Full data view for gene RAD51D

Information The variants shown are described using the NM_002878.3 transcript reference sequence.

475 entries on 5 pages. Showing entries 1 - 100.
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Effect     

Exon     

AscendingDNA change (cDNA)     

RNA change     

Protein     

Allele     

Classification method     

Clinical classification     

DNA change (genomic) (hg19)     

DNA change (hg38)     

Published as     

ISCN     

DB-ID     

Variant remarks     

Reference     

ClinVar ID     

dbSNP ID     

Origin     

Segregation     

Frequency     

Re-site     

VIP     

Methylation     

Template     

Technique     

Tissue     

Remarks     

Disease     

ID_report     

Reference     

Remarks     

Gender     

Consanguinity     

Country     

Population     

Age at death     

VIP     

Data_av     

Treatment     

Panel size     

Owner     
-?/. - c.-150G>T r.(?) p.(=) Unknown - likely benign g.33446782C>A - RAD51D(NM_002878.3):c.-150G>T - FNDC8_000023 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.-116C>T r.(?) p.(=) Unknown - VUS g.33446748G>A - RAD51D(NM_002878.3):c.-116C>T (p.(=)) - FNDC8_000048 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.-39C>T r.(?) p.(=) Parent #1 - VUS g.33446671G>A g.35119652G>A - - RAD51D_000043 - PubMed: Thompson 2013, Journal: Thompson 2013 - - Germline - 1/741 familes breast cancer - - - DNA SEQ - - cancer, breast - PubMed: Thompson 2013, Journal: Thompson 2013 analysis 741 breast cancer families - - Australia - - - - - 1 Johan den Dunnen
-/. - c.-38G>T r.(?) p.(=) Unknown - benign g.33446670C>A - RAD51D(NM_001142571.1):c.-38G>T (p.(=)), RAD51D(NM_002878.3):c.-38G>T, RAD51D(NR_037711.2):n.108G>T - FNDC8_000037 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.-38G>T r.(?) p.(=) Unknown - benign g.33446670C>A - RAD51D(NM_001142571.1):c.-38G>T (p.(=)), RAD51D(NM_002878.3):c.-38G>T, RAD51D(NR_037711.2):n.108G>T - FNDC8_000037 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.-38G>T r.(?) p.(=) Unknown - benign g.33446670C>A - RAD51D(NM_001142571.1):c.-38G>T (p.(=)), RAD51D(NM_002878.3):c.-38G>T, RAD51D(NR_037711.2):n.108G>T - FNDC8_000037 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.-38G>T r.(?) p.(=) Unknown - benign g.33446670C>A - RAD51D(NM_001142571.1):c.-38G>T (p.(=)), RAD51D(NM_002878.3):c.-38G>T, RAD51D(NR_037711.2):n.108G>T - FNDC8_000037 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.-21C>T r.(?) p.(=) Unknown - likely benign g.33446653G>A g.35119634G>A - - FNDC8_000012 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.1A>G r.? p.? Parent #1 - NA g.33446632T>C - chr17_33446632_T_C - RAD51D_000180 the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/60466 cases - - - DNA SEQ-NG - 34-gene panel cancer, breast - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 60466 cases (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
?/. - c.1A>G r.? p.? Parent #1 - NA g.33446632T>C - chr17_33446632_T_C - RAD51D_000180 the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 2/53461 controls - - - DNA SEQ-NG - 34-gene panel Healthy/Control - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 53461 controls (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 2 BRIDGES consortium
?/. - c.4G>A r.(?) p.(Gly2Ser) Parent #1 - NA g.33446629C>T - chr17_33446629_C_T - RAD51D_000179 not in 53461 controls; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/60466 cases - - - DNA SEQ-NG - 34-gene panel cancer, breast - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 60466 cases (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
