protein kinase, DNA-activated, catalytic polypeptide (PRKDC) - coding DNA reference sequence

(used for variant description)

(last modified March 21, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_001081640.1 in the PRKDC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering PRKDC transcript NM_001081640.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    ggggcatttccgggtccgggccgagcgggcgcacgcgcgggagcgggactcggcggc       c.-1

          .         .         .         .         .         .       g.5117
 ATGGCGGGCTCCGGAGCCGGTGTGCGTTGCTCCCTGCTGCGGCTGCAGGAGACCTTGTCC       c.60
 M  A  G  S  G  A  G  V  R  C  S  L  L  R  L  Q  E  T  L  S         p.20

          .         .         .         .         .         .       g.5177
 GCTGCGGACCGCTGCGGTGCTGCCCTGGCCGGTCATCAACTGATCCGCGGCCTGGGGCAG       c.120
 A  A  D  R  C  G  A  A  L  A  G  H  Q  L  I  R  G  L  G  Q         p.40

          .         .         .     | 02   .         .         .    g.7778
 GAATGCGTCCTGAGCAGCAGCCCCGCGGTGCTGG | CATTACAGACATCTTTAGTTTTTTCC    c.180
 E  C  V  L  S  S  S  P  A  V  L  A |   L  Q  T  S  L  V  F  S      p.60

          .         .         .         .         .  | 03      .    g.7929
 AGAGATTTCGGTTTGCTTGTATTTGTCCGGAAGTCACTCAACAGTATTGAA | TTTCGTGAA    c.240
 R  D  F  G  L  L  V  F  V  R  K  S  L  N  S  I  E   | F  R  E      p.80

          .         .         .         .         .         .       g.7989
 TGTAGAGAAGAAATCCTAAAGTTTTTATGTATTTTCTTAGAAAAAATGGGCCAGAAGATC       c.300
 C  R  E  E  I  L  K  F  L  C  I  F  L  E  K  M  G  Q  K  I         p.100

          .         .     | 04   .         .         .         .    g.9271
 GCACCTTACTCTGTTGAAATTAAG | AACACTTGTACCAGTGTTTATACAAAAGATAGAGCT    c.360
 A  P  Y  S  V  E  I  K   | N  T  C  T  S  V  Y  T  K  D  R  A      p.120

          .         .         .          | 05        .         .    g.10758
 GCTAAATGTAAAATTCCAGCCCTGGACCTTCTTATTAAG | TTACTTCAGACTTTTAGAAGT    c.420
 A  K  C  K  I  P  A  L  D  L  L  I  K   | L  L  Q  T  F  R  S      p.140

          .         .         .         .         .         .       g.10818
 TCTAGACTCATGGATGAATTTAAAATTGGAGAATTATTTAGTAAATTCTATGGAGAACTT       c.480
 S  R  L  M  D  E  F  K  I  G  E  L  F  S  K  F  Y  G  E  L         p.160

          .         .         | 06         .         .         .    g.11296
 GCATTGAAAAAAAAAATACCAGATACAG | TTTTAGAAAAAGTATATGAGCTCCTAGGATTA    c.540
 A  L  K  K  K  I  P  D  T  V |   L  E  K  V  Y  E  L  L  G  L      p.180

          .         .         .         .         .         .       g.11356
 TTGGGTGAAGTTCATCCTAGTGAGATGATAAATAATGCAGAAAACCTGTTCCGCGCTTTT       c.600
 L  G  E  V  H  P  S  E  M  I  N  N  A  E  N  L  F  R  A  F         p.200

          .         .  | 07      .         .         .         .    g.11503
 CTGGGTGAACTTAAGACCCAG | ATGACATCAGCAGTAAGAGAGCCCAAACTACCTGTTCTG    c.660
 L  G  E  L  K  T  Q   | M  T  S  A  V  R  E  P  K  L  P  V  L      p.220

          .         .         .         .         .         .       g.11563
 GCAGGATGTCTGAAGGGGTTGTCCTCACTTCTGTGCAACTTCACTAAGTCCATGGAAGAA       c.720
 A  G  C  L  K  G  L  S  S  L  L  C  N  F  T  K  S  M  E  E         p.240

   | 08      .         .         .         .         .        | 09. g.21303
 G | ATCCCCAGACTTCAAGGGAGATTTTTAATTTTGTACTAAAGGCAATTCGTCCTCAG | ATT c.780
 D |   P  Q  T  S  R  E  I  F  N  F  V  L  K  A  I  R  P  Q   | I   p.260

          .         .         | 10         .         .         .    g.21849
 GATCTGAAGAGATATGCTGTGCCCTCAG | CTGGCTTGCGCCTATTTGCCCTGCATGCATCT    c.840
 D  L  K  R  Y  A  V  P  S  A |   G  L  R  L  F  A  L  H  A  S      p.280

          .         .         .         .         .         .       g.21909
 CAGTTTAGCACCTGCCTTCTGGACAACTACGTGTCTCTATTTGAAGTCTTGTTAAAGTGG       c.900
 Q  F  S  T  C  L  L  D  N  Y  V  S  L  F  E  V  L  L  K  W         p.300

          .         .         .         .         .         .       g.21969
 TGTGCCCACACAAATGTAGAATTGAAAAAAGCTGCACTTTCAGCCCTGGAATCCTTTCTG       c.960
 C  A  H  T  N  V  E  L  K  K  A  A  L  S  A  L  E  S  F  L         p.320

        | 11 .         .         .         .         .         .    g.25540
 AAACAG | GTTTCTAATATGGTGGCGAAAAATGCAGAAATGCATAAAAATAAACTGCAGTAC    c.1020
 K  Q   | V  S  N  M  V  A  K  N  A  E  M  H  K  N  K  L  Q  Y      p.340

