26139
 TTCCGTGGGAAATTCTACAAGTGGAAAACGTACCGGGGAG | GGGGCGTGAAGGCCTGCTCG    c.1920
 F  R  G  K  F  Y  K  W  K  T  Y  R  G  G |   G  V  K  A  C  S      p.640

          .         .         .         .         .         .       g.26199
 CTCACGTGCCTAGCGGAAGGCTTCAACTTCTACACGGAGAGGGCGGCAGCCGTGGTGGAC       c.1980
 L  T  C  L  A  E  G  F  N  F  Y  T  E  R  A  A  A  V  V  D         p.660

          .         .         .         .         .     | 18   .    g.26345
 GGGACACCCTGCCGTCCAGACACGGTGGACATTTGCGTCAGTGGCGAATGCAAG | CACGTG    c.2040
 G  T  P  C  R  P  D  T  V  D  I  C  V  S  G  E  C  K   | H  V      p.680

          .         .         .         .         .         .       g.26405
 GGCTGCGACCGAGTCCTGGGCTCCGACCTGCGGGAGGACAAGTGCCGAGTGTGTGGCGGT       c.2100
 G  C  D  R  V  L  G  S  D  L  R  E  D  K  C  R  V  C  G  G         p.700

          .         .         .         .         .         | 19    g.28810
 GACGGCAGTGCCTGCGAGACCATCGAGGGCGTCTTCAGCCCAGCCTCACCTGGGGCCG | GG    c.2160
 D  G  S  A  C  E  T  I  E  G  V  F  S  P  A  S  P  G  A  G |       p.720

          .         .         .         .         .         .       g.28870
 TACGAGGATGTCGTCTGGATTCCCAAAGGCTCCGTCCACATCTTCATCCAGGATCTGAAC       c.2220
 Y  E  D  V  V  W  I  P  K  G  S  V  H  I  F  I  Q  D  L  N         p.740

          .          | 20        .         .         .         .    g.29024
 CTCTCTCTCAGTCACTTGG | CCCTGAAGGGAGACCAGGAGTCCCTGCTGCTGGAGGGGCTG    c.2280
 L  S  L  S  H  L  A |   L  K  G  D  Q  E  S  L  L  L  E  G  L      p.760

          .         .         .         .         .         .       g.29084
 CCTGGGACCCCCCAGCCCCACCGTCTGCCTCTAGCTGGGACCACCTTTCAACTGCGACAG       c.2340
 P  G  T  P  Q  P  H  R  L  P  L  A  G  T  T  F  Q  L  R  Q         p.780

          .         .         .         .         .         .       g.29144
 GGGCCAGACCAGGTCCAGAGCCTCGAAGCCCTGGGACCGATTAATGCATCTCTCATCGTC       c.2400
 G  P  D  Q  V  Q  S  L  E  A  L  G  P  I  N  A  S  L  I  V         p.800

     | 21    .         .         .         .         .         .    g.29291
 ATG | GTGCTGGCCCGGACCGAGCTGCCTGCCCTCCGCTACCGCTTCAATGCCCCCATCGCC    c.2460
 M   | V  L  A  R  T  E  L  P  A  L  R  Y  R  F  N  A  P  I  A      p.820

          .         .         .         .         .         .       g.29351
 CGTGACTCGCTGCCCCCCTACTCCTGGCACTATGCGCCCTGGACCAAGTGCTCGGCCCAG       c.2520
 R  D  S  L  P  P  Y  S  W  H  Y  A  P  W  T  K  C  S  A  Q         p.840

          . | 22       .         .         .         .         .    g.29503
 TGTGCAGGCG | GTAGCCAGGTGCAGGCGGTGGAGTGCCGCAACCAGCTGGACAGCTCCGCG    c.2580
 C  A  G  G |   S  Q  V  Q  A  V  E  C  R  N  Q  L  D  S  S  A      p.860

          .         .         .         .         .         .       g.29563
 GTCGCCCCCCACTACTGCAGTGCCCACAGCAAGCTGCCCAAAAGGCAGCGCGCCTGCAAC       c.2640
 V  A  P  H  Y  C  S  A  H  S  K  L  P  K  R  Q  R  A  C  N         p.880

          .         . | 23       .         .         .         .    g.30084
 ACGGAGCCTTGCCCTCCAGA | CTGGGTTGTAGGGAACTGGTCGCTCTGCAGCCGCAGCTGC    c.2700
 T  E  P  C  P  P  D  |  W  V  V  G  N  W  S  L  C  S  R  S  C      p.900

          .         .         .         .         .         .       g.30144
 GATGCAGGCGTGCGCAGCCGCTCGGTCGTGTGCCAGCGCCGCGTCTCTGCCGCGGAGGAG       c.2760
 D  A  G  V  R  S  R  S  V  V  C  Q  R  R  V  S  A  A  E  E         p.920

