Disease #03381 (cancer, gastric (cancer, gastric (Neoplasm of stomach)), OMIM:613659)

Official abbreviation	cancer, gastric
Name	cancer, gastric (Neoplasm of stomach)
OMIM ID	613659
Human Phenotype Ontology Project (HPO)	HPO
Inheritance	-
Individuals reported having this disease	102
Phenotype entries for this disease	88
Associated with 8 genes	APC, CASP10, ERBB2, FGFR2, IRF1, KLF6, MUTYH, PIK3CA
Associated tissues	-
Disease features	-
Remarks	-
Date created	2014-09-25 23:29:40 +02:00 (CEST)
Date last edited	2017-07-14 15:28:09 +02:00 (CEST)

Individuals

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ID_report: ID of the individual that can be publically shared, e.g. as listed in a publication

Reference: reference to publication describing the individual/family, possibly giving more phenotypic details than listed in this database entry, incl. link to PubMed or other source, e.g. "den Dunnen ASHG2003 P2346"

Remarks: remarks about the individual

Gender: gender individual
All options:

? = unknown
- = not applicable
F = female
M = male
rF = raised as female
rM = raised as male

Consanguinity: indicates whether the parents are related (consanguineous), not related (non-consanguineous) or whether consanguinity is not known (unknown)
All options:

no = non-consanguineous parents
yes = consanguineous parents
likely = consanguinity likely
? = unknown
- = not applicable