          .         .         .         .         .         .       g.25600
 TTTATGGAGCAGTTTTATGGAATCATCAGAAATGTGGATTCGAACAACAAGGAGTTATCT       c.1080
 F  M  E  Q  F  Y  G  I  I  R  N  V  D  S  N  N  K  E  L  S         p.360

          .         .         .    | 12    .         .         .    g.28693
 ATTGCTATCCGTGGATATGGACTTTTTGCAGGA | CCGTGCAAGGTTATAAACGCAAAAGAT    c.1140
 I  A  I  R  G  Y  G  L  F  A  G   | P  C  K  V  I  N  A  K  D      p.380

          .         .         .         .         .         .       g.28753
 GTTGACTTCATGTACGTTGAGCTCATTCAGCGCTGCAAGCAGATGTTCCTCACCCAGACA       c.1200
 V  D  F  M  Y  V  E  L  I  Q  R  C  K  Q  M  F  L  T  Q  T         p.400

          .         .         .         .         .         .       g.28813
 GACACTGGTGACGACCGTGTTTATCAGATGCCAAGCTTCCTCCAGTCTGTTGCAAGCGTC       c.1260
 D  T  G  D  D  R  V  Y  Q  M  P  S  F  L  Q  S  V  A  S  V         p.420

          .         | 13         .         .         .         .    g.29325
 TTGCTGTACCTTGACACA | GTTCCTGAGGTGTATACTCCAGTTCTGGAGCACCTCGTGGTG    c.1320
 L  L  Y  L  D  T   | V  P  E  V  Y  T  P  V  L  E  H  L  V  V      p.440

          .         .         .         .         .         .       g.29385
 ATGCAGATAGACAGTTTCCCACAGTACAGTCCAAAAATGCAGCTGGTGTGTTGCAGAGCC       c.1380
 M  Q  I  D  S  F  P  Q  Y  S  P  K  M  Q  L  V  C  C  R  A         p.460

          .         .         .         .         .         .       g.29445
 ATAGTGAAGGTGTTCCTAGCTTTGGCAGCAAAAGGGCCAGTTCTCAGGAATTGCATTAGT       c.1440
 I  V  K  V  F  L  A  L  A  A  K  G  P  V  L  R  N  C  I  S         p.480

         | 14.         .         .         .         .        | 15. g.31096
 ACTGTGG | TGCATCAGGGTTTAATCAGAATATGTTCTAAACCAGTGGTCCTTCCAAAG | GGC c.1500
 T  V  V |   H  Q  G  L  I  R  I  C  S  K  P  V  V  L  P  K   | G   p.500

          .         .         .         .         .         .       g.31156
 CCTGAGTCTGAATCTGAAGACCACCGTGCTTCAGGGGAAGTCAGAACTGGCAAATGGAAG       c.1560
 P  E  S  E  S  E  D  H  R  A  S  G  E  V  R  T  G  K  W  K         p.520

          .         .         .         .         .         .       g.31216
 GTGCCCACATACAAAGACTACGTGGATCTCTTCAGACATCTCCTGAGCTCTGACCAGATG       c.1620
 V  P  T  Y  K  D  Y  V  D  L  F  R  H  L  L  S  S  D  Q  M         p.540

     | 16    .         .         .         .         .         .    g.32068
 ATG | GATTCTATTTTAGCAGATGAAGCATTTTTCTCTGTGAATTCCTCCAGTGAAAGTCTG    c.1680
 M   | D  S  I  L  A  D  E  A  F  F  S  V  N  S  S  S  E  S  L      p.560

          .         .         .         .         .         .       g.32128
 AATCATTTACTTTATGATGAATTTGTAAAATCCGTTTTGAAGATTGTTGAGAAATTGGAT       c.1740
 N  H  L  L  Y  D  E  F  V  K  S  V  L  K  I  V  E  K  L  D         p.580

          .         .         .       | 17 .         .         .    g.34420
 CTTACACTTGAAATACAGACTGTTGGGGAACAAGAG | AATGGAGATGAGGCGCCTGGTGTT    c.1800
 L  T  L  E  I  Q  T  V  G  E  Q  E   | N  G  D  E  A  P  G  V      p.600

          .         .         .         .         .         .       g.34480
 TGGATGATCCCAACTTCAGATCCAGCGGCTAACTTGCATCCAGCTAAACCTAAAGATTTT       c.1860
 W  M  I  P  T  S  D  P  A  A  N  L  H  P  A  K  P  K  D  F         p.620

          .         .         .   | 18     .         .         .    g.35199
 TCGGCTTTCATTAACCTGGTGGAATTTTGCAG | AGAGATTCTCCCTGAGAAACAAGCAGAA    c.1920
 S  A  F  I  N  L  V  E  F  C  R  |  E  I  L  P  E  K  Q  A  E      p.640

          .         .         .         .         .         .       g.35259
 TTTTTTGAACCATGGGTGTACTCATTTTCATATGAATTAATTTTGCAATCTACAAGGTTG       c.1980
 F  F  E  P  W  V  Y  S  F  S  Y  E  L  I  L  Q  S  T  R  L         p.660

          .         .         .         .         .         .       g.35319
 CCCCTCATCAGTGGTTTCTACAAATTGCTTTCTATTACAGTAAGAAATGCCAAGAAAATA       c.2040
 P  L  I  S  G  F  Y  K  L  L  S  I  T  V  R  N  A  K  K  I         p.680

          .   | 19     .         .         .         .         .    g.36053
 AAATATTTCGAG | GGAGTTAGTCCAAAGAGTCTGAAACACTCTCCTGAAGACCCAGAAAAG    c.2100
 K  Y  F  E   | G  V  S  P  K  S  L  K  H  S  P  E  D  P  E  K      p.700

          .         .         .          | 20        .         .    g.37314
 TATTCTTGCTTTGCTTTATTTGTGAAATTTGGCAAAGAG | GTGGCAGTTAAAATGAAGCAG    c.2160
 Y  S  C  F  A  L  F  V  K  F  G  K  E   | V  A  V  K  M  K  Q      p.720

