hepatic and glial cell adhesion molecule (HEPACAM) - coding DNA reference sequence

(used for variant description)

(last modified November 9, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_152722.4 in the HEPACAM gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering HEPACAM transcript NM_152722.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5046
               gttaggtggagacagggtaggttgggacacaaagtccagttaagtg       c.-361

 .         .         .         .         .         .                g.5106
 tgtgtcccagctcagtgctctgagcccagatcctcatctccctgggtagtgaggctcagc       c.-301

 .         .         .         .         .         .                g.5166
 acagacaagcaaccaactgctgggctgccggtgccccccatgttggaacctgagttggag       c.-241

 .         .         .         .         .         .                g.5226
 attatctcctaagcagatacctgcttccaaactggggatgtagggcttggaaactagaaa       c.-181

 .         .         .         .         .         .                g.5286
 atgccaggtctgagggagaggaaagaacaagtccagcaatacacagagctctgtgtattc       c.-121

 .         .         .         .         .         .                g.5346
 agagggaagttggcagggttgtgttcgggcagagaaactccgagtggtacaaaggggacg       c.-61

 .         .         .         .         .         .                g.5406
 tgcccagagtggagaaatcatgctaattgtctgcactagagctggagaacgccacccaaa       c.-1

          .         .         .         .         .         .       g.5466
 ATGAAGAGAGAAAGGGGAGCCCTGTCCAGAGCCTCCAGGGCCCTGCGCCTTGCTCCTTTT       c.60
 M  K  R  E  R  G  A  L  S  R  A  S  R  A  L  R  L  A  P  F         p.20

          .         .      | 02  .         .         .         .    g.16378
 GTCTACCTTCTTCTGATCCAGACAG | ACCCCCTGGAGGGGGTGAACATCACCAGCCCCGTG    c.120
 V  Y  L  L  L  I  Q  T  D |   P  L  E  G  V  N  I  T  S  P  V      p.40

          .         .         .         .         .         .       g.16438
 CGCCTGATCCATGGCACCGTGGGGAAGTCGGCTCTGCTTTCTGTGCAGTACAGCAGTACC       c.180
 R  L  I  H  G  T  V  G  K  S  A  L  L  S  V  Q  Y  S  S  T         p.60

          .         .         .         .         .         .       g.16498
 AGCAGCGACAGGCCTGTAGTGAAGTGGCAGCTGAAGCGGGACAAGCCAGTGACCGTGGTG       c.240
 S  S  D  R  P  V  V  K  W  Q  L  K  R  D  K  P  V  T  V  V         p.80

          .         .         .         .         .         .       g.16558
 CAGTCCATTGGCACAGAGGTCATCGGCACCCTGCGGCCTGACTATCGAGACCGTATCCGA       c.300
 Q  S  I  G  T  E  V  I  G  T  L  R  P  D  Y  R  D  R  I  R         p.100

          .         .         .         .         .         .       g.16618
 CTCTTTGAAAATGGCTCCCTGCTTCTCAGCGACCTGCAGCTGGCCGATGAGGGCACCTAT       c.360
 L  F  E  N  G  S  L  L  L  S  D  L  Q  L  A  D  E  G  T  Y         p.120

          .         .         .         .         .         .       g.16678
 GAGGTCGAGATCTCCATCACCGACGACACCTTCACTGGGGAGAAGACCATCAACCTTACT       c.420
 E  V  E  I  S  I  T  D  D  T  F  T  G  E  K  T  I  N  L  T         p.140

         | 03.         .         .         .         .         .    g.17455
 GTAGATG | TGCCCATTTCGAGGCCACAGGTGTTGGTGGCTTCAACCACTGTGCTGGAGCTC    c.480
 V  D  V |   P  I  S  R  P  Q  V  L  V  A  S  T  T  V  L  E  L      p.160

          .         .         .         .         .         .       g.17515
 AGCGAGGCCTTCACCTTGAACTGCTCACATGAGAATGGCACCAAGCCCAGCTACACCTGG       c.540
 S  E  A  F  T  L  N  C  S  H  E  N  G  T  K  P  S  Y  T  W         p.180

          .         .         .         .         .         .       g.17575
 CTGAAGGATGGCAAGCCCCTCCTCAATGACTCGAGAATGCTCCTGTCCCCCGACCAAAAG       c.600
 L  K  D  G  K  P  L  L  N  D  S  R  M  L  L  S  P  D  Q  K         p.200

