microtubule associated monoxygenase, calponin and LIM domain containing 1 (MICAL1) - coding DNA reference sequence

(used for variant description)

(last modified February 17, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_022765.3 in the MICAL1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_042833.1, covering MICAL1 transcript NM_022765.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5012
                                                 cccaagactgtc       c.-301

 .         .         .         .         .         .                g.5072
 cccgctggaggcggtagagggatccagaagtaatgagatgctaatgagtcgcgaataaag       c.-241

 .         .         .         .         .         .                g.5132
 cccgggcggcgccccgcgcccctcgcggaagcccacactccgcgcgactccaggcgcacg       c.-181

 .         .         .         .         .         .                g.5192
 ccccgggccgccccgcatcccagcatccccgcccgatctcggcgtttccgcccccgcccc       c.-121

 .         .         .         .         .         .                g.5252
 cgcccccgccctcccacccgctcagacctggttgccagcccaacaggaagcggcccctcc       c.-61

 .         .       | 02 .         .         .         .             g.6791
 cggcttcggagccgccg | ccactcatctctgcccagctgctgccctccccaggaggcctcc    c.-1

          .         .         .         .         .         .       g.6851
 ATGGCTTCACCTACCTCCACCAACCCAGCGCATGCCCACTTTGAGAGCTTCCTGCAGGCC       c.60
 M  A  S  P  T  S  T  N  P  A  H  A  H  F  E  S  F  L  Q  A         p.20

          .         .         .         .         .         .       g.6911
 CAGCTGTGCCAGGACGTGCTGAGCAGCTTCCAGGAGCTGTGTGGGGCCCTGGGGCTGGAA       c.120
 Q  L  C  Q  D  V  L  S  S  F  Q  E  L  C  G  A  L  G  L  E         p.40

          .         .         .         .         .         .       g.6971
 CCCGGTGGGGGGCTGCCCCAGTACCACAAGATCAAGGACCAGCTCAACTACTGGAGCGCC       c.180
 P  G  G  G  L  P  Q  Y  H  K  I  K  D  Q  L  N  Y  W  S  A         p.60

          .         .         .         .         .         .       g.7031
 AAGTCACTGTGGACCAAGCTGGACAAGCGAGCAGGCCAGCCTGTCTACCAGCAGGGCCGG       c.240
 K  S  L  W  T  K  L  D  K  R  A  G  Q  P  V  Y  Q  Q  G  R         p.80

          .         | 03         .         .         .         .    g.7184
 GCCTGCACCAGCACCAAG | TGCCTGGTGGTGGGTGCTGGACCTTGCGGGCTGCGGGTCGCT    c.300
 A  C  T  S  T  K   | C  L  V  V  G  A  G  P  C  G  L  R  V  A      p.100

          .         .         .         .         .         .       g.7244
 GTGGAGCTGGCGCTGCTGGGGGCCCGAGTGGTGCTGGTGGAAAAGCGCACCAAGTTCTCT       c.360
 V  E  L  A  L  L  G  A  R  V  V  L  V  E  K  R  T  K  F  S         p.120

          .         .         .         .         .         .       g.7304
 CGCCACAACGTGCTCCACCTCTGGCCCTTCACCATCCACGACCTGCGGGCACTCGGTGCT       c.420
 R  H  N  V  L  H  L  W  P  F  T  I  H  D  L  R  A  L  G  A         p.140

          .         .         .         .       | 04 .         .    g.7634
 AAGAAGTTCTACGGGCGCTTCTGCACCGGCACCCTGGACCACATCA | GCATCAGGCAGCTC    c.480
 K  K  F  Y  G  R  F  C  T  G  T  L  D  H  I  S |   I  R  Q  L      p.160

          .         .         .         .         .         .       g.7694
 CAGCTGCTTCTGCTGAAGGTAGCATTGCTGCTGGGGGTGGAAATTCACTGGGGTGTCACT       c.540
 Q  L  L  L  L  K  V  A  L  L  L  G  V  E  I  H  W  G  V  T         p.180

          .         .         .  | 05      .         .         .    g.8401
 TTCACTGGCCTCCAGCCCCCTCCTAGGAAGG | GGAGTGGCTGGCGTGCCCAGCTCCAACCC    c.600
 F  T  G  L  Q  P  P  P  R  K  G |   S  G  W  R  A  Q  L  Q  P      p.200

          .         .         .         .         .         .       g.8461
 AACCCCCCTGCCCAGCTGGCCAACTATGAATTTGACGTCCTTATCTCGGCTGCAGGAGGT       c.660
 N  P  P  A  Q  L  A  N  Y  E  F  D  V  L  I  S  A  A  G  G         p.220