          .         .         .         .         .         .       g.37374
 TACAAAGATGAACTTTTGGCCTCTTGTTTGACCTTTCTTCTGTCCTTGCCACACAACATC       c.2220
 Y  K  D  E  L  L  A  S  C  L  T  F  L  L  S  L  P  H  N  I         p.740

          .         .         .          | 21        .         .    g.37851
 ATTGAACTCGATGTTAGAGCCTACGTTCCTGCACTGCAG | ATGGCTTTCAAACTGGGCCTG    c.2280
 I  E  L  D  V  R  A  Y  V  P  A  L  Q   | M  A  F  K  L  G  L      p.760

          .         .         .         .         .         .       g.37911
 AGCTATACCCCCTTGGCAGAAGTAGGCCTGAATGCTCTAGAAGAATGGTCAATTTATATT       c.2340
 S  Y  T  P  L  A  E  V  G  L  N  A  L  E  E  W  S  I  Y  I         p.780

          .         .         .         .         .         .       g.37971
 GACAGACATGTAATGCAGCCTTATTACAAAGACATTCTCCCCTGCCTGGATGGATACCTG       c.2400
 D  R  H  V  M  Q  P  Y  Y  K  D  I  L  P  C  L  D  G  Y  L         p.800

          .          | 22        .         .         .         .    g.46841
 AAGACTTCAGCCTTGTCAG | ATGAGACCAAGAATAACTGGGAAGTGTCAGCTCTTTCTCGG    c.2460
 K  T  S  A  L  S  D |   E  T  K  N  N  W  E  V  S  A  L  S  R      p.820

          .         .         .         .         .         .       g.46901
 GCTGCCCAGAAAGGATTTAATAAAGTGGTGTTAAAGCATCTGAAGAAGACAAAGAACCTT       c.2520
 A  A  Q  K  G  F  N  K  V  V  L  K  H  L  K  K  T  K  N  L         p.840

        | 23 .         .         .         .         .         .    g.49819
 TCATCA | AACGAAGCAATATCCTTAGAAGAAATAAGAATTAGAGTAGTACAAATGCTTGGA    c.2580
 S  S   | N  E  A  I  S  L  E  E  I  R  I  R  V  V  Q  M  L  G      p.860

          .         .         .        | 24.         .         .    g.51142
 TCTCTAGGAGGACAAATAAACAAAAATCTTCTGACAG | TCACGTCCTCAGATGAGATGATG    c.2640
 S  L  G  G  Q  I  N  K  N  L  L  T  V |   T  S  S  D  E  M  M      p.880

          .         .         .         .         .         .       g.51202
 AAGAGCTATGTGGCCTGGGACAGAGAGAAGCGGCTGAGCTTTGCAGTGCCCTTTAGAGAG       c.2700
 K  S  Y  V  A  W  D  R  E  K  R  L  S  F  A  V  P  F  R  E         p.900

          .         .         .         .         .         .       g.51262
 ATGAAACCTGTCATTTTCCTGGATGTGTTCCTGCCTCGAGTCACAGAATTAGCGCTCACA       c.2760
 M  K  P  V  I  F  L  D  V  F  L  P  R  V  T  E  L  A  L  T         p.920

          .         .  | 25      .         .         .         .    g.52660
 GCCAGTGACAGACAAACTAAA | GTTGCAGCCTGTGAACTTTTACATAGCATGGTTATGTTT    c.2820
 A  S  D  R  Q  T  K   | V  A  A  C  E  L  L  H  S  M  V  M  F      p.940

          .         .         .         .         .         .       g.52720
 ATGTTGGGCAAAGCCACGCAGATGCCAGAAGGGGGACAGGGAGCCCCACCCATGTACCAG       c.2880
 M  L  G  K  A  T  Q  M  P  E  G  G  Q  G  A  P  P  M  Y  Q         p.960

          .         .         .         .         .     | 26   .    g.60213
 CTCTATAAGCGGACGTTTCCTGTGCTGCTTCGACTTGCGTGTGATGTTGATCAG | GTGACA    c.2940
 L  Y  K  R  T  F  P  V  L  L  R  L  A  C  D  V  D  Q   | V  T      p.980

          .         .         .         .         .         .       g.60273
 AGGCAACTGTATGAGCCACTAGTTATGCAGCTGATTCACTGGTTCACTAACAACAAGAAA       c.3000
 R  Q  L  Y  E  P  L  V  M  Q  L  I  H  W  F  T  N  N  K  K         p.1000

          .         .         .         .   | 27     .         .    g.62406
 TTTGAAAGTCAGGATACTGTTGCCTTACTAGAAGCTATATTG | GATGGAATTGTGGACCCT    c.3060
 F  E  S  Q  D  T  V  A  L  L  E  A  I  L   | D  G  I  V  D  P      p.1020

          .         .         .         .         .         .       g.62466
 GTTGACAGTACTTTAAGAGATTTTTGTGGTCGGTGTATTCGAGAATTCCTTAAATGGTCC       c.3120
 V  D  S  T  L  R  D  F  C  G  R  C  I  R  E  F  L  K  W  S         p.1040

          .         .         .         .         .         .       g.62526
 ATTAAGCAAATAACACCACAGCAGCAGGAGAAGAGTCCAGTAAACACCAAATCGCTTTTC       c.3180
 I  K  Q  I  T  P  Q  Q  Q  E  K  S  P  V  N  T  K  S  L  F         p.1060

          .         .         .         .         .         .       g.62586
 AAGCGACTTTATAGCCTTGCGCTTCACCCCAATGCTTTCAAGAGGCTGGGAGCATCACTT       c.3240
 K  R  L  Y  S  L  A  L  H  P  N  A  F  K  R  L  G  A  S  L         p.1080