          .         .         .         .         .         .       g.30204
 AAGGCGCTGGACGACAGCGCATGCCCGCAGCCGCGCCCACCTGTACTGGAGGCCTGCCAC       c.2820
 K  A  L  D  D  S  A  C  P  Q  P  R  P  P  V  L  E  A  C  H         p.940

          .         .         .         .      | 24  .         .    g.30411
 GGCCCCACTTGCCCTCCGGAGTGGGCGGCCCTCGACTGGTCTGAG | TGCACCCCCAGCTGC    c.2880
 G  P  T  C  P  P  E  W  A  A  L  D  W  S  E   | C  T  P  S  C      p.960

          .         .         .         .         .         .       g.30471
 GGGCCGGGCCTCCGCCACCGCGTGGTCCTTTGCAAGAGCGCAGACCACCGCGCCACGCTG       c.2940
 G  P  G  L  R  H  R  V  V  L  C  K  S  A  D  H  R  A  T  L         p.980

          .         .         .         .         .         .       g.30531
 CCCCCGGCGCACTGCTCACCCGCCGCCAAGCCACCGGCCACCATGCGCTGCAACTTGCGC       c.3000
 P  P  A  H  C  S  P  A  A  K  P  P  A  T  M  R  C  N  L  R         p.1000

          .         .         .         .   | 25     .         .    g.30668
 CGCTGCCCCCCGGCCCGCTGGGTGGCTGGCGAGTGGGGTGAG | TGCTCTGCACAGTGCGGC    c.3060
 R  C  P  P  A  R  W  V  A  G  E  W  G  E   | C  S  A  Q  C  G      p.1020

          .         .         .         .         .         .       g.30728
 GTCGGGCAGCGGCAGCGCTCGGTGCGCTGCACCAGCCACACGGGCCAGGCGTCGCACGAG       c.3120
 V  G  Q  R  Q  R  S  V  R  C  T  S  H  T  G  Q  A  S  H  E         p.1040

          .         .         .         .         .         .       g.30788
 TGCACGGAGGCCCTGCGGCCGCCCACCACGCAGCAGTGTGAGGCCAAGTGCGACAGCCCA       c.3180
 C  T  E  A  L  R  P  P  T  T  Q  Q  C  E  A  K  C  D  S  P         p.1060

          .         .   | 26     .         .         .         .    g.34740
 ACCCCCGGGGACGGCCCTGAAG | AGTGCAAGGATGTGAACAAGGTCGCCTACTGCCCCCTG    c.3240
 T  P  G  D  G  P  E  E |   C  K  D  V  N  K  V  A  Y  C  P  L      p.1080

          .         .         .         .         .         .       g.34800
 GTGCTCAAATTTCAGTTCTGCAGCCGAGCCTACTTCCGCCAGATGTGCTGCAAAACCTGC       c.3300
 V  L  K  F  Q  F  C  S  R  A  Y  F  R  Q  M  C  C  K  T  C         p.1100

          .                                                         g.34812
 CATGGCCACTAG                                                       c.3312
 H  G  H  X                                                         p.1103

          .         .         .         .         .         .       g.34872
 ggggcgcgcggcacccggagccacagctggcggggtctccgccgccagccctgcagcggg       c.*60

          .         .         .         .         .         .       g.34932
 ccggccagagggggccccgggggggcgggaactgggagggaagggtgagacggagccgga       c.*120

          .         .         .         .         .         .       g.34992
 agttatttattgggaacccctgcagggccctggctggggggatggagaggggctggctat       c.*180

          .         .         .         .         .         .       g.35052
 ccccccagagcccctcttcagcatccgccccttccagttcacatagtgagaccccccctc       c.*240

          .         .         .         .         .         .       g.35112
 cagggtgggtctggggaggggacagctgttcaccccagcaccctttgaacccacccttag       c.*300

          .         .         .         .         .         .       g.35172
 ggagtccccaacactccccccctcctttgatcggaatatgtactgtgaagagtaggggtg       c.*360

          .         .         .         .         .         .       g.35232
 gggaggtggtctgccggtgccctgccccccagcactgccctacccctccactccgagctg       c.*420

          .         .         .         .         .         .       g.35292
 ggggggaatctgtgtctgctatgggaggggggggggtagcaccacctccctgacaccctc       c.*480

          .         .         .         .         .         .       g.35352
 ccctgacctgactagggggaggatccaccccaacctctgccctgcccgccccaggggcac       c.*540

          .         .         .         .         .         .       g.35412
 cccgacatccaggccaccccctcatggtgctacagaccctgccctggggcccacacactc       c.*600

          .         .         .         .         .                 g.35463
 ctgccaggaagccctacatcaataaagttctgtcttgtgtagatttctacg                c.*651

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ADAM metallopeptidase with thrombospondin type 1 motif, 10 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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