matrilin 3 (MATN3) - coding DNA reference sequence

(used for variant description)

(last modified March 6, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_002381.4 in the MATN3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008087.1, covering MATN3 transcript NM_002381.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          aaa       c.-61

 .         .         .         .         .         .                g.5063
 tccgagcctcgcgtgggctcctggcccccgacggacaccaccaggcccacggagcccacc       c.-1

          .         .         .         .         .         .       g.5123
 ATGCCGCGCCCGGCCCCCGCGCGCCGCCTCCCGGGACTCCTCCTGCTGCTCTGGCCGCTG       c.60
 M  P  R  P  A  P  A  R  R  L  P  G  L  L  L  L  L  W  P  L         p.20

          .         .         .         .         .         .       g.5183
 CTGCTGCTGCCCTCCGCCGCCCCCGACCCCGTGGCCCGCCCGGGCTTCCGGAGGCTGGAG       c.120
 L  L  L  P  S  A  A  P  D  P  V  A  R  P  G  F  R  R  L  E         p.40

          .         .         .         .         .         .       g.5243
 ACCCGAGGTCCCGGGGGCAGCCCTGGACGCCGCCCCTCTCCTGCGGCTCCCGACGGCGCG       c.180
 T  R  G  P  G  G  S  P  G  R  R  P  S  P  A  A  P  D  G  A         p.60

          .         .         .         .    | 02    .         .    g.11401
 CCCGCTTCCGGGACCAGCGAGCCTGGCCGCGCCCGCGGTGCAG | GTGTTTGCAAGAGCAGA    c.240
 P  A  S  G  T  S  E  P  G  R  A  R  G  A  G |   V  C  K  S  R      p.80

          .         .         .         .         .         .       g.11461
 CCCTTGGACCTGGTGTTTATCATTGATAGTTCTCGTAGCGTACGGCCCCTGGAATTCACC       c.300
 P  L  D  L  V  F  I  I  D  S  S  R  S  V  R  P  L  E  F  T         p.100

          .         .         .         .         .         .       g.11521
 AAAGTGAAAACTTTTGTCTCCCGGATAATCGACACTCTGGACATTGGGCCAGCCGACACG       c.360
 K  V  K  T  F  V  S  R  I  I  D  T  L  D  I  G  P  A  D  T         p.120

          .         .         .         .         .         .       g.11581
 CGGGTGGCAGTGGTGAACTATGCTAGCACTGTGAAGATCGAGTTCCAACTCCAGGCCTAC       c.420
 R  V  A  V  V  N  Y  A  S  T  V  K  I  E  F  Q  L  Q  A  Y         p.140

          .         .         .         .         .         .       g.11641
 ACAGATAAGCAGTCCCTGAAGCAGGCCGTGGGTCGAATCACACCCTTGTCAACAGGCACC       c.480
 T  D  K  Q  S  L  K  Q  A  V  G  R  I  T  P  L  S  T  G  T         p.160

          .         .         .         .         .         .       g.11701
 ATGTCAGGCCTAGCCATCCAGACAGCAATGGACGAAGCCTTCACAGTGGAGGCAGGGGCT       c.540
 M  S  G  L  A  I  Q  T  A  M  D  E  A  F  T  V  E  A  G  A         p.180

          .         .         .         .         .         .       g.11761
 CGAGAGCCCTCTTCTAACATCCCTAAGGTGGCCATCATTGTTACAGATGGGAGGCCCCAG       c.600
 R  E  P  S  S  N  I  P  K  V  A  I  I  V  T  D  G  R  P  Q         p.200

          .         .         .         .         .         .       g.11821
 GACCAGGTGAATGAGGTGGCGGCTCGGGCCCAAGCATCTGGTATTGAGCTCTATGCTGTG       c.660
 D  Q  V  N  E  V  A  A  R  A  Q  A  S  G  I  E  L  Y  A  V         p.220

          .         .         .         .         .         .       g.11881
 GGCGTGGACCGGGCAGACATGGCGTCCCTCAAGATGATGGCCAGTGAGCCCCTAGAGGAG       c.720
 G  V  D  R  A  D  M  A  S  L  K  M  M  A  S  E  P  L  E  E         p.240

          .         .         .         .         .         .       g.11941
 CATGTTTTCTACGTGGAGACCTATGGGGTCATTGAGAAACTTTCCTCTAGATTCCAGGAA       c.780
 H  V  F  Y  V  E  T  Y  G  V  I  E  K  L  S  S  R  F  Q  E         p.260

          . | 03       .         .         .         .         .    g.14458
 ACCTTCTGTG | CGCTGGACCCCTGTGTGCTTGGAACACACCAGTGCCAGCACGTCTGCATC    c.840
 T  F  C  A |   L  D  P  C  V  L  G  T  H  Q  C  Q  H  V  C  I      p.280

          .         .         .         .         .         .       g.14518
 AGTGATGGGGAAGGCAAGCACCACTGTGAGTGTAGCCAAGGATACACCTTGAATGCCGAC       c.900
 S  D  G  E  G  K  H  H  C  E  C  S  Q  G  Y  T  L  N  A  D         p.300

          .       | 04 .         .         .         .         .    g.15658
 AAGAAAACGTGTTCAG | CTCTTGATAGGTGTGCTCTTAACACCCACGGATGTGAGCACATC    c.960
 K  K  T  C  S  A |   L  D  R  C  A  L  N  T  H  G  C  E  H  I      p.320