          .         .         .         .         .         .       g.17635
 GTGCTCACCATCACCCGCGTGCTCATGGAGGATGACGACCTGTACAGCTGCATGGTGGAG       c.660
 V  L  T  I  T  R  V  L  M  E  D  D  D  L  Y  S  C  M  V  E         p.220

          .         .         .         .          | 04        .    g.17990
 AACCCCATCAGCCAGGGCCGCAGCCTGCCTGTCAAGATCACCGTATACA | GAAGAAGCTCC    c.720
 N  P  I  S  Q  G  R  S  L  P  V  K  I  T  V  Y  R |   R  S  S      p.240

          .         .         .         .         .         .       g.18050
 CTTTACATCATCTTGTCTACAGGAGGCATCTTCCTCCTTGTGACCTTGGTGACAGTCTGT       c.780
 L  Y  I  I  L  S  T  G  G  I  F  L  L  V  T  L  V  T  V  C         p.260

          .         .    | 05    .         .         .         .    g.18631
 GCCTGCTGGAAACCCTCCAAAAG | GAAACAGAAGAAGCTAGAAAAGCAAAACTCCCTGGAA    c.840
 A  C  W  K  P  S  K  R  |  K  Q  K  K  L  E  K  Q  N  S  L  E      p.280

          .         .         .        | 06.         .         .    g.18977
 TACATGGATCAGAATGATGACCGCCTGAAACCAGAAG | CAGACACCCTCCCTCGAAGTGGT    c.900
 Y  M  D  Q  N  D  D  R  L  K  P  E  A |   D  T  L  P  R  S  G      p.300

          .         .         .         .         | 07         .    g.19984
 GAGCAGGAACGGAAGAACCCCATGGCACTCTATATCCTGAAGGACAAG | GACTCCCCGGAG    c.960
 E  Q  E  R  K  N  P  M  A  L  Y  I  L  K  D  K   | D  S  P  E      p.320

          .         .         .         .         .         .       g.20044
 ACCGAGGAGAACCCGGCCCCGGAGCCTCGAAGCGCGACGGAGCCCGGCCCGCCCGGCTAC       c.1020
 T  E  E  N  P  A  P  E  P  R  S  A  T  E  P  G  P  P  G  Y         p.340

          .         .         .         .         .         .       g.20104
 TCCGTGTCTCCCGCCGTGCCCGGCCGCTCGCCGGGGCTGCCCATCCGCTCTGCCCGCCGC       c.1080
 S  V  S  P  A  V  P  G  R  S  P  G  L  P  I  R  S  A  R  R         p.360

          .         .         .         .         .         .       g.20164
 TACCCGCGCTCCCCAGCGCGCTCCCCAGCCACCGGCCGGACACACTCGTCGCCGCCCAGG       c.1140
 Y  P  R  S  P  A  R  S  P  A  T  G  R  T  H  S  S  P  P  R         p.380

          .         .         .         .         .         .       g.20224
 GCCCCGAGCTCGCCCGGCCGCTCGCGCAGCGCCTCGCGCACACTGCGGACTGCGGGCGTG       c.1200
 A  P  S  S  P  G  R  S  R  S  A  S  R  T  L  R  T  A  G  V         p.400

          .         .         .         .         .                 g.20275
 CACATAATCCGCGAGCAAGACGAGGCCGGCCCGGTGGAGATCAGCGCCTGA                c.1251
 H  I  I  R  E  Q  D  E  A  G  P  V  E  I  S  A  X                  p.416

          .         .         .         .         .         .       g.20335
 gccgcctcgggatcccctgagaggcgcccgcggtctgcggccagtggcccgggggaaagc       c.*60

          .         .         .         .         .         .       g.20395
 tggggctgggaagcccgggcgcggcgcgctggggacgaggggaggtcccgggggggcgct       c.*120

          .         .         .         .         .         .       g.20455
 ggtgtctcgggtgtgaacgtgtatgagcatgcgcagacggaggcgggtgcgcggaggcgg       c.*180

          .         .         .         .         .         .       g.20515
 cagtgttgatatggtgaaaccgggtcgcatttgcttccggtttactggctgtgtcctcac       c.*240

          .         .         .         .         .         .       g.20575
 ttggtataggttgtgccctcttaggaccacatagattattacatttctggcccaataccc       c.*300

