activation-induced cytidine deaminase (AICDA) - coding DNA reference sequence

(used for variant description)

(last modified July 27, 2015)

This file was created to facilitate the description of sequence variants on transcript NM_020661.2 in the AICDA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011588.1, covering AICDA transcript NM_020661.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.5019
                                          agagaaccatcattaattg       c.-61

 .         .         .         .         .         .                g.5079
 aagtgagatttttctggcctgagacttgcagggaggcaagaagacactctggacaccact       c.-1

          | 02         .         .         .         .         .    g.10886
 ATGGACAG | CCTCTTGATGAACCGGAGGAAGTTTCTTTACCAATTCAAAAATGTCCGCTGG    c.60
 M  D  S  |  L  L  M  N  R  R  K  F  L  Y  Q  F  K  N  V  R  W      p.20

          .         .         .         .         .         .       g.10946
 GCTAAGGGTCGGCGTGAGACCTACCTGTGCTACGTAGTGAAGAGGCGTGACAGTGCTACA       c.120
 A  K  G  R  R  E  T  Y  L  C  Y  V  V  K  R  R  D  S  A  T         p.40

          .         .         .       | 03 .         .         .    g.12385
 TCCTTTTCACTGGACTTTGGTTATCTTCGCAATAAG | AACGGCTGCCACGTGGAATTGCTC    c.180
 S  F  S  L  D  F  G  Y  L  R  N  K   | N  G  C  H  V  E  L  L      p.60

          .         .         .         .         .         .       g.12445
 TTCCTCCGCTACATCTCGGACTGGGACCTAGACCCTGGCCGCTGCTACCGCGTCACCTGG       c.240
 F  L  R  Y  I  S  D  W  D  L  D  P  G  R  C  Y  R  V  T  W         p.80

          .         .         .         .         .         .       g.12505
 TTCACCTCCTGGAGCCCCTGCTACGACTGTGCCCGACATGTGGCCGACTTTCTGCGAGGG       c.300
 F  T  S  W  S  P  C  Y  D  C  A  R  H  V  A  D  F  L  R  G         p.100

          .         .         .         .         .         .       g.12565
 AACCCCAACCTCAGTCTGAGGATCTTCACCGCGCGCCTCTACTTCTGTGAGGACCGCAAG       c.360
 N  P  N  L  S  L  R  I  F  T  A  R  L  Y  F  C  E  D  R  K         p.120

          .         .         .         .         .         .       g.12625
 GCTGAGCCCGAGGGGCTGCGGCGGCTGCACCGCGCCGGGGTGCAAATAGCCATCATGACC       c.420
 A  E  P  E  G  L  R  R  L  H  R  A  G  V  Q  I  A  I  M  T         p.140

         | 04.         .         .         .         .         .    g.12977
 TTCAAAG | ATTATTTTTACTGCTGGAATACTTTTGTAGAAAACCACGAAAGAACTTTCAAA    c.480
 F  K  D |   Y  F  Y  C  W  N  T  F  V  E  N  H  E  R  T  F  K      p.160

          .         .         .         .         .         .       g.13037
 GCCTGGGAAGGGCTGCATGAAAATTCAGTTCGTCTCTCCAGACAGCTTCGGCGCATCCTT       c.540
 A  W  E  G  L  H  E  N  S  V  R  L  S  R  Q  L  R  R  I  L         p.180

     | 05    .         .         .         .         .              g.13566
 TTG | CCCCTGTATGAGGTTGATGACTTACGAGACGCATTTCGTACTTTGGGACTTTGA       c.597
 L   | P  L  Y  E  V  D  D  L  R  D  A  F  R  T  L  G  L  X         p.198

          .         .         .         .         .         .       g.13626
 tagcaacttccaggaatgtcacacacgatgaaatatctctgctgaagacagtggataaaa       c.*60

          .         .         .         .         .         .       g.13686
 aacagtccttcaagtcttctctgtttttattcttcaactctcactttcttagagtttaca       c.*120

          .         .         .         .         .         .       g.13746
 gaaaaaatatttatatacgactctttaaaaagatctatgtcttgaaaatagagaaggaac       c.*180

          .         .         .         .         .         .       g.13806
 acaggtctggccagggacgtgctgcaattggtgcagttttgaatgcaacattgtccccta       c.*240

          .         .         .         .         .         .       g.13866
 ctgggaataacagaactgcaggacctgggagcatcctaaagtgtcaacgtttttctatga       c.*300

          .         .         .         .         .         .       g.13926
 cttttaggtaggatgagagcagaaggtagatcctaaaaagcatggtgagaggatcaaatg       c.*360

          .         .         .         .         .         .       g.13986
 tttttatatcaacatcctttattatttgattcatttgagttaacagtggtgttagtgata       c.*420