-?/. - c.12C>G r.(?) p.(=) Unknown - likely benign g.33446621G>C - - - FNDC8_000052 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.19G>C r.(?) p.(Gly7Arg) Unknown - likely benign g.33446614C>G - RAD51D(NM_002878.3):c.19G>C (p.G7R) - FNDC8_000027 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.23T>C r.(?) p.(Leu8Pro) Parent #1 - NA g.33446610A>G - chr17_33446610_A_G - RAD51D_000178 not in 60466 cases; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/53461 controls - - - DNA SEQ-NG - 34-gene panel Healthy/Control - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 53461 controls (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
?/. - c.26G>C r.(?) p.(Cys9Ser) Unknown - VUS g.33446607C>G g.35119588C>G RAD51D(NM_001142571.1):c.26G>C (p.(Cys9Ser)) - FNDC8_000014 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.26G>C r.(?) p.(Cys9Ser) Parent #1 - NA g.33446607C>G - chr17_33446607_C_G - FNDC8_000014 the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 10/60466 cases - - - DNA SEQ-NG - 34-gene panel cancer, breast - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 60466 cases (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 10 BRIDGES consortium
?/. - c.26G>C r.(?) p.(Cys9Ser) Parent #1 - NA g.33446607C>G - chr17_33446607_C_G - FNDC8_000014 the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 6/53461 controls - - - DNA SEQ-NG - 34-gene panel Healthy/Control - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 53461 controls (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 6 BRIDGES consortium
?/. - c.26G>C r.(?) p.(Cys9Ser) Unknown - VUS g.33446607C>G - RAD51D(NM_001142571.1):c.26G>C (p.(Cys9Ser)) - FNDC8_000014 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.47T>C r.(?) p.(Met16Thr) Parent #1 - VUS g.33446586A>G g.35119567A>G - - RAD51D_000042 - PubMed: Thompson 2013, Journal: Thompson 2013 - - Germline - 1/741 familes breast cancer - - - DNA SEQ - - cancer, breast - PubMed: Thompson 2013, Journal: Thompson 2013 analysis 741 breast cancer families - - Australia - - - - - 1 Johan den Dunnen
?/. - c.47T>C r.(?) p.(Met16Thr) Unknown - VUS g.33446586A>G - RAD51D(NM_002878.4):c.47T>C (p.M16T) - RAD51D_000042 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.53A>G r.(?) p.(Gln18Arg) Unknown - VUS g.33446580T>C - RAD51D(NM_002878.4):c.53A>G (p.Q18R) - FNDC8_000031 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.82+11G>A r.(=) p.(=) Unknown - VUS g.33446540C>T - RAD51D(NM_002878.4):c.82+11G>A - FNDC8_000036 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.82+32G>A r.(=) p.(=) Unknown - likely benign g.33446519C>T - RAD51D(NM_002878.3):c.82+32G>A - FNDC8_000026 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.82+42C>A r.(=) p.(=) Unknown - likely benign g.33446509G>T - - - FNDC8_000032 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.82+60C>T r.(=) p.(=) Unknown - likely benign g.33446491G>A g.35119472G>A - - FNDC8_000011 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.82+60C>T r.(?) p.(=) Parent #1 - VUS g.33446491G>A g.35119472G>A - - FNDC8_000011 - PubMed: Thompson 2013, Journal: Thompson 2013 - - Germline - 1/406 controls - - - DNA SEQ - - Healthy/Control - PubMed: Thompson 2013, Journal: Thompson 2013 analysis 406 controls - - Australia - - - - - 1 Johan den Dunnen
-?/. - c.83-100C>G r.(=) p.(=) Unknown - likely benign g.33446291G>C - RAD51D(NM_002878.3):c.83-100C>G - FNDC8_000020 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.83-20T>C r.(?) p.(=) Parent #1 - VUS g.33446211A>G g.35119192A>G - - RAD51D_000041 - PubMed: Thompson 2013, Journal: Thompson 2013 - rs182793287 Germline - 1/245 cases ovarian cancer - - - DNA SEQ - - cancer, ovarian - PubMed: Thompson 2013, Journal: Thompson 2013 analysis 245 cases ovarian cancer - - Australia - - - - - 1 Johan den Dunnen