          .         .         .         .         .         .       g.20635
 aaaagggttttatggaaactaacatcagtaacctaacccccgtgactatcctgtgctctt       c.*360

          .         .         .         .         .         .       g.20695
 cctagggagctgtgttgtttcccacccaccacccttccctctgaacaaatgcctgagtgc       c.*420

          .         .         .         .         .         .       g.20755
 tggggcactttttttttttttttttttttttttttttttgcaagttcagattagagaggc       c.*480

          .         .         .         .         .         .       g.20815
 cactttcccagaatccacagctgcactaagctaaggagaagccagatgccggttactggg       c.*540

          .         .         .         .         .         .       g.20875
 tgtgcaggggctgttctgagctggggggatcattgtgaaggccttcttccctgggcacct       c.*600

          .         .         .         .         .         .       g.20935
 ggtacctggggacctacaaggtggtgagggaagggtacgagtacattccttttccctctg       c.*660

          .         .         .         .         .         .       g.20995
 acctgggcgctagcaagggcaaagaacccgagcctgccagcttggcctcctcccacagcc       c.*720

          .         .         .         .         .         .       g.21055
 tccctcggaggcatgccatgccaagcactctttctgtctctgttcatgaataaaagagat       c.*780

          .         .         .         .         .         .       g.21115
 ggatgggcttattcttatagagaagtgaatttcacttactcccctggcccgaaaactaga       c.*840

          .         .         .         .         .         .       g.21175
 ccaaatgaggaactgttttagctcatcaaactcatatattcctcctggcttccttacaaa       c.*900

          .         .         .         .         .         .       g.21235
 acaagcctttcaaacaatcattgtcctcaggaaagttgttgagcttcctccagctgtgag       c.*960

          .         .         .         .         .         .       g.21295
 aataagtcctaatctccagagaaatggtggggggaggaggaggcttattgcttcccagca       c.*1020

          .         .         .         .         .         .       g.21355
 tttggggggaacatgatccaacccctggcctcctgccacccatctgccctgctcccacat       c.*1080

          .         .         .         .         .         .       g.21415
 gctcaggtcccagggcacagaaaaagggcagactccctaatcacactaacatcaaaataa       c.*1140

          .         .         .         .         .         .       g.21475
 agaggctgggccgctgtgtagccaggacatgcccatgccaccgcctattgaacagttcat       c.*1200

          .         .         .         .         .         .       g.21535
 aggagtggcagtaatctactgtgtgaggagagagggcaattaaaaagctgaaagagaagg       c.*1260

          .         .         .         .         .         .       g.21595
 aggccctctgtgtattccattccctcctccttaatgcctccaagggtccttgcatcccta       c.*1320

          .         .         .         .         .         .       g.21655
 gtctcctaaactccagctctgattcgccatcaacccatggagcaattccaaggccccagt       c.*1380

          .         .         .         .         .         .       g.21715
 tacccatcacctccacaccaggtcaagttttgtctcagccccaaaggcactgacatttct       c.*1440

          .         .         .         .         .         .       g.21775
 agtttgccccctctgccctgaaccccacagcatgcctgtctcagctccctgtccctcggc       c.*1500

          .         .         .         .         .         .       g.21835
 acttccccaggctcatttgagcaggtgtgccttcgcagctcccctaaacttcccaggtgc       c.*1560

          .         .         .         .         .         .       g.21895
 ctcatccataatgagataatgcatgtaggggaaaagtttctcaagaaggtggaagaggca       c.*1620

          .         .         .         .         .         .       g.21955
 gcaggacttggataaggagtacctgctggtcagccttgagatgcacaggtgaaggttagg       c.*1680

          .         .         .         .         .         .       g.22015
 gtgagatgagaacatgccataccctggtgctgaatccctgaggggccagcttgccaggct       c.*1740

          .         .         .         .         .         .       g.22075
 taagccaaatctgccttaaattgggggtggggaggggtaagtaaggaagtggggtttgtt       c.*1800

          .         .         .         .         .         .       g.22135
 tttgtgttgttttcatcttcatctttgtattactagcatccagcagagtgcctagcacat       c.*1860

          .         .                                               g.22164
 actggatgctcaataaacttttgatgaaa                                      c.*1889

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Hepatic and glial cell adhesion molecule protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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