SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (SMARCD1) - coding DNA reference sequence

(used for variant description)

(last modified March 22, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_003076.4 in the SMARCD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering SMARCD1 transcript NM_003076.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           agcacgccttttccgctagtcgccccgctctatcccatagtctcgctgcc       c.-121

 .         .         .         .         .         .                g.5110
 ctgagcctcccgtgccggccggccggccgggggaacaggcgggcgctcggggggcgctcg       c.-61

 .         .         .         .         .         .                g.5170
 gggggcggggggagttccggttccggttctttgtgcggctgcatcggcggctccgggaag       c.-1

          .         .         .         .         .         .       g.5230
 ATGGCGGCCCGGGCGGGTTTCCAGTCTGTGGCTCCAAGCGGCGGCGCCGGAGCCTCAGGA       c.60
 M  A  A  R  A  G  F  Q  S  V  A  P  S  G  G  A  G  A  S  G         p.20

          .         .         .         .         .         .       g.5290
 GGGGCGGGCGCGGCTGCTGCCTTGGGCCCGGGCGGAACTCCGGGGCCTCCTGTGCGAATG       c.120
 G  A  G  A  A  A  A  L  G  P  G  G  T  P  G  P  P  V  R  M         p.40

          .         .         .         .         .        | 02.    g.5964
 GGCCCGGCTCCGGGTCAAGGGCTGTACCGCTCCCCGATGCCCGGAGCGGCCTATCCG | AGA    c.180
 G  P  A  P  G  Q  G  L  Y  R  S  P  M  P  G  A  A  Y  P   | R      p.60

          .         .         .         .         .         .       g.6024
 CCAGGTATGTTGCCAGGCAGCCGAATGACACCTCAGGGACCTTCCATGGGACCCCCTGGC       c.240
 P  G  M  L  P  G  S  R  M  T  P  Q  G  P  S  M  G  P  P  G         p.80

          .         .         .         .         .         .       g.6084
 TATGGGGGGAACCCTTCAGTCCGACCTGGCCTGGCCCAGTCAGGGATGGATCAGTCCCGC       c.300
 Y  G  G  N  P  S  V  R  P  G  L  A  Q  S  G  M  D  Q  S  R         p.100

          .         .         .         .         .         .       g.6144
 AAGAGACCTGCCCCTCAGCAGATCCAGCAGGTCCAGCAGCAGGCGGTCCAAAATCGAAAC       c.360
 K  R  P  A  P  Q  Q  I  Q  Q  V  Q  Q  Q  A  V  Q  N  R  N         p.120

       | 03  .         .         .         .         | 04         . g.6568
 CACAA | TGCAAAGAAAAAGAAGATGGCTGACAAAATTCTACCTCAAAGG | ATTCGTGAACTG c.420
 H  N  |  A  K  K  K  K  M  A  D  K  I  L  P  Q  R   | I  R  E  L   p.140

          .         .         .         .         .         .       g.6628
 GTACCAGAATCCCAGGCCTATATGGATCTCTTGGCTTTTGAAAGGAAACTGGACCAGACT       c.480
 V  P  E  S  Q  A  Y  M  D  L  L  A  F  E  R  K  L  D  Q  T         p.160

          .         .         .         .         .  | 05      .    g.7172
 ATCATGAGGAAACGGCTAGATATCCAAGAGGCCTTGAAACGTCCCATCAAG | CAAAAACGG    c.540
 I  M  R  K  R  L  D  I  Q  E  A  L  K  R  P  I  K   | Q  K  R      p.180

          .         .         .         .         .         .       g.7232
 AAGCTGCGAATTTTCATTTCTAACACTTTCAATCCGGCTAAGTCAGATGCCGAGGATGGG       c.600
 K  L  R  I  F  I  S  N  T  F  N  P  A  K  S  D  A  E  D  G         p.200

          .         .         .         .         .     | 06   .    g.8327
 GAAGGGACGGTGGCTTCCTGGGAGCTTCGGGTAGAAGGACGGCTCCTGGAGGAT | TCAGCC    c.660
 E  G  T  V  A  S  W  E  L  R  V  E  G  R  L  L  E  D   | S  A      p.220

          .         .         .         .         .         .       g.8387
 TTGTCCAAATATGATGCCACTAAACAAAAGAGGAAGTTCTCTTCCTTTTTTAAGTCCTTG       c.720
 L  S  K  Y  D  A  T  K  Q  K  R  K  F  S  S  F  F  K  S  L         p.240

