fragile X mental retardation 1 (FMR1) - coding DNA reference sequence

(used for variant description)

(last modified October 31, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_002024.5 in the FMR1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007529.1, covering FMR1 transcript NM_002024.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5049
            acttccggtggagggccgcctctgagcgggcggcgggccgacggcgagc       c.-181

 .         .         .         .         .         .                g.5109
 gcgggcggcggcggtgacggaggcgccgctgccagggggcgtgcggcagcgcggcggcgg       c.-121

 .         .         .         .         .         .                g.5169
 cggcggcggcggcggcggcggaggcggcggcggcggcggcggcggcggcggctgggcctc       c.-61

 .         .         .         .         .         .                g.5229
 gagcgcccgcagcccacctctcgggggcgggctcccggcgctagcagggctgaagagaag       c.-1

          .         .         .         .         .  | 02      .    g.14991
 ATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGCTTTCTACAAG | GCATTTGTA    c.60
 M  E  E  L  V  V  E  V  R  G  S  N  G  A  F  Y  K   | A  F  V      p.20

          .         .         .         .     | 03   .         .    g.18605
 AAGGATGTTCATGAAGATTCAATAACAGTTGCATTTGAAAACAA | CTGGCAGCCTGATAGG    c.120
 K  D  V  H  E  D  S  I  T  V  A  F  E  N  N  |  W  Q  P  D  R      p.40

          .         .         .         .         .         .       g.18665
 CAGATTCCATTTCATGATGTCAGATTCCCACCTCCTGTAGGTTATAATAAAGATATAAAT       c.180
 Q  I  P  F  H  D  V  R  F  P  P  P  V  G  Y  N  K  D  I  N         p.60

          .         | 04         .         .         .         .    g.21413
 GAAAGTGATGAAGTTGAG | GTGTATTCCAGAGCAAATGAAAAAGAGCCTTGCTGTTGGTGG    c.240
 E  S  D  E  V  E   | V  Y  S  R  A  N  E  K  E  P  C  C  W  W      p.80

          .         .         . | 05       .         .         .    g.21738
 TTAGCTAAAGTGAGGATGATAAAGGGTGAG | TTTTATGTGATAGAATATGCAGCATGTGAT    c.300
 L  A  K  V  R  M  I  K  G  E   | F  Y  V  I  E  Y  A  A  C  D      p.100

          .         .         .         .         .         .       g.21798
 GCAACTTACAATGAAATTGTCACAATTGAACGTCTAAGATCTGTTAATCCCAACAAACCT       c.360
 A  T  Y  N  E  I  V  T  I  E  R  L  R  S  V  N  P  N  K  P         p.120

          .         .         .         .         .          | 06    g.22999
 GCCACAAAAGATACTTTCCATAAGATCAAGCTGGATGTGCCAGAAGACTTACGGCAAAT | G    c.420
 A  T  K  D  T  F  H  K  I  K  L  D  V  P  E  D  L  R  Q  M  |      p.140

          .         .         .         .         .         .       g.23059
 TGTGCCAAAGAGGCGGCACATAAGGATTTTAAAAAGGCAGTTGGTGCCTTTTCTGTAACT       c.480
 C  A  K  E  A  A  H  K  D  F  K  K  A  V  G  A  F  S  V  T         p.160

          .         .         .    | 07    .         .         .    g.23205
 TATGATCCAGAAAATTATCAGCTTGTCATTTTG | TCCATCAATGAAGTCACCTCAAAGCGA    c.540
 Y  D  P  E  N  Y  Q  L  V  I  L   | S  I  N  E  V  T  S  K  R      p.180

          .         .         .         .         .         .       g.23265
 GCACATATGCTGATTGACATGCACTTTCGGAGTCTGCGCACTAAGTTGTCTCTGATAATG       c.600
 A  H  M  L  I  D  M  H  F  R  S  L  R  T  K  L  S  L  I  M         p.200

          .         .         . | 08       .         .         .    g.25505
 AGAAATGAAGAAGCTAGTAAGCAGCTGGAG | AGTTCAAGGCAGCTTGCCTCGAGATTTCAT    c.660
 R  N  E  E  A  S  K  Q  L  E   | S  S  R  Q  L  A  S  R  F  H      p.220

