inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG) - coding DNA reference sequence

(used for variant description)

(last modified June 28, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_003639.3 in the IKBKG gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009896.1, covering IKBKG transcript NM_003639.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.10621
                                           agcccgttcctgctccgc       c.-241

 .         .         .         .         .         .                g.10681
 gcttctggagcactggccaaggcgggccgattcaggacccaggttacttgggcggcgagc       c.-181

 .         .         .         .         .         .                g.10741
 tggactgtttctactcctccctcctcctccactgcggggtctgaccctactccttgtgtg       c.-121

 .         .         .         .         .         .                g.10801
 aggactcctctagttcagagacatattctgttcaccaaacttgactgcgctctatcgagg       c.-61

 .         .         .         .         .     | 02   .             g.14759
 tcgttaaattcttcggaaatgcctcacatatagtttggcagctag | cccttgccctgttgg    c.-1

          .         .         .         .         .         .       g.14819
 ATGAATAGGCACCTCTGGAAGAGCCAACTGTGTGAGATGGTGCAGCCCAGTGGTGGCCCG       c.60
 M  N  R  H  L  W  K  S  Q  L  C  E  M  V  Q  P  S  G  G  P         p.20

          .         .         .         .         .         .       g.14879
 GCAGCAGATCAGGACGTACTGGGCGAAGAGTCTCCTCTGGGGAAGCCAGCCATGCTGCAC       c.120
 A  A  D  Q  D  V  L  G  E  E  S  P  L  G  K  P  A  M  L  H         p.40

          .         .         .         .         .         .       g.14939
 CTGCCTTCAGAACAGGGCGCTCCTGAGACCCTCCAGCGCTGCCTGGAGGAGAATCAAGAG       c.180
 L  P  S  E  Q  G  A  P  E  T  L  Q  R  C  L  E  E  N  Q  E         p.60

         | 03.         .         .         .         .         .    g.18974
 CTCCGAG | ATGCCATCCGGCAGAGCAACCAGATTCTGCGGGAGCGCTGCGAGGAGCTTCTG    c.240
 L  R  D |   A  I  R  Q  S  N  Q  I  L  R  E  R  C  E  E  L  L      p.80

          .         .         .         .         .         .       g.19034
 CATTTCCAAGCCAGCCAGAGGGAGGAGAAGGAGTTCCTCATGTGCAAGTTCCAGGAGGCC       c.300
 H  F  Q  A  S  Q  R  E  E  K  E  F  L  M  C  K  F  Q  E  A         p.100

          .         .         .         .         .         .       g.19094
 AGGAAACTGGTGGAGAGACTCGGCCTGGAGAAGCTCGATCTGAAGAGGCAGAAGGAGCAG       c.360
 R  K  L  V  E  R  L  G  L  E  K  L  D  L  K  R  Q  K  E  Q         p.120

          .         .         .          | 04        .         .    g.21309
 GCTCTGCGGGAGGTGGAGCACCTGAAGAGATGCCAGCAG | CAGATGGCTGAGGACAAGGCC    c.420
 A  L  R  E  V  E  H  L  K  R  C  Q  Q   | Q  M  A  E  D  K  A      p.140

          .         .         .         .         .         .       g.21369
 TCTGTGAAAGCCCAGGTGACGTCCTTGCTCGGGGAGCTGCAGGAGAGCCAGAGTCGCTTG       c.480
 S  V  K  A  Q  V  T  S  L  L  G  E  L  Q  E  S  Q  S  R  L         p.160

          .         .         .         | 05         .         .    g.23185
 GAGGCTGCCACTAAGGAATGCCAGGCTCTGGAGGGTCG | GGCCCGGGCGGCCAGCGAGCAG    c.540
 E  A  A  T  K  E  C  Q  A  L  E  G  R  |  A  R  A  A  S  E  Q      p.180

          .         .         .         .         .         .       g.23245
 GCGCGGCAGCTGGAGAGTGAGCGCGAGGCGCTGCAGCAGCAGCACAGCGTGCAGGTGGAC       c.600
 A  R  Q  L  E  S  E  R  E  A  L  Q  Q  Q  H  S  V  Q  V  D         p.200

          .         .         .         .         .         .       g.23305
 CAGCTGCGCATGCAGGGCCAGAGCGTGGAGGCCGCGCTCCGCATGGAGCGCCAGGCCGCC       c.660
 Q  L  R  M  Q  G  Q  S  V  E  A  A  L  R  M  E  R  Q  A  A         p.220

          .  | 06      .         .         .         .         .    g.24493
 TCGGAGGAGAA | GAGGAAGCTGGCCCAGTTGCAGGTGGCCTATCACCAGCTCTTCCAAGAA    c.720
 S  E  E  K  |  R  K  L  A  Q  L  Q  V  A  Y  H  Q  L  F  Q  E      p.240