          .         .          | 28        .         .         .    g.64747
 GCCTTTAATAATATCTACAGGGAATTCAG | GGAAGAAGAGTCTCTGGTGGAACAGTTTGTG    c.3300
 A  F  N  N  I  Y  R  E  F  R  |  E  E  E  S  L  V  E  Q  F  V      p.1100

          .         .         .         .         .         .       g.64807
 TTTGAAGCCTTGGTGATATACATGGAGAGTCTGGCCTTAGCACATGCAGATGAGAAGTCC       c.3360
 F  E  A  L  V  I  Y  M  E  S  L  A  L  A  H  A  D  E  K  S         p.1120

      | 29   .         .         .         .         .         .    g.66670
 TTAG | GTACAATTCAACAGTGTTGTGATGCCATTGATCACCTATGCCGCATCATTGAAAAG    c.3420
 L  G |   T  I  Q  Q  C  C  D  A  I  D  H  L  C  R  I  I  E  K      p.1140

          .         .         .         .     | 30   .         .    g.67905
 AAGCATGTTTCTTTAAATAAAGCAAAGAAACGACGTTTGCCGCG | AGGATTTCCACCTTCC    c.3480
 K  H  V  S  L  N  K  A  K  K  R  R  L  P  R  |  G  F  P  P  S      p.1160

          .         .         .         .         .         .       g.67965
 GCATCATTGTGTTTATTGGATCTGGTCAAGTGGCTTTTAGCTCATTGTGGGAGGCCCCAG       c.3540
 A  S  L  C  L  L  D  L  V  K  W  L  L  A  H  C  G  R  P  Q         p.1180

          .         .         .         .         .         | 31    g.71798
 ACAGAATGTCGACACAAATCCATTGAACTCTTTTATAAATTCGTTCCTTTATTGCCAG | GC    c.3600
 T  E  C  R  H  K  S  I  E  L  F  Y  K  F  V  P  L  L  P  G |       p.1200

          .         .         .         .         .         .       g.71858
 AACAGATCCCCTAATTTGTGGCTGAAAGATGTTCTCAAGGAAGAAGGTGTCTCTTTTCTC       c.3660
 N  R  S  P  N  L  W  L  K  D  V  L  K  E  E  G  V  S  F  L         p.1220

          .         .         .         .         .         .       g.71918
 ATCAACACCTTTGAGGGGGGTGGCTGTGGCCAGCCCTCGGGCATCCTGGCCCAGCCCACC       c.3720
 I  N  T  F  E  G  G  G  C  G  Q  P  S  G  I  L  A  Q  P  T         p.1240

          .         .         .         .         .         .       g.71978
 CTCTTGTACTTCGGGGGCCATTCAGCCTGCAGGCCACGCTATGCTGGCTGGACCTGCTCC       c.3780
 L  L  Y  F  G  G  H  S  A  C  R  P  R  Y  A  G  W  T  C  S         p.1260

          .         .         .         .                           g.72026
 TGGCCGCGTTGGAGTGCTACAACACGTTCATTGGCGAGAGAACTGTAG                   c.3828
 W  P  R  W  S  A  T  T  R  S  L  A  R  E  L  X                     p.1275

          .         | 32         .         .         .         .    g.74744
 gagcgctccaggtcctag | gtactgaagcccagtcttcacttttgaaagcagtggctttct    c.*60

          .         .         .         .         .         .       g.74804
 tcttagaaagcattgccatgcatgacattatagcagcagaaaagtgctttggcactgggg       c.*120

          .         .         .         .         .         .       g.74864
 cagcaggtaacagaacaagcccacaagagggagaaaggtacaactacagcaaatgcaccg       c.*180

          .         .         .         .         .         .       g.74924
 ttgtggtccggattatggagtttaccacgactctgctaaacacctccccggaaggatgga       c.*240

    | 33     .         .         .         .         .         .    g.76018
 ag | ctcctgaagaaggacttgtgtaatacacacctgatgagagtcctggtgcagacgctgt    c.*300

          .         .         .         .         .         .       g.76078
 gtgagcccgcaagcataggtttcaacatcggagacgtccaggttatggctcatcttcctg       c.*360

          .         .         .         .         .         .       g.76138
 atgtttgtgtgaatctgatgaaagctctaaagatgtccccatacaaagatatcctagaga       c.*420

          .         .         .  | 34      .         .         .    g.76561
 cccatctgagagagaaaataacagcacagag | cattgaggagctttgtgccgtcaacttgt    c.*480

          .         .         .         .         .         .       g.76621
 atggccctgacgcgcaagtggacaggagcaggctggctgctgttgtgtctgcctgtaaac       c.*540

          .         .         .         .     | 35   .         .    g.77493
 agcttcacagagctgggcttctgcataatatattaccgtctcag | tccacagatttgcatc    c.*600

          .         .         .         .         .         .       g.77553
 attctgttggcacagaacttctttccctggtttataaaggcattgcccctggagatgaga       c.*660

          .         .         .         .         .         .       g.77613
 gacagtgtctgccttctctagacctcagttgtaagcagctggccagcggacttctggagt       c.*720

          .         .    | 36    .         .         .         .    g.79072
 tagcctttgcttttggaggactg | tgtgagcgccttgtgagtcttctcctgaacccagcgg    c.*780

          .         .         .         .         .         .       g.79132
 tgctgtccacggcgtccttgggcagctcacagggcagcgtcatccacttctcccatgggg       c.*840

          .         .         .         .         .         .       g.79192
 agtatttctatagcttgttctcagaaacgatcaacacggaattattgaaaaatctggatc       c.*900

          .         .         .         .        | 37.         .    g.83098
 ttgctgtattggagctcatgcagtcttcagtggataataccaaaatg | gtgagtgccgttt    c.*960

          .         .         .         .         .         .       g.83158
 tgaacggcatgttagaccagagcttcagggagcgagcaaaccagaaacaccaaggactga       c.*1020