          .         .         .         .         .         .       g.25565
 GAACAGTTTATCGTAAGAGAAGATCTGATGGGTCTAGCTATTGGTACTCATGGTGCTAAT       c.720
 E  Q  F  I  V  R  E  D  L  M  G  L  A  I  G  T  H  G  A  N         p.240

          .         .         .         .         .         .       g.25625
 ATTCAGCAAGCTAGAAAAGTACCTGGGGTCACTGCTATTGATCTAGATGAAGATACCTGC       c.780
 I  Q  Q  A  R  K  V  P  G  V  T  A  I  D  L  D  E  D  T  C         p.260

          .         .  | 09      .         .         .         .    g.25774
 ACATTTCATATTTATGGAGAG | GATCAGGATGCAGTGAAAAAAGCTAGAAGCTTTCTCGAA    c.840
 T  F  H  I  Y  G  E   | D  Q  D  A  V  K  K  A  R  S  F  L  E      p.280

          .         .         .         . | 10       .         .    g.29574
 TTTGCTGAAGATGTAATACAAGTTCCAAGGAACTTAGTAG | GCAAAGTAATAGGAAAAAAT    c.900
 F  A  E  D  V  I  Q  V  P  R  N  L  V  G |   K  V  I  G  K  N      p.300

          .         .         .         .         .         .       g.29634
 GGAAAGCTGATTCAGGAGATTGTGGACAAGTCAGGAGTTGTGAGGGTGAGGATTGAGGCT       c.960
 G  K  L  I  Q  E  I  V  D  K  S  G  V  V  R  V  R  I  E  A         p.320

          .         .         . | 11       .         .         .    g.30546
 GAAAATGAGAAAAATGTTCCACAAGAAGAG | GAAATTATGCCACCAAATTCCCTTCCTTCC    c.1020
 E  N  E  K  N  V  P  Q  E  E   | E  I  M  P  P  N  S  L  P  S      p.340

          .         .         .         .         .         .       g.30606
 AATAATTCAAGGGTTGGACCTAATGCCCCAGAAGAAAAAAAACATTTAGATATAAAGGAA       c.1080
 N  N  S  R  V  G  P  N  A  P  E  E  K  K  H  L  D  I  K  E         p.360

          .         .         .         .      | 12  .         .    g.31164
 AACAGCACCCATTTTTCTCAACCTAACAGTACAAAAGTCCAGAGG | GTGTTAGTGGCTTCA    c.1140
 N  S  T  H  F  S  Q  P  N  S  T  K  V  Q  R   | V  L  V  A  S      p.380

          .         .         .         .         | 13         .    g.33638
 TCAGTTGTAGCAGGGGAATCCCAGAAACCTGAACTCAAGGCTTGGCAG | GGTATGGTACCA    c.1200
 S  V  V  A  G  E  S  Q  K  P  E  L  K  A  W  Q   | G  M  V  P      p.400

          .         .         .         .         .         .       g.33698
 TTTGTTTTTGTGGGAACAAAGGACAGCATCGCTAATGCCACTGTTCTTTTGGATTATCAC       c.1260
 F  V  F  V  G  T  K  D  S  I  A  N  A  T  V  L  L  D  Y  H         p.420

          .      | 14  .         .         .         .         .    g.36227
 CTGAACTATTTAAAG | GAAGTAGACCAGTTGCGTTTGGAGAGATTACAAATTGATGAGCAG    c.1320
 L  N  Y  L  K   | E  V  D  Q  L  R  L  E  R  L  Q  I  D  E  Q      p.440

          .         .         .         .         .         .       g.36287
 TTGCGACAGATTGGAGCTAGTTCTAGACCACCACCAAATCGTACAGATAAGGAAAAAAGC       c.1380
 L  R  Q  I  G  A  S  S  R  P  P  P  N  R  T  D  K  E  K  S         p.460

          .         .         .         .         .         .       g.36347
 TATGTGACTGATGATGGTCAAGGAATGGGTCGAGGTAGTAGACCTTACAGAAATAGGGGG       c.1440
 Y  V  T  D  D  G  Q  G  M  G  R  G  S  R  P  Y  R  N  R  G         p.480

