SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1) - coding DNA reference sequence

(used for variant description)

(last modified September 3, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_003073.3 in the SMARCB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009303.1, covering SMARCB1 transcript NM_003073.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5027
                                  aacgccagcgcctgcgcactgagggcg       c.-181

 .         .         .         .         .         .                g.5087
 gcctggtcgtcgtctgcggcggcggcggcggctgaggagcccggctgaggcgccagtacc       c.-121

 .         .         .         .         .         .                g.5147
 cggcccggtccgcatttcgccttccggcttcggtttccctcggcccagcacgccccggcc       c.-61

 .         .         .         .         .         .                g.5207
 ccgccccagccctcctgatccctcgcagcccggctccggccgcccgcctctgccgccgca       c.-1

          .         .         .         .         .         .       g.5267
 ATGATGATGATGGCGCTGAGCAAGACCTTCGGGCAGAAGCCCGTGAAGTTCCAGCTGGAG       c.60
 M  M  M  M  A  L  S  K  T  F  G  Q  K  P  V  K  F  Q  L  E         p.20

          .         .         .    | 02    .         .         .    g.9820
 GACGACGGCGAGTTCTACATGATCGGCTCCGAG | GTGGGAAACTACCTCCGTATGTTCCGA    c.120
 D  D  G  E  F  Y  M  I  G  S  E   | V  G  N  Y  L  R  M  F  R      p.40

          .         .         .         .         .         .       g.9880
 GGTTCTCTGTACAAGAGATACCCCTCACTCTGGAGGCGACTAGCCACTGTGGAAGAGAGG       c.180
 G  S  L  Y  K  R  Y  P  S  L  W  R  R  L  A  T  V  E  E  R         p.60

          .         .         .         .         .   | 03     .    g.11604
 AAGAAAATAGTTGCATCGTCACATGGTAAAAAAACAAAACCTAACACTAAGG | ATCACGGA    c.240
 K  K  I  V  A  S  S  H  G  K  K  T  K  P  N  T  K  D |   H  G      p.80

          .         .         .         .         .         .       g.11664
 TACACGACTCTAGCCACCAGTGTGACCCTGTTAAAAGCCTCGGAAGTGGAAGAGATTCTG       c.300
 Y  T  T  L  A  T  S  V  T  L  L  K  A  S  E  V  E  E  I  L         p.100

          .         .         .         .         .         .       g.11724
 GATGGCAACGATGAGAAGTACAAGGCTGTGTCCATCAGCACAGAGCCCCCCACCTACCTC       c.360
 D  G  N  D  E  K  Y  K  A  V  S  I  S  T  E  P  P  T  Y  L         p.120

    | 04     .         .         .         .         .         .    g.19039
 AG | GGAACAGAAGGCCAAGAGGAACAGCCAGTGGGTACCCACCCTGCCCAACAGCTCCCAC    c.420
 R  |  E  Q  K  A  K  R  N  S  Q  W  V  P  T  L  P  N  S  S  H      p.140

          .         .         .         .         .         .       g.19099
 CACTTAGATGCCGTGCCATGCTCCACAACCATCAACAGGAACCGCATGGGCCGAGACAAG       c.480
 H  L  D  A  V  P  C  S  T  T  I  N  R  N  R  M  G  R  D  K         p.160

          .         . | 05       .         .         .         .    g.21372
 AAGAGAACCTTCCCCCTTTG | CTTTGATGACCATGACCCAGCTGTGATCCATGAGAACGCA    c.540
 K  R  T  F  P  L  C  |  F  D  D  H  D  P  A  V  I  H  E  N  A      p.180

          .         .         .         .         .         .       g.21432
 TCTCAGCCCGAGGTGCTGGTCCCCATCCGGCTGGACATGGAGATCGATGGGCAGAAGCTG       c.600
 S  Q  P  E  V  L  V  P  I  R  L  D  M  E  I  D  G  Q  K  L         p.200