Country: where (country) does the individual live/recently came from. Give additional details (population, specific sub-group) and when parents come from different countries in "Population". Belgium = individual lives in/recently came from Belgium, (France) = reported by laboratory in France, individual's country of origin not sure
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? (unknown)
- (not applicable)
Afghanistan
(Afghanistan)
Albania
(Albania)
Algeria
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American Samoa
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Andorra
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Angola
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Benin
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Bolivia
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Botswana
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Bouvet Island
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Brazil
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British Indian Ocean Territory
(British Indian Ocean Territory)
Brunei Darussalam
(Brunei Darussalam)
Bulgaria
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Burkina Faso
(Burkina Faso)
Burundi
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Cambodia
(Cambodia)
Cameroon
(Cameroon)
Canada
(Canada)
Cape Verde
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Cayman Islands
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Central African Republic
(Central African Republic)
Central Europe
Chad
(Chad)
Chile
(Chile)
China
(China)
Christmas Island
(Christmas Island)
Cocos (Keeling Islands)
(Cocos (Keeling Islands))
Colombia
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Comoros
(Comoros)
Congo
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Cook Islands
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Costa Rica
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Cote D'Ivoire (Ivory Coast)
(Cote D'Ivoire (Ivory Coast))
Croatia (Hrvatska)
(Croatia (Hrvatska))
Cuba
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Cyprus
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Czech Republic
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Denmark
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Dominica
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Dominican Republic
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Ecuador
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Egypt
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El Salvador
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England
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Equatorial Guinea
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Estonia
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Ethiopia
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Faroe Islands
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Fiji
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Finland
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France
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Gabon
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Gambia
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Georgia
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Germany
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Ghana
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Gibraltar
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Greece
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Greenland
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Grenada
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Guadeloupe
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Guam
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Guatemala
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Guiana, French
(Guiana, French)
Guinea
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Guinea-Bissau
(Guinea-Bissau)
Guyana
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Haiti
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Heard and McDonald Islands
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Honduras
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Hong Kong
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Hungary
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Iceland
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India
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Indonesia
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Iran
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Iraq
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Ireland
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Israel
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Italy
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Jamaica
(Jamaica)
Japan
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Jordan
(Jordan)
Kazakhstan
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Kenya
(Kenya)
Kiribati
(Kiribati)
Korea
(Korea)
Korea, North (People's Republic)
(Korea, North (People's Republic))
Korea, South (Republic)
(Korea, South (Republic))
Kosovo
(Kosovo)
Kuwait
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Kyrgyzstan (Kyrgyz Republic)
(Kyrgyzstan (Kyrgyz Republic))
Laos
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Latvia
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Lebanon
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Lesotho
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Liberia
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Libya
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Liechtenstein
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Lithuania
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Luxembourg
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Macau
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Macedonia
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Madagascar
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Malawi
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Malaysia
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Maldives
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Mali
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Malta
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Marshall Islands
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Martinique
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Mauritius
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Mayotte
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Mexico
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Morocco
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Myanmar
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Neutral Zone (Saudia Arabia/Iraq)
(Neutral Zone (Saudia Arabia/Iraq))
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New Zealand
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Palau
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Palestine
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Panama
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Paraguay
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Peru
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Poland
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Polynesia, French
(Polynesia, French)
Portugal
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Puerto Rico
(Puerto Rico)
Qatar
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Reunion
(Reunion)
Romania
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Russia
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Russian Federation
(Russian Federation)
Rwanda
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S. Georgia and S. Sandwich Isls.
(S. Georgia and S. Sandwich Isls.)
Saint Kitts and Nevis
(Saint Kitts and Nevis)
Saint Lucia
(Saint Lucia)
Saint Vincent and The Grenadines
(Saint Vincent and The Grenadines)
Samoa
(Samoa)
San Marino
(San Marino)
Sao Tome and Principe
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Saudi Arabia
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Scotland
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Senegal
(Senegal)
Serbia
(Serbia)
Seychelles
(Seychelles)
Sierra Leone
(Sierra Leone)
Singapore
(Singapore)
Slovakia (Slovak Republic)
(Slovakia (Slovak Republic))
Slovenia
(Slovenia)
Solomon Islands
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Somalia
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South Africa
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Southern Territories, French
(Southern Territories, French)
Soviet Union (former)
(Soviet Union (former))
Spain
(Spain)
Sri Lanka
(Sri Lanka)
St. Helena, Ascension and Tristan da
Cunha
(St. Helena, Ascension and Tristan da
Cunha)
St. Pierre and Miquelon
(St. Pierre and Miquelon)
Sudan
(Sudan)
Sudan, South
(Sudan, South)
Suriname
(Suriname)
Svalbard and Jan Mayen Islands
(Svalbard and Jan Mayen Islands)
Swaziland
(Swaziland)
Sweden
(Sweden)
Switzerland
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Syria
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Taiwan
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Tajikistan
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Tanzania
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Thailand
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Togo
(Togo)
Tokelau
(Tokelau)
Tonga
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Trinidad and Tobago
(Trinidad and Tobago)
Tunisia
(Tunisia)
Turkey
(Turkey)
Turkmenistan
(Turkmenistan)
Turks and Caicos Islands
(Turks and Caicos Islands)
Tuvalu
(Tuvalu)
Uganda
(Uganda)
Ukraine
(Ukraine)
United Arab Emirates
(United Arab Emirates)
United Kingdom (Great Britain)
(United Kingdom (Great Britain))
United States
(United States)
Uruguay
(Uruguay)
US Minor Outlying Islands
(US Minor Outlying Islands)
Uzbekistan
(Uzbekistan)
Vanuatu
(Vanuatu)
Vatican City State (Holy See)
(Vatican City State (Holy See))
Venezuela
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Viet Nam
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Virgin Islands (British)
(Virgin Islands (British))
Virgin Islands (US)
(Virgin Islands (US))
Wales
(Wales)
Wallis and Futuna Islands
(Wallis and Futuna Islands)
Western Sahara
(Western Sahara)
Yemen
(Yemen)
Yugoslavia
(Yugoslavia)
Zaire
(Zaire)
Zambia
(Zambia)
Zimbabwe
(Zimbabwe)

Population: population the individual (or ancestors) belongs to; e.g. white, gypsy, Jewish-Ashkenazi, Africa-N, Sardinia, etc.

