UPF3 regulator of nonsense transcripts homolog B (yeast) (UPF3B) - coding DNA reference sequence

(used for variant description)

(last modified June 8, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_080632.2 in the UPF3B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000023.10, covering UPF3B transcript NM_080632.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     gcatttgttgggggcggagctttgacgggagcttcccggg       c.-61

 .         .         .         .         .         .                g.5100
 agccgtttgtgcccggggtaaccccgttccggccaagccgcttcagcgggggacgtagcc       c.-1

          .         .         .         .         .         .       g.5160
 ATGAAGGAAGAGAAGGAGCACAGGCCTAAGGAGAAGCGAGTAACCCTGTTAACCCCCGCC       c.60
 M  K  E  E  K  E  H  R  P  K  E  K  R  V  T  L  L  T  P  A         p.20

          .         .         .         .         .         .       g.5220
 GGGGCCACAGGCAGCGGTGGTGGGACCTCGGGGGACAGCTCCAAGGGGGAAGATAAGCAG       c.120
 G  A  T  G  S  G  G  G  T  S  G  D  S  S  K  G  E  D  K  Q         p.40

          .         .         .       | 02 .         .         .    g.6179
 GATCGCAACAAGGAGAAGAAAGAAGCGCTGAGCAAG | GTGGTAATTCGAAGATTACCTCCC    c.180
 D  R  N  K  E  K  K  E  A  L  S  K   | V  V  I  R  R  L  P  P      p.60

          .         .         .         .         .         .       g.6239
 ACTTTGACCAAGGAGCAGCTTCAGGAACATCTTCAACCTATGCCTGAGCATGATTATTTT       c.240
 T  L  T  K  E  Q  L  Q  E  H  L  Q  P  M  P  E  H  D  Y  F         p.80

          .         .    | 03    .         .         .         .    g.6464
 GAGTTTTTTTCTAATGATACGAG | TTTGTATCCTCATATGTATGCCAGAGCATACATCAAC    c.300
 E  F  F  S  N  D  T  S  |  L  Y  P  H  M  Y  A  R  A  Y  I  N      p.100

          .         .         .         .         .         .       g.6524
 TTTAAAAACCAAGAGGACATTATTTTGTTCAGGGATCGCTTTGATGGTTATGTATTCCTT       c.360
 F  K  N  Q  E  D  I  I  L  F  R  D  R  F  D  G  Y  V  F  L         p.120

          . | 04       .         .         .         .         .    g.12782
 GACAATAAAG | GTCAGGAATATCCCGCTATAGTAGAATTTGCACCTTTTCAAAAAGCTGCA    c.420
 D  N  K  G |   Q  E  Y  P  A  I  V  E  F  A  P  F  Q  K  A  A      p.140

          .         .         .         .          | 05        .    g.14738
 AAAAAGAAGACTAAGAAAAGAGATACCAAAGTCGGGACTATCGATGATG | ATCCAGAATAT    c.480
 K  K  K  T  K  K  R  D  T  K  V  G  T  I  D  D  D |   P  E  Y      p.160

          .         .         .         .         .         .       g.14798
 AGAAAGTTTTTGGAAAGTTATGCCACAGATAATGAGAAAATGACATCTACTCCAGAGACA       c.540
 R  K  F  L  E  S  Y  A  T  D  N  E  K  M  T  S  T  P  E  T         p.180

          .         .         .         . | 06       .         .    g.16270
 CTGCTAGAGGAAATAGAAGCAAAAAATAGAGAATTAATAG | CTAAAAAGACAACCCCACTT    c.600
 L  L  E  E  I  E  A  K  N  R  E  L  I  A |   K  K  T  T  P  L      p.200

          .         .     | 07   .         .         .         .    g.16806
 TTGAGCTTCCTGAAAAACAAGCAG | AGAATGAGAGAAGAAAAGAGAGAAGAAAGGAGGAGG    c.660
 L  S  F  L  K  N  K  Q   | R  M  R  E  E  K  R  E  E  R  R  R      p.220

          .         .         .         .         .         .       g.16866
 AGAGAAATAGAAAGAAAAAGACAAAGAGAAGAAGAGAGGAGGAAATGGAAAGAAGAAGAG       c.720
 R  E  I  E  R  K  R  Q  R  E  E  E  R  R  K  W  K  E  E  E         p.240

          .         .         .         .         .         .       g.16926
 AAACGAAAAAGGAAAGATATAGAAAAGCTAAAGAAGATAGACAGAATTCCAGAAAGGGAC       c.780
 K  R  K  R  K  D  I  E  K  L  K  K  I  D  R  I  P  E  R  D         p.260

          .         .        | 08.         .         .         .    g.17377
 AAATTAAAGGATGAACCAAAGATTAAG | GTACACAGGTTTCTGTTACAAGCTGTGAATCAG    c.840
 K  L  K  D  E  P  K  I  K   | V  H  R  F  L  L  Q  A  V  N  Q      p.280

        | 09 .         .         .         .         .         .    g.19555
 AAAAAT | CTGCTCAAGAAGCCAGAAAAAGGAGATGAAAAAGAATTGGACAAAAGAGAAAAA    c.900
 K  N   | L  L  K  K  P  E  K  G  D  E  K  E  L  D  K  R  E  K      p.300

