Full data view for gene ALK

Information The variants shown are described using the NM_004304.4 transcript reference sequence.

116 entries on 2 pages. Showing entries 1 - 100.
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Effect     

Exon     

AscendingDNA change (cDNA)     

RNA change     

Protein     

Allele     

Classification method     

Clinical classification     

DNA change (genomic) (hg19)     

DNA change (hg38)     

Published as     

ISCN     

DB-ID     

Variant remarks     

Reference     

ClinVar ID     

dbSNP ID     

Origin     

Segregation     

Frequency     

Re-site     

VIP     

Methylation     

Template     

Technique     

Tissue     

Remarks     

Disease     

ID_report     

Reference     

Remarks     

Gender     

Consanguinity     

Country     

Population     

Age at death     

VIP     

Data_av     

Treatment     

Panel size     

Owner     
-/. - c.27C>G r.(?) p.(Leu9=) Unknown - benign g.30143499G>C g.29920633G>C ALK(NM_004304.3):c.27C>G (p.L9=) - ALK_000065 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.27C>G r.(?) p.(Leu9=) Unknown - benign g.30143499G>C g.29920633G>C ALK(NM_004304.3):c.27C>G (p.L9=) - ALK_000065 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.72G>A r.(?) p.(Gly24=) Unknown - likely benign g.30143454C>T - ALK(NM_004304.3):c.72G>A (p.G24=) - ALK_000094 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.262C>A r.(?) p.(Arg88Ser) Unknown - likely benign g.30143264G>T g.29920398G>T ALK(NM_004304.3):c.262C>A (p.R88S) - ALK_000064 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.469C>T r.(?) p.(Pro157Ser) Unknown - likely benign g.30143057G>A g.29920191G>A ALK(NM_004304.3):c.469C>T (p.P157S) - ALK_000063 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.615C>A r.(?) p.(Ser205=) Unknown - likely benign g.30142911G>T g.29920045G>T ALK(NM_004304.3):c.615C>A (p.S205=) - ALK_000062 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.654G>A r.(?) p.(Gln218=) Unknown - likely benign g.30142872C>T g.29920006C>T ALK(NM_004304.3):c.654G>A (p.Q218=) - ALK_000061 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.661G>C r.(?) p.(Gly221Arg) Unknown - likely benign g.30142865C>G g.29919999C>G ALK(NM_004304.3):c.661G>C (p.G221R) - ALK_000083 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.702T>A r.(?) p.(Pro234=) Unknown - benign g.29940529A>T g.29717663A>T ALK(NM_004304.3):c.702T>A (p.P234=) - ALK_000067 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.702T>A r.(?) p.(Pro234=) Unknown - benign g.29940529A>T g.29717663A>T ALK(NM_004304.3):c.702T>A (p.P234=) - ALK_000067 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.891G>A r.(?) p.(Glu297=) Unknown - likely benign g.29917777C>T g.29694911C>T ALK(NM_004304.3):c.891G>A (p.E297=) - ALK_000060 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.925G>A r.(?) p.(Ala309Thr) Unknown - likely benign g.29917743C>T g.29694877C>T ALK(NM_004304.3):c.925G>A (p.A309T) - ALK_000059 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.952+1G>A r.spl? p.? Unknown - VUS g.29917715C>T g.29694849C>T - - ALK_000082 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.952+16C>T r.(=) p.(=) Unknown - benign g.29917700G>A g.29694834G>A ALK(NM_004304.3):c.952+16C>T - ALK_000058 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.952+16C>T r.(=) p.(=) Unknown - benign g.29917700G>A g.29694834G>A ALK(NM_004304.3):c.952+16C>T - ALK_000058 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.953-41006A>C r.(=) p.(=) Unknown - VUS g.29795988T>G g.29573122T>G - - ALK_000001 - - - - Germline - - - - - DNA SEQ-NG-I - - CHTE - PubMed: Sun 2011, Journal: Sun 2011 - M no Netherlands - - 0 - - 1 Yu Sun