          .         .         .  | 15      .         .         .    g.37949
 CACGGCAGACGCGGTCCTGGATATACTTCAG | GAACTAATTCTGAAGCATCAAATGCTTCT    c.1500
 H  G  R  R  G  P  G  Y  T  S  G |   T  N  S  E  A  S  N  A  S      p.500

          .         .         .         .         .         .       g.38009
 GAAACAGAATCTGACCACAGAGACGAACTCAGTGATTGGTCATTAGCTCCAACAGAGGAA       c.1560
 E  T  E  S  D  H  R  D  E  L  S  D  W  S  L  A  P  T  E  E         p.520

          .         .         .         .         .         .       g.38069
 GAGAGGGAGAGCTTCCTGCGCAGAGGAGACGGACGGCGGCGTGGAGGGGGAGGAAGAGGA       c.1620
 E  R  E  S  F  L  R  R  G  D  G  R  R  R  G  G  G  G  R  G         p.540

          .         .         .     | 16   .         .         .    g.38611
 CAAGGAGGAAGAGGACGTGGAGGAGGCTTCAAAG | GAAACGACGATCACTCCCGAACAGAT    c.1680
 Q  G  G  R  G  R  G  G  G  F  K  G |   N  D  D  H  S  R  T  D      p.560

          .         .         .         .         .        | 17.    g.41737
 AATCGTCCACGTAATCCAAGAGAGGCTAAAGGAAGAACAACAGATGGATCCCTTCAG | ATC    c.1740
 N  R  P  R  N  P  R  E  A  K  G  R  T  T  D  G  S  L  Q   | I      p.580

          .         .         .         .         .         .       g.41797
 AGAGTTGACTGCAATAATGAAAGGAGTGTCCACACTAAAACATTACAGAATACCTCCAGT       c.1800
 R  V  D  C  N  N  E  R  S  V  H  T  K  T  L  Q  N  T  S  S         p.600

          .         .         .         .         .         .       g.41857
 GAAGGTAGTCGGCTGCGCACGGGTAAAGATCGTAACCAGAAGAAAGAGAAGCCAGACAGC       c.1860
 E  G  S  R  L  R  T  G  K  D  R  N  Q  K  K  E  K  P  D  S         p.620

          .         .         .                                     g.41896
 GTGGATGGTCAGCAACCACTCGTGAATGGAGTACCCTAA                            c.1899
 V  D  G  Q  Q  P  L  V  N  G  V  P  X                              p.632

          .         .         .         .         .         .       g.41956
 actgcataattctgaagttatatttcctataccatttccgtaattcttattccatattag       c.*60

          .         .         .         .         .         .       g.42016
 aaaactttgttaggccaaagacaaatagtaggcaagatggcacagggcatgaaatgaaca       c.*120

          .         .         .         .         .         .       g.42076
 caaattatgctaagaattttttattttttggtattggccataagcaacaattttcagatt       c.*180

          .         .         .         .         .         .       g.42136
 tgcacaaaaagataccttaaaatttgaaacattgcttttaaaactacttagcacttcagg       c.*240

          .         .         .         .         .         .       g.42196
 gcagattttagttttattttctaaagtactgagcagtgatattctttgttaatttggacc       c.*300

          .         .         .         .         .         .       g.42256
 attttcctgcattgggtgatcattcaccagtacattctcagtttttcttaatatatagca       c.*360

          .         .         .         .         .         .       g.42316
 tttatggtaatcatattagacttctgttttcaatctcgtatagaagtcttcatgaaatgc       c.*420

          .         .         .         .         .         .       g.42376
 tatgtcatttcatgtcctgtgtcagtttatgttttggtccacttttccagtattttagtg       c.*480

          .         .         .         .         .         .       g.42436
 gaccctgaaatgtgtgtgatgtgacatttgtcattttcattagcaaaaaaagttgtatga       c.*540

          .         .         .         .         .         .       g.42496
 tctgtgccttttttatatcttggcaggtaggaatattatatttggatgcagagttcaggg       c.*600

          .         .         .         .         .         .       g.42556
 aagataagttggaaacactaaatgttaaagatgtagcaaaccctgtcaaacattagtact       c.*660

          .         .         .         .         .         .       g.42616
 ttatagaagaatgcatgctttccatatttttttccttacataaacatcaggttaggcagt       c.*720