-?/. - c.83-20T>C r.(=) p.(=) Unknown - likely benign g.33446211A>G - - - RAD51D_000041 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.83-2A>G r.spl? p.? Parent #1 - NA g.33446193T>C - chr17_33446193_T_C - RAD51D_000177 not in 53461 controls; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/60466 cases - - - DNA SEQ-NG - 34-gene panel cancer, breast - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 60466 cases (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
?/. - c.83T>C r.(?) p.(Val28Ala) Parent #1 - NA g.33446191A>G - chr17_33446191_A_G - RAD51D_000176 not in 53461 controls; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/60466 cases - - - DNA SEQ-NG - 34-gene panel cancer, breast - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 60466 cases (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
-?/. - c.90C>T r.(?) p.(Asp30=) Unknown - likely benign g.33446184G>A - RAD51D(NM_002878.3):c.90C>T (p.D30=) - FNDC8_000025 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.108G>A r.(?) p.(=) Unknown - likely benign g.33446166C>T - RAD51D(NM_002878.4):c.108G>A (p.L36=) - FNDC8_000051 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.115G>A r.(?) p.(Val39Ile) Parent #1 - NA g.33446159C>T - chr17_33446159_C_T - RAD51D_000175 not in 60466 cases; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/53461 controls - - - DNA SEQ-NG - 34-gene panel Healthy/Control - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 53461 controls (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
-?/. - c.117A>T r.(?) p.(=) Parent #1 - VUS g.33446157T>A g.35119138T>A - - RAD51D_000040 - PubMed: Thompson 2013, Journal: Thompson 2013 - - Germline - 1/741 familes breast cancer - - - DNA SEQ - - cancer, breast - PubMed: Thompson 2013, Journal: Thompson 2013 analysis 741 breast cancer families - - Australia - - - - - 1 Johan den Dunnen
?/. - c.118G>C r.(?) p.(Ala40Pro) Parent #1 - NA g.33446156C>G - chr17_33446156_C_G - RAD51D_000174 not in 53461 controls; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/60466 cases - - - DNA SEQ-NG - 34-gene panel cancer, breast - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 60466 cases (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
?/. - c.127T>C r.(?) p.(Cys43Arg) Parent #1 - NA g.33446147A>G - chr17_33446147_A_G - RAD51D_000173 not in 60466 cases; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/53461 controls - - - DNA SEQ-NG - 34-gene panel Healthy/Control - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 53461 controls (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
?/. - c.131G>C r.(?) p.(Gly44Ala) Parent #1 - NA g.33446143C>G - chr17_33446143_C_G - RAD51D_000172 not in 53461 controls; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/60466 cases - - - DNA SEQ-NG - 34-gene panel cancer, breast - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 60466 cases (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
?/. - c.136T>C r.(?) p.(Ser46Pro) Parent #1 - NA g.33446138A>G - chr17_33446138_A_G - RAD51D_000171 not in 60466 cases; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/53461 controls - - - DNA SEQ-NG - 34-gene panel Healthy/Control - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 53461 controls (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
?/. - c.137C>G r.(?) p.(Ser46Cys) Unknown - VUS g.33446137G>C - RAD51D(NM_001142571.1):c.137C>G (p.(Ser46Cys)) - FNDC8_000019 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.137C>G r.(?) p.(Ser46Cys) Parent #1 - NA g.33446137G>C - chr17_33446137_G_C - FNDC8_000019 the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 3/60466 cases - - - DNA SEQ-NG - 34-gene panel cancer, breast - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 60466 cases (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 3 BRIDGES consortium
?/. - c.137C>G r.(?) p.(Ser46Cys) Parent #1 - NA g.33446137G>C - chr17_33446137_G_C - FNDC8_000019 the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/53461 controls - - - DNA SEQ-NG - 34-gene panel Healthy/Control - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 53461 controls (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
