spastic paraplegia 11 (autosomal recessive) (SPG11) - coding DNA reference sequence

(used for variant description)

(last modified June 15, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_025137.3 in the SPG11 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008885.1, covering SPG11 transcript NM_025137.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              gaaagtgaccggaagtaaccgccgggccaag       c.-1

          .         .         .         .         .         .       g.5091
 ATGGCTGCAGAGGAAGGGGTCGCGAGTGCTGCTTCCGCCGGCGGTAGCTGGGGCACCGCG       c.60
 M  A  A  E  E  G  V  A  S  A  A  S  A  G  G  S  W  G  T  A         p.20

          .         .         .         .         .         .       g.5151
 GCCATGGGGCGGGTTCTACCGATGCTGTTGGTGCCAGTCCCCGCCGAGGCGATGGGGCAG       c.120
 A  M  G  R  V  L  P  M  L  L  V  P  V  P  A  E  A  M  G  Q         p.40

          .         .         .         .         .         .       g.5211
 CTCGGCTCCCGGGCGCAGCTGCGCACACAGCCGGAGGCTCTGGGGAGCCTGACGGCTGCG       c.180
 L  G  S  R  A  Q  L  R  T  Q  P  E  A  L  G  S  L  T  A  A         p.60

          .         .         .         .         .         .       g.5271
 GGCAGCCTCCAAGTGCTTTCTTTGACGCCTGGCAGCCGGGGCGGGGGTCGCTGCTGCCTG       c.240
 G  S  L  Q  V  L  S  L  T  P  G  S  R  G  G  G  R  C  C  L         p.80

          .        | 02.         .         .         .         .    g.8105
 GAGGGCCCCTTCTGGCA | CTTTCTATGGGAGGATTCTCGTAACAGCAGCACACCAACTGAA    c.300
 E  G  P  F  W  H  |  F  L  W  E  D  S  R  N  S  S  T  P  T  E      p.100

          .         .         .         .         .         .       g.8165
 AAGCCCAAACTGCTCGCTCTTGGTGAAAATTATGAACTGCTTATCTATGAATTTAATTTG       c.360
 K  P  K  L  L  A  L  G  E  N  Y  E  L  L  I  Y  E  F  N  L         p.120

          .         .         .         .         .         .       g.8225
 AAAGATGGAAGATGTGATGCAACCATTTTGTATAGCTGTAGTAGGGAGGCATTGCAAAAG       c.420
 K  D  G  R  C  D  A  T  I  L  Y  S  C  S  R  E  A  L  Q  K         p.140

          .         .   | 03     .         .         .         .    g.9413
 CTCATTGACGATCAAGATATCA | GTATTTCCTTATTGTCTTTGAGAATCCTGTCATTTCAC    c.480
 L  I  D  D  Q  D  I  S |   I  S  L  L  S  L  R  I  L  S  F  H      p.160

          .         .         .         .         .         .       g.9473
 AATAACACATCATTACTGTTCATCAACAAATGTGTCATCCTACATATTATATTTCCTGAA       c.540
 N  N  T  S  L  L  F  I  N  K  C  V  I  L  H  I  I  F  P  E         p.180

          .         .         .         .         .         .       g.9533
 AGAGATGCTGCAATTAGAGTACTCAACTGTTTCACACTTCCCTTGCCTGCACAGGCAGTG       c.600
 R  D  A  A  I  R  V  L  N  C  F  T  L  P  L  P  A  Q  A  V         p.200

          .         .         .         .         .         .       g.9593
 GACATGATTATTGACACGCAGCTCTGCAGAGGAATTCTTTTTGTTTTGAGTAGTTTAGGC       c.660
 D  M  I  I  D  T  Q  L  C  R  G  I  L  F  V  L  S  S  L  G         p.220

         | 04.         .         .         .         .         .    g.11435
 TGGATCT | ACATTTTTGATGTTGTGGATGGTACATATGTAGCTCATGTGGATTTAGCACTT    c.720
 W  I  Y |   I  F  D  V  V  D  G  T  Y  V  A  H  V  D  L  A  L      p.240

          .         .         .         .         .         .       g.11495
 CACAAAGAAGACATGTGTAATGAGCAGCAACAGGAGCCAGCCAAGATTTCTTCATTTACT       c.780
 H  K  E  D  M  C  N  E  Q  Q  Q  E  P  A  K  I  S  S  F  T         p.260

          .         .         .         .         .         .       g.11555
 TCACTGAAAGTTTCTCAAGACCTCGATGTTGCAGTGATTGTCAGCTCCTCCAACTCCGCA       c.840
 S  L  K  V  S  Q  D  L  D  V  A  V  I  V  S  S  S  N  S  A         p.280

          .         .          | 05        .         .         .    g.16443
 GTTGCTCTTAACTTAAATTTGTATTTCAG | GCAACACCCAGGACACCTACTGTGTGAAAGA    c.900
 V  A  L  N  L  N  L  Y  F  R  |  Q  H  P  G  H  L  L  C  E  R      p.300

