The APC gene homepage


General information
Gene symbol APC
Gene name adenomatous polyposis coli
Chromosome 5
Chromosomal band q21-q22
Imprinted Unknown
Genomic reference LRG_130
Transcript reference NM_000038.5
Associated with diseases cancer, gastric, cancer, liver, CRC, FAP-1, HDD, polyposis
Citation reference(s) -
Refseq URL Genomic reference sequence
Curators (3) Stefan Aretz, Isabel Spier, and Xiaoyu Sherry Yin
Total number of public variants reported 5527
Unique public DNA variants reported 1829
Individuals with public variants 5097
Hidden variants 42
Notes Aliases for APC: BTPS2, DP2, DP2.5, DP3, GS.
this is one of the InSiGHT gene variant databases.
We gratefully acknowledge the work of Kirsten Wöllner acting as curator (until 2018).
Date created September 09, 2009
Date last updated November 25, 2021
Version APC:211125

Graphical displays and utilities
Graphs Graphs displaying summary information of all variants in the database »
UCSC Genome Browser Show variants in the UCSC Genome Browser (full view, compact view)
Ensembl Genome Browser Show variants in the Ensembl Genome Browser (full view, compact view)
NCBI Sequence Viewer Show distribution histogram of variants in the NCBI Sequence Viewer

Links to other resources
Homepage URL https://www.LOVD.nl/APC
External URL For submissions please use the LOVDv2 databaste
InSiGHT
Institut für Humangenetik, Universität Bonn

UMD APC database
HGNC 583
Entrez Gene 324
PubMed articles APC
OMIM - Gene 611731
OMIM - Diseases cancer, gastric (cancer, gastric (Neoplasm of stomach))
cancer, liver (cancer, hepatocellular)
CRC (cancer, colorectal (CRC))
FAP-1 (adenomatous polyposis, familial, type 1 (FAP-1, Gardner syndrome))
HDD (desmoid disease, hereditary (HDD))
HGMD APC
GeneCards APC
GeneTests APC
Orphanet APC


Active transcripts


ID     

Chr     

Name     

NCBI ID     

NCBI Protein ID     

DescendingVariants     
00002660 5 transcript variant 3 NM_000038.5 NP_000029.2 5527


Copyright & disclaimer
The contents of this LOVD database are the intellectual property of the respective submitter(s) and curator(s) of the individual records. Individual data entries may indicate which data license applies to that specific record. When no license is listed, no permissions are granted. Any unauthorized use, copying, storage, or distribution of this material without written permission from the curator(s) will lead to copyright infringement with possible ensuing litigation. Copyright © 2009-2021. All Rights Reserved. For further details, refer to Directive 96/9/EC of the European Parliament and the Council of March 11 (1996) on the legal protection of databases.

We have used all reasonable efforts to ensure that the information displayed on these pages and contained in the databases is of high quality. We make no warranty, express or implied, as to its accuracy or that the information is fit for a particular purpose, and will not be held responsible for any consequences arising from any inaccuracies or omissions. Individuals, organizations, and companies that use this database do so on the understanding that no liability whatsoever, either direct or indirect, shall rest upon the data submitter(s), curator(s), or any of their employees or agents for the effects of any product, process, or method that may be produced or adopted by any part, notwithstanding that the formulation of such product, process or method may be based upon information here provided.