CCCTC-binding factor (zinc finger protein) (CTCF) - coding DNA reference sequence

(used for variant description)

(last modified July 10, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_006565.3 in the CTCF gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering CTCF transcript NM_006565.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5024
                                     cccatgctgccctgcgccaacccc       c.-421

 .         .         .         .         .         .                g.5084
 tcccctcacctttcctcccccgccctctactcgccgcccggccggtccccccacccgtcc       c.-361

 .         .         .         .         .         .                g.5144
 cttcccttatcagcacccgcggccccggcagcgccgacgcaggcgcactgcaccgcgccg       c.-301

 .         .         .         .         .         .                g.5204
 ccgccattttgtgtctgagcctgtggagcgattaaaccgtgcgcggagctgcttctttgg       c.-241

 .         .         .         .         .         .                g.5264
 cggcagcggcggcggcggtggccggtgcggacgcgcggagctcgccggagacgccgggtg       c.-181

 .         .         .         .         .         .    | 02        g.13747
 gccggagccgtggagcggcggcggagcgggcgccgcggggggtgtggcgcggag | aatgat    c.-121

 .         .         .         .         .         .                g.13807
 tacggacctgaagccaaagaacaagatgcgctagtggacagattgctgaccaggggcttg       c.-61

 .         .         .         .         .         . | 03           g.53426
 agagctgggttctattttccctcctcaaactgactttgcagccacggagag | gcaggggaa    c.-1

          .         .         .         .         .         .       g.53486
 ATGGAAGGTGATGCAGTCGAAGCCATTGTGGAGGAGTCCGAAACTTTTATTAAAGGAAAG       c.60
 M  E  G  D  A  V  E  A  I  V  E  E  S  E  T  F  I  K  G  K         p.20

          .         .         .         .         .         .       g.53546
 GAGAGAAAGACTTACCAGAGACGCCGGGAAGGGGGCCAGGAAGAAGATGCCTGCCACTTA       c.120
 E  R  K  T  Y  Q  R  R  R  E  G  G  Q  E  E  D  A  C  H  L         p.40

          .         .         .         .         .         .       g.53606
 CCCCAGAACCAGACGGATGGGGGTGAGGTGGTCCAGGATGTCAACAGCAGTGTACAGATG       c.180
 P  Q  N  Q  T  D  G  G  E  V  V  Q  D  V  N  S  S  V  Q  M         p.60

          .         .         .         .         .         .       g.53666
 GTGATGATGGAACAGCTGGACCCCACCCTTCTTCAGATGAAGACTGAAGTAATGGAGGGC       c.240
 V  M  M  E  Q  L  D  P  T  L  L  Q  M  K  T  E  V  M  E  G         p.80

          .         .         .         .         .         .       g.53726
 ACAGTGGCTCCAGAAGCAGAGGCTGCTGTGGACGATACCCAGATTATAACTTTACAGGTT       c.300
 T  V  A  P  E  A  E  A  A  V  D  D  T  Q  I  I  T  L  Q  V         p.100

          .         .         .         .         .         .       g.53786
 GTAAATATGGAGGAACAGCCCATAAACATAGGAGAACTTCAGCTTGTTCAAGTACCTGTT       c.360
 V  N  M  E  E  Q  P  I  N  I  G  E  L  Q  L  V  Q  V  P  V         p.120

          .         .         .         .         .         .       g.53846
 CCTGTGACTGTACCTGTTGCTACCACTTCAGTAGAAGAACTTCAGGGGGCTTATGAAAAT       c.420
 P  V  T  V  P  V  A  T  T  S  V  E  E  L  Q  G  A  Y  E  N         p.140

          .         .         .         .         .         .       g.53906
 GAAGTGTCTAAAGAGGGCCTTGCGGAAAGTGAACCCATGATATGCCACACCCTACCTTTG       c.480
 E  V  S  K  E  G  L  A  E  S  E  P  M  I  C  H  T  L  P  L         p.160

          .         .         .         .         .         .       g.53966
 CCTGAAGGGTTTCAGGTGGTTAAAGTGGGGGCCAATGGAGAGGTGGAGACACTAGAACAA       c.540
 P  E  G  F  Q  V  V  K  V  G  A  N  G  E  V  E  T  L  E  Q         p.180

