megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) - coding DNA reference sequence

(used for variant description)

(last modified January 26, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_015166.3 in the MLC1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009162.1, covering MLC1 transcript NM_015166.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           gtttttctctgcttggtgagcagagataaagggg       c.-601

 .         .         .         .         .         .                g.5094
 gcagcaggaccgggcccaccagccatccgggctgcccacgcaaaccacagggccgaatcc       c.-541

 .         .         .         .         .         .                g.5154
 ggagccgcccaaggccacacagctaagccgagtgcgtgaatgcttatgtgaccgtgtgaa       c.-481

 .         .         .         .         .         .                g.5214
 ggaggttcccaccgtgtggctgtgggggatggaaaaaggctacttggaaagatgtagaag       c.-421

 .         .         .         .         .         .                g.5274
 accttcgagtaaacagttacgtttcagaaacagagcctgctcagaatgtgtacttggtgg       c.-361

 .         .         .         .         .         .                g.5334
 gattctattcttagggacgcttctttcttctgagagacccgagctctgtggcgagtggca       c.-301

 .         .         .         .         .         .                g.5394
 caggcagggccccttcctttcctagttgggttctgacagctccgaggcagtggtttacac       c.-241

 .         .         .         .         .         .                g.5454
 aaccaacacgaaacatttctacgatccacccgattcctcccctcattgatattcaggaag       c.-181

 .         .         .         .         .         .                g.5514
 cagctctccttcccctgccttcagctcaagtttgctgagcttttgtttcatttgtgaata       c.-121

 .         .         .         .         .         .                g.5574
 cttcttgctggaagtccctcacccagagaccagtgctcccaacggcagagcagcggggga       c.-61

 . | 02       .         .         .         .         .             g.6027
 g | ataaagaactggtgacacgtggctgtacattcagcacagctgtggtgtccccaagtgcc    c.-1

          .         .         .         .         .         .       g.6087
 ATGACCCAGGAGCCATTCAGAGAGGAGCTGGCCTATGACCGGATGCCCACGCTGGAGCGG       c.60
 M  T  Q  E  P  F  R  E  E  L  A  Y  D  R  M  P  T  L  E  R         p.20

          .         .         .         .         .         .       g.6147
 GGCCGGCAAGACCCCGCCAGCTATGCCCCAGACGCGAAGCCGAGCGACCTGCAGCTGTCG       c.120
 G  R  Q  D  P  A  S  Y  A  P  D  A  K  P  S  D  L  Q  L  S         p.40

          .         .         .         .         .        | 03.    g.7759
 AAGAGACTGCCCCCCTGCTTCAGCCACAAGACGTGGGTCTTCTCTGTGCTGATGGGG | AGC    c.180
 K  R  L  P  P  C  F  S  H  K  T  W  V  F  S  V  L  M  G   | S      p.60

          .         .         .         .         .         .       g.7819
 TGCCTCCTGGTGACCTCGGGGTTTTCGCTGTACCTGGGGAACGTGTTCCCGGCTGAGATG       c.240
 C  L  L  V  T  S  G  F  S  L  Y  L  G  N  V  F  P  A  E  M         p.80

          .         .        | 04.         .         .         .    g.10565
 GATTACTTGCGCTGTGCTGCAGGCTCT | TGCATCCCCTCGGCAATTGTGAGCTTCACCGTC    c.300
 D  Y  L  R  C  A  A  G  S   | C  I  P  S  A  I  V  S  F  T  V      p.100

          .         .  | 05      .         .         .         .    g.10949
 TCCAGGAGGAACGCCAATGTG | ATTCCCAACTTTCAGATATTGTTTGTTTCCACGTTTGCT    c.360
 S  R  R  N  A  N  V   | I  P  N  F  Q  I  L  F  V  S  T  F  A      p.120

          .         .         .         .         .         .       g.11009
 GTGACCACTACGTGTTTAATTTGGTTTGGATGCAAACTAGTCCTGAACCCATCAGCAATA       c.420
 V  T  T  T  C  L  I  W  F  G  C  K  L  V  L  N  P  S  A  I         p.140

     | 06    .         .         .         .         .         .    g.13484
 AAC | ATCAACTTCAACCTCATCCTGCTGCTCCTGCTGGAGCTGCTCATGGCGGCCACGGTG    c.480
 N   | I  N  F  N  L  I  L  L  L  L  L  E  L  L  M  A  A  T  V      p.160

          .         .         .         .      | 07  .         .    g.14032
 ATCATCGCTGCACGGTCCAGCGAGGAGGACTGCAAGAAAAAGAAG | GGCTCCATGTCTGAC    c.540
 I  I  A  A  R  S  S  E  E  D  C  K  K  K  K   | G  S  M  S  D      p.180

