retina and anterior neural fold homeobox (RAX) - coding DNA reference sequence

(used for variant description)

(last modified November 10, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_013435.2 in the RAX gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000018.9, covering RAX transcript NM_013435.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      ctgggac       c.-181

 .         .         .         .         .         .                g.5067
 taaggcggcagcgggctgagcgctcggccacccccagcgtgcgcagcccgggcgggcttc       c.-121

 .         .         .         .         .         .                g.5127
 gcccgcggagcttgacctagggtcgggacccgtcgggttgcaccgccgcactcgggaaga       c.-61

 .         .         .         .         .         .                g.5187
 cccggcttcgagcctctcctctccgtctccaaagcgccctcccgcctcccggcgctcccc       c.-1

          .         .         .         .         .         .       g.5247
 ATGCACCTGCCGGGCTGCGCGCCAGCCATGGCCGACGGGAGCTTCTCGCTTGCCGGCCAC       c.60
 M  H  L  P  G  C  A  P  A  M  A  D  G  S  F  S  L  A  G  H         p.20

          .         .         .         .         .         .       g.5307
 CTGCTCCGCAGCCCGGGCGGGAGCACCTCGCGACTTCACAGCATCGAGGCCATCCTGGGG       c.120
 L  L  R  S  P  G  G  S  T  S  R  L  H  S  I  E  A  I  L  G         p.40

          .         .         .         .         .         .       g.5367
 TTTACCAAGGACGACGGGATCCTCGGCACCTTCCCGGCGGAGCGGGGCGCCCGGGGCGCG       c.180
 F  T  K  D  D  G  I  L  G  T  F  P  A  E  R  G  A  R  G  A         p.60

          .         .         .         .         .         .       g.5427
 AAGGAGCGGGATAGGAGGCTGGGCGCGCGGCCCGCCTGCCCCAAGGCGCCCGAGGAAGGC       c.240
 K  E  R  D  R  R  L  G  A  R  P  A  C  P  K  A  P  E  E  G         p.80

          .         .         .         .          | 02        .    g.5790
 TCCGAGCCCTCCCCGCCGCCAGCCCCGGCGCCCGCCCCCGAGTACGAAG | CCCCTCGACCC    c.300
 S  E  P  S  P  P  P  A  P  A  P  A  P  E  Y  E  A |   P  R  P      p.100

          .         .         .         .         .         .       g.5850
 TACTGCCCCAAGGAGCCCGGGGAGGCACGGCCGAGCCCAGGGCTGCCCGTCGGGCCAGCC       c.360
 Y  C  P  K  E  P  G  E  A  R  P  S  P  G  L  P  V  G  P  A         p.120

          .         .         .         .         .         .       g.5910
 ACCGGCGAAGCGAAACTGTCAGAGGAGGAACAGCCCAAGAAAAAGCATCGGCGGAACCGC       c.420
 T  G  E  A  K  L  S  E  E  E  Q  P  K  K  K  H  R  R  N  R         p.140

          .         .         .         .         .         .       g.5970
 ACGACTTTCACCACGTACCAGCTGCATGAGCTGGAGCGCGCGTTCGAGAAGTCCCACTAC       c.480
 T  T  F  T  T  Y  Q  L  H  E  L  E  R  A  F  E  K  S  H  Y         p.160

          .         .         .         .         .         .       g.6030
 CCGGACGTGTACAGCCGCGAGGAGCTGGCCGGCAAGGTCAACCTACCAGAGGTCCGGGTC       c.540
 P  D  V  Y  S  R  E  E  L  A  G  K  V  N  L  P  E  V  R  V         p.180

     | 03    .         .         .         .         .         .    g.8949
 CAG | GTGTGGTTCCAGAACCGACGGGCTAAGTGGCGGCGGCAGGAGAAGCTGGAAGTGTCC    c.600
 Q   | V  W  F  Q  N  R  R  A  K  W  R  R  Q  E  K  L  E  V  S      p.200