          .         .         .         .         .         .       g.16503
 ATACTAGAAGATCTTCCTATTCAAGGACCTAAGGGCGTAGATGAAGATGATCCTGTTAAC       c.960
 I  L  E  D  L  P  I  Q  G  P  K  G  V  D  E  D  D  P  V  N         p.320

          .         .         .         .        | 06.         .    g.16752
 TCTGCCTACAACATGAAACTGGCCAAGTTTTCCTTCCAAATTGATAG | GTCTTGGAAAGCC    c.1020
 S  A  Y  N  M  K  L  A  K  F  S  F  Q  I  D  R  |  S  W  K  A      p.340

          .         .         .         .         .         .       g.16812
 CAGCTATCATCATTGAATGAAACAATAAAGAACTCCAAACTGGAGGTTTCCTGTTGTGCT       c.1080
 Q  L  S  S  L  N  E  T  I  K  N  S  K  L  E  V  S  C  C  A         p.360

          .         .         .         .         .         .       g.16872
 CCATGGTTCCAGGATATTTTGCATTTGGAGTCACCTGAATCTGGTAACCACAGTACAAGT       c.1140
 P  W  F  Q  D  I  L  H  L  E  S  P  E  S  G  N  H  S  T  S         p.380

          .         .         .         .         .         .       g.16932
 GTGCAGAGCTGGGCCTTCATTCCACAGGACATAATGCATGGGCAATATAATGTTCTACAG       c.1200
 V  Q  S  W  A  F  I  P  Q  D  I  M  H  G  Q  Y  N  V  L  Q         p.400

          .         .         .         .         .         .       g.16992
 AAAGATCATGCCAAGACCAGTGATCCAGGAAGATCATGGAAAATAATGCACATCAGTGAA       c.1260
 K  D  H  A  K  T  S  D  P  G  R  S  W  K  I  M  H  I  S  E         p.420

          .         .         .         .         .         .       g.17052
 CAAGAGGAACCCATAGAGCTTAAATGTGTGTCTGTGACAGGATTCACTGCACTGTTTACT       c.1320
 Q  E  E  P  I  E  L  K  C  V  S  V  T  G  F  T  A  L  F  T         p.440

          .         .         .         .         .         .       g.17112
 TGGGAAGTGGAAAGGATGGGCTATACCATTACCCTCTGGGATTTGGAGACCCAGGGCATG       c.1380
 W  E  V  E  R  M  G  Y  T  I  T  L  W  D  L  E  T  Q  G  M         p.460

          .         .         .         .         .         .       g.17172
 CAGTGTTTTTCCCTTGGCACAAAGTGTATTCCTGTAGACAGTAGTGGAGACCAGCAGCTG       c.1440
 Q  C  F  S  L  G  T  K  C  I  P  V  D  S  S  G  D  Q  Q  L         p.480

          .       | 07 .         .         .         .         .    g.19711
 TGCTTTGTTTTGACAG | AGAATGGACTCTCTCTGATTTTGTTTGGTTTGACTCAAGAAGAG    c.1500
 C  F  V  L  T  E |   N  G  L  S  L  I  L  F  G  L  T  Q  E  E      p.500

          .         .         .         .         .         .       g.19771
 TTTTTAAACAGACTCATGATCCATGGAAGTGCCAGCACTGTGGACACTCTTTGTCATCTC       c.1560
 F  L  N  R  L  M  I  H  G  S  A  S  T  V  D  T  L  C  H  L         p.520

          .         .         .         .   | 08     .         .    g.35059
 AATGGCTGGGGAAGGTGCTCAATTCCCATACATGCACTAGAG | GCCGGGATAGAAAATCGT    c.1620
 N  G  W  G  R  C  S  I  P  I  H  A  L  E   | A  G  I  E  N  R      p.540

          .         .         .         .         .         .       g.35119
 CAGCTGGACACAGTAAATTTCTTTTTGAAGAGCAAGGAAAATCTTTTTAATCCATCCTCA       c.1680
 Q  L  D  T  V  N  F  F  L  K  S  K  E  N  L  F  N  P  S  S         p.560

          .         .         .         .         .      | 09  .    g.39295
 AAATCTTCTGTATCTGATCAGTTTGATCACTTGTCATCCCATTTATATTTAAGAA | ATGTG    c.1740
 K  S  S  V  S  D  Q  F  D  H  L  S  S  H  L  Y  L  R  N |   V      p.580

          .         .         .         .         .         .       g.39355
 GAAGAGCTGATACCAGCATTGGATTTACTTTGCTCGGCAATTAGAGAAAGTTATTCTGAA       c.1800
 E  E  L  I  P  A  L  D  L  L  C  S  A  I  R  E  S  Y  S  E         p.600

          .         .         .         .         .         .       g.39415
 CCCCAAAGCAAACACTTTTCAGAACAATTGCTTAATCTTACACTGTCTTTCCTTAACAAC       c.1860
 P  Q  S  K  H  F  S  E  Q  L  L  N  L  T  L  S  F  L  N  N         p.620

