parathyroid hormone 1 receptor (PTH1R) - coding DNA reference sequence

(used for variant description)

(last modified May 9, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000316.2 in the PTH1R gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008864.1, covering PTH1R transcript NM_000316.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5023
                                      ccacagaagctgctcagggacta       c.-181

 .         .         .         .         .         .                g.5083
 tccatggcctccccgtggccaacttgagtctgctctgcagctttaggcccgacttggaag       c.-121

 .         .     | 02   .         .         .         .             g.8361
 gcccatgggctgcag | atgaggaaactgaggtccagacagccgaagagtggtagtgtccag    c.-61

 .         .  | 03      .         .         .         .             g.10814
 gacacacaactg | ggccggcggcggcggctgccccgagggacgcggccctaggcggtggcg    c.-1

          .         .         .         .         .         .       g.10874
 ATGGGGACCGCCCGGATCGCACCCGGCCTGGCGCTCCTGCTCTGCTGCCCCGTGCTCAGC       c.60
 M  G  T  A  R  I  A  P  G  L  A  L  L  L  C  C  P  V  L  S         p.20

          .      | 04  .         .         .         .         .    g.21206
 TCCGCGTACGCGCTG | GTGGATGCAGATGACGTCATGACTAAAGAGGAACAGATCTTCCTG    c.120
 S  A  Y  A  L   | V  D  A  D  D  V  M  T  K  E  E  Q  I  F  L      p.40

          .         .         .         .         .         | 05    g.22991
 CTGCACCGTGCTCAGGCCCAGTGCGAAAAACGGCTCAAGGAGGTCCTGCAGAGGCCAG | CC    c.180
 L  H  R  A  Q  A  Q  C  E  K  R  L  K  E  V  L  Q  R  P  A |       p.60

          .         .         .         .         .         .       g.23051
 AGCATAATGGAATCAGACAAGGGATGGACATCTGCGTCCACATCAGGGAAGCCCAGGAAA       c.240
 S  I  M  E  S  D  K  G  W  T  S  A  S  T  S  G  K  P  R  K         p.80

          .         .         .         .         .         .       g.23111
 GATAAGGCATCTGGGAAGCTCTACCCTGAGTCTGAGGAGGACAAGGAGGCACCCACTGGC       c.300
 D  K  A  S  G  K  L  Y  P  E  S  E  E  D  K  E  A  P  T  G         p.100

          .    | 06    .         .         .         .         .    g.25156
 AGCAGGTACCGAG | GGCGCCCCTGTCTGCCGGAATGGGACCACATCCTGTGCTGGCCGCTG    c.360
 S  R  Y  R  G |   R  P  C  L  P  E  W  D  H  I  L  C  W  P  L      p.120

          .         .         .         .         .         .       g.25216
 GGGGCACCAGGTGAGGTGGTGGCTGTGCCCTGTCCGGACTACATTTATGACTTCAATCAC       c.420
 G  A  P  G  E  V  V  A  V  P  C  P  D  Y  I  Y  D  F  N  H         p.140

      | 07   .         .         .         .         .         .    g.25384
 AAAG | GCCATGCCTACCGACGCTGTGACCGCAATGGCAGCTGGGAGCTGGTGCCTGGGCAC    c.480
 K  G |   H  A  Y  R  R  C  D  R  N  G  S  W  E  L  V  P  G  H      p.160

          .         .         .         .         .         .       g.25444
 AACAGGACGTGGGCCAACTACAGCGAGTGTGTCAAATTTCTCACCAATGAGACTCGTGAA       c.540
 N  R  T  W  A  N  Y  S  E  C  V  K  F  L  T  N  E  T  R  E         p.180

     | 08    .         .         .         .         .         .    g.25689
 CGG | GAGGTGTTTGACCGCCTGGGCATGATTTACACCGTGGGCTACTCCGTGTCCCTGGCG    c.600
 R   | E  V  F  D  R  L  G  M  I  Y  T  V  G  Y  S  V  S  L  A      p.200

          .         .         .         | 09         .         .    g.25938
 TCCCTCACCGTAGCTGTGCTCATCCTGGCCTACTTTAG | GCGGCTGCACTGCACGCGCAAC    c.660
 S  L  T  V  A  V  L  I  L  A  Y  F  R  |  R  L  H  C  T  R  N      p.220

          .         .         .         .         .         .       g.25998
 TACATCCACATGCACCTGTTCCTGTCCTTCATGCTGCGCGCCGTGAGCATCTTCGTCAAG       c.720
 Y  I  H  M  H  L  F  L  S  F  M  L  R  A  V  S  I  F  V  K         p.240

          .         .         .         .         .         .       g.26058
 GACGCTGTGCTCTACTCTGGCGCCACGCTTGATGAGGCTGAGCGCCTCACCGAGGAGGAG       c.780
 D  A  V  L  Y  S  G  A  T  L  D  E  A  E  R  L  T  E  E  E         p.260

          .         .         .         .         .     | 10   .    g.26563
 CTGCGCGCCATCGCCCAGGCGCCCCCGCCGCCTGCCACCGCCGCTGCCGGCTAC | GCGGGC    c.840
 L  R  A  I  A  Q  A  P  P  P  P  A  T  A  A  A  G  Y   | A  G      p.280

