sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B (SEMA6B) - coding DNA reference sequence

(used for variant description)

(last modified June 21, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_032108.3 in the SEMA6B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering SEMA6B transcript NM_032108.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       gaggtcttcctgtttttggagg       c.-241

 .         .         .         .         .         .                g.5082
 gggcaggcaccccagggccgattgtcgcgaatcaccttcacctctgggggctcagaatcc       c.-181

 .         .         .         .         .         .                g.5142
 ctgagccagaaggccagggcagggctgggggatacccctgctgctcagacaggaaaatgg       c.-121

 .         .         .         .         .         .                g.5202
 gctcggagcttgcccaatacttcccagaaggacgaggctgctgaacttctcattcggggc       c.-61

 .         .         .        | 02.         .         .             g.6302
 tccgggacctggactgtacccctttctg | gcgtcacctcctcctgtcgcctggccctcgcc    c.-1

          .         .         .         .         .         .       g.6362
 ATGCAGACCCCGCGAGCGTCCCCTCCCCGCCCGGCCCTGCTGCTTCTGCTGCTGCTACTG       c.60
 M  Q  T  P  R  A  S  P  P  R  P  A  L  L  L  L  L  L  L  L         p.20

          .         .         .         .         .         .       g.6422
 GGGGGCGCCCACGGCCTCTTTCCTGAGGAGCCGCCGCCGCTTAGCGTGGCCCCCAGGGAC       c.120
 G  G  A  H  G  L  F  P  E  E  P  P  P  L  S  V  A  P  R  D         p.40

   | 03      .         .         .         .         .         .    g.6669
 T | ACCTGAACCACTATCCCGTGTTTGTGGGCAGCGGGCCCGGACGCCTGACCCCCGCAGAA    c.180
 Y |   L  N  H  Y  P  V  F  V  G  S  G  P  G  R  L  T  P  A  E      p.60

          .         .         .         .         .         .       g.6729
 GGTGCTGACGACCTCAACATCCAGCGAGTCCTGCGGGTCAACAGGACGCTGTTCATTGGG       c.240
 G  A  D  D  L  N  I  Q  R  V  L  R  V  N  R  T  L  F  I  G         p.80

       | 04  .         .         .         .         .         .    g.7591
 GACAG | GGACAACCTCTACCGCGTAGAGCTGGAGCCCCCCACGTCCACGGAGCTGCGGTAC    c.300
 D  R  |  D  N  L  Y  R  V  E  L  E  P  P  T  S  T  E  L  R  Y      p.100

        | 05 .         .         .         .         .         .    g.7800
 CAGAGG | AAGCTGACCTGGAGATCTAACCCCAGCGACATAAACGTGTGTCGGATGAAGGGC    c.360
 Q  R   | K  L  T  W  R  S  N  P  S  D  I  N  V  C  R  M  K  G      p.120

           | 06        .         .         .         .         .    g.8721
 AAACAGGAG | GGCGAGTGTCGAAACTTCGTAAAGGTGCTGCTCCTTCGGGACGAGTCCACG    c.420
 K  Q  E   | G  E  C  R  N  F  V  K  V  L  L  L  R  D  E  S  T      p.140

          .         .         .         .         .  | 07      .    g.9204
 CTCTTTGTGTGCGGTTCCAACGCCTTCAACCCGGTGTGCGCCAACTACAGC | ATAGACACC    c.480
 L  F  V  C  G  S  N  A  F  N  P  V  C  A  N  Y  S   | I  D  T      p.160

          .         .         .         .         .         .       g.9264
 CTGCAGCCCGTCGGAGACAACATCAGCGGTATGGCCCGCTGCCCGTACGACCCCAAGCAC       c.540
 L  Q  P  V  G  D  N  I  S  G  M  A  R  C  P  Y  D  P  K  H         p.180

          .         .   | 08     .         .         .         .    g.9702
 GCCAATGTTGCCCTCTTCTCTG | ACGGGATGCTCTTCACAGCTACTGTTACCGACTTCCTA    c.600
 A  N  V  A  L  F  S  D |   G  M  L  F  T  A  T  V  T  D  F  L      p.200

          .         .         .         .         .         .       g.9762
 GCCATTGATGCTGTCATCTACCGCAGCCTCGGGGACAGGCCCACCCTGCGCACCGTGAAA       c.660
 A  I  D  A  V  I  Y  R  S  L  G  D  R  P  T  L  R  T  V  K         p.220