          .         .         .         .         | 07         .    g.25578
 TACGACAACCACATCAAGAGCAGCGTGGTGGGCAGTGAGCGGAAGCGA | GGAATGCAGCTG    c.780
 Y  D  N  H  I  K  S  S  V  V  G  S  E  R  K  R   | G  M  Q  L      p.260

          .         .         .         .         .         .       g.25638
 GAAGATCTCAAACAGCAGCTCCAGCAGGCCGAGGAGGCCCTGGTGGCCAAACAGGAGGTG       c.840
 E  D  L  K  Q  Q  L  Q  Q  A  E  E  A  L  V  A  K  Q  E  V         p.280

          .         .         .         .         .         .       g.25698
 ATCGATAAGCTGAAGGAGGAGGCCGAGCAGCACAAGATTGTGATGGAGACCGTTCCGGTG       c.900
 I  D  K  L  K  E  E  A  E  Q  H  K  I  V  M  E  T  V  P  V         p.300

          .   | 08     .         .         .         .         .    g.26363
 CTGAAGGCCCAG | GCGGATATCTACAAGGCGGACTTCCAGGCTGAGAGGCAGGCCCGGGAG    c.960
 L  K  A  Q   | A  D  I  Y  K  A  D  F  Q  A  E  R  Q  A  R  E      p.320

          .         .         .         .         .         .       g.26423
 AAGCTGGCCGAGAAGAAGGAGCTCCTGCAGGAGCAGCTGGAGCAGCTGCAGAGGGAGTAC       c.1020
 K  L  A  E  K  K  E  L  L  Q  E  Q  L  E  Q  L  Q  R  E  Y         p.340

          .         .         .      | 09  .         .         .    g.26740
 AGCAAACTGAAGGCCAGCTGTCAGGAGTCGGCCAG | GATCGAGGACATGAGGAAGCGGCAT    c.1080
 S  K  L  K  A  S  C  Q  E  S  A  R  |  I  E  D  M  R  K  R  H      p.360

          .         .         .        | 10.         .         .    g.27098
 GTCGAGGTCTCCCAGGCCCCCTTGCCCCCCGCCCCTG | CCTACCTCTCCTCTCCCCTGGCC    c.1140
 V  E  V  S  Q  A  P  L  P  P  A  P  A |   Y  L  S  S  P  L  A      p.380

          .         .         .         .         .         .       g.27158
 CTGCCCAGCCAGAGGAGGAGCCCCCCCGAGGAGCCACCTGACTTCTGCTGTCCCAAGTGC       c.1200
 L  P  S  Q  R  R  S  P  P  E  E  P  P  D  F  C  C  P  K  C         p.400

          .         .         .         .         .         .       g.27218
 CAGTATCAGGCCCCTGATATGGACACCCTGCAGATACATGTCATGGAGTGCATTGAGTAG       c.1260
 Q  Y  Q  A  P  D  M  D  T  L  Q  I  H  V  M  E  C  I  E  X         p.419

          .         .         .         .         .         .       g.27278
 ggccggccagtgcaaggccactgcctgccgaggacgtgcccgggaccgtgcagtctgcgc       c.*60

          .         .         .         .         .         .       g.27338
 tttcctctcccgcctgcctagcccaggatgaagggctgggtggccacaactgggatgcca       c.*120

          .         .         .         .         .         .       g.27398
 cctggagccccacccaggagctggccgcggcaccttacgcttcagctgttgatccgctgg       c.*180

          .         .         .         .         .         .       g.27458
 tcccctcttttggggtagatgcggccccgatcaggcctgactcgctgctctttttgttcc       c.*240

          .         .         .         .         .         .       g.27518
 cttctgtctgctcgaaccacttgcctcgggctaatccctccctcttcctccacccggcac       c.*300

          .         .         .         .         .         .       g.27578
 tggggaagtcaagaatggggcctggggctctcagggagaactgcttcccctggcagagct       c.*360

          .         .         .         .         .         .       g.27638
 gggtggcagctcttcctcccaccggacaccgacccgcccgctgctgtgccctgggagtgc       c.*420

          .         .         .         .         .         .       g.27698
 tgccctcttaccatgcacacgggtgctctccttttgggctgcatgctattccattttgca       c.*480

          .         .         .         .         .         .       g.27758
 gccagaccgatgtgtatttaaccagtcactattgatggacatttgggttgtttcccatct       c.*540

          .         .         .         .                           g.27803
 ttttgttaccataaataatggcatagtaaaaatccttgtgcatta                      c.*585

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 05
©2004-2013 Leiden University Medical Center