          .         .         .         .         .         .       g.26623
 TGCAGGGTGGCTGTGACCTTCTTCCTTTACTTCCTGGCCACCAACTACTACTGGATTCTG       c.900
 C  R  V  A  V  T  F  F  L  Y  F  L  A  T  N  Y  Y  W  I  L         p.300

          .         .         .         .         .         .       g.26683
 GTGGAGGGGCTGTACCTGCACAGCCTCATCTTCATGGCCTTCTTCTCAGAGAAGAAGTAC       c.960
 V  E  G  L  Y  L  H  S  L  I  F  M  A  F  F  S  E  K  K  Y         p.320

          .         .         | 11         .         .         .    g.28311
 CTGTGGGGCTTCACAGTCTTCGGCTGGG | GTCTGCCCGCTGTCTTCGTGGCTGTGTGGGTC    c.1020
 L  W  G  F  T  V  F  G  W  G |   L  P  A  V  F  V  A  V  W  V      p.340

          .         .          | 12        .         .         .    g.28699
 AGTGTCAGAGCTACCCTGGCCAACACCGG | GTGCTGGGACTTGAGCTCCGGGAACAAAAAG    c.1080
 S  V  R  A  T  L  A  N  T  G  |  C  W  D  L  S  S  G  N  K  K      p.360

          .         .         .       | 13 .         .         .    g.29044
 TGGATCATCCAGGTGCCCATCCTGGCCTCCATTGTG | CTCAACTTCATCCTCTTCATCAAT    c.1140
 W  I  I  Q  V  P  I  L  A  S  I  V   | L  N  F  I  L  F  I  N      p.380

          .         .         .         .         .         .       g.29104
 ATCGTCCGGGTGCTCGCCACCAAGCTGCGGGAGACCAACGCCGGCCGGTGTGACACACGG       c.1200
 I  V  R  V  L  A  T  K  L  R  E  T  N  A  G  R  C  D  T  R         p.400

          .  | 14      .         .         .         .         .    g.29829
 CAGCAGTACCG | GAAGCTGCTCAAATCCACGCTGGTGCTCATGCCCCTCTTTGGCGTCCAC    c.1260
 Q  Q  Y  R  |  K  L  L  K  S  T  L  V  L  M  P  L  F  G  V  H      p.420

          .         .         .         .         .         .       g.29889
 TACATTGTCTTCATGGCCACACCATACACCGAGGTCTCAGGGACGCTCTGGCAAGTCCAG       c.1320
 Y  I  V  F  M  A  T  P  Y  T  E  V  S  G  T  L  W  Q  V  Q         p.440

          .         .         .    | 15    .         .         .    g.30030
 ATGCACTATGAGATGCTCTTCAACTCCTTCCAG | GGATTTTTTGTCGCAATCATATACTGT    c.1380
 M  H  Y  E  M  L  F  N  S  F  Q   | G  F  F  V  A  I  I  Y  C      p.460

          .      | 16  .         .         .         .         .    g.30569
 TTCTGCAATGGCGAG | GTACAAGCTGAGATCAAGAAATCTTGGAGCCGCTGGACACTGGCA    c.1440
 F  C  N  G  E   | V  Q  A  E  I  K  K  S  W  S  R  W  T  L  A      p.480

          .         .         .         .         .         .       g.30629
 CTGGACTTCAAGCGAAAGGCACGCAGCGGGAGCAGCAGCTATAGCTACGGCCCCATGGTG       c.1500
 L  D  F  K  R  K  A  R  S  G  S  S  S  Y  S  Y  G  P  M  V         p.500

          .         .         .         .         .         .       g.30689
 TCCCACACAAGTGTGACCAATGTCGGCCCCCGTGTGGGACTCGGCCTGCCCCTCAGCCCC       c.1560
 S  H  T  S  V  T  N  V  G  P  R  V  G  L  G  L  P  L  S  P         p.520

          .         .         .         .         .         .       g.30749
 CGCCTACTGCCCACTGCCACCACCAACGGCCACCCTCAGCTGCCTGGCCATGCCAAGCCA       c.1620
 R  L  L  P  T  A  T  T  N  G  H  P  Q  L  P  G  H  A  K  P         p.540

          .         .         .         .         .         .       g.30809
 GGGACCCCAGCCCTGGAGACCCTCGAGACCACACCACCTGCCATGGCTGCTCCCAAGGAC       c.1680
 G  T  P  A  L  E  T  L  E  T  T  P  P  A  M  A  A  P  K  D         p.560

          .         .         .         .         .         .       g.30869
 GATGGGTTCCTCAACGGCTCCTGCTCAGGCCTGGACGAGGAGGCCTCTGGGCCTGAGCGG       c.1740
 D  G  F  L  N  G  S  C  S  G  L  D  E  E  A  S  G  P  E  R         p.580

          .         .         .         .                           g.30911
 CCACCTGCCCTGCTACAGGAAGAGTGGGAGACAGTCATGTGA                         c.1782
 P  P  A  L  L  Q  E  E  W  E  T  V  M  X                           p.593

          .         .         .         .         .         .       g.30971
 ccaggcgctgggggctggacctgctgacatagtggatggacagatggaccaaaagatggg       c.*60

          .         .         .         .         .         .       g.31031
 tggttgaatgatttcccactcagggctggggccaagaggaaaaacagggaaaaaaagaaa       c.*120

          .         .                                               g.31054
 aaaaaaagaaaaaggaaaaggaa                                            c.*143

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Parathyroid hormone 1 receptor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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