          .         .         .         .         .         .       g.19615
 GCCAAGAAATTGGACAAAGAGAATCTCAGTGATGAAAGAGCCAGTGGGCAAAGTTGTACA       c.960
 A  K  K  L  D  K  E  N  L  S  D  E  R  A  S  G  Q  S  C  T         p.320

          .         .         .         .        | 10.         .    g.19990
 TTGCCCAAGCGTTCTGATAGCGAACTTAAAGATGAAAAACCAAAGAG | ACCTGAAGATGAG    c.1020
 L  P  K  R  S  D  S  E  L  K  D  E  K  P  K  R  |  P  E  D  E      p.340

          .         .         .         .         .         .       g.20050
 AGCGGCAGAGACTATAGGGAGAGGGAACGGGAATATGAACGAGATCAGGAGCGCATACTT       c.1080
 S  G  R  D  Y  R  E  R  E  R  E  Y  E  R  D  Q  E  R  I  L         p.360

          .         .         .         .         .         .       g.20110
 CGAGAAAGAGAGAGGCTGAAGCGGCAAGAAGAAGAGCGCCGTAGGCAGAAGGAGCGCTAT       c.1140
 R  E  R  E  R  L  K  R  Q  E  E  E  R  R  R  Q  K  E  R  Y         p.380

          .         .         .         .         .         .       g.20170
 GAGAAAGAGAAGACTTTTAAGAGAAAAGAAGAAGAAATGAAAAAAGAGAAAGACACACTT       c.1200
 E  K  E  K  T  F  K  R  K  E  E  E  M  K  K  E  K  D  T  L         p.400

          .         .         .         .         .         .       g.20230
 CGGGATAAAGGAAAGAAGGCTGAAAGTACAGAATCAATAGGCAGCTCAGAAAAAACTGAA       c.1260
 R  D  K  G  K  K  A  E  S  T  E  S  I  G  S  S  E  K  T  E         p.420

          .         .         .         .   | 11     .         .    g.23019
 AAGAAAGAAGAAGTGGTCAAGAGAGATCGAATAAGAAACAAG | GATCGTCCAGCGATGCAG    c.1320
 K  K  E  E  V  V  K  R  D  R  I  R  N  K   | D  R  P  A  M  Q      p.440

          .         .         .         .         .         .       g.23079
 CTTTACCAACCAGGAGCTCGAAGCCGAAATCGACTCTGTCCCCCTGATGACAGCACCAAG       c.1380
 L  Y  Q  P  G  A  R  S  R  N  R  L  C  P  P  D  D  S  T  K         p.460

          .         .         .         .         .         .       g.23139
 TCTGGAGATTCAGCAGCAGAAAGGAAGCAGGAAAGTGGTATTAGCCATAGAAAAGAAGGA       c.1440
 S  G  D  S  A  A  E  R  K  Q  E  S  G  I  S  H  R  K  E  G         p.480

          .                                                         g.23151
 GGAGAGGAGTGA                                                       c.1452
 G  E  E  X                                                         p.483

          .         .         .         .         .         .       g.23211
 taagtccagatggccttaggtgtcctgactgtctaggcagccaaagagcacacgttaagc       c.*60

          .         .         .         .         .         .       g.23271
 aatccagaggtgccttcagggcaaagaatagagagaaagggagccgctgtgctggtgggg       c.*120

          .         .         .         .         .         .       g.23331
 tacactgcagaggagtaagtcttgtgtcaaagcaggaatctgatcagaggttcagaattg       c.*180

          .         .         .         .         .         .       g.23391
 gaagtacaatttcattgcttttgcaatttctacaaattaattttaaagtgtcagaaaaag       c.*240

          .         .         .         .         .         .       g.23451
 gtgacggcaaggacatgcattgcaatttgcagggggaattgtcaagtgaggacttcatca       c.*300

          .         .         .         .         .         .       g.23511
 catatgacacgagagaaaagtaagagctggttctaaaatcaaaagctgttgttcatcctg       c.*360

          .         .         .         .         .         .       g.23571
 aattgaattttctgaatttgggtggagcagagtcgctttgaagccttgttccgatctaat       c.*420

          .         .         .         .         .         .       g.23631
 tctattgtattgttgatgataagtgttgacattgggtagtgtagaagcaacaagcatgtc       c.*480

          .         .         .         .         .         .       g.23691
 cttgtagtacaggtacagtgaaggatagaacacactttcgttgatacaaaaatttaaata       c.*540

          .         .         .         .         .         .       g.23751
 gttatgttacttctgtatccagtgtcctaaagttttaggattagttttagttttttgttt       c.*600

          .         .         .         .         .         .       g.23811
 gcttatatgagcttagcgtaaagaatatttttaaacttcgtgttttgtcatcagcatctt       c.*660

          .         .         .         .         .         .       g.23871
 ttctattaagaggtaaaatgtagtccttgtttgactcttgacaatccagtgtgtttgatc       c.*720

          .         .         .         .         .         .       g.23931
 ttaggtctcatgatctgagtgcataccctctccaggaaggaaactgcaccagtgtctatt       c.*780

          .         .         .         .         .         .       g.23991
 cctgttaaatagcaacttttagtctcagcttgtttcgttttgatgtcaataaatagtaac       c.*840

          .                                                         g.24003
 agcattcaagtg                                                       c.*852

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The UPF3 regulator of nonsense transcripts homolog B (yeast) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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