          .         .         .         .         .         .       g.83218
 aacttgcgactacaattctgcaacactggaagaagtgtgattcatggtgggccaaagatt       c.*1080

          .         .         .         .         .    | 38    .    g.83669
 cccctctcgaaactaaaatggcagtgctggccttactggcaaaaattttacag | attgatt    c.*1140

          .         .         .         .         .         .       g.83729
 catctgtatcttttaatacaagtcatggttcattccctgaagtctttacaacatatatta       c.*1200

          .         .         .         | 39         .         .    g.85546
 gtctacttgctgacacaaagctggatctacatttaaag | ggccaagctgtcactcttcttc    c.*1260

          .         .         .         .         .         .       g.85606
 cattcttcaccagcctcactggaggcagtctggaggaacttagacgtgttctggagcagc       c.*1320

          .         .         .         .         .         .       g.85666
 tcatcgttgctcacttccccatgcagtccagggaatttcctccaggaactccgcggttca       c.*1380

          .         .       | 40 .         .         .         .    g.87365
 ataattatgtggactgcatgaaaaag | tttctagatgcattggaattatctcaaagcccta    c.*1440

          .         .         .         .         .         .       g.87425
 tgttgttggaattgatgacagaagttctttgtcgggaacagcagcatgtcatggaagaat       c.*1500

          .         .         .     | 41   .         .         .    g.100445
 tatttcaatccagtttcaggaggattgccagaag | gggttcatgtgtcacacaagtaggcc    c.*1560

          .         .         .         .         .         .       g.100505
 ttctggaaagcgtgtatgaaatgttcaggaaggatgacccccgcctaagtttcacacgcc       c.*1620

          .         .         .         .         .         .       g.100565
 agtcctttgtggaccgctccctcctcactctgctgtggcactgtagcctggatgctttga       c.*1680

          .         .         .         .         .         .       g.100625
 gagaattcttcagcacaattgtggtggatgccattgatgtgttgaagtccaggtttacaa       c.*1740

    | 42     .         .         .         .         .         .    g.101663
 ag | ctaaatgaatctacctttgatactcaaatcaccaagaagatgggctactataagattc    c.*1800

          .         .         .         .         .         .       g.101723
 tagacgtgatgtattctcgccttcccaaagatgatgttcatgctaaggaatcaaaaatta       c.*1860

          .         .         .         .         .         .       g.101783
 atcaagttttccatggctcgtgtattacagaaggaaatgaacttacaaagacattgatta       c.*1920

   | 43      .         .         .         .         .         .    g.102700
 a | attgtgctacgatgcatttacagagaacatggcaggagagaatcagctgctggagagga    c.*1980

          .         .         .         .         .         .       g.102760
 gaagactttaccattgtgcagcatacaactgcgccatatctgtcatctgctgtgtcttca       c.*2040

          .         .         .         .         . | 44       .    g.103065
 atgagttaaaattttaccaaggttttctgtttagtgaaaaaccagaaaag | aacttgctta    c.*2100

          .         .         .         .         .       | 45 .    g.104215
 tttttgaaaatctgatcgacctgaagcgccgctataattttcctgtagaagttgag | gttc    c.*2160

          .         .         .         .         .         .       g.104275
 ctatggaaagaaagaaaaagtacattgaaattaggaaagaagccagagaagcagcaaatg       c.*2220

           | 46        .         .         .         .         .    g.105474
 gggattcag | atggtccttcctatatgtcttccctgtcatatttggcagacagtaccctga    c.*2280

          .         .         .         .         .         .       g.105534
 gtgaggaaatgagtcaatttgatttctcaaccggagttcagagctattcatacagctccc       c.*2340

          .         .         .         | 47         .         .    g.106218
 aagaccctagacctgccactggtcgttttcggagacgg | gagcagcgggaccccacggtgc    c.*2400

          .         .         .         .         .         .       g.106278
 atgatgatgtgctggagctggagatggacgagctcaatcggcatgagtgcatggcgcccc       c.*2460

          .         .         .         .         .       | 48 .    g.106551
 tgacggccctggtcaagcacatgcacagaagcctgggcccgcctcaaggagaagag | gatt    c.*2520

          .         .         .         .         .         .       g.106611
 cagtgccaagagatcttccttcttggatgaaattcctccatggcaaactgggaaatccaa       c.*2580

          .         .         .         .         .       | 49 .    g.107887
 tagtaccattaaatatccgtctcttcttagccaagcttgttattaatacagaagag | gtct    c.*2640

          .         .         .         .         .         .       g.107947
 ttcgcccttacgcgaagcactggcttagccccttgctgcagctggctgcttctgaaaaca       c.*2700

          .         .         .         .         .         .       g.108007
 atggaggagaaggaattcactacatggtggttgagatagtggccactattctttcatgga       c.*2760

          .         . | 50       .         .         .         .    g.109849
 caggcttggccactccaaca | ggggtccctaaagatgaagtgttagcaaatcgattgctta    c.*2820

          .         .         .         .         .         .       g.109909
 atttcctaatgaaacatgtctttcatccaaaaagagctgtgtttagacacaaccttgaaa       c.*2880

          .         .         .         .         .   | 51     .    g.110976
 ttataaagacccttgtcgagtgctggaaggattgtttatccatcccttatag | gttaatat    c.*2940

          .         .         .         .         .         .       g.111036
 ttgaaaagttttccggtaaagatcctaattctaaagacaactcagtagggattcaattgc       c.*3000

          .         .         .         .         .         .       g.111096
 taggcatcgtgatggccaatgacctgcctccctatgacccacagtgtggcatccagagta       c.*3060

      | 52   .         .         .         .         .         .    g.112454
 gcga | atacttccaggctttggtgaataatatgtcctttgtaagatataaagaagtgtatg    c.*3120