-/. - c.953-21G>A r.(=) p.(=) Unknown - benign g.29755003C>T g.29532137C>T ALK(NM_004304.3):c.953-21G>A - ALK_000057 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.1155-20_1155-19del r.(=) p.(=) Unknown - benign g.29606746_29606747del g.29383880_29383881del ALK(NM_004304.3):c.1155-20_1155-19delCT - ALK_000056 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.1234C>T r.(?) p.(Arg412Cys) Unknown - VUS g.29606646G>A g.29383780G>A ALK(NM_004304.3):c.1234C>T (p.R412C) - ALK_000055 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.1317C>T r.(?) p.(Ser439=) Unknown - likely benign g.29551313G>A g.29328447G>A ALK(NM_004304.3):c.1317C>T (p.S439=) - ALK_000054 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
./. - c.1414+1G>A r.spl? p.? Unknown - likely pathogenic g.29551215C>T g.29328349C>T NM_004304.4(ALK):c.1414+1G>A r.spl p.? - ALK_000003 variant could not be associated with disease phenotype PubMed: Vogelaar 2017, Journal: Vogelaar 2017 - - Germline - - - 0 - DNA SEQ-NG - - cancer, gastric Vogelaar-511A PubMed: Vogelaar 2017, Journal: Vogelaar 2017 54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer - - - - - 0 - - 1 Marjolijn JL Ligtenberg
?/. - c.1414+375C>G r.(=) p.(=) Both (homozygous) - VUS g.29550841G>C g.29327975G>C - - ALK_000002 - - - - Germline - - - - - DNA SEQ-NG-I - - CHTE - PubMed: Sun 2011, Journal: Sun 2011 - M no Netherlands - - 0 - - 1 Yu Sun
-/. - c.1427T>C r.(?) p.(Val476Ala) Unknown - benign g.29543736A>G g.29320870A>G ALK(NM_004304.3):c.1427T>C (p.V476A) - ALK_000053 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.1427T>C r.(?) p.(Val476Ala) Unknown - benign g.29543736A>G g.29320870A>G ALK(NM_004304.3):c.1427T>C (p.V476A) - ALK_000053 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.1427T>C r.(?) p.(Val476Ala) Parent #1 - likely benign g.29543736A>G g.29320870A>G - - ALK_000053 103 heterozygous; Clinindb (India) PubMed: Narang 2020, Journal: Narang 2020 - rs35093491 Germline - 103/2795 individuals - 0 - DNA arraySNP - Infinium Global Screening Array v1.0 ? - PubMed: Narang 2020, Journal: Narang 2020 analysis 2794 individuals (India) - - India - - 0 - - 103 Mohammed Faruq
-?/. - c.1427T>C r.(?) p.(Val476Ala) Both (homozygous) - likely benign g.29543736A>G g.29320870A>G - - ALK_000053 1 homozygous; Clinindb (India) PubMed: Narang 2020, Journal: Narang 2020 - rs35093491 Germline - 1/2795 individuals - 0 - DNA arraySNP - Infinium Global Screening Array v1.0 ? - PubMed: Narang 2020, Journal: Narang 2020 analysis 2794 individuals (India) - - India - - 0 - - 1 Mohammed Faruq
-/. - c.1464C>T r.(?) p.(Gly488=) Unknown - benign g.29543699G>A g.29320833G>A ALK(NM_004304.3):c.1464C>T (p.G488=) - ALK_000052 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.1500A>G r.(?) p.(Gln500=) Unknown - benign g.29543663T>C g.29320797T>C ALK(NM_004304.3):c.1500A>G (p.Q500=) - ALK_000051 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.1500A>G r.(?) p.(Gln500=) Unknown - benign g.29543663T>C g.29320797T>C ALK(NM_004304.3):c.1500A>G (p.Q500=) - ALK_000051 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.1547-29G>A r.(=) p.