          .         .         .         .         .         .       g.15718
 TGTGTGAATGACAGAAGTGGCTCTTATCATTGTGAGTGCTATGAAGGTTATACCTTGAAT       c.1020
 C  V  N  D  R  S  G  S  Y  H  C  E  C  Y  E  G  Y  T  L  N         p.340

          .         .   | 05     .         .         .         .    g.17166
 GAAGACAGGAAAACTTGTTCAG | CTCAAGATAAATGTGCTTTGGGTACCCATGGGTGTCAG    c.1080
 E  D  R  K  T  C  S  A |   Q  D  K  C  A  L  G  T  H  G  C  Q      p.360

          .         .         .         .         .         .       g.17226
 CACATTTGTGTGAATGACAGAACAGGGTCCCATCATTGTGAATGCTATGAGGGCTACACT       c.1140
 H  I  C  V  N  D  R  T  G  S  H  H  C  E  C  Y  E  G  Y  T         p.380

          .         .         | 06         .         .         .    g.20467
 CTGAATGCAGATAAAAAAACATGTTCAG | TCCGTGACAAGTGTGCCCTAGGCTCTCATGGT    c.1200
 L  N  A  D  K  K  T  C  S  V |   R  D  K  C  A  L  G  S  H  G      p.400

          .         .         .         .         .         .       g.20527
 TGCCAGCACATTTGTGTGAGTGATGGGGCCGCATCCTACCACTGTGATTGCTATCCTGGC       c.1260
 C  Q  H  I  C  V  S  D  G  A  A  S  Y  H  C  D  C  Y  P  G         p.420

          .         .         .     | 07   .         .         .    g.23311
 TACACCTTAAATGAGGACAAGAAAACATGTTCAG | CCACTGAGGAAGCACGAAGACTTGTT    c.1320
 Y  T  L  N  E  D  K  K  T  C  S  A |   T  E  E  A  R  R  L  V      p.440

          .         .         .         .         .         .       g.23371
 TCCACTGAAGATGCTTGTGGATGTGAAGCTACACTGGCATTCCAGGACAAGGTCAGCTCG       c.1380
 S  T  E  D  A  C  G  C  E  A  T  L  A  F  Q  D  K  V  S  S         p.460

          .         .      | 08  .         .         .         .    g.24563
 TATCTTCAAAGACTGAACACTAAAC | TTGATGACATTTTGGAGAAGTTGAAAATAAATGAA    c.1440
 Y  L  Q  R  L  N  T  K  L |   D  D  I  L  E  K  L  K  I  N  E      p.480

          .         .                                               g.24584
 TATGGACAAATACATCGTTAA                                              c.1461
 Y  G  Q  I  H  R  X                                                p.486

          .         .         .         .         .         .       g.24644
 attgctccaatttctcacctgaaaatgtggacagcttggtgtacttaatactcatgcatt       c.*60

          .         .         .         .         .         .       g.24704
 cttttgcacacctgttattgccaatgttcctgctaataatttgccattatctgtattaat       c.*120

          .         .         .         .         .         .       g.24764
 gcttgaatattactggataaattgtatgaagatcttctgcagaatcagcatgattcttcc       c.*180

          .         .         .         .         .         .       g.24824
 aaggaaatacatatgcagatacttattaagagcaaactttagtgtctctaagttatgact       c.*240

          .         .         .         .         .         .       g.24884
 gtgaaatgattggtaggaaatagaatgaaaagtttagtgtttctttatctactaattgag       c.*300

          .         .         .         .         .         .       g.24944
 ccatttaatttttaaatgtttatattagataaccatattcacaatggaaactttaggtct       c.*360

          .         .         .         .         .         .       g.25004
 agtttcttttgatagtatttataatataaatcaatcttattactgagagtgcaaattgta       c.*420

          .         .         .         .         .         .       g.25064
 caaggtatttacacatacaacttcatataactgagatgaatgtaattttgaactgtttaa       c.*480

          .         .         .         .         .         .       g.25124
 cactttttgttttttgcttattttgttggagtattattgaagatgtgatcaatagattgt       c.*540

          .         .         .         .         .         .       g.25184
 aatacacatatctaaaaatagttaacacagatcaagtgaacattacattgccatttttaa       c.*600

          .         .         .         .         .         .       g.25244
 ttcattctggtctttgaaagaaatgtactactaaagagcactagttgtgaatttagggtg       c.*660

          .         .         .         .         .         .       g.25304
 ttaaactttttaccaagtacaaaaatcccaaattcactttattattttgcttcaggatcc       c.*720

          .         .         .         .         .         .       g.25364
 aagtgacaaagttatatatttataaaattgctataaatcgacaaaatctaatgttgtctt       c.*780

          .         .         .         .         .         .       g.25424
 tttaatgttagtgatccacctgcctcagcctcccaaagtgctgggattacaggcttgaaa       c.*840

          .         .         .         .         .         .       g.25484
 gtctaacttttttttacttatatatttgatacatataattcttttggctttgaaacttgc       c.*900

          .         .         .         .         .         .       g.25544
 aactttgagaacaaaacagtcctttaaattttgcactgctcaattctgtttttcgtttgc       c.*960

          .         .         .         .         .         .       g.25604
 attgtctttaatataataaaagttattacctttacatattatcatgtctatttttgatga       c.*1020

          .         .         .                                     g.25643
 ctcatcaattttgtctattaaagatatttctttaaatta                            c.*1059

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Matrilin 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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