          .         .         .         .         .       | 53 .    g.115683
 ccgctgcagcagaagttctaggacttatacttcgatatgttatggagagaaaaaac | atac    c.*3180

          .         .         .         .         .         .       g.115743
 tggaggagtctctgtgtgaactggttgcgaaacaattgaagcaacatcagaatactatgg       c.*3240

          .         .         .         .         .         .       g.115803
 aggacaagtttattgtgtgcttgaacaaagtgaccaagagcttccctcctcttgcagaca       c.*3300

   | 54      .         .         .         .         .         .    g.115938
 g | gttcatgaatgctgtgttctttctgctgccaaaatttcatggagtgttgaaaacactct    c.*3360

          .         .         .         .         .         .       g.115998
 gtctggaggtggtactttgtcgtgtggagggaatgacagagctgtacttccagttaaaga       c.*3420

          .         .         .  | 55      .         .         .    g.125022
 gcaaggacttcgttcaagtcatgagacatag | agatgatgaaagacaaaaagtatgtttgg    c.*3480

          .         .         .         .         .         .       g.125082
 acataatttataagatgatgccaaagttaaaaccagtagaactccgagaacttctgaacc       c.*3540

          .         .         .         .         .         .       g.125142
 ccgttgtggaattcgtttcccatccttctacaacatgtagggaacaaatgtataatattc       c.*3600

          .         .      | 56  .         .         .         .    g.125971
 tcatgtggattcatgataattacag | agatccagaaagtgagacagataatgactcccagg    c.*3660

          .         .         .         .         .         .       g.126031
 aaatatttaagttggcaaaagatgtgctgattcaaggattgatcgatgagaaccctggac       c.*3720

      | 57   .         .         .         .         .         .    g.127819
 ttca | attaattattcgaaatttctggagccatgaaactaggttaccttcaaataccttgg    c.*3780

          .         .         .         .         .         .       g.127879
 accggttgctggcactaaattccttatattctcctaagatagaagtgcactttttaagtt       c.*3840

          .         .         .         .         .         .       g.127939
 tagcaacaaattttctgctcgaaatgaccagcatgagcccagattatccaaaccccatgt       c.*3900

          .         .         .   | 58     .         .         .    g.128683
 tcgagcatcctctgtcagaatgcgaatttcag | gaatataccattgattctgattggcgtt    c.*3960

          .         .         .         .         .         .       g.128743
 tccgaagtactgttctcactccgatgtttgtggagacccaggcctcccagggcactctcc       c.*4020

          .         .         .         .         .         .       g.128803
 agacccgtacccaggaagggtccctctcagctcgctggccagtggcagggcagataaggg       c.*4080

          .         .         .         .   | 59     .         .    g.130804
 ccacccagcagcagcatgacttcacactgacacagactgcag | atggaagaagctcatttg    c.*4140

          .         .         .         .         .         .       g.130864
 attggctgaccgggagcagcactgacccgctggtcgaccacaccagtccctcatctgact       c.*4200

          .         .         .         .         .         .       g.130924
 ccttgctgtttgcccacaagaggagtgaaaggttacagagagcacccttgaagtcagtgg       c.*4260

          .         .         .         .         .         .       g.130984
 ggcctgattttgggaaaaaaaggctgggccttccaggggacgaggtggataacaaagtga       c.*4320

     | 60    .         .         .         .         .         .    g.133313
 aag | gtgcggccggccggacggacctactacgactgcgcagacggtttatgagggaccagg    c.*4380

          .         .         .         .         .       | 61 .    g.134450
 agaagctcagtttgatgtatgccagaaaaggcgttgctgagcaaaaacgagagaag | gaaa    c.*4440

          .         .         .         .         .         .       g.134510
 tcaagagtgagttaaaaatgaagcaggatgcccaggtcgttctgtacagaagctaccggc       c.*4500

          .         .         .         .         .         .       g.134570
 acggagaccttcctgacattcagatcaagcacagcagcctcatcaccccgttacaggccg       c.*4560

          | 62         .         .         .         .         .    g.136887
 tggcccag | agggacccaataattgcaaaacagctctttagcagcttgttttctggaattt    c.*4620

          .         .         .         .         .         .       g.136947
 tgaaagagatggataaatttaagacactgtctgaaaaaaacaacatcactcaaaagttgc       c.*4680

          .         .         .         .         .         .       g.137007
 ttcaagacttcaatcgttttcttaataccaccttctctttctttccaccctttgtctctt       c.*4740

          | 63         .         .         .         .         .    g.138373
 gtattcag | gacattagctgtcagcacgcagccctgctgagcctcgacccagcggctgtta    c.*4800

          .         .         .         .         .         .       g.138433
 gcgctggttgcctggccagcctacagcagcccgtgggcatccgcctgctagaggaggctc       c.*4860

          .         .         .         .         .         .       g.138493
 tgctccgcctgctgcctgctgagctgcctgccaagcgagtccgtgggaaggcccgcctcc       c.*4920

          .         .         .     | 64   .         .         .    g.141212
 ctcctgatgtcctcagatgggtggagcttgctaa | gctgtatagatcaattggagaatacg    c.*4980

          .         .         .         .         .         .       g.141272
 acgtcctccgtgggatttttaccagtgagataggaacaaagcaaatcactcagagtgcat       c.*5040

          .         .         .         .         .    | 65    .    g.143397
 tattagcagaagccagaagtgattattctgaagctgctaagcagtatgatgag | gctctca    c.*5100

          .         .         .         .         .         .       g.143457
 ataaacaagactgggtagatggtgagcccacagaagccgagaaggatttttgggaacttg       c.*5160

          .         .         .         .         .         .       g.143517
 catcccttgactgttacaaccaccttgctgagtggaaatcacttgaatactgttctacag       c.*5220