Age at death: age at which the individual deceased (when applicable):

35y = 35 years
>43y = still alive at 43y
04y08m = 4 years and 8 months
00y00m01d12h = 1 day and 12 hours
18y? = around 18 years
30y-40y = between 30 and 40 years
>54y = older than 54
? = unknown

VIP: individual/phenotype VIP-status was requested for matchmaking - need collaboration(s) to crack the case - please contact the submitter/curator. NOTE: to get VIP status ask the curator.

Data_av: are additional data available upon request: e.g. pedigree (yes/no/?)

Treatment: treatment of patient

Variants in genes: The individual has variants for this gene.

Panel size: Number of individuals this entry represents; e.g. 1 for an individual, 5 for a family with 5 affected members.

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102 entries on 2 pages. Showing entries 1 - 100.

	Legend	How to query	« First	‹ Prev		1	2		Next ›	Last »

Individual ID	ID_report	Reference	Remarks	Gender	Consanguinity	Country	Population	Age at death	VIP	Data_av	Treatment	Disease	Phenotype details	Genes screened	Variants in genes	Variants	Panel size	Owner
00035135	-	-	-	-	-	Germany	-	-	-	-	-	cancer, gastric	-	CDH1	CDH1	1	1	Andreas Laner
00035137	-	-	-	-	-	Germany	-	-	-	-	-	cancer, gastric	diffuse gastric cancer and mental handicap, suspected hereditary tumour predisposition	CDH1	CDH1	1	1	Andreas Laner
00035139	-	-	-	-	-	Germany	-	-	-	-	-	cancer, gastric	gastric Siegelringzell cancer, AO 46; daughter osteosarcoma AO17	CDH1	CDH1	1	1	Andreas Laner
00035140	-	-	family history	-	-	Germany	-	-	-	-	-	cancer, gastric	42y-diffuse gastric cancer; fathe diffuse gastric cancer, ED 68; aunt (paternal) 70y-gastric cancer	CDH1	CDH1	1	1	Andreas Laner
00035143	-	-	-	-	-	Germany	-	-	-	-	-	cancer, gastric	58y-diffuse gastric cancer; sister (45y) and aunt (42y) died from gastric cancer	CDH1	CDH1	1	1	Andreas Laner
00035144	-	-	-	-	-	Germany	-	-	-	-	-	cancer, gastric	gastric cancer	CDH1	CDH1	1	1	Andreas Laner
00035145	-	-	-	-	-	Germany	-	-	-	-	-	cancer, gastric	family history thalassemia minor (mother and sister maternal), gastric cancer 2x, bone cancer 1x, hematopoietic tissue cancer	CDH1	CDH1	1	1	Andreas Laner
00047897	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	1	1	Sian Jones
00047898	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	1	1	Sian Jones
00047899	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	3	1	Sian Jones
00047900	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	1	1	Sian Jones
00047901	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	1	1	Sian Jones
00047902	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	1	1	Sian Jones
00047903	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	2	1	Sian Jones
00047904	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	1	1	Sian Jones
00047905	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	1	1	Sian Jones
00047906	-	-	-	-	-	-	-	-	-	-	-	cancer, gastric	-	ARID1A	ARID1A	1	1	Sian Jones
00103989	Vogelaar-005A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	COL4A3	1	1	Marjolijn JL Ligtenberg
00103990	Vogelaar-018A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	COL4A5, DLG1	2	1	Marjolijn JL Ligtenberg
