Full data view for gene CYP2D6

CYP2D6 reference haplotypes. Download the current CYP2D6 DRAFT reference haplotype list (ver.2015-07-24).
NOTE: the coding DNA reference sequence represents haplotype CYP2D6*1 which differs from the reference genome sequence (build hg19). For the coding region the differences include c.408C>G, c.886T>C and c.1457C>G.
Information The variants shown are described using the NM_000106.4 transcript reference sequence.

279 entries on 3 pages. Showing entries 1 - 100.
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Effect     

Exon     

AscendingDNA change (cDNA)     

RNA change     

Protein     

Haplotype     

Allele     

Classification method     

Clinical classification     

DNA change (genomic) (hg19)     

DNA change (hg38)     

Published as     

ISCN     

DB-ID     

Variant remarks     

Reference     

ClinVar ID     

dbSNP ID     

Origin     

Segregation     

Frequency     

Re-site     

VIP     

Methylation     

Template     

Technique     

Tissue     

Remarks     

Disease     

ID_report     

Reference     

Remarks     

Gender     

Consanguinity     

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Population     

Age at death     

VIP     

Data_av     

Treatment     

Panel size     

Owner     
-/. 3 c.408G>C r.408g>c p.Val136= - Parent #1 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Gough 1990 - - Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBCYP2D6 - PubMed: Gough 1990 - - - United Kingdom (Great Britain) - - - - - 1 Johan den Dunnen
-?/. 3 c.408G>C r.(?) p.(=) - Parent #1 - likely benign g.42525132= g.42129130C>G G1749C - CYP2D6_000011 44 kb XbaI allele PubMed: Hanioka 1990 - - Germline - - - - - DNA PCR, SEQ - - DMBCYP2D6 - PubMed: Hanioka 1990 - - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*10A Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*10A Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBi - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*8 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*8 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*11 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*11 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*12 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*12 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*17 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*17 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBi - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/. 3 c.408G>C r.408g>c p.Val136= CYP2D6*41 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*41 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBi - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2A Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2A Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2B Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2B Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2C Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2C Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2E Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2E Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2F Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2F Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2G Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2G Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2H Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2H Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2XN Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2XN Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2J;CYP2D6*59 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*59 (*2J) Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBi - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2K Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2K Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2L Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2L (formerly CYP2D6*41B) Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*2M Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*2M Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4A Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4A Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4C Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4C Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4D Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4D Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4E Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4E Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4F Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4F Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4G Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4G Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4H Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4H Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4J Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4J Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4K Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4K Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4L Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4L Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4M Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4M Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4N;CYP2D6*4X2 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4N Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*4P Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*4P Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline yes - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*10B Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*10B Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBi - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*10D Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*10D Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline no - - - - DNA, RNA RT-PCR, SEQ - - DMBi - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*14B Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*14B Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*20A Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*20A Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline no - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*19A Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*19A Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*28 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*28 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*30 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*30 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*32 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*32 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline no - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*35A Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*35A Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*35X2 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*35X2 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBr - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*39 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*39 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*37 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*37 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*40 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*40 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*42 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*42 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/. 3 c.408G>C r.(=) p.(Val136=) CYP2D6*41 Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - Healthy/Control - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*35A Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - Healthy/Control - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*2A Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - Healthy/Control - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*2A Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - Healthy/Control - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*2AX2 Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBur - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*41 Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*2A Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - Healthy/Control - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*4M/*35A Both (homozygous) - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*2A/*4M Both (homozygous) - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*2A/*41 Both (homozygous) - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(Val136=) CYP2D6*4M Both (homozygous) - benign g.42525132= g.42129130C>G - - CYP2D6_000011 other alelle *68 like (JF307779.1) PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBp - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*40/*42 Both (homozygous) - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 - PubMed: Gaedigk 2003, Journal: Gaedigk 2003 - rs1058164 Germline - - - - - DNA SEQ - - DMBp - PubMed: Gaedigk 2003, Journal: Gaedigk 2003 - ? no United States African-American >00y12m - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*17/*42 Both (homozygous) - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 - PubMed: Gaedigk 2003, Journal: Gaedigk 2003 - rs1058164 Germline - - - - - DNA SEQ - - ? - PubMed: Gaedigk 2003, Journal: Gaedigk 2003 - - - United States - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*17/*42 Both (homozygous) - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 - PubMed: Gaedigk 2003, Journal: Gaedigk 2003 - rs1058164 Germline - - - - - DNA SEQ - - ? - PubMed: Gaedigk 2003, Journal: Gaedigk 2003 - ? ? United States - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(=) p.Val136= CYP2D6*47 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*47; negligible activity Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(=) p.Val136= CYP2D6*49 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*49; decreased activity Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - DMBi - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(=) p.Val136= CYP2D6*36 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*36 (formerly *10C); no activity Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(=) p.Val136= CYP2D6*36X2 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*36X2 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(=) p.Val136= CYP2D6*31 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*31 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(=) p.Val136= CYP2D6*21A Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*21A Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(=) p.Val136= CYP2D6*21B Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*21B Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(=) p.Val136= CYP2D6*35B Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*35B Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(=) p.Val136= CYP2D6*46 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*46 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - Healthy/Control - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(?) - CYP2D6*29 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*29 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA, RNA RT-PCR, SEQ - - DMBi - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*94A Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*94A Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*94B Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*94B Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*95 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*95 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*87 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*87 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.408g>c p.Val136= CYP2D6*88 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*88 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(?) p.Val136= CYP2D6*85 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*85 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(?) p.Val136= CYP2D6*84 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*84 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(?) p.Val136= CYP2D6*73 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*73 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(?) p.Val136= CYP2D6*72 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*72 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(?) p.Val136= CYP2D6*70 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*70 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(?) p.Val136= CYP2D6*69 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*69 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - DMBp - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*41 Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*41X2 Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*4M Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*4M Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*2A Both (homozygous) - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBur - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*2A Both (homozygous) - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*17 Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*4M Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBp - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*35A Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*35A Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBur - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*35A Both (homozygous) - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*2A Parent #2 - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/- 3 c.408G>C r.(?) p.(=) CYP2D6*10D Both (homozygous) - benign g.42525132= g.42129130C>G - - CYP2D6_000011 - PubMed: Buermans 2017, Journal: Buermans 2017 - - Germline - - - - - DNA SEQ, SEQ-PB - - DMBi - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - - - - 1 Henk Buermans
-/. 3 c.408G>C r.408g>c p.Val136= CYP2D6*17XN Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*17XN Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/. 3 c.408G>C r.408g>c p.Val136= CYP2D6*10X2 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*10X2 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/. 3 c.408G>C r.408g>c p.Val136= CYP2D6*45B Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*45B Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/. 3 c.408G>C r.408g>c p.Val136= CYP2D6*45A Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*45A Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
-/. 3 c.408G>C r.408g>c p.Val136= CYP2D6*51 Parent #1 - benign g.42525132= g.42129130C>G 1661G>C - CYP2D6_000011 reference haplotype CYP2D6*51 Reference haplotype - Human P450 (CYP) Allele Nomenclature Committee - rs1058164 Germline - - - - - DNA SEQ - - - - - reference haplotype - - - - - - - - 1 Johan den Dunnen
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