?/. - c.137C>G r.(?) p.(Ser46Cys) Unknown - VUS g.33446137G>C - RAD51D(NM_001142571.1):c.137C>G (p.(Ser46Cys)) - FNDC8_000019 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.140A>G r.(?) p.(Tyr47Cys) Parent #1 - NA g.33446134T>C - chr17_33446134_T_C - RAD51D_000170 not in 60466 cases; the study was not designed to clinically classify individual variants but performed burden-type association analyses, grouping certain variant types PubMed: Dorling 2021, Journal: Dorling 2021 - - Germline - 1/53461 controls - - - DNA SEQ-NG - 34-gene panel Healthy/Control - PubMed: Dorling 2021, Journal: Dorling 2021 analysis 53461 controls (BRIDGES) - - - - - - bcac.ccge.medschl.cam.ac.uk/contact - 1 BRIDGES consortium
+/. - c.141C>G r.(?) p.(Tyr47*) Unknown - pathogenic g.33446133G>C - RAD51D(NM_002878.3):c.141C>G (p.Y47*), RAD51D(NM_002878.4):c.141C>G (p.Y47*) - FNDC8_000029 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
+/. - c.141C>G r.(?) p.(Tyr47*) Unknown - pathogenic g.33446133G>C - RAD51D(NM_002878.3):c.141C>G (p.Y47*), RAD51D(NM_002878.4):c.141C>G (p.Y47*) - FNDC8_000029 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
+/. - c.141C>G r.(?) p.(Tyr47*) Unknown - pathogenic g.33446133G>C - RAD51D(NM_002878.3):c.141C>G (p.Y47*), RAD51D(NM_002878.4):c.141C>G (p.Y47*) - FNDC8_000029 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. 2i_3 c.144+67_144+68ins144+68_229inv r.? p.? Unknown ACMG VUS g.33446062_33446063ins33445554_33446062inv g.35119043_35119044ins35118535_35119043inv - - RAD51D_000226 insertion of inverted sequence of part of intron 2 and part of exon 3 in intron 2 - - - Germline - - - - - DNA SEQ-NG - - cancer, prostate - - - M - - - - - - - 1 Albain Chansavang
-?/. - c.145-94G>A r.(=) p.(=) Unknown - likely benign g.33445732C>T g.35118713C>T - - FNDC8_000010 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.145-47G>C r.(=) p.(=) Unknown - likely benign g.33445685C>G - - - FNDC8_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.145-40C>T r.(=) p.(=) Unknown - likely benign g.33445678G>A - RAD51D(NM_002878.3):c.145-40C>T - FNDC8_000035 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.145-39G>T r.(=) p.(=) Unknown - benign g.33445677C>A g.35118658C>A RAD51D(NM_002878.3):c.145-39G>T - FNDC8_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.145-39G>T r.(=) p.(=) Unknown - likely benign g.33445677C>A - RAD51D(NM_002878.3):c.145-39G>T - FNDC8_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.145-35A>T r.(=) p.(=) Unknown - likely benign g.33445673T>A - - - FNDC8_000028 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.145-14G>C r.(=) p.(=) Unknown - likely benign g.33445652C>G - - - FNDC8_000050 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.145-12G>A r.(=) p.(=) Unknown - likely benign g.33445650C>T g.35118631C>T - - FNDC8_000013 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.145-4G>A r.spl? p.? Unknown - likely benign g.33445642C>T g.35118623C>T RAD51D(NM_001142571.2):c.144+488G>A, RAD51D(NM_002878.4):c.145-4G>A - RAD51D_000010 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.145-4G>A r.spl? p.? Unknown - likely benign g.33445642C>T g.35118623C>T RAD51D(NM_001142571.2):c.144+488G>A, RAD51D(NM_002878.4):c.145-4G>A - RAD51D_000010 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.145-4G>A r.spl? p.? Unknown - likely benign g.33445642C>T - RAD51D(NM_001142571.2):c.144+488G>A, RAD51D(NM_002878.4):c.145-4G>A - RAD51D_000010 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.147C>T r.(?) p.(Ala49=) Unknown - likely benign g.33445636G>A - - - FNDC8_000015 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.156C>T r.(?) p.(=) Unknown - VUS g.33445627G>A - - - FNDC8_000040 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.163C>T r.