          .         .         | 06         .         .         .    g.34839
 CGAGACGCCTTCACCTGGAACATGAATG | AGAAGTTGATGACGCCTGAGATGTTTTCAGAA    c.660
 R  D  A  F  T  W  N  M  N  E |   K  L  M  T  P  E  M  F  S  E      p.220

          .         .         .         .         .         .       g.34899
 ATCCTCTGTGACGATCTGGATTTGAACCCGCTGACGTTTGTGCCAGCCATCGCCTCTGCC       c.720
 I  L  C  D  D  L  D  L  N  P  L  T  F  V  P  A  I  A  S  A         p.240

          .         .         .         .         .         .       g.34959
 ATCAGACAGCAGATCGAGTCCTACCCCACGGACAGCATCCTGGAGGACCAGTCAGACCAG       c.780
 I  R  Q  Q  I  E  S  Y  P  T  D  S  I  L  E  D  Q  S  D  Q         p.260

          .      | 07  .         .         .         .         .    g.43307
 CGCGTCATCATCAAG | CTGAACATCCATGTGGGAAACATTTCCCTGGTGGACCAGTTTGAG    c.840
 R  V  I  I  K   | L  N  I  H  V  G  N  I  S  L  V  D  Q  F  E      p.280

          .         .         .         .         .         .       g.43367
 TGGGACATGTCAGAGAAGGAGAACTCACCAGAGAAGTTTGCCCTGAAGCTGTGCTCGGAG       c.900
 W  D  M  S  E  K  E  N  S  P  E  K  F  A  L  K  L  C  S  E         p.300

          .         .         .         .         .         .       g.43427
 CTGGGGTTGGGCGGGGAGTTTGTCACCACCATCGCATACAGCATCCGGGGACAGCTGAGC       c.960
 L  G  L  G  G  E  F  V  T  T  I  A  Y  S  I  R  G  Q  L  S         p.320

          .         .       | 08 .         .         .         .    g.51643
 TGGCATCAGAAGACCTACGCCTTCAG | CGAGAACCCTCTGCCCACAGTGGAGATTGCCATC    c.1020
 W  H  Q  K  T  Y  A  F  S  |  E  N  P  L  P  T  V  E  I  A  I      p.340

          .         .         .         .         .         .       g.51703
 CGGAACACGGGCGATGCGGACCAGTGGTGCCCACTGCTGGAGACTCTGACAGACGCTGAG       c.1080
 R  N  T  G  D  A  D  Q  W  C  P  L  L  E  T  L  T  D  A  E         p.360

          .         .         .         | 09         .         .    g.52200
 ATGGAGAAGAAGATCCGCGACCAGGACAGGAACACGAG | GCGGATGAGGCGTCTTGCCAAC    c.1140
 M  E  K  K  I  R  D  Q  D  R  N  T  R  |  R  M  R  R  L  A  N      p.380

          .                                                         g.52218
 ACGGCCCCGGCCTGGTAA                                                 c.1158
 T  A  P  A  W  X                                                   p.385

          .         .         .         .         .         .       g.52278
 ccagcccatcagcacacggctcccacggagcatctcagaagattgggccgcctctcctcc       c.*60

          .         .         .         .         .         .       g.52338
 atcttctggcaaggacagaggcgaggggacagcccagcgccatcctgaggatcgggtggg       c.*120

          .         .         .         .         .         .       g.52398
 ggtggagtgggggcttccaggtggcccttcccggcacacattccatttgttgagccccag       c.*180

          .         .         .         .         .         .       g.52458
 tcctgccccccaccccaccctccctacccctccccagtctctggggtcaggaagaaacct       c.*240

          .         .         .         .         .         .       g.52518
 tattttaggttgtgttttgtttttgtataggagccccaggcagggctagtaacagttttt       c.*300

          .         .         .                                     g.52556
 aaataaaaggcaacaggtcatgttcaatttcttcaaca                             c.*338

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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