          .       | 06 .         .         .         .         .    g.8630
 AAATTCGTCCCTGAAG | GCTTCAAAGTTCGAGAAATGCGAGGCAAACTGGCCATTGGCATC    c.720
 K  F  V  P  E  G |   F  K  V  R  E  M  R  G  K  L  A  I  G  I      p.240

          .         .         .         .         .         .       g.8690
 ACAGCCAACTTTGTGAATGGACGCACCGTGGAGGAGACACAGGTGCCGGAGATCAGTGGT       c.780
 T  A  N  F  V  N  G  R  T  V  E  E  T  Q  V  P  E  I  S  G         p.260

          .         .         .         .         .   | 07     .    g.9295
 GTAGCCAGGATCTACAACCAGAGCTTCTTCCAGAGCCTTCTCAAAGCCACAG | GCATTGAT    c.840
 V  A  R  I  Y  N  Q  S  F  F  Q  S  L  L  K  A  T  G |   I  D      p.280

          .         .         .         .         .         .       g.9355
 CTGGAGAACATTGTGTACTACAAGGACGACACCCACTACTTTGTGATGACAGCCAAGAAG       c.900
 L  E  N  I  V  Y  Y  K  D  D  T  H  Y  F  V  M  T  A  K  K         p.300

          .         .         .    | 08    .         .         .    g.10457
 CAGTGCCTGCTGCGGCTGGGGGTGCTGCGCCAG | GACTGGCCAGACACCAATCGGCTGCTG    c.960
 Q  C  L  L  R  L  G  V  L  R  Q   | D  W  P  D  T  N  R  L  L      p.320

          .         .         .         .         .         .       g.10517
 GGCAGTGCCAATGTGGTGCCCGAGGCTCTGCAGCGCTTTACCCGGGCAGCTGCTGACTTT       c.1020
 G  S  A  N  V  V  P  E  A  L  Q  R  F  T  R  A  A  A  D  F         p.340

          .         .         .         .         .         .       g.10577
 GCCACCCATGGCAAGCTCGGGAAACTAGAGTTTGCCCAGGATGCCCATGGGCAGCCTGAT       c.1080
 A  T  H  G  K  L  G  K  L  E  F  A  Q  D  A  H  G  Q  P  D         p.360

          .         .         .         .         .         .       g.10637
 GTCTCTGCCTTTGACTTCACGAGCATGATGCGGGCAGAGAGTTCTGCTCGTGTGCAAGAG       c.1140
 V  S  A  F  D  F  T  S  M  M  R  A  E  S  S  A  R  V  Q  E         p.380

          .         .         .         .         .  | 09      .    g.10911
 AAGCATGGCGCCCGCCTGCTGCTGGGACTGGTGGGGGACTGCCTGGTGGAG | CCCTTCTGG    c.1200
 K  H  G  A  R  L  L  L  G  L  V  G  D  C  L  V  E   | P  F  W      p.400

          .         .         .         .         .         .       g.10971
 CCCCTGGGCACTGGAGTGGCACGGGGCTTCCTGGCAGCCTTTGATGCAGCCTGGATGGTG       c.1260
 P  L  G  T  G  V  A  R  G  F  L  A  A  F  D  A  A  W  M  V         p.420

          .         .         .         .        | 10.         .    g.11217
 AAGCGGTGGGCAGAGGGCGCTGAGTCCCTAGAGGTGTTGGCTGAGCG | TGAGAGCCTGTAC    c.1320
 K  R  W  A  E  G  A  E  S  L  E  V  L  A  E  R  |  E  S  L  Y      p.440

          .         .         .         .         .         .       g.11277
 CAGCTTCTGTCACAGACATCCCCAGAAAACATGCATCGCAATGTGGCCCAGTATGGGCTG       c.1380
 Q  L  L  S  Q  T  S  P  E  N  M  H  R  N  V  A  Q  Y  G  L         p.460

          .         .         .         .         .     | 11   .    g.11512
 GACCCAGCCACCCGCTACCCCAACCTGAACCTCCGGGCAGTGACCCCCAATCAG | GTACGA    c.1440
 D  P  A  T  R  Y  P  N  L  N  L  R  A  V  T  P  N  Q   | V  R      p.480

          .         .         .         .         .         .       g.11572
 GACCTGTATGATGTGCTAGCCAAGGAGCCTGTGCAGAGGAACAACGACAAGACAGATACA       c.1500
 D  L  Y  D  V  L  A  K  E  P  V  Q  R  N  N  D  K  T  D  T         p.500

          .       | 12 .         .         .         .         .    g.12152
 GGGATGCCAGCCACCG | GGTCGGCAGGCACCCAGGAGGAGCTGCTACGCTGGTGCCAGGAG    c.1560
 G  M  P  A  T  G |   S  A  G  T  Q  E  E  L  L  R  W  C  Q  E      p.520