(?) p.(Arg55Trp) Unknown - VUS g.33445620G>A g.35118601G>A - - FNDC8_000008 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.180G>T r.(?) p.(Gln60His) Unknown - VUS g.33445603C>A g.35118584C>A RAD51D(NM_002878.4):c.180G>T (p.Q60H) - FNDC8_000007 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.180G>T r.(?) p.(Gln60His) Unknown - VUS g.33445603C>A - RAD51D(NM_002878.4):c.180G>T (p.Q60H) - FNDC8_000007 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.196G>A r.(?) p.(Val66Met) Unknown - likely benign g.33445587C>T g.35118568C>T RAD51D(NM_002878.3):c.196G>A (p.V66M), RAD51D(NM_002878.4):c.196G>A (p.V66M) - RAD51D_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.196G>A r.(?) p.(Val66Met) Unknown - likely benign g.33445587C>T g.35118568C>T RAD51D(NM_002878.3):c.196G>A (p.V66M), RAD51D(NM_002878.4):c.196G>A (p.V66M) - RAD51D_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.196G>A r.(?) p.(Val66Met) Unknown - likely benign g.33445587C>T - RAD51D(NM_002878.3):c.196G>A (p.V66M), RAD51D(NM_002878.4):c.196G>A (p.V66M) - RAD51D_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.202G>A r.(?) p.(Gly68Ser) Unknown - VUS g.33445581C>T g.35118562C>T RAD51D(NM_002878.3):c.202G>A (p.G68S, p.(Gly68Ser)), RAD51D(NM_002878.4):c.202G>A (p.G68S) - FNDC8_000006 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.202G>A r.(?) p.(Gly68Ser) Unknown - VUS g.33445581C>T g.35118562C>T RAD51D(NM_002878.3):c.202G>A (p.G68S, p.(Gly68Ser)), RAD51D(NM_002878.4):c.202G>A (p.G68S) - FNDC8_000006 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.202G>A r.(?) p.(Gly68Ser) Unknown - VUS g.33445581C>T g.35118562C>T RAD51D(NM_002878.3):c.202G>A (p.G68S, p.(Gly68Ser)), RAD51D(NM_002878.4):c.202G>A (p.G68S) - FNDC8_000006 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.202G>A r.(?) p.(Gly68Ser) Unknown - VUS g.33445581C>T g.35118562C>T RAD51D(NM_002878.3):c.202G>A (p.G68S, p.(Gly68Ser)), RAD51D(NM_002878.4):c.202G>A (p.G68S) - FNDC8_000006 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.202G>A r.(?) p.(Gly68Ser) Unknown - VUS g.33445581C>T g.35118562C>T RAD51D(NM_002878.3):c.202G>A (p.G68S, p.(Gly68Ser)), RAD51D(NM_002878.4):c.202G>A (p.G68S) - FNDC8_000006 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.202G>A r.(?) p.(Gly68Ser) Unknown - VUS g.33445581C>T - RAD51D(NM_002878.3):c.202G>A (p.G68S, p.(Gly68Ser)), RAD51D(NM_002878.4):c.202G>A (p.G68S) - FNDC8_000006 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.204C>T r.(?) p.(Gly68=) Unknown - likely benign g.33445579G>A g.35118560G>A RAD51D(NM_002878.4):c.204C>T (p.G68=) - FNDC8_000005 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.204C>T r.(?) p.(Gly68=) Unknown - likely benign g.33445579G>A - RAD51D(NM_002878.4):c.204C>T (p.G68=) - FNDC8_000005 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.205G>A r.(?) p.(Ala69Thr) Unknown - VUS g.33445578C>T - RAD51D(NM_002878.4):c.205G>A (p.A69T) - FNDC8_000049 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.211C>T r.(?) p.(Leu71Phe) Unknown - VUS g.33445572G>A - RAD51D(NM_002878.4):c.211C>T (p.L71F) - FNDC8_000034 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.211C>T r.(?) p.(Leu71Phe) Unknown - VUS g.33445572G>A - RAD51D(NM_002878.4):c.211C>T (p.L71F) - FNDC8_000034 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.216C>T r.(?) p.(Tyr72=) Unknown - likely benign g.33445567G>A g.35118548G>A RAD51D(NM_002878.3):c.216C>T (p.Y72=) - RAD51D_000008 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.234C>T r.(?) p.(Ser78=) Unknown - benign g.33445549G>A g.35118530G>A RAD51D(NM_002878.3):c.234C>T (p.S78=) - FNDC8_000004 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.234C>T r.(?) p.(Ser78=) Unknown - benign g.33445549G>A g.35118530G>A RAD51D(NM_002878.3):c.234C>T (p.S78=) - FNDC8_000004 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.239C>T r.(?) p.(Ala80Val) Unknown ACMG likely benign g.33445544G>A g.35118525G>A - - RAD51D_000012 co-occurrence with the pathogenic variant in BRCA1 c.3193dup (p.Asp1065Glyfs*2) - ClinVar-230011 rs876658332 Germline ? - - - - DNA SEQ-NG-I - - cancer, breast 128175 - - F ? Germany - - - - - 1 Andreas Laner