00103991	Vogelaar-023A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ARHGAP35, ST5	2	1	Marjolijn JL Ligtenberg
00103992	Vogelaar-025A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	BAI2, MTOR, RNASEL, VAV3	4	1	Marjolijn JL Ligtenberg
00103993	Vogelaar-036A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	COL7A1, CYGB, LAMA1, MYD88, PMS1, SLIT2, THBS4, UNC93A	8	1	Marjolijn JL Ligtenberg
00103994	Vogelaar-042A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	LAMA2	1	1	Marjolijn JL Ligtenberg
00103995	Vogelaar-049A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	G6PC, TCF7L1, VIL1	3	1	Marjolijn JL Ligtenberg
00103996	Vogelaar-059A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ATM, PHOX2B, PVRL2, TCF7L1	5	1	Marjolijn JL Ligtenberg
00103997	Vogelaar-059B	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ATM, FOXC1, PMS1, PPP3CC, TCF7L1	5	1	Marjolijn JL Ligtenberg
00103998	Vogelaar-107A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	AK2, COL18A1, DHFR, HAX1, MCM4, MSH3, MTSS1, PRKCQ	7	1	Marjolijn JL Ligtenberg
00103999	Vogelaar-112A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	AK2, DUSP22, FOXC1, IBSP, LAMB1, PEG3, TAB1, TCF7L1, TLR4, VIL1, VWA5A, ZIM2	11	1	Marjolijn JL Ligtenberg
00104000	Vogelaar-119A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	DUSP22, JMJD1C, PTPRC, RB1, STAT3	5	1	Marjolijn JL Ligtenberg
00104001	Vogelaar-120A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	IL22RA2, LAMB1, LRP1B, PPARD, PRDM2, TLR5, UFL1, XRN1	8	1	Marjolijn JL Ligtenberg
00104002	Vogelaar-121A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	KDM8	1	1	Marjolijn JL Ligtenberg
00104003	Vogelaar-124A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ABCC4, COL11A1, PTPRK, PVRL1, RASGRP2	5	1	Marjolijn JL Ligtenberg
00104004	Vogelaar-125A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	G6PC, ITGA2, LRP1B, MAP4K1, THOC5	5	1	Marjolijn JL Ligtenberg
00104005	Vogelaar-135A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	COL6A2, LPIN2	2	1	Marjolijn JL Ligtenberg
00104006	Vogelaar-162A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	AK2, E2F3, FLNA, LAMB2, TCF7	5	1	Marjolijn JL Ligtenberg
00104007	Vogelaar-164A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ADPRH, AK2, ANXA1, CDH13, LRP1B, TCF7L1, TRIM35, WNT9B	8	1	Marjolijn JL Ligtenberg
00104008	Vogelaar-167A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ACTN2, FLNA, FOXC1, HPGD, HSP90AA1, MAP3K6, PTCH2, TGFBR1	8	1	Marjolijn JL Ligtenberg
00104009	Vogelaar-509A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	EGFR, ESR2, FANCI, KL, KMT2D, MAP4K1, SOS1, THBS4	8	1	Marjolijn JL Ligtenberg
00104010	Vogelaar-510A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	COL2A1, UNC5B	2	1	Marjolijn JL Ligtenberg
00104011	Vogelaar-511A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ALK, MSH3, SMAD3, THBS3	4	1	Marjolijn JL Ligtenberg
00104012	Vogelaar-512A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	CFP, COL1A2	2	1	Marjolijn JL Ligtenberg
00104013	Vogelaar-513A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	GLTSCR1, NCKAP1, RB1CC1, TSC22D1	4	1	Marjolijn JL Ligtenberg
00104014	Vogelaar-516A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	APC, FN1, IQGAP2, MAP2K6	4	1	Marjolijn JL Ligtenberg