          .         .         .         .         .         .       g.143577
 ccagtatagacagtgagaaccccccagacctaaataaaatctggagtgaaccattttatc       c.*5280

    | 66     .         .         .         .         .         .    g.144297
 ag | gaaacatatctaccttacatgatccgcagcaagctgaagctgctgctccagggagagg    c.*5340

          .         .         .         .         .         .       g.144357
 ctgaccagtccctgctgacatttattgacaaagctatgcacggggagctccagaaggcga       c.*5400

          .         .         .         .         .         .       g.144417
 ttctagagcttcattacagtcaagagctgagtctgctttacctcctgcaagatgatgttg       c.*5460

          .         .         .         .        | 67.         .    g.145685
 acagagccaaatattacattcaaaatggcattcagagttttatgcag | aattattctagta    c.*5520

          .         .         .         .         .         .       g.145745
 ttgatgtcctcttacaccaaagtagactcaccaaattgcagtctgtacaggctttaacag       c.*5580

          .         .         .       | 68 .         .         .    g.147645
 aaattcaggagttcatcagctttataagcaaacaag | gcaatttatcatctcaagttcccc    c.*5640

          .         .         .         .         .         .       g.147705
 ttaagagacttctgaacacctggacaaacagatatccagatgctaaaatggacccaatga       c.*5700

          .         .         | 69         .         .         .    g.157888
 acatctgggatgacatcatcacaaatcg | atgtttctttctcagcaaaatagaggagaagc    c.*5760

          .         .         .         .         .         .       g.157948
 ttacccctcttccagaagataatagtatgaatgtggatcaagatggagaccccagtgaca       c.*5820

          .         .         .         .         .         .       g.158008
 ggatggaagtgcaagagcaggaagaagatatcagctccctgatcaggagttgcaagtttt       c.*5880

          .         .         .         | 70         .         .    g.161724
 ccatgaaaatgaagatgatagacagtgcccggaagcag | aacaatttctcacttgctatga    c.*5940

          .         .         .         .         .         .       g.161784
 aactactgaaggagctgcataaagagtcaaaaaccagagacgattggctggtgagctggg       c.*6000

          .         .         .         .         .         .       g.161844
 tgcagagctactgccgcctgagccactgccggagccggtcccagggctgctctgagcagg       c.*6060

          .         .         .    | 71    .         .         .    g.164223
 tgctcactgtgctgaaaacagtctctttgttgg | atgagaacaacgtgtcaagctacttaa    c.*6120

          .         .         .         .         .         .       g.164283
 gcaaaaatattctggctttccgtgaccagaacattctcttgggtacaacttacaggatca       c.*6180

          .         .         .         .         .         .       g.164343
 tagcgaatgctctcagcagtgagccagcctgccttgctgaaatcgaggaggacaaggcta       c.*6240

          .         .         .         .        | 72.         .    g.165805
 gaagaatcttagagctttctggatccagttcagaggattcagagaag | gtgatcgcgggtc    c.*6300

          .         .         .         .         .         .       g.165865
 tgtaccagagagcattccagcacctctctgaggctgtgcaggcggctgaggaggaggccc       c.*6360

          .         .         .         .         .         .       g.165925
 agcctccctcctggagctgtgggcctgcagctggggtgattgatgcttacatgacgctgg       c.*6420

          .         .         .         .         | 73         .    g.166797
 cagatttctgtgaccaacagctgcgcaaggaggaagagaatgcatcag | ttattgattctg    c.*6480

          .         .         .         .         .         .       g.166857
 cagaactgcaggcgtatccagcacttgtggtggagaaaatgttgaaagctttaaaattaa       c.*6540

          .         .         .         .         .         .       g.166917
 attccaatgaagccagattgaagtttcctagattacttcagattatagaacggtatccag       c.*6600

          .         .          | 74        .         .         .    g.170712
 aggagactttgagcctcatgacaaaagag | atctcttccgttccctgctggcagttcatca    c.*6660

          .         .         .         .         .         .       g.170772
 gctggatcagccacatggtggccttactggacaaagaccaagccgttgctgttcagcact       c.*6720

          .         .         .         .         .         .       g.170832
 ctgtggaagaaatcactgataactacccgcaggctattgtttatcccttcatcataagca       c.*6780

          .         .         .         .         .         .       g.170892
 gcgaaagctattccttcaaggatacttctactggtcataagaataaggagtttgtggcaa       c.*6840

   | 75      .         .         .         .         .         .    g.176003
 g | gattaaaagtaagttggatcaaggaggagtgattcaagattttattaatgccttagatc    c.*6900

          .         .          | 76        .         .         .    g.176164
 agctctctaatcctgaactgctctttaag | gattggagcaatgatgtaagagctgaactag    c.*6960

          .         .         .         .         .         .       g.176224
 caaaaacccctgtaaataaaaaaaacattgaaaaaatgtatgaaagaatgtatgcagcct       c.*7020

          .         .         .         .         .    | 77    .    g.179872
 tgggtgacccaaaggctccaggcctgggggcctttagaaggaagtttattcag | acttttg    c.*7080

          .         .         .         .         .         .       g.179932
 gaaaagaatttgataaacattttgggaaaggaggttctaaactactgagaatgaagctca       c.*7140

          .         .         .         .         .         .       g.179992
 gtgacttcaacgacattaccaacatgctacttttaaaaatgaacaaagactcaaagcccc       c.*7200

          .         .         .         .         .         .       g.180052
 ctgggaatctgaaagaatgttcaccctggatgagcgacttcaaagtggagttcctgagaa       c.*7260

          .         | 78         .         .         .         .    g.181415
 atgagctggagattcccg | gtcagtatgacggtaggggaaagccattgccagagtaccacg    c.*7320

          .         .       | 79 .         .         .         .    g.182618
 tgcgaatcgccgggtttgatgagcgg | gtgacagtcatggcgtctctgcgaaggcccaagc    c.*7380