          .         .         .         .         .  | 07      .    g.9693
 GTGATTGAACTGGACAAAGACCTGTATGGGCCAGACAACCATCTGGTAGAA | TGGCACAGG    c.780
 V  I  E  L  D  K  D  L  Y  G  P  D  N  H  L  V  E   | W  H  R      p.260

          .         .         .         .         .         .       g.9753
 ACCGCCACTACCCAGGAGACCGATGGCTTTCAGGTGAAGCGGCCGGGAGACGTGAATGTA       c.840
 T  A  T  T  Q  E  T  D  G  F  Q  V  K  R  P  G  D  V  N  V         p.280

          .         .         .    | 08    .         .         .    g.10068
 CGGTGTACTGTCCTACTGATGCTGGATTACCAG | CCTCCCCAGTTTAAATTAGACCCCCGC    c.900
 R  C  T  V  L  L  M  L  D  Y  Q   | P  P  Q  F  K  L  D  P  R      p.300

          .         .         .         .         .         .       g.10128
 CTAGCTCGACTCCTGGGCATCCATACCCAGACTCGTCCAGTGATCATCCAAGCACTGTGG       c.960
 L  A  R  L  L  G  I  H  T  Q  T  R  P  V  I  I  Q  A  L  W         p.320

          .         .         .         .         .         .       g.10188
 CAATATATTAAGACACATAAGCTCCAGGACCCTCACGAGCGGGAGTTTGTCATCTGTGAC       c.1020
 Q  Y  I  K  T  H  K  L  Q  D  P  H  E  R  E  F  V  I  C  D         p.340

          .      | 09  .         .         .         .         .    g.10338
 AAGTACCTGCAGCAG | ATCTTTGAGTCTCAACGTATGAAGTTTTCAGAGATCCCTCAGCGG    c.1080
 K  Y  L  Q  Q   | I  F  E  S  Q  R  M  K  F  S  E  I  P  Q  R      p.360

          .         .         .         .         .    | 10    .    g.14244
 CTCCATGCCTTGCTTATGCCACCAGAACCTATCATCATTAATCATGTCATCAG | TGTTGAC    c.1140
 L  H  A  L  L  M  P  P  E  P  I  I  I  N  H  V  I  S  |  V  D      p.380

          .         .         .         .         .         .       g.14304
 CCGAATGATCAGAAAAAGACAGCTTGTTATGACATTGATGTTGAAGTGGATGACACCTTG       c.1200
 P  N  D  Q  K  K  T  A  C  Y  D  I  D  V  E  V  D  D  T  L         p.400

          .         .         .         .         .         .       g.14364
 AAGACCCAGATGAATTCTTTTCTGCTGTCCACTGCCAGCCAACAGGAGATTGCTACTCTA       c.1260
 K  T  Q  M  N  S  F  L  L  S  T  A  S  Q  Q  E  I  A  T  L         p.420

           | 11        .         .         .         .         .    g.16701
 GACAACAAG | ATCCATGAGACAATAGAAACCATCAACCAGCTGAAGACTCAGCGGGAGTTC    c.1320
 D  N  K   | I  H  E  T  I  E  T  I  N  Q  L  K  T  Q  R  E  F      p.440

          .         .         .         .         .         .       g.16761
 ATGCTGAGCTTTGCCAGAGACCCTCAGGGTTTCATCAATGACTGGCTTCAGTCCCAGTGC       c.1380
 M  L  S  F  A  R  D  P  Q  G  F  I  N  D  W  L  Q  S  Q  C         p.460

          .   | 12     .         .         .         .         .    g.18562
 AGGGACCTCAAG | ACAATGACTGATGTGGTGGGTAACCCAGAGGAGGAGCGCCGAGCTGAG    c.1440
 R  D  L  K   | T  M  T  D  V  V  G  N  P  E  E  E  R  R  A  E      p.480

          .         .         .         .         .     | 13   .    g.18753
 TTCTACTTCCAGCCCTGGGCTCAGGAGGCTGTGTGCCGATACTTCTACTCCAAG | GTGCAG    c.1500
 F  Y  F  Q  P  W  A  Q  E  A  V  C  R  Y  F  Y  S  K   | V  Q      p.500

          .         .         .         .                           g.18801
 CAGAGACGACAAGAATTAGAGCAAGCCCTGGGAATCCGGAATACATAG                   c.1548
 Q  R  R  Q  E  L  E  Q  A  L  G  I  R  N  T  X                     p.515