          .         .         .  | 10      .         .         .    g.39863
 CAAATAAAGGAGCTTTTCATTCACACTGAAG | AACTAGATGAACATCTGCAAAAAGGAGTG    c.1920
 Q  I  K  E  L  F  I  H  T  E  E |   L  D  E  H  L  Q  K  G  V      p.640

          .         .         .         .         .         .       g.39923
 AACATTTTGACTAGCTACATTAATGAACTTCGAACCTTCATGATAAAGTTTCCTTGGAAG       c.1980
 N  I  L  T  S  Y  I  N  E  L  R  T  F  M  I  K  F  P  W  K         p.660

          .         .         .         .         .         .       g.39983
 CTAACAGATGCTATAGATGAATATGATGTACATGAAAATGTCCCCAAAGTAAAGGAGAGC       c.2040
 L  T  D  A  I  D  E  Y  D  V  H  E  N  V  P  K  V  K  E  S         p.680

          .         .        | 11.         .         .         .    g.42204
 AATATATGGAAGAAACTCAGCTTTGAG | GAAGTTATTGCCAGCGCCATTTTAAACAACAAA    c.2100
 N  I  W  K  K  L  S  F  E   | E  V  I  A  S  A  I  L  N  N  K      p.700

          .         .         .         .         .         .       g.42264
 ATACCAGAGGCACAGACTTTCTTCAGGATTGATAGTCATTCTGCTCAAAAACTTGAGGAG       c.2160
 I  P  E  A  Q  T  F  F  R  I  D  S  H  S  A  Q  K  L  E  E         p.720

          .         .         .         .         .         .       g.42324
 CTTATTGGCATAGGCCTAAATTTGGTCTTTGACAATTTAAAAAAGAACAATATAAAGGAA       c.2220
 L  I  G  I  G  L  N  L  V  F  D  N  L  K  K  N  N  I  K  E         p.740

          .         .     | 12   .         .         .         .    g.45915
 GCCTCTGAACTTTTGAAGAATATG | GGGTTTGATGTAAAAGGCCAATTGCTCAAGATCTGC    c.2280
 A  S  E  L  L  K  N  M   | G  F  D  V  K  G  Q  L  L  K  I  C      p.760

          .         .         .       | 13 .         .         .    g.46355
 TTCTATACAACTAATAAAAATATACGTGACTTTTTG | GTTGAAATTTTAAAAGAAAAAAAT    c.2340
 F  Y  T  T  N  K  N  I  R  D  F  L   | V  E  I  L  K  E  K  N      p.780

          .         .         .         .         .         .       g.46415
 TATTTTTCTGAAAAAGAGAAAAGAACTATAGACTTCGTGCATCAAGTTGAGAAGCTTTAT       c.2400
 Y  F  S  E  K  E  K  R  T  I  D  F  V  H  Q  V  E  K  L  Y         p.800

          .         .         .         .     | 14   .         .    g.46760
 TTGGGACATTTCCAAGAAAATATGCAAATCCAGTCATTTCCCAG | GTACTGGATAAAGGAA    c.2460
 L  G  H  F  Q  E  N  M  Q  I  Q  S  F  P  R  |  Y  W  I  K  E      p.820

          .         .         .         .         .         .       g.46820
 CAAGATTTTTTCAAGCACAAGTCTGTTTTGGACTCATTCCTGAAATATGATTGTAAAGAT       c.2520
 Q  D  F  F  K  H  K  S  V  L  D  S  F  L  K  Y  D  C  K  D         p.840

          .         .         .         .         .         .       g.46880
 GAATTTAACAAACAGGACCATAGAATTGTGTTAAATTGGGCTCTGTGGTGGGATCAACTA       c.2580
 E  F  N  K  Q  D  H  R  I  V  L  N  W  A  L  W  W  D  Q  L         p.860

          .         .         .         . | 15       .         .    g.48295
 ACACAAGAATCCATCCTTCTCCCCAGGATAAGTCCAGAAG | AATACAAATCATATTCCCCT    c.2640
 T  Q  E  S  I  L  L  P  R  I  S  P  E  E |   Y  K  S  Y  S  P      p.880

          .         .         .         .         .         .       g.48355
 GAAGCCCTCTGGAGATACCTCACAGCTCGCCATGATTGGTTAAACATTATCTTATGGATT       c.2700
 E  A  L  W  R  Y  L  T  A  R  H  D  W  L  N  I  I  L  W  I         p.900

          .         .         .         .         .         .       g.48415
 GGAGAATTTCAAACCCAGCATAGTTATGCTTCACTTCAGCAGAACAAATGGCCCCTTCTG       c.2760
 G  E  F  Q  T  Q  H  S  Y  A  S  L  Q  Q  N  K  W  P  L  L         p.920

          .         .         .         .         .         .       g.48475
 ACTGTTGATGTTATTAACCAGAATACTTCCTGTAACAACTACATGAGGAATGAAATTTTA       c.2820
 T  V  D  V  I  N  Q  N  T  S  C  N  N  Y  M  R  N  E  I  L         p.940