00104015	Vogelaar-520A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ARHGEF12, COL5A1, ITGA11, MYO18B	5	1	Marjolijn JL Ligtenberg
00104016	Vogelaar-521A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	BIVM-ERCC5, ERCC5, PIDD, PLXNC1	3	1	Marjolijn JL Ligtenberg
00104017	Vogelaar-522A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	GGNBP2, NDOR1	2	1	Marjolijn JL Ligtenberg
00104018	Vogelaar-529A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ADAMTS9, BAI2, COL3A1, PTGFRN, RB1, TNC	6	1	Marjolijn JL Ligtenberg
00104019	Vogelaar-530A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ARNT2, DOCK8, SCRIB	3	1	Marjolijn JL Ligtenberg
00104020	Vogelaar-531A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ARHGEF12, FAT4, NFKB1, PTK2B, RAG1	6	1	Marjolijn JL Ligtenberg
00104021	Vogelaar-532A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	MLLT4, PARD3, SDK1, TNFRSF10B	4	1	Marjolijn JL Ligtenberg
00104022	Vogelaar-701A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	PTCH2, TNC	2	1	Marjolijn JL Ligtenberg
00104023	Vogelaar-703A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	BRF1, CYBA, FGF2, FOXC1, TCF7L1	5	1	Marjolijn JL Ligtenberg
00104024	Vogelaar-711A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	IQGAP3, SBDS	2	1	Marjolijn JL Ligtenberg
00104025	Vogelaar-716A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	APOL1, CDH11, ERBB4, GJB2, IL17RD, KIF1B, PTPN2, PTPRZ1	8	1	Marjolijn JL Ligtenberg
00104026	Vogelaar-725A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	FAM120A, FAM120AOS, LSR, MYO1A, PAK7, WRAP53	5	1	Marjolijn JL Ligtenberg
00104027	Vogelaar-727A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	DMBT1, ITGA1, RELN	3	1	Marjolijn JL Ligtenberg
00104028	Vogelaar-729A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	COL4A4, PCDH10, PIP5K1C, PKD1, SHC2, SMARCA4	7	1	Marjolijn JL Ligtenberg
00104029	Vogelaar-730A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	C4A, C4B, CEACAM1, MMP11, ZAP70	5	1	Marjolijn JL Ligtenberg
00104030	Vogelaar-731A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	AR, DOCK8, MAP3K6, PTCH2, RFX5	5	1	Marjolijn JL Ligtenberg
00104031	Vogelaar-733A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	AK2, AR, BAIAP2, HDAC1, MAPK12	5	1	Marjolijn JL Ligtenberg
00104032	Vogelaar-741A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ATM, C4B, CTNNA3, DPH1, F2, PANX2, SCGB3A1, SDK1, SLC26A3	9	1	Marjolijn JL Ligtenberg
00104033	Vogelaar-743A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ATM, FLNB, SPINK5	3	1	Marjolijn JL Ligtenberg
00104034	Vogelaar-755A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	MYO5A, NME1, NME1-NME2, NOD2, PBRM1, POU6F2, RPL11, UNC5B	7	1	Marjolijn JL Ligtenberg
00104035	Vogelaar-756A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	GADD45GIP1, RELN, SDK1, SYT13	4	1	Marjolijn JL Ligtenberg
00104036	Vogelaar-759A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	ARID2, FARP2, HIC1, HSP90B1, MFSD2A, SCRIB	6	1	Marjolijn JL Ligtenberg
00104037	Vogelaar-760A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	BMP4, MASP2, NCKAP1, PTPRB, VPS53	5	1	Marjolijn JL Ligtenberg