          .         .         .         .         .         .       g.14046
 gatttttctattcttttcccttgacgtttactttcaagtaacacaaactcttccatcagg       c.*480

          .         .         .         .         .         .       g.14106
 ccatgatctataggacctcctaatgagagtatctgggtgattgtgaccccaaaccatctc       c.*540

          .         .         .         .         .         .       g.14166
 tccaaagcattaatatccaatcatgcgctgtatgttttaatcagcagaagcatgttttta       c.*600

          .         .         .         .         .         .       g.14226
 tgtttgtacaaaagaagattgttatgggtggggatggaggtatagaccatgcatggtcac       c.*660

          .         .         .         .         .         .       g.14286
 cttcaagctactttaataaaggatcttaaaatgggcaggaggactgtgaacaagacaccc       c.*720

          .         .         .         .         .         .       g.14346
 taataatgggttgatgtctgaagtagcaaatcttctggaaacgcaaactcttttaaggaa       c.*780

          .         .         .         .         .         .       g.14406
 gtccctaatttagaaacacccacaaacttcacatatcataattagcaaacaattggaagg       c.*840

          .         .         .         .         .         .       g.14466
 aagttgcttgaatgttggggagaggaaaatctattggctctcgtgggtctcttcatctca       c.*900

          .         .         .         .         .         .       g.14526
 gaaatgccaatcaggtcaaggtttgctacattttgtatgtgtgtgatgcttctcccaaag       c.*960

          .         .         .         .         .         .       g.14586
 gtatattaactatataagagagttgtgacaaaacagaatgataaagctgcgaaccgtggc       c.*1020

          .         .         .         .         .         .       g.14646
 acacgctcatagttctagctgcttgggaggttgaggagggaggatggcttgaacacaggt       c.*1080

          .         .         .         .         .         .       g.14706
 gttcaaggccagcctgggcaacataacaagatcctgtctctcaaaaaaaaaaaaaaaaaa       c.*1140

          .         .         .         .         .         .       g.14766
 aagaaagagagagggccgggcgtggtggctcacgcctgtaatcccagcactttgggaggc       c.*1200

          .         .         .         .         .         .       g.14826
 cgagccgggcggatcacctgtggtcaggagtttgagaccagcctggccaacatggcaaaa       c.*1260

          .         .         .         .         .         .       g.14886
 ccccgtctgtactcaaaatgcaaaaattagccaggcgtggtagcaggcacctgtaatccc       c.*1320

          .         .         .         .         .         .       g.14946
 agctacttgggaggctgaggcaggagaatcgcttgaacccaggaggtggaggttgcagta       c.*1380

          .         .         .         .         .         .       g.15006
 agctgagatcgtgccgttgcactccagcctgggcgacaagagcaagactctgtctcagaa       c.*1440

          .         .         .         .         .         .       g.15066
 aaaaaaaaaaaaaagagagagagagagaaagagaacaatatttgggagagaaggatgggg       c.*1500

          .         .         .         .         .         .       g.15126
 aagcattgcaaggaaattgtgctttatccaacaaaatgtaaggagccaataagggatccc       c.*1560

          .         .         .         .         .         .       g.15186
 tatttgtctcttttggtgtctatttgtccctaacaactgtctttgacagtgagaaaaata       c.*1620

          .         .         .         .         .         .       g.15246
 ttcagaataaccatatccctgtgccgttattacctagcaacccttgcaatgaagatgagc       c.*1680

          .         .         .         .         .         .       g.15306
 agatccacaggaaaacttgaatgcacaactgtcttattttaatcttattgtacataagtt       c.*1740

          .         .         .         .         .         .       g.15366
 tgtaaaagagttaaaaattgttacttcatgtattcatttatattttatattattttgcgt       c.*1800

          .         .         .         .         .         .       g.15426
 ctaatgattttttattaacatgatttccttttctgatatattgaaatggagtctcaaagc       c.*1860

          .         .         .         .         .         .       g.15486
 ttcataaatttataactttagaaatgattctaataacaacgtatgtaattgtaacattgc       c.*1920

          .         .         .         .         .         .       g.15546
 agtaatggtgctacgaagccatttctcttgatttttagtaaacttttatgacagcaaatt       c.*1980

          .         .         .         .         .         .       g.15606
 tgcttctggctcactttcaatcagttaaataaatgataaataattttggaagctgtgaag       c.*2040

          .         .         .         .         .         .       g.15666
 ataaaataccaaataaaataatataaaagtgatttatatgaagttaaaataaaaaatcag       c.*2100

          .                                                         g.15684
 tatgatggaataaacttg                                                 c.*2118

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Activation-induced cytidine deaminase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.