STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase (STUB1) - coding DNA reference sequence

(used for variant description)

(last modified November 16, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_005861.2 in the STUB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_034141.1, covering STUB1 transcript NM_005861.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          gctgttgcgggagcgcgccctcagcgaagcaagtgaggcatctcactggga       c.-361

 .         .         .         .         .         .                g.5111
 aagtcgaatgtgtgtggcggccgccgccgaggcgggttccgaagagacctcagcagggca       c.-301

 .         .         .         .         .         .                g.5171
 ggccagggcctacgcgaacgcccacccttaagagcgcggggacagggaactggagcgttc       c.-241

 .         .         .         .         .         .                g.5231
 ctcccagcccccgacgtcgcgggcccagtgtccccgtccaggctggttgggcgcacgcgc       c.-181

 .         .         .         .         .         .                g.5291
 ggccccactcgcccccacgcgtgcgtccccgctggtcccgcccccggccggaagttccgg       c.-121

 .         .         .         .         .         .                g.5351
 cggcggagctgggccgggcccgagcggatcgcgggctcgggctgcggggctccggctgcg       c.-61

 .         .         .         .         .         .                g.5411
 ggcgctgggccgcgaggcgcggagcttgggagcggagcccaggccgtgccgcgcggcgcc       c.-1

          .         .         .         .         .         .       g.5471
 ATGAAGGGCAAGGAGGAGAAGGAGGGCGGCGCACGGCTGGGCGCTGGCGGCGGAAGCCCC       c.60
 M  K  G  K  E  E  K  E  G  G  A  R  L  G  A  G  G  G  S  P         p.20

          .         .         .         .         .         .       g.5531
 GAGAAGAGCCCGAGCGCGCAGGAGCTCAAGGAGCAGGGCAATCGTCTGTTCGTGGGCCGA       c.120
 E  K  S  P  S  A  Q  E  L  K  E  Q  G  N  R  L  F  V  G  R         p.40

          .         .         .          | 02        .         .    g.6058
 AAGTACCCGGAGGCGGCGGCCTGCTACGGCCGCGCGATC | ACCCGGAACCCGCTGGTGGCC    c.180
 K  Y  P  E  A  A  A  C  Y  G  R  A  I   | T  R  N  P  L  V  A      p.60

          .         .         .         .         .         .       g.6118
 GTGTATTACACCAACCGGGCCTTGTGCTACCTGAAGATGCAGCAGCACGAGCAGGCCCTG       c.240
 V  Y  Y  T  N  R  A  L  C  Y  L  K  M  Q  Q  H  E  Q  A  L         p.80

          .         .         .         .         .         .       g.6178
 GCCGACTGCCGGCGCGCCCTGGAGCTGGACGGGCAGTCTGTGAAGGCGCACTTCTTCCTG       c.300
 A  D  C  R  R  A  L  E  L  D  G  Q  S  V  K  A  H  F  F  L         p.100

          .         .         .         .         .         | 03    g.6325
 GGGCAGTGCCAGCTGGAGATGGAGAGCTATGATGAGGCCATCGCCAATCTGCAGCGAG | CT    c.360
 G  Q  C  Q  L  E  M  E  S  Y  D  E  A  I  A  N  L  Q  R  A |       p.120

          .         .         .         .         .         .       g.6385
 TACAGCCTGGCCAAGGAGCAGCGGCTGAACTTCGGGGACGACATCCCCAGCGCTCTTCGA       c.420
 Y  S  L  A  K  E  Q  R  L  N  F  G  D  D  I  P  S  A  L  R         p.140

          .         .         .         .         .         .       g.6445
 ATCGCGAAGAAGAAGCGCTGGAACAGCATTGAGGAGCGGCGCATCCACCAGGAGAGCGAG       c.480
 I  A  K  K  K  R  W  N  S  I  E  E  R  R  I  H  Q  E  S  E         p.160

          .         .         .         .     | 04   .         .    g.6694
 CTGCACTCCTACCTCTCCAGGCTCATTGCCGCGGAGCGTGAGAG | GGAGCTGGAAGAGTGC    c.540
 L  H  S  Y  L  S  R  L  I  A  A  E  R  E  R  |  E  L  E  E  C      p.180

          .         .         .         .         .         .       g.6754
 CAGCGAAACCACGAGGGTGATGAGGACGACAGCCACGTCCGGGCCCAGCAGGCCTGCATT       c.600
 Q  R  N  H  E  G  D  E  D  D  S  H  V  R  A  Q  Q  A  C  I         p.200

          .   | 05     .         .         .         .         .    g.6953
 GAGGCCAAGCAC | GACAAGTACATGGCGGACATGGACGAGCTTTTTTCTCAGGTGGATGAG    c.660
 E  A  K  H   | D  K  Y  M  A  D  M  D  E  L  F  S  Q  V  D  E      p.220

           | 06        .         .         .         .         .    g.7101
 AAGAGGAAG | AAGCGAGACATCCCCGACTACCTGTGTGGCAAGATCAGCTTTGAGCTGATG    c.720
 K  R  K   | K  R  D  I  P  D  Y  L  C  G  K  I  S  F  E  L  M      p.240

          .         .         .         .         .         .       g.7161
 CGGGAGCCGTGCATCACGCCCAGTGGCATCACCTACGACCGCAAGGACATCGAGGAGCAC       c.780
 R  E  P  C  I  T  P  S  G  I  T  Y  D  R  K  D  I  E  E  H         p.260

        | 07 .         .         .         .         .         .    g.7303
 CTGCAG | CGTGTGGGTCATTTTGACCCCGTGACCCGGAGCCCCCTGACCCAGGAACAGCTC    c.840
 L  Q   | R  V  G  H  F  D  P  V  T  R  S  P  L  T  Q  E  Q  L      p.280

          .         .         .         .         .         .       g.7363
 ATCCCCAACTTGGCTATGAAGGAGGTTATTGACGCATTCATCTCTGAGAATGGCTGGGTG       c.900
 I  P  N  L  A  M  K  E  V  I  D  A  F  I  S  E  N  G  W  V         p.300

          .                                                         g.7375
 GAGGACTACTGA                                                       c.912
 E  D  Y  X                                                         p.303

          .         .         .         .         .         .       g.7435
 ggttccctgccctacctggcgtcctggtccaggggagccctgggcagaagcccccggccc       c.*60

          .         .         .         .         .         .       g.7495
 ctatacatagtttatgttcctggccaccccgaccgcttcccccaagttctgctgttggac       c.*120

          .         .         .         .         .         .       g.7555
 tctggactgtttcccctctcagcatcgcttttgctgggccgtgatcgtccccctttgtgg       c.*180

          .         .         .         .         .         .       g.7615
 gctggaaaagcaggtgagggtgggctgggctgaggccattgccgccactatctgtgtaat       c.*240

          .         .         .                                     g.7654
 aaaatccgtgagcacgaggtgggacgtgctggtgtgtga                            c.*279

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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