00104038	Vogelaar-762A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	CHEK1, CHRDL2, LAMB4, PIP5K1C, PKD1, PLA2G16	6	1	Marjolijn JL Ligtenberg
00104039	Vogelaar-772A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	AK2, FOXC1, HLTF, LDHD, NEO1, NME1, NME1-NME2, PTPRJ	7	1	Marjolijn JL Ligtenberg
00104040	Vogelaar-774A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	CDH13, ERBB4, RRAS	3	1	Marjolijn JL Ligtenberg
00104041	Vogelaar-780A	PubMed: Vogelaar 2017, Journal: Vogelaar 2017	54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer	-	-	-	-	-	-	-	-	cancer, gastric	diffuse-type or intestinal-type gastric cancer	-	FAT1, LAMB4, MAP3K6, NOTCH1, RNASEH2B, SPINT2, THBS1, WNT16	8	1	Marjolijn JL Ligtenberg
00105356	43	PubMed: Park 2001	-	-	-	-	-	-	-	-	-	cancer, gastric	Gastric cancer	TNFRSF10B	TNFRSF10B	1	1	Zoe Baily
00105362	33	PubMed: Park 2001	-	-	-	-	-	-	-	-	-	cancer, gastric	Gastric cancer	TNFRSF10B	TNFRSF10B	1	1	Zoe Baily
00105376	38	PubMed: Park 2001	-	-	-	-	-	-	-	-	-	cancer, gastric	Gastric cancer	TNFRSF10B	TNFRSF10B	1	1	Zoe Baily
00116797	P586	-	-	M	no	Italy	white	41y	-	yes	yes	cancer, gastric	-	CDH1	CDH1	1	1	Valli De Re
00180252	20719348-Fam1Pat1	PubMed: Pandalai 2011	-	F	-	United States	-	-	-	-	-	cancer, gastric	see paper; …	CDH1	CDH1	1	1	Johan den Dunnen
00180253	20719348-Fam2Pat2	PubMed: Pandalai 2011	-	M	-	United States	-	-	-	-	-	cancer, gastric	see paper; …	CDH1	CDH1	1	1	Johan den Dunnen
00180254	20719348-Fam3Pat3	PubMed: Pandalai 2011	-	M	-	United States	-	-	-	-	-	cancer, gastric	see paper; …	CDH1	CDH1	1	1	Johan den Dunnen
00180255	20719348-Fam4Pat4/5/6	PubMed: Pandalai 2011	family, 3 affected (F, 2M)	F;M	-	United States	-	-	-	-	-	cancer, gastric	see paper; …	CDH1	CDH1	1	3	Johan den Dunnen
00180256	20719348-Fam5Pat7/8/9	PubMed: Pandalai 2011	family, 3 affected (F, 2M)	F;M	-	United States	-	-	-	-	-	cancer, gastric	see paper; …	CDH1	CDH1	1	3	Johan den Dunnen
00180257	20719348-Fam6Pat10	PubMed: Pandalai 2011	-	M	-	United States	-	-	-	-	-	cancer, gastric	see paper; …	CDH1	CDH1	1	1	Johan den Dunnen
00187028	-	-	32 y died from gastric cancer, CDH1 normal ; gastric-Ca: MSI-low (1 of 5, D17S250;) IHC predominant loss of PMS2, MLH1, MSH2, MSH6 positive ; second pathology: MSI-high (5 of 10), IHC no clear result obtainable for PMS2 expression	-	-	-	-	-	-	-	-	cancer, gastric	-	PMS2	PMS2	1	1	Elke Holinski-Feder
00196040	-	PubMed: Marafie 2009	Daughter of patient 2.01;InSiGHT LOVDv2 ID:1011248;	F	-	Kuwait	Arab	-	-	pedigree	-	cancer, gastric	cancer, gastric - stomach (7 years)	MSH2	MSH2	1	1	Makia Marafie
00196199	-	-	-	M	-	Spain	-	-	-	-	-	cancer, gastric	Intestinal type gastric adenocarcinoma poorly differentiated	MSH2	MSH2	1	1	Daniel Rueda
00200928	-	-	The family history includes colon, endometrial, stomach, bladder and lung cancers with a number of other tumours such as medullablastoma, pituitary tumour and testicular cancer.; ; The only other family member we have been able to test was distant relative (maternal cousin’s daughter) who was diagnosed with endometrial cancer age 44. She also carries the same MSH6 VUS. Testing on endometrial tumour did not show MSI or loss of proteins.	M	-	United Kingdom (Great Britain)	-	-	-	pedigree	-	cancer, gastric, CRC	adenocarcinoma of the stomach, adenocarcinoma transverse colon age 64 with additional TV adenomas, moderately differentiated adenocarcinoma of splenic flexure	MSH2, MSH6, MUTYH	MSH6, MUTYH	2	1	InSiGHT - John-Paul Plazzer