(=) Unknown - benign g.29541299C>T g.29318433C>T ALK(NM_004304.3):c.1547-29G>A - ALK_000050 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.1690G>A r.(?) p.(Val564Met) Unknown - VUS g.29519881C>T g.29297015C>T ALK(NM_004304.3):c.1690G>A (p.V564M) - ALK_000049 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.1755C>T r.(?) p.(Ala585=) Unknown - likely benign g.29519816G>A g.29296950G>A ALK(NM_004304.3):c.1755C>T (p.A585=) - ALK_000086 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.1817+123G>A r.(=) p.(=) Unknown - benign g.29519631C>T g.29296765C>T ALK(NM_004304.3):c.1817+123G>A - ALK_000048 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.1817+132G>A r.(=) p.(=) Unknown - benign g.29519622C>T g.29296756C>T ALK(NM_004304.3):c.1817+132G>A - ALK_000047 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.1817+162_1817+165dup r.(=) p.(=) Unknown - benign g.29519604_29519607dup g.29296738_29296741dup ALK(NM_004304.3):c.1817+162_1817+165dupACAC - ALK_000080 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.1817+164_1817+165dup r.(=) p.(=) Unknown - benign g.29519606_29519607dup g.29296740_29296741dup ALK(NM_004304.3):c.1817+164_1817+165dupAC - ALK_000081 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.2039C>T r.(?) p.(Thr680Ile) Unknown - benign g.29497967G>A g.29275101G>A ALK(NM_004304.3):c.2039C>T (p.T680I) - ALK_000044 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2039C>T r.(?) p.(Thr680Ile) Unknown - likely benign g.29497967G>A g.29275101G>A ALK(NM_004304.3):c.2039C>T (p.T680I) - ALK_000044 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2039C>T r.(?) p.(Thr680Ile) Parent #1 - likely benign g.29497967G>A g.29275101G>A - - ALK_000044 23 heterozygous, no homozygous; Clinindb (India) PubMed: Narang 2020, Journal: Narang 2020 - rs35228363 Germline - 23/2794 individuals - 0 - DNA arraySNP - Infinium Global Screening Array v1.0 ? - PubMed: Narang 2020, Journal: Narang 2020 analysis 2794 individuals (India) - - India - - 0 - - 23 Mohammed Faruq
-?/. - c.2073C>G r.(?) p.(Ser691Arg) Unknown - likely benign g.29474102G>C g.29251236G>C ALK(NM_004304.3):c.2073C>G (p.S691R) - ALK_000085 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.2149G>A r.(?) p.(Glu717Lys) Unknown - VUS g.29474026C>T - ALK(NM_004304.3):c.2149G>A (p.E717K) - ALK_000093 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.2250C>G r.(?) p.(Thr750=) Unknown - likely benign g.29462651G>C g.29239785G>C ALK(NM_004304.3):c.2250C>G (p.T750=) - ALK_000043 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.2269G>A r.(?) p.(Val757Met) Unknown - VUS g.29462632C>T - ALK(NM_004304.3):c.2269G>A (p.V757M) - ALK_000092 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.2355+26C>T r.(=) p.(=) Unknown - benign g.29462520G>A g.29239654G>A ALK(NM_004304.3):c.2355+26C>T - ALK_000042 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.2416C>T r.(?) p.(Arg806Cys) Unknown - VUS g.29456502G>A g.29233636G>A ALK(NM_004304.3):c.2416C>T (p.R806C) - ALK_000041 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2430C>T r.(?) p.(Ser810=) Unknown - likely benign g.29456488G>A g.29233622G>A ALK(NM_004304.3):c.2430C>T (p.S810=) - ALK_000090 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.2478C>T r.(?) p.(Tyr826=) Unknown - likely benign g.29456440G>A g.29233574G>A ALK(NM_004304.3):c.2478C>T (p.Y826=) - ALK_000040 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2488-8C>G r.(=) p.