          .     | 16   .         .         .         .         .    g.53158
 GATAAGCTGGCCAG | GAATGGGGTTTTTTTGGCATCTGAACTGGAAGACTTTGAATGCTTC    c.2880
 D  K  L  A  R  |  N  G  V  F  L  A  S  E  L  E  D  F  E  C  F      p.960

          .         .         .         .         .         .       g.53218
 CTCCTAAGACTGAGCCGTATTGGAGGTGTAATACAGGATACCCTCCCTGTTCAAAACTAC       c.2940
 L  L  R  L  S  R  I  G  G  V  I  Q  D  T  L  P  V  Q  N  Y         p.980

          .         .         .         .         .         .       g.53278
 AAGACCAAAGAAGGTTGGGATTTCCATTCTCAATTCATTCTCTATTGTTTGGAGCACAGT       c.3000
 K  T  K  E  G  W  D  F  H  S  Q  F  I  L  Y  C  L  E  H  S         p.1000

          .         .         .         | 17         .         .    g.55164
 CTGCAGCATCTTCTTTATGTCTACCTTGACTGTTACAA | ACTTAGTCCTGAAAATTGTCCC    c.3060
 L  Q  H  L  L  Y  V  Y  L  D  C  Y  K  |  L  S  P  E  N  C  P      p.1020

          .         .         .         .         .         .       g.55224
 TTTTTGGAAAAAAAAGAGTTACATGAAGCACACCCTTGGTTTGAATTTTTAGTTCAGTGT       c.3120
 F  L  E  K  K  E  L  H  E  A  H  P  W  F  E  F  L  V  Q  C         p.1040

          .         .      | 18  .         .         .         .    g.57728
 CGACAAGTTGCCAGTAACTTAACAG | ATCCCAAACTGATCTTCCAGGCTAGCCTTGCAAAT    c.3180
 R  Q  V  A  S  N  L  T  D |   P  K  L  I  F  Q  A  S  L  A  N      p.1060

          .         .         .         .         .         .       g.57788
 GCTCAGATTTTGATTCCCACCAATCAGGCCAGTGTAAGCAGTATGCTATTGGAAGGACAT       c.3240
 A  Q  I  L  I  P  T  N  Q  A  S  V  S  S  M  L  L  E  G  H         p.1080

          .         .         .         .         .  | 19      .    g.60082
 ACCCTCCTGGCCCTTGCTACTACAATGTATTCTCCTGGGGGTGTCAGTCAG | GTTGTTCAG    c.3300
 T  L  L  A  L  A  T  T  M  Y  S  P  G  G  V  S  Q   | V  V  Q      p.1100

          .         .         .         .         .         .       g.60142
 AATGAAGAAAATGAAAACTGTTTGAAGAAAGTGGATCCCCAGCTATTGAAGATGGCATTA       c.3360
 N  E  E  N  E  N  C  L  K  K  V  D  P  Q  L  L  K  M  A  L         p.1120

          .         .         .         .         .         .       g.60202
 ACTCCTTACCCCAAGCTAAAAACTGCTCTCTTCCCACAGTGCACTCCTCCTAGTGTCCTG       c.3420
 T  P  Y  P  K  L  K  T  A  L  F  P  Q  C  T  P  P  S  V  L         p.1140

          .         .         .    | 20    .         .         .    g.62614
 CCATCTGATATTACAATCTACCACCTTATTCAG | TCATTATCACCCTTTGATCCTAGCAGA    c.3480
 P  S  D  I  T  I  Y  H  L  I  Q   | S  L  S  P  F  D  P  S  R      p.1160

          .         .         .         . | 21       .         .    g.68066
 TTGTTTGGCTGGCAGTCTGCTAACACACTAGCTATAGGAG | ATGCATGGAGTCATCTCCCA    c.3540
 L  F  G  W  Q  S  A  N  T  L  A  I  G  D |   A  W  S  H  L  P      p.1180

          .         .         .         .         .         .       g.68126
 CATTTCTCTAGCCCTGACCTGGTTAATAAATATGCTATAGTGGAACGTCTGAATTTTGCT       c.3600
 H  F  S  S  P  D  L  V  N  K  Y  A  I  V  E  R  L  N  F  A         p.1200

          .         .         .         .         .         .       g.68186
 TATTATTTACATAATGGGCGGCCATCATTTGCATTTGGTACTTTTCTGGTCCAGGAATTA       c.3660
 Y  Y  L  H  N  G  R  P  S  F  A  F  G  T  F  L  V  Q  E  L         p.1220

          .         .       | 22 .         .         .         .    g.69876
 ATCAAGAGCAAGACTCCCAAGCAGCT | GATCCAGCAAGTAGGCAATGAAGCCTATGTTATA    c.3720
 I  K  S  K  T  P  K  Q  L  |  I  Q  Q  V  G  N  E  A  Y  V  I      p.1240

          .         .         .         .         .         .       g.69936
 GGGCTCTCCTCCTTCCACATACCTTCAATAGGAGCTGCATGTGTTTGTTTCTTAGAATTG       c.3780
 G  L  S  S  F  H  I  P  S  I  G  A  A  C  V  C  F  L  E  L         p.1260