          .         .   | 09     .         .         .         .    g.10321
 CATGACTCCAAGTGGTTCAAAG | AGCCTTACTTTGTCCATGCGGTGGAGTGGGGCAGCCAT    c.720
 H  D  S  K  W  F  K  E |   P  Y  F  V  H  A  V  E  W  G  S  H      p.240

          .         .         .         .         .  | 10      .    g.12129
 GTCTACTTCTTCTTCCGGGAGATTGCGATGGAGTTTAACTACCTGGAGAAG | GTGGTGGTG    c.780
 V  Y  F  F  F  R  E  I  A  M  E  F  N  Y  L  E  K   | V  V  V      p.260

          .         .         .         .         .         .       g.12189
 TCCCGCGTGGCCCGAGTGTGCAAGAACGACGTGGGAGGCTCCCCCCGCGTGCTGGAGAAG       c.840
 S  R  V  A  R  V  C  K  N  D  V  G  G  S  P  R  V  L  E  K         p.280

          .         .         .         .         .         .       g.12249
 CAGTGGACGTCCTTCCTGAAGGCGCGGCTCAACTGCTCTGTACCCGGAGACTCCCATTTC       c.900
 Q  W  T  S  F  L  K  A  R  L  N  C  S  V  P  G  D  S  H  F         p.300

          .         .         .         .         .         .       g.12309
 TACTTCAACGTGCTGCAGGCTGTCACGGGCGTGGTCAGCCTCGGGGGCCGGCCCGTGGTC       c.960
 Y  F  N  V  L  Q  A  V  T  G  V  V  S  L  G  G  R  P  V  V         p.320

          .         .          | 11        .         .         .    g.13860
 CTGGCCGTTTTTTCCACGCCCAGCAACAG | CATCCCTGGCTCGGCTGTCTGCGCCTTTGAC    c.1020
 L  A  V  F  S  T  P  S  N  S  |  I  P  G  S  A  V  C  A  F  D      p.340

          .         .         .         .         .         .       g.13920
 CTGACACAGGTGGCAGCTGTGTTTGAAGGCCGCTTCCGAGAGCAGAAGTCCCCCGAGTCC       c.1080
 L  T  Q  V  A  A  V  F  E  G  R  F  R  E  Q  K  S  P  E  S         p.360

          .         .         .         .  | 12      .         .    g.14506
 ATCTGGACGCCGGTGCCGGAGGATCAGGTGCCTCGACCCCG | GCCCGGGTGCTGCGCAGCC    c.1140
 I  W  T  P  V  P  E  D  Q  V  P  R  P  R  |  P  G  C  C  A  A      p.380

          .         .         .         .         .         .       g.14566
 CCCGGGATGCAGTACAATGCCTCCAGCGCCTTGCCGGATGACATCCTCAACTTTGTCAAG       c.1200
 P  G  M  Q  Y  N  A  S  S  A  L  P  D  D  I  L  N  F  V  K         p.400

          .         .         .         .         .         .       g.14626
 ACCCACCCTCTGATGGACGAGGCGGTGCCCTCGCTGGGCCATGCGCCCTGGATCCTGCGG       c.1260
 T  H  P  L  M  D  E  A  V  P  S  L  G  H  A  P  W  I  L  R         p.420

          .  | 13      .         .         .         .         .    g.16363
 ACCCTGATGAG | GCACCAGCTGACTCGAGTGGCTGTGGACGTGGGAGCCGGCCCCTGGGGC    c.1320
 T  L  M  R  |  H  Q  L  T  R  V  A  V  D  V  G  A  G  P  W  G      p.440

          .         .         .         .         .         .       g.16423
 AACCAGACCGTTGTCTTCCTGGGTTCTGAGGCGGGGACGGTCCTCAAGTTCCTCGTCCGG       c.1380
 N  Q  T  V  V  F  L  G  S  E  A  G  T  V  L  K  F  L  V  R         p.460

          .         .         .         .         .         .       g.16483
 CCCAATGCCAGCACCTCAGGGACGTCTGGGCTCAGTGTCTTCCTGGAGGAGTTTGAGACC       c.1440
 P  N  A  S  T  S  G  T  S  G  L  S  V  F  L  E  E  F  E  T         p.480

          .     | 14   .         .         .         .         .    g.16632
 TACCGGCCGGACAG | GTGTGGACGGCCCGGCGGTGGCGAGACAGGGCAGCGGCTGCTGAGC    c.1500
 Y  R  P  D  R  |  C  G  R  P  G  G  G  E  T  G  Q  R  L  L  S      p.500