          .         .         .         .         .         .       g.54026
 GGGGAACTTCCACCCCAGGAAGATCCTAGTTGGCAAAAAGACCCAGACTATCAGCCACCA       c.600
 G  E  L  P  P  Q  E  D  P  S  W  Q  K  D  P  D  Y  Q  P  P         p.200

          .         .         .         .         .         .       g.54086
 GCCAAAAAAACAAAGAAAACCAAAAAGAGCAAACTGCGTTATACAGAGGAGGGCAAAGAT       c.660
 A  K  K  T  K  K  T  K  K  S  K  L  R  Y  T  E  E  G  K  D         p.220

          .         .         .         .         .         .       g.54146
 GTAGATGTGTCTGTCTACGATTTTGAGGAAGAACAGCAGGAGGGTCTGCTATCAGAGGTT       c.720
 V  D  V  S  V  Y  D  F  E  E  E  Q  Q  E  G  L  L  S  E  V         p.240

          .         .         .         .         .         .       g.54206
 AATGCAGAGAAAGTGGTTGGTAATATGAAGCCTCCAAAGCCAACAAAAATTAAAAAGAAA       c.780
 N  A  E  K  V  V  G  N  M  K  P  P  K  P  T  K  I  K  K  K         p.260

   | 04      .         .         .         .         .         .    g.54603
 G | GTGTAAAGAAGACATTCCAGTGTGAGCTTTGCAGTTACACGTGTCCACGGCGTTCAAAT    c.840
 G |   V  K  K  T  F  Q  C  E  L  C  S  Y  T  C  P  R  R  S  N      p.280

          .         .         .         .         .         .       g.54663
 TTGGATCGTCACATGAAAAGCCACACTGATGAGAGACCACACAAGTGCCATCTCTGTGGC       c.900
 L  D  R  H  M  K  S  H  T  D  E  R  P  H  K  C  H  L  C  G         p.300

          .         .         .         .         .   | 05     .    g.59346
 AGGGCATTCAGAACAGTCACCCTCCTGAGGAATCACCTTAACACACACACAG | GTACTCGT    c.960
 R  A  F  R  T  V  T  L  L  R  N  H  L  N  T  H  T  G |   T  R      p.320

          .         .         .         .         .         .       g.59406
 CCTCACAAGTGCCCAGACTGCGACATGGCCTTTGTGACCAGTGGAGAATTGGTTCGGCAT       c.1020
 P  H  K  C  P  D  C  D  M  A  F  V  T  S  G  E  L  V  R  H         p.340

          .         .         .         .         .         .       g.59466
 CGTCGTTACAAACACACCCACGAGAAGCCATTCAAGTGTTCCATGTGCGATTACGCCAGT       c.1080
 R  R  Y  K  H  T  H  E  K  P  F  K  C  S  M  C  D  Y  A  S         p.360

        | 06 .         .         .         .         .         .    g.63344
 GTAGAA | GTCAGCAAATTAAAACGTCACATTCGCTCTCATACTGGAGAGCGTCCGTTTCAG    c.1140
 V  E   | V  S  K  L  K  R  H  I  R  S  H  T  G  E  R  P  F  Q      p.380

          .         .         .         .         .         .       g.63404
 TGCAGTTTGTGCAGTTATGCCAGCAGGGACACATACAAGCTGAAAAGGCACATGAGAACC       c.1200
 C  S  L  C  S  Y  A  S  R  D  T  Y  K  L  K  R  H  M  R  T         p.400

         | 07.         .         .         .         .         .    g.64088
 CATTCAG | GGGAAAAGCCTTATGAATGTTATATTTGTCATGCTCGGTTTACCCAAAGTGGT    c.1260
 H  S  G |   E  K  P  Y  E  C  Y  I  C  H  A  R  F  T  Q  S  G      p.420

          .         .         .         .         .         .       g.64148
 ACCATGAAGATGCACATTTTACAGAAGCACACAGAAAATGTGGCCAAATTTCACTGTCCC       c.1320
 T  M  K  M  H  I  L  Q  K  H  T  E  N  V  A  K  F  H  C  P         p.440