          .         .         .         .         .         .       g.182678
 gcatcatcatccgtggccatgacgagagggaacaccctttcctggtgaagggtggcgagg       c.*7440

          .         .         .         .         .         .       g.182738
 acctgcggcaggaccagcgcgtggagcagctcttccaggtcatgaatgggatcctggccc       c.*7500

          .         .         .         .         .         .       g.182798
 aagactccgcctgcagccagagggccctgcagctgaggacctatagcgttgtgcccatga       c.*7560

         | 80.         .         .         .         .         .    g.186142
 cctccag | tgatcccagggcaccgccgtgtgaatataaagattggctgacaaaaatgtcag    c.*7620

          .         .         .        | 81.         .         .    g.186406
 gaaaacatgatgttggagcttacatgctaatgtataa | gggcgctaatcgtactgaaacag    c.*7680

          .         .         .         .          | 82        .    g.186533
 tcacgtcttttagaaaacgagaaagtaaagtgcctgctgatctcttaaa | gcgggccttcg    c.*7740

          .         .         .         .         .         .       g.186593
 tgaggatgagtacaagccctgaggctttcctggcgctccgctcccacttcgccagctctc       c.*7800

          .         .         .         .         .         .       g.186653
 acgctctgatatgcatcagccactggatcctcgggattggagacagacatctgaacaact       c.*7860

          .         .         .         .         .         .       g.186713
 ttatggtggccatggagactggcggcgtgatcgggatcgactttgggcatgcgtttggat       c.*7920

          .  | 83      .         .         .         .         .    g.187357
 ccgctacacag | tttctgccagtccctgagttgatgccttttcggctaactcgccagttta    c.*7980

          .         .         .         .         .         .       g.187417
 tcaatctgatgttaccaatgaaagaaacgggccttatgtacagcatcatggtacacgcac       c.*8040

          .         .         .         .         .         .       g.187477
 tccgggccttccgctcagaccctggcctgctcaccaacaccatggatgtgtttgtcaagg       c.*8100

          .         . | 84       .         .         .         .    g.188239
 agccctcctttgattggaaa | aattttgaacagaaaatgctgaaaaaaggagggtcatgga    c.*8160

          .         .         .         .         .         .       g.188299
 ttcaagaaataaatgttgctgaaaaaaattggtacccccgacagaaaatatgttacgcta       c.*8220

          .         .         .         . | 85       .         .    g.190825
 agagaaagttagcaggtgccaatccagcagtcattacttg | tgatgagctactcctgggtc    c.*8280

          .         .         .         .         .         .       g.190885
 atgagaaggcccctgccttcagagactatgtggctgtggcacgaggaagcaaagatcaca       c.*8340

          .         .         .         .         .         .       g.190945
 acattcgtgcccaagaaccagagagtgggctttcagaagagactcaagtgaagtgcctga       c.*8400

          .         .         .         .         .         .       g.191005
 tggaccaggcaacagaccccaacatccttggcagaacctgggaaggatgggagccctgga       c.*8460

          .         .         .         .         .         .       g.191065
 tgtgaggtctgtgggagtctgcagatagaaagcattacattgtttaaagaatctactata       c.*8520

          .         .         .         .         .         .       g.191125
 ctttggttggcagcattccatgagctgattttcctgaaacactaaagagaaatgtctttt       c.*8580

          .         .         .         .         .         .       g.191185
 gtgctacagtttcgtagcatgagtttaaatcaagattatgatgagtaaatgtgtatgggt       c.*8640

          .         .         .         .         .         .       g.191245
 taaatcaaagataaggttatagtaacatcaaagattaggtgaggtttatagaaagataga       c.*8700

          .         .         .         .         .         .       g.191305
 tatccaggcttaccaaagtattaagtcaagaatataatatgtgatcagctttcaaagcat       c.*8760

          .         .         .         .         .         .       g.191365
 ttacaagtgctgcaagttagtgaaacagctgtctccgtaaatggaggaaatgtggggaag       c.*8820

          .         .         .         .         .         .       g.191425
 ccttggaatgcccttctggttctggcacattggaaagcacactcagaaggcttcatcacc       c.*8880

          .         .         .         .         .         .       g.191485
 aagattttgggagagtaaagctaagtatagttgatgtaacattgtagaagcagcatagga       c.*8940

          .         .         .         .         .         .       g.191545
 acaataagaacaataggtaaagctataattatggcttatatttagaaatgactgcatttg       c.*9000

          .         .         .         .         .         .       g.191605
 atattttaggatatttttctaggttttttcctttcattttattctcttctagttttgaca       c.*9060

          .         .         .         .         .         .       g.191665
 ttttatgatagatttgctctctagaaggaaacgtctttatttaggagggcaaaaattttg       c.*9120

          .         .         .         .         .         .       g.191725
 gtcatagcattcacttttgctattccaatctacaactggaagatacataaaagtgctttg       c.*9180

          .         .         .         .         .         .       g.191785
 cattgaatttgggataacttcaaaaatcccatggttgttgttagggatagtactaagcat       c.*9240

          .         .         .         .         .         .       g.191845
 ttcagttccaggagaataaaagaaattcctatttgaaatgaattcctcatttggaggaaa       c.*9300

          .         .         .         .         .         .       g.191905
 aaaagcatgcattctagcacaacaagatgaaattatggaatacaaaagtggctccttccc       c.*9360

          .         .         .         .         .         .       g.191965
 atgtgcagtccctgtccccccccgccagtcctccacacccaaactgtttctgattggctt       c.*9420

          .         .         .         .         .         .       g.192025
 ttagctttttgttgtttttttttttccttctaacacttgtatttggaggctcttctgtga       c.*9480

          .         .         .         .         .                 g.192075
 ttttgagaagtatactcttgagtgtttaataaagtttttttccaaaagta                 c.*9530

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein kinase, DNA-activated, catalytic polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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