          .         .         .         .         .         .       g.42676
 ataaagaataggacttgtttttgtttttgttttgttgcactgaagtttgataaatagtgt       c.*780

          .         .         .         .         .         .       g.42736
 tattgagagagatgtgtaatttttctgtatagacaggagaagaaagaactatcttcatct       c.*840

          .         .         .         .         .         .       g.42796
 gagagaggctaaaatgttttcagctaggaacaaatcttcctggtcgaaagttagtaggat       c.*900

          .         .         .         .         .         .       g.42856
 atgcctgctctttggcctgatgaccaattttaacttagagctttttttttttaattttgt       c.*960

          .         .         .         .         .         .       g.42916
 ctgccccaagttttgtgaaatttttcatattttaatttcaagcttattttggagagatag       c.*1020

          .         .         .         .         .         .       g.42976
 gaaggtcatttccatgtatgcataataatcctgcaaagtacaggtactttgtctaagaaa       c.*1080

          .         .         .         .         .         .       g.43036
 cattggaagcaggttaaatgttttgtaaactttgaaatatatggtctaatgtttaagcag       c.*1140

          .         .         .         .         .         .       g.43096
 aattggaaaagactaagatcggttaacaaataacaacttttttttctttttttcttttgt       c.*1200

          .         .         .         .         .         .       g.43156
 tttttgaagtgttggggtttggttttgttttttgagtcttttttttttaagtgaaattta       c.*1260

          .         .         .         .         .         .       g.43216
 ttgaggaaaaatatgtgaaggaccttcactctaagatgttatatttttcttaaaaagtaa       c.*1320

          .         .         .         .         .         .       g.43276
 ctcctagtaggggtaccactgaatctgtacagagccgtaaaaactgaagttctgcctctg       c.*1380

          .         .         .         .         .         .       g.43336
 atgtattttgtgagtttgtttctttgaattttcattttacagttacttttccttgcatac       c.*1440

          .         .         .         .         .         .       g.43396
 aaacaagcatataaaatggcaacaaactgcacatgatttcacaaatattaaaaagtcttt       c.*1500

          .         .         .         .         .         .       g.43456
 taaaaagtattgccaaacattaatgttgatttctagttatttattctgggaatgtatagt       c.*1560

          .         .         .         .         .         .       g.43516
 atttgaaaacagaaattggtaccttgcacacatcatctgtaagctgtttggttttaaaat       c.*1620

          .         .         .         .         .         .       g.43576
 actgtagataattaaccaaggtagaatgaccttgtaatgtaactgctcttgggcaatatt       c.*1680

          .         .         .         .         .         .       g.43636
 ctctgtacatattagcgacaacagattggattttatgttgacatttgtttggttatagtg       c.*1740

          .         .         .         .         .         .       g.43696
 caatatattttgtatgcaagcagtttcaataaagtttgatcttcctctgctaaattgatg       c.*1800

          .         .         .         .         .         .       g.43756
 ttgatgcaatccttacaaatgattgcttttaaaattttaagctaggaaaagaaatctata       c.*1860

          .         .         .         .         .         .       g.43816
 gaaagtgttctgttacaaaatgtaactgttaccattggaaatttcacgtcataggaagtt       c.*1920

          .         .         .         .         .         .       g.43876
 agcctttatctaccaactttcaagaacttgtttaataaagcgaaaaactcaaccaaatgg       c.*1980

          .         .         .         .         .         .       g.43936
 tacaaaaccacagtgtaccattaaaatatgcactaagtctcttttttacaaaggctgtat       c.*2040

          .         .         .         .         .         .       g.43996
 tcagcaaggcgctaacttgcttaaatgtgaattactaacttctaaaactgtactttgatt       c.*2100

          .         .         .         .         .         .       g.44056
 cacatgttttcaaatggagttggagttcattcatattacaatatttgtgtgctaaacgtg       c.*2160

          .         .         .         .         .         .       g.44116
 tatgtttttcagttcaaagtcatgatgtttttaaaatcttattaaagtttcaaaaatctg       c.*2220

          .         .         .         .         .         .       g.44176
 aagattgtttatctagatgtaaatttttattaaaaagttgcacttatgaaaaagcaaaaa       c.*2280

                                                                    g.44179
 att                                                                c.*2283

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fragile X mental retardation 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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