00201509	-	Fry, Palmer-Smith, Murray, Frayling, Hodgson, Tripathi	Mother and aff'd son have VUS: MLH1 c.790+10A>G, but aff'd father (MSI+ BRAF- CR;Ca 53y) has neither mutation. Maybe father's Rectal;Carcinoma needs IHC and/or his MSH2 sequencing needs looking at in case he is a low level de novo mosaic himself.; Father: Rectal;Carcinoma 53y [MSI-H, BRAF wt; MSH2-, MSH6-, MLH1+, PMS2+]	M	-	-	-	-	-	-	-	cancer, gastric, cancer, rectal	gastric;carcinoma 50y, rectal;carcinoma; BRAF V600E negative	-	MSH2	1	1	Ian Frayling
00202534	PMID15273732_1	PubMed: Kim 2004, OMIM:var0006	-	-	-	Korea, South (Republic)	-	-	-	-	-	cancer, gastric	in gastric tumor of patient with sporadic gastric cancer, H.pylori +. Not in normal DNA.	MUTYH	MUTYH	2	1	Carli Tops
00203202	-	PubMed: Goto 2008	Among 23 Japanese gastric cancer patients	-	-	Japan	-	-	-	-	-	cancer, gastric	-	MUTYH	MUTYH	1	1	Astrid Out
00203203	-	PubMed: Goto 2008	Among 23 Japanese gastric cancer patients	-	-	Japan	-	-	-	-	-	cancer, gastric	-	MUTYH	MUTYH	1	7	Astrid Out
00203204	-	PubMed: Goto 2008	Among 23 Japanese gastric cancer patients	-	-	Japan	-	-	-	-	-	cancer, gastric	-	MUTYH	MUTYH	2	5	Astrid Out
00203205	-	PubMed: Goto 2008	Among 23 Japanese gastric cancer patients	-	-	Japan	-	-	-	-	-	cancer, gastric	-	MUTYH	MUTYH	1	12	Astrid Out
00245644	-	-	-	M	-	Spain	-	-	-	-	-	cancer, gastric, lymphoma	-	MSH2	-	-	1	Gabriel Capella
00248088	-	-	-	M	-	Spain	-	-	-	-	-	cancer, gastric	-	MSH2	MSH2	1	1	Gabriel Capella
00327392	-	-	-	F	?	-	-	-	-	-	-	cancer, gastric	-	-	PIK3CA	1	1	Richarda de Voer
00375755	-	-	Also seen in two other families tested by us; Selection criteria for proband testing: Family history	F	-	(United Kingdom (Great Britain))	-	-	-	-	-	cancer, gastric	Stomach	MLH1, MSH2, MSH6	MLH1, MSH2	2	1	Treena Cranston
00402408	JI-007	PubMed: Ben Aissa-Haj 2022, Journal: Ben Aissa-Haj 2022	3-generation family, 1 affected	M	no	Tunisia	-	25y	-	-	-	cancer, cancer, gastric	25y-deceased; silent pedigree without gastric carcinoma or other cancers	CDH1, CTNNA1	CDH1	1	1	Jihenne Ben Aissa-Haj
00402409	JI-014	PubMed: Ben Aissa-Haj 2022, Journal: Ben Aissa-Haj 2022	4-generation family, 3 affected (F, 2M)	F	no	(Tunisia)	-	-	-	-	Palliative Chemotherapy	cancer, gastric	suspected of DGC at antro pyloric, treated with palliative chemotherapy; brother and paternal uncle were diagnosed with GC and died at the age 25y/80y resp.	CDH1, CTNNA1	CDH1	1	3	Jihenne Ben Aissa-Haj
00411612	JI-020	PubMed: Ben Aissa-Haj 2022, Journal: Ben Aissa-Haj 2022	3-generation family, 1 affected	F	-	(Tunisia)	-	-	-	-	-	cancer, gastric	see paper; ...	CDH1	-	-	3	Jihenne Ben Aissa-Haj
00412304	TCGA-HF-7132-01	-	-	M	?	-	-	-	-	-	-	cancer, gastric	-	-	SMAD9	1	1	Litika Vermani
00412311	TCGA-FP-A4BE-01	-	-	M	-	-	-	-	-	-	-	cancer, gastric	-	-	SMAD9	1	1	Litika Vermani
00412496	ESO-169	PubMed: Dulak 2013	-	M	-	-	-	-	-	-	-	cancer, gastric	-	-	SMAD9	1	1	Litika Vermani

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Global Variome shared LOVD

RAB18 (RAB18, member RAS oncogene family)