          .         .         .         .         .         .       g.69996
 CTTGGCCTTGACAGCCTCAAGCTCAGAGTTGATATGAAAGTGGCCAATATAATTTTGAGC       c.3840
 L  G  L  D  S  L  K  L  R  V  D  M  K  V  A  N  I  I  L  S         p.1280

          .         .         .         .         .   | 23     .    g.70313
 TACAAGTGCAGAAATGAAGATGCTCAGTACAGCTTTATCAGAGAGTCTGTAG | CCGAAAAA    c.3900
 Y  K  C  R  N  E  D  A  Q  Y  S  F  I  R  E  S  V  A |   E  K      p.1300

          .         .         .         .         .         .       g.70373
 CTATCTAAACTAGCTGATGGTGAAAAGACAACCACAGAAGAATTGCTTGTTCTCTTAGAA       c.3960
 L  S  K  L  A  D  G  E  K  T  T  T  E  E  L  L  V  L  L  E         p.1320

          .         .         .         .  | 24      .         .    g.71754
 GAAGGTACATGGAACAGCATTCAGCAACAGGAAATAAAGAG | GTTATCCAGTGAATCTAGC    c.4020
 E  G  T  W  N  S  I  Q  Q  Q  E  I  K  R  |  L  S  S  E  S  S      p.1340

          .         .         .         .         .         .       g.71814
 AGCCAATGGGCATTAGTGGTGCAGTTCTGCAGGCTACACAATATGAAACTAAGCATATCT       c.4080
 S  Q  W  A  L  V  V  Q  F  C  R  L  H  N  M  K  L  S  I  S         p.1360

          .         .         .         .         .         .       g.71874
 TACCTTAGAGAATGTGCCAAAGCAAATGATTGGCTGCAGTTCATTATTCACAGCCAACTC       c.4140
 Y  L  R  E  C  A  K  A  N  D  W  L  Q  F  I  I  H  S  Q  L         p.1380

          .         .  | 25      .         .         .         .    g.72362
 CACAACTACCACCCAGCAGAG | GTGAAATCCCTTATCCAGTACTTCAGCCCAGTCATTCAA    c.4200
 H  N  Y  H  P  A  E   | V  K  S  L  I  Q  Y  F  S  P  V  I  Q      p.1400

          .         .         .         .         .         .       g.72422
 GACCACTTAAGGCTGGCTTTTGAGAACTTGCCCTCAGTGCCCACCTCCAAAATGGACAGC       c.4260
 D  H  L  R  L  A  F  E  N  L  P  S  V  P  T  S  K  M  D  S         p.1420

          .         .         .         .         .         .       g.72482
 GATCAAGTCTGCAATAAGTGCCCCCAGGAACTTCAAGGAAGCAAACAAGAGATGACCGAT       c.4320
 D  Q  V  C  N  K  C  P  Q  E  L  Q  G  S  K  Q  E  M  T  D         p.1440

          .         .         .         .         .         .       g.72542
 TTATTTGAAATTCTGCTCCAATGCTCAGAGGAGCCAGACTCCTGGCACTGGCTTCTGGTT       c.4380
 L  F  E  I  L  L  Q  C  S  E  E  P  D  S  W  H  W  L  L  V         p.1460

          .         .         .         .         .     | 26   .    g.73225
 GAAGCAGTGAAACAACAGGCCCCTATCCTCAGTGTTCTGGCCTCATGTCTCCAG | GGTGCC    c.4440
 E  A  V  K  Q  Q  A  P  I  L  S  V  L  A  S  C  L  Q   | G  A      p.1480

          .         .         .         .         .         .       g.73285
 AGTGCCATTTCTTGTCTCTGTGTTTGGATCATCACTTCTGTGGAGGACAATGTTGCAACT       c.4500
 S  A  I  S  C  L  C  V  W  I  I  T  S  V  E  D  N  V  A  T         p.1500

          .         .         .         .         .         .       g.73345
 GAAGCAATGGGACACATTCAGGACTCAACAGAGGACCATACCTGGAACCTTGAGGATCTT       c.4560
 E  A  M  G  H  I  Q  D  S  T  E  D  H  T  W  N  L  E  D  L         p.1520

          .         .         .         .         .         .       g.73405
 TCAGTCATCTGGAGAACATTATTAACAAGACAAAAGAGCAAAACTCTCATCAGAGGTTTC       c.4620
 S  V  I  W  R  T  L  L  T  R  Q  K  S  K  T  L  I  R  G  F         p.1540

          .      | 27  .         .         .         .         .    g.76285
 CAGCTTTTCTTTAAG | GATTCCCCGTTACTACTGGTGATGGAGATGTATGAACTGTGTATG    c.4680
 Q  L  F  F  K   | D  S  P  L  L  L  V  M  E  M  Y  E  L  C  M      p.1560