(=) Unknown - likely benign g.29455322G>C g.29232456G>C ALK(NM_004304.3):c.2488-8C>G - ALK_000039 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2526C>T r.(?) p.(Ala842=) Unknown - likely benign g.29455276G>A g.29232410G>A ALK(NM_004304.3):c.2526C>T (p.A842=) - ALK_000038 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.2535T>C r.(?) p.(Gly845=) Unknown - benign g.29455267A>G g.29232401A>G ALK(NM_004304.3):c.2535T>C (p.G845=) - ALK_000079 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.2535T>C r.(?) p.(Gly845=) Unknown - benign g.29455267A>G g.29232401A>G ALK(NM_004304.3):c.2535T>C (p.G845=) - ALK_000079 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.2632+17G>A r.(=) p.(=) Unknown - likely benign g.29455153C>T g.29232287C>T ALK(NM_004304.3):c.2632+17G>A - ALK_000037 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2754A>G r.(?) p.(Arg918=) Unknown - likely benign g.29451811T>C g.29228945T>C ALK(NM_004304.3):c.2754A>G (p.R918=) - ALK_000036 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.2763C>G r.(?) p.(Phe921Leu) Unknown - benign g.29451802G>C g.29228936G>C ALK(NM_004304.3):c.2763C>G (p.F921L) - ALK_000076 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.2766A>G r.(?) p.(Gly922=) Unknown - likely benign g.29451799T>C g.29228933T>C ALK(NM_004304.3):c.2766A>G (p.G922=) - ALK_000035 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2772T>G r.(?) p.(Gly924=) Unknown - likely benign g.29451793A>C g.29228927A>C ALK(NM_004304.3):c.2772T>G (p.G924=) - ALK_000034 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2775A>G r.(?) p.(Gly925=) Unknown - likely benign g.29451790T>C g.29228924T>C ALK(NM_004304.3):c.2775A>G (p.G925=) - ALK_000033 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2781dup r.(?) p.(Cys928ValfsTer20) Unknown - likely benign g.29451789dup g.29228923dup ALK(NM_004304.4):c.2781dup (p.(Cys928ValfsTer20)) - ALK_000075 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.2815+74_2815+75insCGCCC r.(=) p.(=) Unknown - benign g.29451679_29451680insGGGGC g.29228813_29228814insGGGGC ALK(NM_004304.3):c.2815+74_2815+75insCGCCC - ALK_000074 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.2816-3C>T r.spl? p.? Unknown - likely benign g.29450541G>A g.29227675G>A ALK(NM_004304.3):c.2816-3C>T - ALK_000031 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2853T>C r.(?) p.(Asp951=) Unknown - likely benign g.29450501A>G g.29227635A>G ALK(NM_004304.3):c.2853T>C (p.D951=) - ALK_000066 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.2928C>T r.(?) p.(His976=) Unknown - likely benign g.29449927G>A g.29227061G>A ALK(NM_004304.3):c.2928C>T (p.H976=) - ALK_000073 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.3030C>T r.(?) p.(His1010=) Unknown - likely benign g.29449825G>A g.29226959G>A ALK(NM_004304.3):c.3030C>T (p.H1010=) - ALK_000030 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.3035C>T r.(?) p.(Thr1012Met) Parent #1 - likely benign g.29449820G>A g.29226954G>A - - ALK_000089 6 heterozygous, no homozygous; Clinindb (India) PubMed: Narang 2020, Journal: Narang 2020 - rs35073634 Germline - 6/2795 individuals - 0 - DNA arraySNP - Infinium Global Screening Array v1.0 ? - PubMed: Narang 2020, Journal: Narang 2020 analysis 2794 individuals (India) - - India - - 0 - - 6 Mohammed Faruq