          .         .         .         .         .         .       g.12212
 CAGACAGCTGGGTACCCGGGAGTCCACGTCTCCGATTTGTCTTCCTCCTGGGCTGATGGG       c.1620
 Q  T  A  G  Y  P  G  V  H  V  S  D  L  S  S  S  W  A  D  G         p.540

          .         .         .         .     | 13   .         .    g.12610
 CTAGCTCTGTGTGCCCTGGTGTACCGGCTGCAGCCTGGCCTGCT | GGAACCCTCAGAGCTG    c.1680
 L  A  L  C  A  L  V  Y  R  L  Q  P  G  L  L  |  E  P  S  E  L      p.560

          .         .         .         .         .         .       g.12670
 CAGGGGCTGGGAGCTCTGGAAGCAACTGCTTGGGCACTAAAGGTGGCAGAGAATGAGCTG       c.1740
 Q  G  L  G  A  L  E  A  T  A  W  A  L  K  V  A  E  N  E  L         p.580

          .         .         .         .         .         .       g.12730
 GGCATCACACCGGTGGTGTCTGCACAGGCCGTGGTAGCAGGGAGTGACCCACTGGGCCTC       c.1800
 G  I  T  P  V  V  S  A  Q  A  V  V  A  G  S  D  P  L  G  L         p.600

          .         .         .         .         .      | 14  .    g.13029
 ATTGCCTACCTCAGCCACTTCCACAGTGCCTTCAAGAGCATGGCCCACAGCCCAG | GCCCT    c.1860
 I  A  Y  L  S  H  F  H  S  A  F  K  S  M  A  H  S  P  G |   P      p.620

          .         .         .         .         .         .       g.13089
 GTCAGCCAGGCCTCCCCAGGGACCTCCAGTGCTGTATTATTCCTTAGTAAACTTCAGAGG       c.1920
 V  S  Q  A  S  P  G  T  S  S  A  V  L  F  L  S  K  L  Q  R         p.640

          .         .     | 15   .         .         .         .    g.13301
 ACCCTGCAGCGATCCCGGGCCAAG | GAAAATGCAGAGGATGCTGGTGGCAAGAAGCTGCGC    c.1980
 T  L  Q  R  S  R  A  K   | E  N  A  E  D  A  G  G  K  K  L  R      p.660

        | 16 .         .         .         .         .         .    g.13601
 TTGGAG | ATGGAGGCCGAGACCCCAAGTACTGAGGTGCCACCTGACCCAGAGCCTGGTGTA    c.2040
 L  E   | M  E  A  E  T  P  S  T  E  V  P  P  D  P  E  P  G  V      p.680

          .         .         . | 17       .         .         .    g.13788
 CCCCTGACACCCCCATCCCAACACCAGGAG | GCCGGTGCTGGGGACCTGTGTGCACTTTGT    c.2100
 P  L  T  P  P  S  Q  H  Q  E   | A  G  A  G  D  L  C  A  L  C      p.700

          .         .         .         .         .         .       g.13848
 GGGGAACACCTCTATGTCCTGGAACGCCTCTGTGTCAACGGCCATTTCTTCCACCGGAGC       c.2160
 G  E  H  L  Y  V  L  E  R  L  C  V  N  G  H  F  F  H  R  S         p.720

          .         .         .         .         .         .       g.13908
 TGCTTCCGCTGCCATACCTGTGAGGCCACACTGTGGCCAGGTGGCTACGAGCAGCACCCA       c.2220
 C  F  R  C  H  T  C  E  A  T  L  W  P  G  G  Y  E  Q  H  P         p.740

         | 18.         .         .         .         .         .    g.14268
 GGAGATG | GACATTTCTACTGCCTCCAGCACCTGCCCCAGACAGACCACAAAGCGGAAGGC    c.2280
 G  D  G |   H  F  Y  C  L  Q  H  L  P  Q  T  D  H  K  A  E  G      p.760

          .         .     | 19   .         .         .         .    g.14611
 AGCGATAGAGGCCCTGAGAGTCCG | GAGCTCCCCACACCAAGTGAGAATAGCATGCCACCA    c.2340
 S  D  R  G  P  E  S  P   | E  L  P  T  P  S  E  N  S  M  P  P      p.780

          .         .         .         .         .         .       g.14671
 GGCCTCTCAACTCCCACAGCCTCGCAGGAGGGGGCCGGTCCTGTTCCAGATCCCAGCCAG       c.2400
 G  L  S  T  P  T  A  S  Q  E  G  A  G  P  V  P  D  P  S  Q         p.800

          .         .         .         .         .         .       g.14731
 CCCACCCGTCGGCAGATCCGCCTCTCCAGCCCGGAGCGCCAGCGGTTGTCCTCCCTTAAC       c.2460
 P  T  R  R  Q  I  R  L  S  S  P  E  R  Q  R  L  S  S  L  N         p.820