          .         .         .         .         .         .       g.76345
 TTCTTCAGGAATTATAAAGAAGCTGAAGCTAAACTTCTGGAGTTTCAGAAGAGCCTTGAA       c.4740
 F  F  R  N  Y  K  E  A  E  A  K  L  L  E  F  Q  K  S  L  E         p.1580

     | 28    .         .         .         .         .         .    g.79321
 ACG | CTTAACACAGCAGCCACAAAGGTCCACCCTGTCATCCCTGCCATGTGGCTGGAGGAT    c.4800
 T   | L  N  T  A  A  T  K  V  H  P  V  I  P  A  M  W  L  E  D      p.1600

          .         .         .         .         .         .       g.79381
 CAGGTGTGTTTCCTTTTGAAGCTTATGCTACAGCAGTGTAAGACCCAGTATGAGCTGGGG       c.4860
 Q  V  C  F  L  L  K  L  M  L  Q  Q  C  K  T  Q  Y  E  L  G         p.1620

          .         .         .         .       | 29 .         .    g.82842
 AAGCTTTTACAGCTCTTTGTTGAAAGAGAGCATCTCTTCTCTGATG | GTCCAGATGTGAAA    c.4920
 K  L  L  Q  L  F  V  E  R  E  H  L  F  S  D  G |   P  D  V  K      p.1640

          .         .         .         .         .         .       g.82902
 AAGCTTTGCATCCTTTGCCAGATTTTGAAGGATACATCCATAGCCATTAATCATACAATT       c.4980
 K  L  C  I  L  C  Q  I  L  K  D  T  S  I  A  I  N  H  T  I         p.1660

          .         .         .         .         .         .       g.82962
 ATTACCAGCTACAGCATTGAGAATCTTCAGCATGAATGTAGATCTATTTTGGAAAGACTG       c.5040
 I  T  S  Y  S  I  E  N  L  Q  H  E  C  R  S  I  L  E  R  L         p.1680

          .         .         .         .         .         .       g.83022
 CAGACAGATGGACAATTCGCTTTGGCCAGGAGGGTAGCAGAATTAGCTGAGTTACCTGTG       c.5100
 Q  T  D  G  Q  F  A  L  A  R  R  V  A  E  L  A  E  L  P  V         p.1700

          .         .  | 30      .         .         .         .    g.84159
 GACAACTTGGTTATTAAAGAG | ATAACACAGGAAATGCAGACCCTAAAACACATTGAACAG    c.5160
 D  N  L  V  I  K  E   | I  T  Q  E  M  Q  T  L  K  H  I  E  Q      p.1720

          .         .         .         .         .         .       g.84219
 TGGTCACTAAAACAAGCAAGAATTGACTTCTGGAAAAAATGCCATGAGAATTTTAAGAAA       c.5220
 W  S  L  K  Q  A  R  I  D  F  W  K  K  C  H  E  N  F  K  K         p.1740

          .         .         .         .         .         .       g.84279
 AATTCAATTTCAAGCAAAGCAGCTTCTTCCTTTTTCTCAACCCAGGCCCATGTGGCATGT       c.5280
 N  S  I  S  S  K  A  A  S  S  F  F  S  T  Q  A  H  V  A  C         p.1760

          .         .         .         .         .         .       g.84339
 GAGCACCCAACTGGATGGAGCAGCATGGAGGAGCGCCATCTGCTGCTCACCTTGGCAGGG       c.5340
 E  H  P  T  G  W  S  S  M  E  E  R  H  L  L  L  T  L  A  G         p.1780

          .         .         .         .         .         .       g.84399
 CACTGGCTTGCCCAGGAGGACGTGGTGCCCTTGGATAAGCTGGAGGAGCTGGAGAAGCAG       c.5400
 H  W  L  A  Q  E  D  V  V  P  L  D  K  L  E  E  L  E  K  Q         p.1800

          .         .         .         .         .         .       g.84459
 ATCTGGCTGTGCCGCATCACCCAGCACACTCTTGGAAGAAATCAGGAGGAAACAGAGCCC       c.5460
 I  W  L  C  R  I  T  Q  H  T  L  G  R  N  Q  E  E  T  E  P         p.1820

          .         .         .         .         .         .       g.84519
 AGATTTTCTCGACAGATCTCAACTAGTGGTGAACTTTCCTTTGATAGTTTAGCCAGTGAG       c.5520
 R  F  S  R  Q  I  S  T  S  G  E  L  S  F  D  S  L  A  S  E         p.1840

          .         .         .         .         .         .       g.84579
 TTTTCCTTCTCCAAGTTGGCTGCTCTGAACACATCAAAATACTTAGAACTTAACAGCCTT       c.5580
 F  S  F  S  K  L  A  A  L  N  T  S  K  Y  L  E  L  N  S  L         p.1860

          .         .         .         .         .         .       g.84639
 CCATCCAAAGAGACATGCGAGAATAGATTGGATTGGAAAGAGCAGGAGTCACTAAACTTT       c.5640
 P  S  K  E  T  C  E  N  R  L  D  W  K  E  Q  E  S  L  N  F         p.1880

          .         .         .         .         .         .       g.84699
 TTGATTGGGCGCCTACTGGATGATGGCTGTGTGCATGAAGCAAGTAGAGTATGCCGGTAT       c.5700
 L  I  G  R  L  L  D  D  G  C  V  H  E  A  S  R  V  C  R  Y         p.1900