-/. - c.3036G>A r.(?) p.(Thr1012=) Unknown - benign g.29449819C>T g.29226953C>T ALK(NM_004304.3):c.3036G>A (p.T1012=) - ALK_000029 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3057C>A r.(?) p.(Val1019=) Unknown - benign g.29449798G>T g.29226932G>T ALK(NM_004304.3):c.3057C>A (p.V1019=) - ALK_000028 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.3336G>A r.(?) p.(Pro1112=) Parent #1 - likely benign g.29446231C>T g.29223365C>T - - ALK_000088 2 heterozygous, no homozygous; Clinindb (India) PubMed: Narang 2020, Journal: Narang 2020 - rs146074150 Germline - 2/2794 individuals - 0 - DNA arraySNP - Infinium Global Screening Array v1.0 ? - PubMed: Narang 2020, Journal: Narang 2020 analysis 2794 individuals (India) - - India - - 0 - - 2 Mohammed Faruq
-/. - c.3359+6C>T r.(=) p.(=) Unknown - benign g.29446202G>A g.29223336G>A ALK(NM_004304.3):c.3359+6C>T - ALK_000026 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3359+6C>T r.(=) p.(=) Unknown - benign g.29446202G>A g.29223336G>A ALK(NM_004304.3):c.3359+6C>T - ALK_000026 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.3359+7G>A r.(=) p.(=) Unknown - likely benign g.29446201C>T g.29223335C>T ALK(NM_004304.3):c.3359+7G>A - ALK_000025 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3359+24G>C r.(=) p.(=) Unknown - benign g.29446184C>G g.29223318C>G ALK(NM_004304.3):c.3359+24G>C - ALK_000024 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3375C>A r.(?) p.(Gly1125=) Unknown - benign g.29445458G>T g.29222592G>T ALK(NM_004304.3):c.3375C>A (p.G1125=) - ALK_000023 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3375C>A r.(?) p.(Gly1125=) Unknown - benign g.29445458G>T g.29222592G>T ALK(NM_004304.3):c.3375C>A (p.G1125=) - ALK_000023 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3408C>T r.(?) p.(Ser1136=) Unknown - benign g.29445425G>A g.29222559G>A ALK(NM_004304.3):c.3408C>T (p.S1136=) - ALK_000022 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+/. - c.3452C>T r.(?) p.(Thr1151Met) Parent #1 - pathogenic g.29445273G>A g.29222407G>A - - ALK_000087 risk factor; 80 heterozygous, no homozygous; Clinindb (India) PubMed: Narang 2020, Journal: Narang 2020 - rs113994091 Germline - 80/2795 individuals - 0 - DNA arraySNP - Infinium Global Screening Array v1.0 ? - PubMed: Narang 2020, Journal: Narang 2020 analysis 2794 individuals (India) - - India - - 0 - - 80 Mohammed Faruq
-/. - c.3515+18C>T r.(=) p.(=) Unknown - benign g.29445192G>A g.29222326G>A ALK(NM_004304.3):c.3515+18C>T - ALK_000021 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3516-394G>A r.(=) p.(=) Unknown - benign g.29444095C>T g.29221229C>T ALK(NM_004304.3):c.3516-394G>A - ALK_000020 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3516-375C>A r.(=) p.(=) Unknown - benign g.29444076G>T g.29221210G>T ALK(NM_004304.3):c.3516-375C>A - ALK_000019 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+/? 23 c.3520T>G r.(?) p.(Phe1147Val) Unknown - pathogenic g.29443697A>C g.29220831A>C - - ALK_000069 - Journal: de Pontual et al 2011 - - De novo - - - 0 - DNA SEQ - - neuroblastoma - Journal: de Pontual et al 2011 - F - France - - 0 - - 1 -