          .         .         .         .         .         .       g.14791
 CTTACCCCTGACCCGGAAATGGAGCCTCCACCCAAGCCTCCCCGCAGCTGCTCCGCCTTG       c.2520
 L  T  P  D  P  E  M  E  P  P  P  K  P  P  R  S  C  S  A  L         p.840

          .         .         .         .         .         .       g.14851
 GCCCGCCACGCCCTGGAGAGCAGCTTTGTGGGCTGGGGCCTGCCAGTCCAGAGCCCTCAA       c.2580
 A  R  H  A  L  E  S  S  F  V  G  W  G  L  P  V  Q  S  P  Q         p.860

   | 20      .         .         .         .         .         .    g.15184
 G | CTCTTGTGGCCATGGAGAAGGAGGAAAAAGAGAGTCCCTTCTCCAGTGAAGAGGAAGAA    c.2640
 A |   L  V  A  M  E  K  E  E  K  E  S  P  F  S  S  E  E  E  E      p.880

          .         .         .    | 21    .         .         .    g.15485
 GAAGATGTGCCTTTGGACTCAGATGTGGAACAG | GCCCTGCAGACCTTTGCCAAGACCTCA    c.2700
 E  D  V  P  L  D  S  D  V  E  Q   | A  L  Q  T  F  A  K  T  S      p.900

          .         .         .         .         .         .       g.15545
 GGCACCATGAATAACTACCCAACATGGCGTCGGACTCTGCTGCGCCGTGCGAAGGAGGAG       c.2760
 G  T  M  N  N  Y  P  T  W  R  R  T  L  L  R  R  A  K  E  E         p.920

          .         .        | 22.         .         .         .    g.15730
 GAGATGAAGAGGTTCTGCAAGGCCCAG | ACCATCCAACGGCGACTAAATGAGATTGAGGCT    c.2820
 E  M  K  R  F  C  K  A  Q   | T  I  Q  R  R  L  N  E  I  E  A      p.940

          .         .         .         .         .         .       g.15790
 GCCTTGAGGGAGCTAGAGGCCGAGGGCGTGAAGCTGGAGCTGGCCTTGAGGCGCCAGAGC       c.2880
 A  L  R  E  L  E  A  E  G  V  K  L  E  L  A  L  R  R  Q  S         p.960

   | 23      .         .         .         .         .         .    g.16051
 A | GTTCCCCAGAACAGCAAAAGAAACTATGGGTAGGACAGCTGCTACAGCTCGTTGACAAG    c.2940
 S |   S  P  E  Q  Q  K  K  L  W  V  G  Q  L  L  Q  L  V  D  K      p.980

          .         .         .         .  | 24      .         .    g.16208
 AAAAACAGCCTGGTGGCTGAGGAGGCCGAGCTCATGATCAC | GGTGCAGGAATTGAATCTG    c.3000
 K  N  S  L  V  A  E  E  A  E  L  M  I  T  |  V  Q  E  L  N  L      p.1000

          .         .         .         .         .      | 25  .    g.16653
 GAGGAGAAACAGTGGCAGCTGGACCAGGAGCTACGAGGCTACATGAACCGGGAAG | AAAAC    c.3060
 E  E  K  Q  W  Q  L  D  Q  E  L  R  G  Y  M  N  R  E  E |   N      p.1020

          .         .         .         .         .         .       g.16713
 CTAAAGACAGCTGCTGATCGGCAGGCTGAGGACCAGGTCCTGAGGAAGCTGGTGGATTTG       c.3120
 L  K  T  A  A  D  R  Q  A  E  D  Q  V  L  R  K  L  V  D  L         p.1040

          .         .         .         .         .         .       g.16773
 GTCAACCAGAGAGATGCCCTCATCCGCTTCCAGGAGGAGCGCAGGCTCAGCGAGCTGGCC       c.3180
 V  N  Q  R  D  A  L  I  R  F  Q  E  E  R  R  L  S  E  L  A         p.1060

          .         .                                               g.16797
 TTGGGGACAGGGGCCCAGGGCTAG                                           c.3204
 L  G  T  G  A  Q  G  X                                             p.1067

          .         .         .         .         .         .       g.16857
 acgagggtgggccgtctgctttcgttcccacaaagaaagcacctcaccccagcacagtgc       c.*60

          .         .         .         .         .         .       g.16917
 cacccctgttcatctgggctgcctggcagagagccttgctgtttacaattaaaatgtttc       c.*120

                                                                    g.16926
 tgccacaaa                                                          c.*129

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Microtubule associated monoxygenase, calponin and LIM domain containing 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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