          .         .         .         .         .         .       g.84759
 TTTCATTTTTATAATCCAGATGTCGCCTTGGTATTGCACTGCAGAGCACTGGCCTCAGGG       c.5760
 F  H  F  Y  N  P  D  V  A  L  V  L  H  C  R  A  L  A  S  G         p.1920

          .         .         .         .         .         .       g.84819
 GAAGCTAGTATGGAGGATCTGCACCCAGAGATCCATGCTCTCCTACAAAGTGCTGAGCTG       c.5820
 E  A  S  M  E  D  L  H  P  E  I  H  A  L  L  Q  S  A  E  L         p.1940

          .         .         .         .       | 31 .         .    g.93651
 CTTGAGGAAGAAGCACCCGACATTCCCCTAAGGAGAGTCCACAGCA | CTTCAAGTCTGGAT    c.5880
 L  E  E  E  A  P  D  I  P  L  R  R  V  H  S  T |   S  S  L  D      p.1960

          .         .         .         .         .         .       g.93711
 AGTCAGAAGTTTGTGACAGTGCCCTCCAGTAATGAAGTGGTAACTAACCTGGAAGTGCTG       c.5940
 S  Q  K  F  V  T  V  P  S  S  N  E  V  V  T  N  L  E  V  L         p.1980

          .         .         .         .         .         .       g.93771
 ACAAGCAAATGCCTCCATGGGAAGAACTACTGTCGACAGGTCCTCTGTCTGTATGATCTT       c.6000
 T  S  K  C  L  H  G  K  N  Y  C  R  Q  V  L  C  L  Y  D  L         p.2000

        | 32 .         .         .         .         .         .    g.94987
 GCCAAG | GAGTTGGGCTGTTCCTACACAGATGTTGCTGCTCAGGATGGTGAAGCCATGCTC    c.6060
 A  K   | E  L  G  C  S  Y  T  D  V  A  A  Q  D  G  E  A  M  L      p.2020

          .         .         .         .         .         .       g.95047
 CGGAAAATCTTGGCCTCTCAGCAGCCTGACCGATGCAAACGAGCCCAGGCCTTCATCAGC       c.6120
 R  K  I  L  A  S  Q  Q  P  D  R  C  K  R  A  Q  A  F  I  S         p.2040

          .         .         .         .         .         .       g.95107
 ACACAGGGCCTTAAGCCAGATACTGTGGCTGAACTCGTGGCAGAAGAGGTGACACGGGAG       c.6180
 T  Q  G  L  K  P  D  T  V  A  E  L  V  A  E  E  V  T  R  E         p.2060

          .         .      | 33  .         .         .         .    g.95893
 CTGCTTACTTCATCACAGGGAACAG | GACATAAGCAGATGTTCAACCCAACAGAGGAAAGC    c.6240
 L  L  T  S  S  Q  G  T  G |   H  K  Q  M  F  N  P  T  E  E  S      p.2080

          .         .         .         .         .         .       g.95953
 CAGACATTTCTTCAGCTGACCACTCTGTGTCAAGACCGCACATTGGTAGGCATGAAGTTG       c.6300
 Q  T  F  L  Q  L  T  T  L  C  Q  D  R  T  L  V  G  M  K  L         p.2100

          .         .         .         .    | 34    .         .    g.98037
 TTGGATAAGATTTCCTCCGTTCCCCATGGGGAACTGTCTTGCA | CCACAGAGCTCCTGATC    c.6360
 L  D  K  I  S  S  V  P  H  G  E  L  S  C  T |   T  E  L  L  I      p.2120

          .         .         .         .         .         .       g.98097
 CTGGCCCATCATTGCTTCACCCTGACGTGCCACATGGAGGGCATCATCCGAGTCCTACAG       c.6420
 L  A  H  H  C  F  T  L  T  C  H  M  E  G  I  I  R  V  L  Q         p.2140

          .         .         .         .         .        | 35.    g.99176
 GCCGCCCACATGCTCACAGATAACCACCTGGCCCCCAGTGAGGAGTATGGGCTGGTG | GTA    c.6480
 A  A  H  M  L  T  D  N  H  L  A  P  S  E  E  Y  G  L  V   | V      p.2160

          .         .         .         .         .         .       g.99236
 CGGCTCCTCACTGGCATTGGAAGGTACAACGAGATGACATACATATTTGATTTGCTGCAT       c.6540
 R  L  L  T  G  I  G  R  Y  N  E  M  T  Y  I  F  D  L  L  H         p.2180

          .         .         .         .      | 36  .         .    g.101101
 AAAAAGCACTACTTTGAAGTGCTAATGAGGAAGAAGTTGGATCCG | AGTGGTACCCTGAAA    c.6600
 K  K  H  Y  F  E  V  L  M  R  K  K  L  D  P   | S  G  T  L  K      p.2200