-?/. - c.3594C>T r.(?) p.(Leu1198=) Unknown - likely benign g.29443623G>A g.29220757G>A ALK(NM_004304.3):c.3594C>T (p.L1198=) - ALK_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3594C>T r.(?) p.(Leu1198=) Unknown - benign g.29443623G>A g.29220757G>A ALK(NM_004304.3):c.3594C>T (p.L1198=) - ALK_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.3594C>T r.(?) p.(Leu1198=) Unknown - likely benign g.29443623G>A g.29220757G>A ALK(NM_004304.3):c.3594C>T (p.L1198=) - ALK_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.3594C>T r.(?) p.(Leu1198=) Unknown - benign g.29443623G>A g.29220757G>A ALK(NM_004304.3):c.3594C>T (p.L1198=) - ALK_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.3600G>C r.(?) p.(Ala1200=) Unknown - benign g.29443617C>G g.29220751C>G ALK(NM_004304.3):c.3600G>C (p.A1200=) - ALK_000017 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.3600G>C r.(?) p.(Ala1200=) Unknown - benign g.29443617C>G - ALK(NM_004304.3):c.3600G>C (p.A1200=) - ALK_000017 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.3633C>A r.(?) p.(Thr1211=) Unknown - likely benign g.29443584G>T g.29220718G>T ALK(NM_004304.3):c.3633C>A (p.T1211=) - ALK_000016 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.3633C>A r.(?) p.(Thr1211=) Unknown - likely benign g.29443584G>T g.29220718G>T ALK(NM_004304.3):c.3633C>A (p.T1211=) - ALK_000016 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+/? 24 c.3733T>G r.(?) p.(Phe1245Val) Unknown - pathogenic g.29436860A>C g.29213994A>C - - ALK_000068 - Journal: de Pontual et al 2011 - - De novo - - - 0 - DNA SEQ - - neuroblastoma - Journal: de Pontual et al 2011 - F - France - - 0 - - 1 -
-/. - c.3836+27G>T r.(=) p.(=) Unknown - benign g.29432625C>A g.29209759C>A ALK(NM_004304.3):c.3836+27G>T - ALK_000015 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.4165-6C>T r.(=) p.(=) Unknown - benign g.29416794G>A g.29193928G>A ALK(NM_004304.3):c.4165-6C>T - ALK_000014 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.4193C>T r.(?) p.(Pro1398Leu) Unknown - VUS g.29416760G>A g.29193894G>A ALK(NM_004304.3):c.4193C>T (p.P1398L) - ALK_000084 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.4194G>C r.(?) p.(Pro1398=) Unknown - likely benign g.29416759C>G g.29193893C>G ALK(NM_004304.3):c.4194G>C (p.P1398=) - ALK_000013 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.4200A>C r.(?) p.(Glu1400Asp) Unknown - likely benign g.29416753T>G g.29193887T>G ALK(NM_004304.3):c.4200A>C (p.E1400D) - ALK_000012 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.4203T>C r.(?) p.(Tyr1401=) Unknown - benign g.29416750A>G g.29193884A>G ALK(NM_004304.3):c.4203T>C (p.Y1401=) - ALK_000011 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.4275G>A r.(?) p.(Leu1425=) Unknown - likely benign g.29416678C>T g.29193812C>T ALK(NM_004304.3):c.4275G>A (p.L1425=) - ALK_000010 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.4338C>T r.(?) p.(Thr1446=) Unknown - benign g.29416615G>A g.29193749G>A ALK(NM_004304.3):c.4338C>T (p.T1446=) - ALK_000072 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.4381A>G r.(?) p.(Ile1461Val) Unknown - benign g.29416572T>C g.29193706T>C ALK(NM_004304.3):c.4381A>G (p.I1461V) - ALK_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.4381A>G r.(?) p.(Ile1461Val) Unknown - benign g.29416572T>C g.29193706T>C ALK(NM_004304.3):c.4381A>G (p.I1461V) - ALK_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.4381A>G r.(?) p.(Ile1461Val) Unknown - benign g.29416572T>C g.29193706T>C ALK(NM_004304.3):c.4381A>G (p.I1461V) - ALK_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.4381A>G r.(?) p.(Ile1461Val) Unknown - benign g.29416572T>C g.29193706T>C ALK(NM_004304.3):c.4381A>G (p.I1461V) - ALK_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
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