          .         .         .         .         .        | 08.    g.16600
 AGCGCCAACATTCTGGACGAAGTGCCATTTCCTGCTCGGGTCCTGAAATCTTACTCA | GTC    c.600
 S  A  N  I  L  D  E  V  P  F  P  A  R  V  L  K  S  Y  S   | V      p.200

          .         .         .         .         .         .       g.16660
 GTCGAGGTAATCGCAGGCATCTCTGCCGTCCTCGGGGGGATCATTGCCCTGAACGTGGAT       c.660
 V  E  V  I  A  G  I  S  A  V  L  G  G  I  I  A  L  N  V  D         p.220

          .         .         .         .         .     | 09   .    g.20352
 GACTCAGTTTCAGGCCCACACCTCTCAGTGACGTTCTTTTGGATCCTAGTGGCC | TGCTTT    c.720
 D  S  V  S  G  P  H  L  S  V  T  F  F  W  I  L  V  A   | C  F      p.240

          .         .         .         .         .  | 10      .    g.22383
 CCAAGTGCCATTGCCAGTCATGTGGCAGCAGAGTGTCCCAGCAAGTGTCTG | GTGGAGGTC    c.780
 P  S  A  I  A  S  H  V  A  A  E  C  P  S  K  C  L   | V  E  V      p.260

          .         .         .         .         .         .       g.22443
 CTGATTGCCATAAGCAGCCTCACGTCTCCGCTGCTGTTCACAGCCTCTGGATATCTGTCA       c.840
 L  I  A  I  S  S  L  T  S  P  L  L  F  T  A  S  G  Y  L  S         p.280

          .         .         .         .         .     | 11   .    g.26737
 TTCAGCATCATGAGAATCGTGGAGATGTTTAAGGATTACCCGCCAGCCATAAAA | CCATCC    c.900
 F  S  I  M  R  I  V  E  M  F  K  D  Y  P  P  A  I  K   | P  S      p.300

          .         .         .         .         .         .       g.26797
 TACGATGTGCTGCTGCTGCTGCTGCTGCTAGTGCTCCTGCTGCAGGCCGGCCTCAACACG       c.960
 Y  D  V  L  L  L  L  L  L  L  V  L  L  L  Q  A  G  L  N  T         p.320

          .         .         .         .         .         .       g.26857
 GGCACCGCCATCCAGTGCGTGCGCTTCAAGGTCAGTGCAAGGCTGCAGGGTGCATCCTGG       c.1020
 G  T  A  I  Q  C  V  R  F  K  V  S  A  R  L  Q  G  A  S  W         p.340

          .         .         .          | 12        .         .    g.29293
 GACACCCAGAACGGCCCGCAGGAGCGCCTGGCTGGGGAG | GTGGCCAGGAGCCCCCTGAAG    c.1080
 D  T  Q  N  G  P  Q  E  R  L  A  G  E   | V  A  R  S  P  L  K      p.360

          .         .         .         .         .                 g.29347
 GAGTTCGACAAGGAGAAAGCCTGGAGAGCCGTCGTGGTGCAAATGGCCCAGTGA             c.1134
 E  F  D  K  E  K  A  W  R  A  V  V  V  Q  M  A  Q  X               p.377

          .         .         .         .         .         .       g.29407
 cccccagacgcggaaaccgggtggcagcgcccagcctggccccaagcatggaaacgcaca       c.*60

          .         .         .         .         .         .       g.29467
 acccctaatcgccctgagctactgcttctaacacctcttttcccttgtgtgagggcaaac       c.*120

          .         .         .         .         .         .       g.29527
 caggctgcaggtggggttttcacttcctagggtagtttaattttaaaataggccaatgtt       c.*180

          .         .         .         .         .         .       g.29587
 ggctagtctgtgcctcagtgagatcagtcagctccgagtggctcccgtgtcgtaacagca       c.*240

          .         .         .         .         .         .       g.29647
 ggagcatggccgcaacttcccaggccgaggaagggcccccggctcggcctcttgagagcc       c.*300

          .         .         .         .         .         .       g.29707
 ccacccctgaactggccccagctcctcttcctgcctctctcatggcttgggctggagtgg       c.*360

          .         .         .         .         .         .       g.29767
 gctctctggacctgaccagactgtgggtccctgcgtctcctgcccactctgaccgggctt       c.*420

          .         .         .         .         .         .       g.29827
 cctccctccacgcttagggtctgtcccgggtactcagtcagcccagtgggatcttaccca       c.*480