          .         .         .        | 08.         .         .    g.69171
 CACTGTGACACAGTCATAGCCCGAAAAAGTGATTTGG | GTGTCCACTTGCGAAAGCAGCAT    c.1380
 H  C  D  T  V  I  A  R  K  S  D  L  G |   V  H  L  R  K  Q  H      p.460

          .         .         .         .         .         .       g.69231
 TCCTATATTGAGCAAGGCAAGAAATGCCGTTACTGTGATGCTGTGTTTCATGAGCGCTAT       c.1440
 S  Y  I  E  Q  G  K  K  C  R  Y  C  D  A  V  F  H  E  R  Y         p.480

          .         .         .         .         .         .       g.69291
 GCCCTCATCCAGCATCAGAAGTCACACAAGAATGAGAAGCGCTTTAAGTGTGACCAGTGT       c.1500
 A  L  I  Q  H  Q  K  S  H  K  N  E  K  R  F  K  C  D  Q  C         p.500

          .         | 09         .         .         .         .    g.71005
 GATTACGCTTGTAGACAG | GAGAGGCACATGATCATGCACAAGCGCACCCACACCGGGGAG    c.1560
 D  Y  A  C  R  Q   | E  R  H  M  I  M  H  K  R  T  H  T  G  E      p.520

          .         .         .         .         .         .       g.71065
 AAGCCTTACGCCTGCAGCCACTGCGATAAGACCTTCCGCCAGAAGCAGCTTCTCGACATG       c.1620
 K  P  Y  A  C  S  H  C  D  K  T  F  R  Q  K  Q  L  L  D  M         p.540

          .         .         .         .         .         .       g.71125
 CACTTCAAGCGCTATCACGACCCCAACTTCGTCCCTGCGGCTTTTGTCTGTTCTAAGTGT       c.1680
 H  F  K  R  Y  H  D  P  N  F  V  P  A  A  F  V  C  S  K  C         p.560

          .         .  | 10      .         .         .         .    g.72030
 GGGAAAACATTTACACGTCGG | AATACCATGGCAAGACATGCTGATAATTGTGCTGGCCCA    c.1740
 G  K  T  F  T  R  R   | N  T  M  A  R  H  A  D  N  C  A  G  P      p.580

          .         .         .         .         .         .       g.72090
 GATGGCGTAGAGGGGGAAAATGGAGGAGAAACGAAGAAGAGTAAACGTGGAAGAAAAAGA       c.1800
 D  G  V  E  G  E  N  G  G  E  T  K  K  S  K  R  G  R  K  R         p.600

          .         .         .        | 11.         .         .    g.79306
 AAGATGCGCTCTAAGAAAGAAGATTCCTCTGACAGTG | AAAATGCTGAACCAGATCTGGAC    c.1860
 K  M  R  S  K  K  E  D  S  S  D  S  E |   N  A  E  P  D  L  D      p.620

          .         .         .         .         .         .       g.79366
 GACAATGAGGATGAGGAGGAGCCTGCCGTAGAAATTGAACCTGAGCCAGAGCCTCAGCCT       c.1920
 D  N  E  D  E  E  E  P  A  V  E  I  E  P  E  P  E  P  Q  P         p.640

          .         .         .         .         .         .       g.79426
 GTGACCCCAGCCCCACCACCCGCCAAGAAGCGGAGAGGACGACCCCCTGGCAGAACCAAC       c.1980
 V  T  P  A  P  P  P  A  K  K  R  R  G  R  P  P  G  R  T  N         p.660

          .          | 12        .         .         .         .    g.80322
 CAGCCCAAACAGAACCAGC | CAACAGCTATCATTCAGGTTGAAGACCAGAATACAGGTGCA    c.2040
 Q  P  K  Q  N  Q  P |   T  A  I  I  Q  V  E  D  Q  N  T  G  A      p.680

          .         .         .         .         .         .       g.80382
 ATTGAGAACATTATAGTTGAAGTAAAAAAAGAGCCAGATGCTGAGCCCGCAGAGGGAGAG       c.2100
 I  E  N  I  I  V  E  V  K  K  E  P  D  A  E  P  A  E  G  E         p.700

