transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila) (TLE6) - coding DNA reference sequence

(used for variant description)

(last modified December 27, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_001143986.1 in the TLE6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering TLE6 transcript NM_001143986.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5049
            aaatggcccccggtgggggaaggaggagtttcctcttggcctgaacttg       c.-61

 .         .         .    | 02    .         .         .             g.5696
 gctgacctccgcagcttccgcccg | actctggctaaagtcttggaggctactgccttgaag    c.-1

          .         .         .         .         .  | 03      .    g.7571
 ATGACCTCTAGGGACCAGCCCAGACCCAAGGGCCCCCCGAAAAGCACTTCG | CCTTGTCCT    c.60
 M  T  S  R  D  Q  P  R  P  K  G  P  P  K  S  T  S   | P  C  P      p.20

          .         .         .         .         .         .       g.7631
 GGGATCTCGAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCTAAATCGGCTC       c.120
 G  I  S  N  S  E  S  S  P  T  L  N  Y  Q  G  I  L  N  R  L         p.40

          .     | 04   .         .         .         .         .    g.9046
 AAGCAGTTCCCCAG | GTTTTCTCCTCATTTTGCTGCGGAGTTGGAGAGCATTTACTACTCG    c.180
 K  Q  F  P  R  |  F  S  P  H  F  A  A  E  L  E  S  I  Y  Y  S      p.60

  | 05       .         .         .         .   | 06     .         . g.14309
  | CTGCACAAGATCCAGCAGGATGTGGCAGAACATCACAAGCAG | ATAGGAAACGTCTTACAG c.240
  | L  H  K  I  Q  Q  D  V  A  E  H  H  K  Q   | I  G  N  V  L  Q   p.80

          .         .         .         .      | 07  .         .    g.14460
 ATTGTGGAGAGCTGCAGCCAACTCCAGGGTTTCCAGTCTGAGGAG | GTCTCACCTGCTGAA    c.300
 I  V  E  S  C  S  Q  L  Q  G  F  Q  S  E  E   | V  S  P  A  E      p.100

          .         .         .         .         .         .       g.14520
 CCAGCCAGCCCTGGGACGCCCCAGCAGGTGAAGGACAAGACCCTGCAGGAGTCGAGCTTT       c.360
 P  A  S  P  G  T  P  Q  Q  V  K  D  K  T  L  Q  E  S  S  F         p.120

          .         .         .         .         .         .       g.14580
 GAGGACATCATGGCCACCAGGTCCTCCGACTGGCTCCGGCGGCCTTTGGGGGAGGACAAT       c.420
 E  D  I  M  A  T  R  S  S  D  W  L  R  R  P  L  G  E  D  N         p.140

          .         .         .         .         .         .       g.14640
 CAGCCGGAGACCCAGCTGTTCTGGGACAAGGAGCCTTGGTTTTGGCACGACACTCTGACC       c.480
 Q  P  E  T  Q  L  F  W  D  K  E  P  W  F  W  H  D  T  L  T         p.160

          .         .         .         .         .         .       g.14700
 GAGCAACTCTGGCGGATTTTTGCCGGCGTCCACGATGAGAAGGCAAAGCCCAGAGACAGA       c.540
 E  Q  L  W  R  I  F  A  G  V  H  D  E  K  A  K  P  R  D  R         p.180

   | 08      .         | 09         .         .         .         . g.15228
 C | AGCAGGCACCAGGCCTG | GGGCAGGAAAGCAAGGCACCAGGATCCTGTGACCCAGGAACA c.600
 Q |   Q  A  P  G  L   | G  Q  E  S  K  A  P  G  S  C  D  P  G  T   p.200

          .         .      | 10  .         .         .         .    g.15395
 GACCCATGTCCTGAAGATGCCTCCA | CCCCCAGGCCACCTGAGGCCTCCTCCAGTCCCCCT    c.660
 D  P  C  P  E  D  A  S  T |   P  R  P  P  E  A  S  S  S  P  P      p.220

          .         .         .         .   | 11     .         .    g.15571
 GAGGGTTCCCAAGACAGGAACACAAGTTGGGGTGTGGTCCAG | GAGCCTCCTGGAAGAGCC    c.720
 E  G  S  Q  D  R  N  T  S  W  G  V  V  Q   | E  P  P  G  R  A      p.240

          .         . | 12       .         .         .         .    g.16563
 TCTCGGTTTCTACAGTCCAT | ATCCTGGGACCCTGAGGACTTTGAAGATGCATGGAAGAGG    c.780
 S  R  F  L  Q  S  I  |  S  W  D  P  E  D  F  E  D  A  W  K  R      p.260

          .         .         .         .         .         .       g.16623
 CCAGATGCCTTGCCCGGGCAGTCAAAGAGACTCGCCGTCCCGTGCAAACTGGAAAAGATG       c.840
 P  D  A  L  P  G  Q  S  K  R  L  A  V  P  C  K  L  E  K  M         p.280