          .         .         .         .         .         .       g.29887
 cttccctgcaaggtgcacctgccccaggctcaggctgcccagcggctcttcctggacagt       c.*540

          .         .         .         .         .         .       g.29947
 gagagcagggctgggcgcctctgtcctggcccgggagccgcaggggcccctcctccagag       c.*600

          .         .         .         .         .         .       g.30007
 cctgggcgcaagcgacacaggctgccgctgctctcccaggtgaaatccacaccagtccac       c.*660

          .         .         .         .         .         .       g.30067
 gccgggtcgcctgccctgtctccctacttagacccagtcattctagagggatccaccgcc       c.*720

          .         .         .         .         .         .       g.30127
 acactggccggcccacgtcctgggtgctgtcatgcccagcttggagtgccacgtggccgc       c.*780

          .         .         .         .         .         .       g.30187
 tgcccacgtcccgggcactgtcatgcccagcttggagtgccacatggccgctgcccacgt       c.*840

          .         .         .         .         .         .       g.30247
 cccgggcactgtcatgcccagcttggagtgccacgtggccgctgctgtgacaggcagtgt       c.*900

          .         .         .         .         .         .       g.30307
 tcttgggggtggggctgcatccaaggctttgtaaaccggctggaccacgtctccctggcc       c.*960

          .         .         .         .         .         .       g.30367
 ccagtgaccgggggaagctgagcccctccctcctgtgtttgctcccattactcaaaatgc       c.*1020

          .         .         .         .         .         .       g.30427
 aggacagatcaggtcagagcccaggaattctcacaggttcacccagcgccctctacctcc       c.*1080

          .         .         .         .         .         .       g.30487
 tagcaagtactttgtcttgatcctcactgagaaggccccagggcagcggtcttctccatc       c.*1140

          .         .         .         .         .         .       g.30547
 tccgctgttttggggtcttagggtacagcccaggcggtcactgcccacctgccaggctgc       c.*1200

          .         .         .         .         .         .       g.30607
 agggacagttgggtgtgagaataacactggctttgggtagtgccatggccaggagtgggt       c.*1260

          .         .         .         .         .         .       g.30667
 ttccctgcgtctcctcgtcccgagggcgcctgggtcctcccagctgacggcagtaaatcc       c.*1320

          .         .         .         .         .         .       g.30727
 acagtgagttggggcgactgtgaaactggaatgctgttactttgataattactttccagc       c.*1380

          .         .         .         .         .         .       g.30787
 aggtgttttccttcacaatggttttgtttctttccttctgatctgagaagacatgaacgt       c.*1440

          .         .         .         .         .         .       g.30847
 tttctcttcaccgccgtggggtgtattgactggtcccccatgggctgctggaaaggcccg       c.*1500

          .         .         .         .         .         .       g.30907
 gagatgcatctgtggcctggggccatcaagatcaaagaaccaggaggcctgggagatgca       c.*1560

          .         .         .         .         .         .       g.30967
 gctggatggggcggcctgcagaccctgccagggggtttgaggaccctcccaggtttccca       c.*1620

          .         .         .         .         .         .       g.31027
 ctgcggaacaggagtgactctggctgccaagataccttcatggtgttcatgacaagtgga       c.*1680

          .         .         .         .         .         .       g.31087
 atcattattttcaaccattgaagggggatgcaggcaagacaccttcccagctgctcctag       c.*1740

          .         .         .         .         .         .       g.31147
 aggggacaagccaggccctctctgcagtcctcggcagctccggaaggacacagtcagggg       c.*1800

          .         .         .         .         .         .       g.31207
 ccgggcaaacactttggccacagccccaaacaagcgccaccgtgggagaggagaggctgc       c.*1860

          .         .         .         .         .         .       g.31267
 tgtcactggtaccggatgcagaccccaccctgtctgcaggccacccccacctccctgcag       c.*1920

          .         .         .         .         .         .       g.31327
 ctttgaggctggcggggtctgctcctgggaatggggtgggagccacagggacgacccggg       c.*1980

          .         .         .         .         .         .       g.31387
 gcgggctgatgtcttcttgggggcagaccagagagctcaagtttcagagtcagaattagg       c.*2040

          .         .         .         .         .         .       g.31447
 cacttggagcgtttttgctggcttgcactttcttattttcttattttagagcgcttaaaa       c.*2100

          .         .         .         .         .         .       g.31507
 aatccggaaaaatggggtttaaaagaactgtctctttcagtctacatttttgtttaatac       c.*2160

          .         .         .                                     g.31539
 gcttgagcaataaacgctgacttgcagacgtg                                   c.*2192

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Megalencephalic leukoencephalopathy with subcortical cysts 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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