APC gene homepage

General information
Gene symbol APC
Gene name adenomatous polyposis coli
Chromosome 5
Chromosomal band q21-q22
Imprinted Unknown
Genomic reference LRG_130
Transcript reference NM_000038.5
Associated with diseases cancer, gastric, cancer, liver, CRC, FAP-1, HDD, polyposis
Citation reference(s) -
Refseq URL Genomic reference sequence
Curators (3) Stefan Aretz, Isabel Spier and Xiaoyu Sherry Yin
Total number of public variants reported 5455
Unique public DNA variants reported 1800
Individuals with public variants 5070
Hidden variants 41
Notes Aliases for APC: BTPS2, DP2, DP2.5, DP3, GS.
this is one of the InSiGHT gene variant databases.
We gratefully acknowledge the work of Kirsten Wöllner acting as curator (until 2018).
Date created September 09, 2009
Date last updated September 15, 2020
Version APC:200915

Graphical displays and utilities
Graphs Graphs displaying summary information of all variants in the database »
UCSC Genome Browser Show variants in the UCSC Genome Browser (full view, compact view)
Ensembl Genome Browser Show variants in the Ensembl Genome Browser (full view, compact view)
NCBI Sequence Viewer Show distribution histogram of variants in the NCBI Sequence Viewer

Links to other resources
Homepage URL https://www.LOVD.nl/APC
External URL For submissions please use the LOVDv2 databaste
Institut für Humangenetik, Universität Bonn
UMD APC database
HGNC 583
Entrez Gene 324
PubMed articles APC
OMIM - Gene 611731
OMIM - Diseases cancer, gastric (cancer, gastric (Neoplasm of stomach))
cancer, liver (cancer, hepatocellular)
CRC (cancer, colorectal (CRC))
FAP-1 (adenomatous polyposis, familial, type 1 (FAP-1, Gardner syndrome))
HDD (desmoid disease, hereditary (HDD))
GeneCards APC
GeneTests APC

Active transcripts




NCBI ID     

NCBI Protein ID     

00002660 5 transcript variant 3 NM_000038.5 NP_000029.2 5455

Copyright & disclaimer
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We have used all reasonable efforts to ensure that the information displayed on these pages and contained in the databases is of high quality. We make no warranty, express or implied, as to its accuracy or that the information is fit for a particular purpose, and will not be held responsible for any consequences arising out of any inaccuracies or omissions. Individuals, organisations and companies which use this database do so on the understanding that no liability whatsoever either direct or indirect shall rest upon the curator(s) or any of their employees or agents for the effects of any product, process or method that may be produced or adopted by any part, notwithstanding that the formulation of such product, process or method may be based upon information here provided.