The APC gene homepage

General information
Gene symbol APC
Gene name adenomatous polyposis coli
Chromosome 5
Chromosomal band q21-q22
Imprinted Unknown
Genomic reference LRG_130
Transcript reference NM_000038.5
Associated with diseases cancer, gastric, cancer, liver, CRC, DESMD, FAP1, polyposis
Citation reference(s) -
Refseq URL Genomic reference sequence
Curators (3) Stefan Aretz, Isabel Spier, and Xiaoyu Sherry Yin
Total number of public variants reported 5809
Unique public DNA variants reported 1964
Individuals with public variants 5240
Hidden variants 30
Notes Aliases for APC: BTPS2, DP2, DP2.5, DP3, GS.
this is one of the InSiGHT gene variant databases.
We gratefully acknowledge the work of Kirsten Wöllner acting as curator (until 2018).
Date created September 09, 2009
Date last updated November 27, 2023
Version APC:231127

Graphical displays and utilities
Graphs Graphs displaying summary information of all variants in the database »
UCSC Genome Browser Show variants in the UCSC Genome Browser (full view, compact view)
Ensembl Genome Browser Show variants in the Ensembl Genome Browser (full view, compact view)
NCBI Sequence Viewer Show distribution histogram of variants in the NCBI Sequence Viewer

Links to other resources
Homepage URL
External URL InSiGHT
Institut für Humangenetik, Universität Bonn
UMD APC database
HGNC 583
Entrez Gene 324
PubMed articles APC
OMIM - Gene 611731
OMIM - Diseases cancer, gastric (cancer, gastric (Neoplasm of stomach))
cancer, liver (cancer, hepatocellular (HCC))
CRC (cancer, colorectal, susceptibility to (CRC))
DESMD (desmoid disease, hereditary)
FAP1 (adenomatous polyposis, familial, type 1 (FAP-1, Gardner syndrome))
GeneCards APC
GeneTests APC
Orphanet APC

Active transcripts




NCBI ID     

NCBI Protein ID     

00002660 5 transcript variant 3 NM_000038.5 NP_000029.2 5809

Copyright & disclaimer
The contents of this LOVD database are the intellectual property of the respective submitter(s) and curator(s) of the individual records. Individual data entries may indicate which data license applies to that specific record. When no license is listed, no permissions are granted. Any unauthorized use, copying, storage, or distribution of this material without written permission from the curator(s) will lead to copyright infringement with possible ensuing litigation. Copyright © 2009-2023. All Rights Reserved. For further details, refer to Directive 96/9/EC of the European Parliament and the Council of March 11 (1996) on the legal protection of databases.

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