          .         .         .         .         .         .       g.101161
 ACAGCCCTGCTGGACTACATCAAACGCTGCCGTCCTGGAGACAGTGAAAAGCACAATATG       c.6660
 T  A  L  L  D  Y  I  K  R  C  R  P  G  D  S  E  K  H  N  M         p.2220

          .         .         .         .         .         .       g.101221
 ATTGCCCTGTGCTTCAGCATGTGCCGGGAGATTGGCGAGAACCACGAGGCAGCTGCCCGC       c.6720
 I  A  L  C  F  S  M  C  R  E  I  G  E  N  H  E  A  A  A  R         p.2240

          .         .         .     | 37   .         .         .    g.102399
 ATCCAACTGAAATTGATTGAGTCTCAGCCCTGGG | AGGACAGCCTCAAGGATGGGCACCAG    c.6780
 I  Q  L  K  L  I  E  S  Q  P  W  E |   D  S  L  K  D  G  H  Q      p.2260

          .         .         .         .         .         .       g.102459
 CTGAAACAACTGCTGCTGAAGGCCCTGACTCTGATGTTGGATGCAGCAGAGAGTTATGCC       c.6840
 L  K  Q  L  L  L  K  A  L  T  L  M  L  D  A  A  E  S  Y  A         p.2280

     | 38    .         .         .         .         .         .    g.102726
 AAG | GACTCCTGTGTGCGACAGGCCCAGCACTGTCAGCGGCTCACCAAGTTGATAACTCTG    c.6900
 K   | D  S  C  V  R  Q  A  Q  H  C  Q  R  L  T  K  L  I  T  L      p.2300

          .         .         .         .         .         .       g.102786
 CAGATTCACTTTCTGAACACTGGCCAGAACACAATGCTCATCAACTTGGGCCGCCACAAG       c.6960
 Q  I  H  F  L  N  T  G  Q  N  T  M  L  I  N  L  G  R  H  K         p.2320

          .         .         .          | 39        .         .    g.104001
 CTGATGGACTGTATTCTGGCCCTACCTCGGTTCTACCAG | GCTTCTATTGTGGCTGAGGCC    c.7020
 L  M  D  C  I  L  A  L  P  R  F  Y  Q   | A  S  I  V  A  E  A      p.2340

          .         .         .         .         .         .       g.104061
 TACGATTTTGTTCCAGATTGGGCTGAAATTTTATACCAGCAAGTGATTCTTAAAGGAGAC       c.7080
 Y  D  F  V  P  D  W  A  E  I  L  Y  Q  Q  V  I  L  K  G  D         p.2360

          .         .         .         .         .         .       g.104121
 TTTAATTACTTGGAAGAATTTAAGCAGCAAAGGTTATTAAAGTCCAGTATATTTGAAGAG       c.7140
 F  N  Y  L  E  E  F  K  Q  Q  R  L  L  K  S  S  I  F  E  E         p.2380

          .  | 40      .         .         .         .         .    g.105426
 ATTTCCAAAAA | ATATAAACAACATCAGCCTACTGACATGGTCATGGAAAACCTGAAGAAA    c.7200
 I  S  K  K  |  Y  K  Q  H  Q  P  T  D  M  V  M  E  N  L  K  K      p.2400

          .         .         .         .         .         .       g.105486
 TTACTCACATATTGTGAAGATGTTTACCTGTATTACAAGTTGGCATACGAACACAAGTTT       c.7260
 L  L  T  Y  C  E  D  V  Y  L  Y  Y  K  L  A  Y  E  H  K  F         p.2420

          .         .         .         .         .         .       g.105546
 TATGAAATTGTAAATGTGCTTCTGAAGGACCCTCAGACAGGTTGCTGTCTAAAGGACATG       c.7320
 Y  E  I  V  N  V  L  L  K  D  P  Q  T  G  C  C  L  K  D  M         p.2440

          .                                                         g.105558
 CTAGCAGGTTAG                                                       c.7332
 L  A  G  X                                                         p.2443

          .         .         .         .         .         .       g.105618
 atgatttcataggtgtctgttttcttgtactgttagcagattctgacagatgtgatgaga       c.*60

          .         .         .         .         .         .       g.105678
 agaagaatgcattggagatctttgctaaagttgaacaatcccggtactgtaccatatcag       c.*120

          .         .         .         .         .         .       g.105738
 tcctttgtgggtagtaggtagcaagtaagaaacttttcaggaggaaattcctatttaaaa       c.*180

          .         .         .         .         .         .       g.105798
 tagattgattttagatgattgttcatccacaccattttatatagatactagtattaagat       c.*240

          .         .         .         .         .         .       g.105858
 caaaagcttcctcttcctcaggacagcttctactttagatgatccaataatgattaaaga       c.*300

          .         .         .         .         .         .       g.105918
 atacctgtacctgcagattccagtttcaaagaaatttaattattatttacacagttaagg       c.*360

          .         .         .         .         .         .       g.105978
 aacaggtgatacattttcatttgttagaaactgatctttctgtaataaaatagattttca       c.*420

                                                                    g.105983
 attca                                                              c.*425

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Spastic paraplegia 11 (autosomal recessive) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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