          .         .         .         .         .         .       g.16683
 CGGATCTTGGCACACGGGGAGCTCGTGCTCGCCACGGCCATCAGCAGCTTCACGCGGCAC       c.900
 R  I  L  A  H  G  E  L  V  L  A  T  A  I  S  S  F  T  R  H         p.300

          .         .         .         .         .         .       g.16743
 GTGTTCACCTGTGGCAGAAGAGGCATCAAGGTGTGGAGCCTGACTGGACAGGTGGCTGAG       c.960
 V  F  T  C  G  R  R  G  I  K  V  W  S  L  T  G  Q  V  A  E         p.320

          .         .         .    | 13    .         .         .    g.17024
 GACAGGTTCCCTGAGAGCCACCTGCCTATACAG | ACCCCTGGGGCCTTCCTGCGCACCTGC    c.1020
 D  R  F  P  E  S  H  L  P  I  Q   | T  P  G  A  F  L  R  T  C      p.340

          .         .         .         .         .         .       g.17084
 CTGCTGTCCTCAAACAGCAGGAGCCTGCTCACCGGTGGCTACAACCTGGCCAGCGTGAGC       c.1080
 L  L  S  S  N  S  R  S  L  L  T  G  G  Y  N  L  A  S  V  S         p.360

          .         .         .         .         .         .       g.17144
 GTGTGGGACCTGGCGGCGCCCTCCCTGCATGTGAAGGAGCAGTTGCCCTGTGCAGGTCTC       c.1140
 V  W  D  L  A  A  P  S  L  H  V  K  E  Q  L  P  C  A  G  L         p.380

          .         .         .         .         .         .       g.17204
 AACTGCCAGGCCCTGGATGCCAACCTGGATGCCAACCTGGCCTTCGCCAGCTTCACCAGT       c.1200
 N  C  Q  A  L  D  A  N  L  D  A  N  L  A  F  A  S  F  T  S         p.400

          .         .         .         .     | 14   .         .    g.19321
 GGTGTGGTCAGGATCTGGGACCTGCGGGATCAGAGTGTGGTCAG | GGACCTCAAGGGTTAT    c.1260
 G  V  V  R  I  W  D  L  R  D  Q  S  V  V  R  |  D  L  K  G  Y      p.420

          .         .         .         .         .         .       g.19381
 CCTGATGGAGTCAAGAGTATCGTGGTCAAGGGCTACAACATCTGGACTGGGGGTCCGGAT       c.1320
 P  D  G  V  K  S  I  V  V  K  G  Y  N  I  W  T  G  G  P  D         p.440

          .         .         .         .         .         .       g.19441
 GCCTGTCTGCGGTGCTGGGACCAGAGGACCATCATGAAACCTCTGGAGTACCAATTCAAG       c.1380
 A  C  L  R  C  W  D  Q  R  T  I  M  K  P  L  E  Y  Q  F  K         p.460

        | 15 .         .         .         .         .         .    g.20948
 TCTCAG | ATAATGAGCCTGTCCCACAGCCCCCAGGAGGACTGGGTGCTGCTGGGCATGGCC    c.1440
 S  Q   | I  M  S  L  S  H  S  P  Q  E  D  W  V  L  L  G  M  A      p.480

          .         .         .         .         .         .       g.21008
 AATGGCCAGCAGTGGCTGCAAAGCACCAGCGGGAGCCAGCGGCACATGGTGGGGCAAAAA       c.1500
 N  G  Q  Q  W  L  Q  S  T  S  G  S  Q  R  H  M  V  G  Q  K         p.500

          .         .         .        | 16.         .         .    g.21504
 GACAGCGTCATCCTGAGCGTCAAGTTCTCCCCCTTTG | GCCAGTGGTGGGCAAGCGTTGGA    c.1560
 D  S  V  I  L  S  V  K  F  S  P  F  G |   Q  W  W  A  S  V  G      p.520

          .         .         .         .         .     | 17   .    g.22368
 ATGGACGACTTCCTTGGCGTCTACAGCATGCCGGCGGGGACAAAAGTGTTCGAG | GTGCCT    c.1620
 M  D  D  F  L  G  V  Y  S  M  P  A  G  T  K  V  F  E   | V  P      p.540

          .         .         .         .         .         .       g.22428
 GAGATGTCTCCAGTCACGTGCTGTGACGTCTCTTCCAACAACCGCCTCGTTGTCACAGGC       c.1680
 E  M  S  P  V  T  C  C  D  V  S  S  N  N  R  L  V  V  T  G         p.560

          .         .         .                                     g.22467
 TCCGGGGAGCACGCCTCCGTGTACCAGATCACCTACTGA                            c.1719
 S  G  E  H  A  S  V  Y  Q  I  T  Y  X                              p.572

          .         .         .         .         .         .       g.22527
 ggggcctcgctgctgtcatcccactccggctcctcttttcatccccccccttcccccccc       c.*60

          .         .         .         .         .         .       g.22587
 ccaacaagggggacatggtggagggaagcgggaaggctcttctgtggcatcgcacgatct       c.*120

          .         .         .         .         .         .       g.22647
 agtctgtggtgtagactggtcgccatcacgtgtaataaagcacccgggaaaggcagagtg       c.*180

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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