          .         .         .         .         .         .       g.80442
 GAAGAGGAGGCCCAGCCAGCTGCCACAGATGCCCCCAACGGAGACCTCACGCCCGAGATG       c.2160
 E  E  E  A  Q  P  A  A  T  D  A  P  N  G  D  L  T  P  E  M         p.720

          .         .                                               g.80466
 ATCCTCAGCATGATGGACCGGTGA                                           c.2184
 I  L  S  M  M  D  R  X                                             p.727

          .         .         .         .         .         .       g.80526
 tggcggagccttgtgcgtcgccaggacttctctgggctgtgtttaaacggcccgcatctt       c.*60

          .         .         .         .         .         .       g.80586
 aatttttctcccttctttctttttttggctttgggaaaagcatcattttaccaaacatac       c.*120

          .         .         .         .         .         .       g.80646
 cgagaacgaaaacttcaaggatgatgttagaaaaaaatgtgatttaactagaacttgctg       c.*180

          .         .         .         .         .         .       g.80706
 tctgatgttagcaaatcatggaatgttctgagtccctgagggtttactgtgaagtgctga       c.*240

          .         .         .         .         .         .       g.80766
 ggacagtgttgacaactaactcgttttcctagatggaaacggagacattgacccctccct       c.*300

          .         .         .         .         .         .       g.80826
 ccatgtggtaaaccactccagaatggccaccaggcttcccagagttctatggtcttcttc       c.*360

          .         .         .         .         .         .       g.80886
 ccaagagagtttttaattgtaaatgcatacttgggaaggacttagagttttaaactgttt       c.*420

          .         .         .         .         .         .       g.80946
 tttgcttttgcttttccctgactccctttgcttggagtcagctgcacaccagtagtatgg       c.*480

          .         .         .         .         .         .       g.81006
 catgctacgatcaggttctgtcctgaaagctttgcctctttcttggcaaagtttctggta       c.*540

          .         .         .         .         .         .       g.81066
 tggtcaagcttgtaaataactttttttacattttaatcttttccattaattaagaggttg       c.*600

          .         .         .         .         .         .       g.81126
 aaaagaagtgcagtgtaagaaaacccagcattttaattacttgcaaattaagttaccaca       c.*660

          .         .         .         .         .         .       g.81186
 gactctgtagtgtgtaaatgttgacaaggaattggatcacaatcatgtagcagaatggca       c.*720

          .         .         .         .         .         .       g.81246
 cccagaccactgcccaccagtgacggacatgcacgtggcagatcatgatttccagcccac       c.*780

          .         .         .         .         .         .       g.81306
 ggagccagcatttgaaccttgtataattaactttcagttatgatttcccatcgacatttt       c.*840

          .         .         .         .         .         .       g.81366
 ctttgccctgtttgtagctgattgttgtgttttataaatcttctgttaaggcagaagggt       c.*900

          .         .         .         .         .         .       g.81426
 gattatgagtggttcacagcagcccttataagctgggccagaaaatttcactaggtcagt       c.*960

          .         .         .         .         .         .       g.81486
 aatttaaaccttggatcttcaaaaaataaaataatgtgaagcaaaaccaactaaaaagtg       c.*1020

          .         .         .         .         .         .       g.81546
 attcttgcacatgaactgtcacatgtttaaaaatgtgttttttagagagcctcagtctta       c.*1080

          .         .         .         .         .         .       g.81606
 ctgatttcaaacacttttttcttctgtgtattgcttttaagagagccatcagttagctat       c.*1140

          .         .         .         .         .         .       g.81666
 cagactctaggttgatgcattttgtacttagctgtactgtgtgatatttttcattatttt       c.*1200

          .         .         .         .         .         .       g.81726
 aggacgccaacatgagacctgtaataaaatatgtaatggggttgaaagctggggaggagg       c.*1260

          .         .         .         .         .                 g.81779
 atctactgctgtacagctaataaatcataacggattaacaagtgctccaaaga              c.*1313

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The CCCTC-binding factor (zinc finger protein) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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