          .         .         .         .         .         .       g.16692
 TTGGAGCTGGACGCAGCTTCGGGGGGCCTGCTGGCTGCCTTCCCCCGCTGCGTGGTCCGA       c.1560
 L  E  L  D  A  A  S  G  G  L  L  A  A  F  P  R  C  V  V  R         p.520

          .         .         .         .  | 15      .         .    g.18309
 GTGCCTGTGGCTCGCTGCCAGCAGTACTCGGGGTGTATGAA | GAACTGTATCGGCAGTCAG    c.1620
 V  P  V  A  R  C  Q  Q  Y  S  G  C  M  K  |  N  C  I  G  S  Q      p.540

          .         .         .         .         .          | 16    g.18486
 GACCCCTACTGCGGGTGGGCCCCCGACGGCTCCTGCATCTTCCTCAGCCCGGGCACCAG | A    c.1680
 D  P  Y  C  G  W  A  P  D  G  S  C  I  F  L  S  P  G  T  R  |      p.560

          .         .         .         .         .         | 17    g.20232
 GCCGCCTTTGAGCAGGACGTGTCCGGGGCCAGCACCTCAGGCTTAGGGGACTGCACAG | GA    c.1740
 A  A  F  E  Q  D  V  S  G  A  S  T  S  G  L  G  D  C  T  G |       p.580

          .         .         .         .         .         .       g.20292
 CTCCTGCGGGCCAGCCTCTCCGAGGACCGCGCGGGGCTGGTGTCGGTGAACCTGCTGGTA       c.1800
 L  L  R  A  S  L  S  E  D  R  A  G  L  V  S  V  N  L  L  V         p.600

          .         .         .         .         .         .       g.20352
 ACGTCGTCGGTGGCGGCCTTCGTGGTGGGAGCCGTGGTGTCCGGCTTCAGCGTGGGCTGG       c.1860
 T  S  S  V  A  A  F  V  V  G  A  V  V  S  G  F  S  V  G  W         p.620

          .         .         .         .         .         .       g.20412
 TTCGTGGGCCTCCGTGAGCGGCGGGAGCTGGCCCGGCGCAAGGACAAGGAGGCCATCCTG       c.1920
 F  V  G  L  R  E  R  R  E  L  A  R  R  K  D  K  E  A  I  L         p.640

          .         .         .         .         .         .       g.20472
 GCGCACGGGGCGGGCGAGGCGGTGCTGAGCGTCAGCCGCCTGGGCGAGCGCAGGGCGCAG       c.1980
 A  H  G  A  G  E  A  V  L  S  V  S  R  L  G  E  R  R  A  Q         p.660

          .         .         .         .         .         .       g.20532
 GGTCCCGGGGGCCGGGGCGGAGGCGGTGGCGGTGGCGCCGGGGTTCCCCCGGAGGCCCTG       c.2040
 G  P  G  G  R  G  G  G  G  G  G  G  A  G  V  P  P  E  A  L         p.680

          .         .         .         .         .         .       g.20592
 CTGGCGCCCCTGATGCAGAACGGCTGGGCCAAGGCCACGCTGCTGCAGGGCGGGCCCCAC       c.2100
 L  A  P  L  M  Q  N  G  W  A  K  A  T  L  L  Q  G  G  P  H         p.700

          .         .         .         .         .         .       g.20652
 GACCTGGACTCGGGGCTGCTGCCCACGCCCGAGCAGACGCCGCTGCCGCAGAAGCGCCTG       c.2160
 D  L  D  S  G  L  L  P  T  P  E  Q  T  P  L  P  Q  K  R  L         p.720

          .         .         .         .         .         .       g.20712
 CCCACTCCGCACCCGCACCCCCACGCCCTGGGCCCCCGCGCCTGGGACCACGGCCACCCC       c.2220
 P  T  P  H  P  H  P  H  A  L  G  P  R  A  W  D  H  G  H  P         p.740

          .         .         .         .         .         .       g.20772
 CTGCTCCCGGCCTCCGCTTCATCCTCCCTCCTGCTGCTGGCGCCCGCCCGGGCCCCCGAG       c.2280
 L  L  P  A  S  A  S  S  S  L  L  L  L  A  P  A  R  A  P  E         p.760

          .         .         .         .         .         .       g.20832
 CAGCCCCCCGCGCCTGGGGAGCCGACCCCCGACGGCCGCCTCTATGCTGCCCGGCCCGGC       c.2340
 Q  P  P  A  P  G  E  P  T  P  D  G  R  L  Y  A  A  R  P  G         p.780