          .         .         .         .         .         .       g.9009
 TCCATGAAGCTGCAGGACTCGCCCCTCCTCTCCTTCAGCCGCTCCCCGCCCTCCGCGACG       c.660
 S  M  K  L  Q  D  S  P  L  L  S  F  S  R  S  P  P  S  A  T         p.220

          .         .         .         .         .         .       g.9069
 CTGTCGCCCCTCGGGGCGGGCCCGGGCAGCGGTGGCGGGCCGGCTGGGGGCGCGCTGCCG       c.720
 L  S  P  L  G  A  G  P  G  S  G  G  G  P  A  G  G  A  L  P         p.240

          .         .         .         .         .         .       g.9129
 CTGGAGTCCTGGCTCGGGCCGCCGCTGCCGGGCGGGGGCGCCACGGCGCTGCAGAGCCTG       c.780
 L  E  S  W  L  G  P  P  L  P  G  G  G  A  T  A  L  Q  S  L         p.260

          .         .         .         .         .         .       g.9189
 CCGGGCTTCGGGCCGCCGGCGCAGAGCCTGCCTGCCAGCTACACGCCACCGCCGCCGCCT       c.840
 P  G  F  G  P  P  A  Q  S  L  P  A  S  Y  T  P  P  P  P  P         p.280

          .         .         .         .         .         .       g.9249
 CCGCCCTTCCTGAACTCCCCGCCGTTGGGCCCCGGCCTGCAACCTCTCGCGCCGCCGCCG       c.900
 P  P  F  L  N  S  P  P  L  G  P  G  L  Q  P  L  A  P  P  P         p.300

          .         .         .         .         .         .       g.9309
 CCCTCCTACCCGTGCGGGCCCGGCTTCGGGGACAAGTTCCCGCTGGACGAGGCGGACCCG       c.960
 P  S  Y  P  C  G  P  G  F  G  D  K  F  P  L  D  E  A  D  P         p.320

          .         .         .         .         .         .       g.9369
 CGCAACAGCAGCATCGCGGCGCTGCGTCTGAAAGCCAAGGAGCACATCCAGGCCATCGGG       c.1020
 R  N  S  S  I  A  A  L  R  L  K  A  K  E  H  I  Q  A  I  G         p.340

          .         .                                               g.9390
 AAGCCGTGGCAGGCCCTCTAG                                              c.1041
 K  P  W  Q  A  L  X                                                p.346

          .         .         .         .         .         .       g.9450
 gggcactggggaacgtcttgggatccgaccccgggccgaccgcaccgtacccgcatcctc       c.*60

          .         .         .         .         .         .       g.9510
 tctcccagggacaacccccctccccagctcggcccctctttccctgtcgcctgcagccac       c.*120

          .         .         .         .         .         .       g.9570
 ccgccaagcatagttcagggccacgcgcctgctcccgatgcacggggagaagggcgactt       c.*180

          .         .         .         .         .         .       g.9630
 tcaggcctgaggagaggccctctggccgcctcaacgcacttcgcggacctcagccctgca       c.*240

          .         .         .         .         .         .       g.9690
 gctggagggcaacaggctgccgggccccgctggccacgccgctcccatcaccgcaggcgc       c.*300

          .         .         .         .         .         .       g.9750
 tggagcctccaggcccaaacaggctgaagctcctaaacttggccattcccaggaggcttg       c.*360

          .         .         .         .         .         .       g.9810
 gagacccccagataaccataacagggaagcaggggaggcggaaaaatagagtttgagaaa       c.*420

          .         .         .         .         .         .       g.9870
 cttttgtataagtagtttcaaactatttgagaggagaattaaagacatgcttgttttgtt       c.*480

          .         .         .         .         .         .       g.9930
 tcgactctgtttaagcacgctcaggacttggggagaggagtgaatattggggtacgggag       c.*540