?/. - c.242T>C r.(?) p.(Ile81Thr) Unknown - VUS g.33445541A>G - RAD51D(NM_002878.3):c.242T>C (p.(Ile81Thr)) - FNDC8_000042 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.246G>A r.(?) p.(=) Unknown - likely benign g.33445537C>T - RAD51D(NM_002878.4):c.246G>A (p.L82=) - FNDC8_000047 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
+/. - c.263+1G>A r.spl? p.? Unknown - pathogenic g.33445519C>T g.35118500C>T - - FNDC8_000003 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1455del r.(=) p.(=) Unknown - likely benign g.33444067del - RAD51D(NM_002878.3):c.263+1455delA - FNDC8_000022 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.263+1462A>C r.(=) p.(=) Unknown - VUS g.33444058T>G - RAD51D(NM_002878.4):c.263+1462A>C - FNDC8_000024 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.263+1474C>T r.(=) p.(=) Unknown - benign g.33444046G>A - RAD51D(NM_002878.3):c.263+1474C>T - FNDC8_000039 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1474C>T r.(=) p.(=) Unknown - likely benign g.33444046G>A - RAD51D(NM_002878.3):c.263+1474C>T - FNDC8_000039 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1478C>T r.(=) p.(=) Unknown - likely benign g.33444042G>A - RAD51D(NM_001142571.1):c.159C>T (p.(His53=)), RAD51D(NM_002878.3):c.263+1478C>T - FNDC8_000021 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1478C>T r.(=) p.(=) Unknown - likely benign g.33444042G>A - RAD51D(NM_001142571.1):c.159C>T (p.(His53=)), RAD51D(NM_002878.3):c.263+1478C>T - FNDC8_000021 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1478C>T r.(=) p.(=) Unknown - likely benign g.33444042G>A - RAD51D(NM_001142571.1):c.159C>T (p.(His53=)), RAD51D(NM_002878.3):c.263+1478C>T - FNDC8_000021 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1504A>G r.(=) p.(=) Unknown - likely benign g.33444016T>C - RAD51D(NM_002878.3):c.263+1504A>G - FNDC8_000017 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1521G>A r.(=) p.(=) Unknown - likely benign g.33443999C>T - - - FNDC8_000045 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1521G>T r.(=) p.(=) Unknown - likely benign g.33443999C>A - - - FNDC8_000044 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.263+1588A>G r.(=) p.(=) Unknown - VUS g.33443932T>C g.35116913T>C RAD51D(NM_001142571.1):c.269A>G (p.(Asp90Gly)), RAD51D(NM_001142571.2):c.269A>G (p.D90G), RAD51D(NM_002878.3):c.263+1588A>G - FNDC8_000002 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1588A>G r.(=) p.(=) Unknown - likely benign g.33443932T>C g.35116913T>C RAD51D(NM_001142571.1):c.269A>G (p.(Asp90Gly)), RAD51D(NM_001142571.2):c.269A>G (p.D90G), RAD51D(NM_002878.3):c.263+1588A>G - FNDC8_000002 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1588A>G r.(=) p.(=) Unknown - likely benign g.33443932T>C - RAD51D(NM_001142571.1):c.269A>G (p.(Asp90Gly)), RAD51D(NM_001142571.2):c.269A>G (p.D90G), RAD51D(NM_002878.3):c.263+1588A>G - FNDC8_000002 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.263+1588A>G r.(=) p.(=) Unknown - benign g.33443932T>C - RAD51D(NM_001142571.1):c.269A>G (p.(Asp90Gly)), RAD51D(NM_001142571.2):c.269A>G (p.D90G), RAD51D(NM_002878.3):c.263+1588A>G - FNDC8_000002 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.263+1588A>G r.(=) p.(=) Unknown - likely benign g.33443932T>C - RAD51D(NM_001142571.1):c.269A>G (p.(Asp90Gly)), RAD51D(NM_001142571.2):c.269A>G (p.D90G), RAD51D(NM_002878.3):c.263+1588A>G - FNDC8_000002 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
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