          .         .         .         .         .         .       g.18861
 ggcctctcccacagccctgattcgactgcaccaattcttgatttgggccctgtgctgcct       c.*60

          .         .         .         .         .         .       g.18921
 gcctcatagtatctgccttggtcttgcttggggcgttccaggggatgctgttggttcaag       c.*120

          .         .         .         .         .         .       g.18981
 gacaacaccagaatgaagagggtctcacaagacacctgttatcctcttctttcaccctat       c.*180

          .         .         .         .         .         .       g.19041
 ctcttcccacccccagcttccctttgccccacaaagttcccatgtgcctgtaccctcccc       c.*240

          .         .         .         .         .         .       g.19101
 tggtctacataggacctctagatagtgttagagagagaacatgtagtggtaatgagtgct       c.*300

          .         .         .         .         .         .       g.19161
 tggaatggattgggcctcaggccaggtggtcttcaaggggaccagctaactgatcctgcc       c.*360

          .         .         .         .         .         .       g.19221
 cttcagagacccaggagttgggagctttcgctccttctccaagactcaggcctgtgggca       c.*420

          .         .         .         .         .         .       g.19281
 ctctataagctagttgatcttggctctcctgataacagaatccaatttccttccttccct       c.*480

          .         .         .         .         .         .       g.19341
 ccacaggtttggaacaaactctcccttcacttgttgccctgtagcactacagaaaccctg       c.*540

          .         .         .         .         .         .       g.19401
 gttcttgggctccactgagccccaggtcagtccccagccctctgggttggcctgctgtca       c.*600

          .         .         .         .         .         .       g.19461
 gtgcttctctcactccttagttggggtccacatcagtattggagttttgttctttattgc       c.*660

          .         .         .         .         .         .       g.19521
 tccctcccagacactccctgtggctgccctttgtgattccctcagatctgccctaatccc       c.*720

          .         .         .         .         .         .       g.19581
 gggcatttgggtgggggaatcttgcctttccctttcagagccccagggatctcatctggg       c.*780

          .         .         .         .         .         .       g.19641
 gaactgtcattgccagcagaggctgttccttcctgctgtttggagatgtgactcattcat       c.*840

          .         .         .         .         .         .       g.19701
 tcactcactccaccctgcctctgcatcccttaatggagaaacgggcctaaaaccaaacgg       c.*900

          .         .         .         .         .         .       g.19761
 gtaaaaagccctgggccatccctgtcttcctgtcccttgtctgcccagttgacacctact       c.*960

          .         .         .         .         .         .       g.19821
 ggtgacttctagggcactgaggagtgaaagcgcctagggctggagaatagcgctgagttg       c.*1020

          .         .         .         .         .         .       g.19881
 ggtttgtgactcttccctctccctgcctcacaggattgtgactccccagcccctgccctc       c.*1080

          .         .         .         .         .         .       g.19941
 aaagcttcagacccctcaggtagcagcaggaccttgtgatcttggccccttggatctgag       c.*1140

          .         .         .         .         .         .       g.20001
 atggtttttgcatctttccaggagagcctcacattcttcttccaggttgtatcacccccg       c.*1200

          .         .         .         .         .         .       g.20061
 agttagcatatcccaggctcgcagactcaacacagcaagggtgggagacagctgggcaca       c.*1260

          .         .         .         .         .         .       g.20121
 aagggggaattccgttcagcatgggctctaaacccacagaactgacaaagcccctgcttc       c.*1320

          .         .         .         .         .         .       g.20181
 cccaccccctcctcaggctcctgcgagcacacccccacccccaaatccctccctgttcta       c.*1380

          .         .         .         .         .         .       g.20241
 cactggggacagcagaattttctccccgtcttccccttcctgccattttccctcccttga       c.*1440

          .         .         .         .         .         .       g.20301
 aaggttgacactggacaaccttggggcagctgagccctggccgcctcctggctggaacca       c.*1500

          .         .         .         .         .         .       g.20361
 tgagaaggaagctcagtacttcccacagtgtccctgttgataactgtttttattaactga       c.*1560

          .         .         .         .         .         .       g.20421
 attgtttttttcatggaccaaacttttttttgtactgtccccttattgatgttacccagt       c.*1620

          .         .         .         .         .         .       g.20481
 tttaataaaagaatcttctgaaggatgggtcctcctacctactgtgagagagctcttccc       c.*1680

          .         .         .                                     g.20512
 tgagctcttcttccttcaataccattagcca                                    c.*1711

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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