          .         .         .         .         .         .       g.9990
 gagggtgcgttgacggacagggtgggtcagggaaagaggaggactgagaagaagctcagg       c.*600

          .         .         .         .         .         .       g.10050
 gtttccttgtgaaaattctagggacacttcgctgcagcagagaatcgtccccattccgaa       c.*660

          .         .         .         .         .         .       g.10110
 cgcttcggcggcctagaccagaggcgcccttccctggagccggcgtgcgcgcttggggtc       c.*720

          .         .         .         .         .         .       g.10170
 cggagtggatggggctaaggctcagatgctagcgcgctcccagttcccccgctagcccca       c.*780

          .         .         .         .         .         .       g.10230
 tagtccagcggcagctgatattttcaagtttgacttcaatagaaagcgtcaagaccacct       c.*840

          .         .         .         .         .         .       g.10290
 tccctagggcgagagcgaagtgtcccccggcccctggcgtccccgctctcctaaggactc       c.*900

          .         .         .         .         .         .       g.10350
 ctctcagttcaccaagcagatctccggttcggtgccagtccctaacacccaaggttgatc       c.*960

          .         .         .         .         .         .       g.10410
 accagcggtacaagaactgaggcaaagagatgcttttccttttcggagccgcgagactct       c.*1020

          .         .         .         .         .         .       g.10470
 ctaacctccccaactcgctccacactcgccaacccagagttcggtaaaaggcgcgtctgg       c.*1080

          .         .         .         .         .         .       g.10530
 tgaggtgccgcgctcggagagtgtcctggagcgccctacgccaccgccccgagagctagt       c.*1140

          .         .         .         .         .         .       g.10590
 tcttgcgggcgtgccctggacagtatctgcagttctttggcgccggctctagggcgagga       c.*1200

          .         .         .         .         .         .       g.10650
 aggaatctcgaaatctcagcccgcttcacaatctcctgagactctctgaagaaggagagt       c.*1260

          .         .         .         .         .         .       g.10710
 cccggactcccgcctgagcgtgctcgatatccaccgttgacactggaagctgggcgaccg       c.*1320

          .         .         .         .         .         .       g.10770
 ccagcagaacctggatgcccgccaacaggtcctggcacggggggggggggggcgtccacc       c.*1380

          .         .         .         .         .         .       g.10830
 ccacaacccccgtccctaagcgtgctttcaggatgatgcccccagagccttaattagcat       c.*1440

          .         .         .         .         .         .       g.10890
 caactggctactgtctgtcggtcctgagcaaattagtgaagctcccagtcccctttcctc       c.*1500

          .         .         .         .         .         .       g.10950
 gtctaaataaactctgtctctctggaaggtgggaaagatggaataagatcacctgtaaag       c.*1560

          .         .         .         .         .         .       g.11010
 gctttgtggaaagtaccaagaccctggcatgacgcaatatggattgtaatcatcgtcccc       c.*1620

          .         .         .         .         .         .       g.11070
 atttccccgaaattccctggctgttctccggttcctgaaaccgacttgggaaaaggatga       c.*1680

          .         .         .         .         .         .       g.11130
 ccacgctggagctgggaatatgggaagcctcatcatagtttccagtcctttctctgcggg       c.*1740

          .         .         .         .         .         .       g.11190
 tctaagaggctattgcataaccagggctgtgtacccctagacctccagatggtgccttgc       c.*1800

          .         .         .         .         .         .       g.11250
 acacagtaggctgatcagtaaaaatgtactgaataaattattcccccccaagaggtaggg       c.*1860

          .         .         .         .         .         .       g.11310
 agtaatatctgcacttttcctcacaaggatgtctccttgggggaggaggatggagcagcc       c.*1920

          .         .         .         .                           g.11359
 cgtgtgttatcaccttttagcaagaaaacaaaacaaaacaaaaccagaa                  c.*1969

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Retina and anterior neural fold homeobox protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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