          .         .         .         .         .         .       g.20892
 CGCGCCTCCCACGGCGACTTCCCGCTCACCCCCCACGCCAGCCCGGACCGCCGGCGGGTG       c.2400
 R  A  S  H  G  D  F  P  L  T  P  H  A  S  P  D  R  R  R  V         p.800

          .         .         .         .         .         .       g.20952
 GTGTCCGCGCCCACGGGCCCCTTGGACCCAGCCTCAGCCGCCGATGGCCTCCCGCGGCCC       c.2460
 V  S  A  P  T  G  P  L  D  P  A  S  A  A  D  G  L  P  R  P         p.820

          .         .         .         .         .         .       g.21012
 TGGAGCCCGCCCCCGACGGGCAGCCTGAGGAGGCCACTGGGCCCCCACGCCCCTCCGGCC       c.2520
 W  S  P  P  P  T  G  S  L  R  R  P  L  G  P  H  A  P  P  A         p.840

          .         .         .         .         .         .       g.21072
 GCCACCCTGCGCCGCACCCACACGTTCAACAGCGGCGAGGCCCGGCCTGGGGACCGCCAC       c.2580
 A  T  L  R  R  T  H  T  F  N  S  G  E  A  R  P  G  D  R  H         p.860

          .         .         .         .         .         .       g.21132
 CGCGGCTGCCACGCCCGGCCGGGCACAGACTTGGCCCACCTCCTCCCCTATGGGGGGGCG       c.2640
 R  G  C  H  A  R  P  G  T  D  L  A  H  L  L  P  Y  G  G  A         p.880

          .         .                                               g.21159
 GACAGGACTGCGCCCCCCGTGCCCTAG                                        c.2667
 D  R  T  A  P  P  V  P  X                                          p.888

          .         .         .         .         .         .       g.21219
 gccgggggccccccgatgccttggcagtgccagccacgggaaccaggagcgagagacggt       c.*60

          .         .         .         .         .         .       g.21279
 gccagaacgccggggcccggggcaactccgagtgggtgctcaagtcccccccgcgaccca       c.*120

          .         .         .         .         .         .       g.21339
 cccgcggagtggggggccccctccgccacaaggaagcacaaccagctcgccctcccccta       c.*180

          .         .         .         .         .         .       g.21399
 cccggggccgcaggacgctgagacggtttgggggtgggtgggcgggaggactttgctatg       c.*240

          .         .         .         .         .         .       g.21459
 gatttgaggttgaccttatgcgcgtaggttttggttttttttgcagttttggtttctttt       c.*300

          .         .         .         .         .         .       g.21519
 gcggttttctaaccaattgcacaactccgttctcggggtggcggcaggcaggggaggctt       c.*360

          .         .         .         .         .         .       g.21579
 ggacgccggtggggaatggggggccacagctgcagacctaagccctcccccacccctgga       c.*420

          .         .         .         .         .         .       g.21639
 aaggtccctccccaacccaggcccctggcgtgtgtgggtgtgcgtgcgtgtgcgtgccgt       c.*480

          .         .         .         .         .         .       g.21699
 gttcgtgtgcaaggggccggggaggtgggcgtgtgtgtgcgtgccagcgaaggctgctgt       c.*540

          .         .         .         .         .         .       g.21759
 gggcgtgtgtgtcaagtgggccacgcgtgcagggtgtgtgtccacgagcgacgatcgtgg       c.*600

          .         .         .         .         .         .       g.21819
 tggccccagcggcctgggcgttggctgagccgacgctggggcttccagaaggcccggggg       c.*660

          .         .         .         .         .         .       g.21879
 tctccgaggtgccggttaggagtttgaaccccccccactctgcagagggaagcggggaca       c.*720

          .         .         .         .         .         .       g.21939
 atgccggggtttcaggcaggagacacgaggagggcctgcccggaagtcacatcggcagca       c.*780

          .         .         .         .         .         .       g.21999
 gctgtctaaagggcttgggggcctggggggcggcgaaggtgggtggggcccctctgtaaa       c.*840

          .         .         .         .         .         .       g.22059
 tacggccccagggtggtgagagagtcccatgccacccgtccccttgtgacctcccccctc       c.*900

          .         .         .         .         .         .       g.22119
 tgacctccagctgaccatgcatgccacgtggctggctgggtcctctgccctctctggagt       c.*960

          .         .         .         .         .                 g.22172
 ttgcctcccccagccccctccccatcaataaaactctgtttacaaccaccggc              c.*1013

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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