All transcript variants in gene KRAS

Information The variants shown are described using the NM_004985.3 transcript reference sequence.

47 entries on 1 page. Showing entries 1 - 47.
Legend  

Effect     

Exon     

AscendingDNA change (cDNA)     

ClassClinical     

RNA change     

Protein     

DNA change (genomic) (hg19)     

DNA change (hg38)     

Published as     

ISCN     

DB-ID     

Variant remarks     

Reference     

ClinVar ID     

dbSNP ID     

Origin     

Segregation     

Frequency     

Re-site     

VIP     

Methylation     

Owner     
-?/. - c.24A>G likely benign r.(=) p.(=) g.25398295T>C - KRAS:NM_033360.3:c.24A>G (=) - KRAS_000033 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
?/. 2 c.32_35delinsGTGC - r.(?) p.(Ala11_Gly12delinsGlyAla) g.25398284_25398287delinsGCAC g.25245350_25245353delinsGCAC - - KRAS_000007 - - - - Somatic - - - 0 - Johan den Dunnen
+?/. 1 c.34G>A - r.(?) p.(Gly12Ser) g.25398285C>T g.25245351C>T - - KRAS_000012 - PubMed: Joyce 2016 - rs121913530 Unknown ? - - 0 - Pia Ostergaard
?/. - c.34G>A VUS r.(?) p.(Gly12Ser) g.25398285C>T - KRAS:c.34G>A (G12S) - KRAS_000012 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Rotterdam
?/. 2 c.34_35delinsCT - r.(?) p.(Gly12Leu) g.25398284_25398285delinsAG g.25245350_25245351delinsAG - - KRAS_000006 - - - - Somatic - - - 0 - Johan den Dunnen
?/. 2 c.35G>A - r.(?) p.(Gly12Asp) g.25398284C>T g.25245350C>T - - KRAS_000001 - - - - Somatic - - - 0 - Phil Chambers
+/. 2 c.35G>T - r.(?) p.(Gly12Val) g.25398284C>A g.25245350C>A - - KRAS_000002 - - - - Somatic - - - 0 - Phil Chambers
+/. - c.35G>T - r.(?) p.(Gly12Val) g.25398284C>A g.25245350C>A - - KRAS_000002 - - - - Germline - - - 0 - Andreas Laner
?/. 2 c.37G>T - r.(?) p.(Gly13Cys) g.25398282C>A g.25245348C>A - - KRAS_000008 - - - - Somatic - - - 0 - Johan den Dunnen
+/. - c.37G>T - r.(?) p.(Gly13Cys) g.25398282C>A g.25245348C>A - - KRAS_000008 - PubMed: Tarailo-Graovac 2016, Journal: Tarailo-Graovac 2016 - - Somatic - - - 0 - Johan den Dunnen
+/. 2 c.38G>A - r.(?) p.(Gly13Asp) g.25398281C>T g.25245347C>T - - KRAS_000003 - - - - Somatic - - - 0 - Phil Chambers
+/. - c.38G>A pathogenic r.(?) p.(Gly13Asp) g.25398281C>T - KRAS:NM_004985.3:c.38G>A (Gly13Asp) - KRAS_000003 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
+/. - c.40G>A pathogenic r.(?) p.(Val14Ile) g.25398279C>T - KRAS:NM_004985.3:c.40G>A (Val14Ile) - KRAS_000032 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
+?/. - c.40G>A likely pathogenic r.(?) p.(Val14Ile) g.25398279C>T - - - KRAS_000032 - - - - Somatic - - - 0 - Lisa-Marie Niestroj
+?/. - c.53C>T likely pathogenic r.(?) p.(Ala18Val) g.25398266G>A - KRAS:NM_033360.2:c.53C>T (Ala18Val) - KRAS_000031 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
?/. 2 c.64C>A - r.(?) p.(Gln22Lys) g.25398255G>T g.25245321G>T - - KRAS_000009 - - - - Somatic - - - 0 - Johan den Dunnen
+/. - c.65A>G pathogenic r.(?) p.(Gln22Arg) g.25398254T>C - KRAS:NM_033360.3:c.65A>G (Gln22Arg) - KRAS_000030 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
+?/. - c.68T>G likely pathogenic r.(?) p.(Leu23Arg) g.25398251A>C - KRAS:NM_033360.3:c.68T>G (Leu23Arg) - KRAS_000029 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
+/. - c.108A>G pathogenic r.(?) p.(Ile36Met) g.25398211T>C - KRAS:NM_004985.3:c.108A>G (Ile36Met) - KRAS_000028 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
+?/. 2 c.178G>C - r.(?) p.(Gly60Arg) g.25380280C>G g.25227346C>G - - KRAS_000013 - PubMed: Joyce 2016 - rs104894359 Unknown ? - - 0 - Pia Ostergaard
+?/. - c.179G>A likely pathogenic r.(?) p.(Gly60Asp) g.25380279C>T - KRAS:c.179G>A (G60D) - KRAS_000037 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_AMC
+?/. - c.182A>C ACMG: 4 r.(?) p.(Gln61Pro) g.25380276T>G g.25227342T>G - - KRAS_000014 - Trujillano et al., submitted - - De novo - - - 0 - Daniel Trujillano
+?/. 3 c.182A>T - r.(?) p.(Gln61Leu) g.25380276T>A g.25227342T>A - - KRAS_000004 - - - - Somatic - - - 0 - Phil Chambers
+?/. 3 c.183A>T - r.(?) p.(Gln61His) g.25380275T>A g.25227341T>A - - KRAS_000005 - - - - Somatic - - - 0 - Phil Chambers
+?/. - c.347A>G likely pathogenic r.(?) p.(Asn116Ser) g.25378651T>C - KRAS:NM_033360.2:c.347A>G (Asn116Ser) - KRAS_000027 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
?/. - c.400G>A VUS r.(?) p.(Ala134Thr) g.25378598C>T - KRAS:NM_033360.2:c.400G>A (Ala134Thr) - KRAS_000026 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
+/. 4 c.440A>G ACMG: 5 r.(?) p.(Lys147Arg) g.25378558T>C g.25225624T>C - - KRAS_000015 - - - - Germline/De novo (untested) yes - - 0 - Bernt Popp
-/. - c.451-5749del benign r.(=) p.(=) g.25368594del - KRAS:c.451-100delA - KRAS_000036 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Utrecht
-?/. - c.451-5669A>G likely benign r.(=) p.(=) g.25368514T>C - KRAS:NM_033360.2:c.451-20A>G (spl?) - KRAS_000025 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
-/. - c.451-5658A>G benign r.(=) p.(=) g.25368503T>C - KRAS:NM_004985.4:c.451-9G>A (?) - KRAS_000024 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
?/. - c.451-5622G>A VUS r.(=) p.(=) g.25368467C>T - KRAS:NM_033360:c.478G>A (Val160Met) - KRAS_000023 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
-/. - c.451-5617G>A benign r.(=) p.(=) g.25368462C>T - KRAS:c.483G>A (=) - KRAS_000035 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_AMC
-/. - c.451-5617G>A benign r.(=) p.(=) g.25368462C>T - KRAS:c.483G>A (=) - KRAS_000035 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Groningen
-?/. - c.451-5604T>A likely benign r.(=) p.(=) g.25368449A>T - KRAS:NM_033360.3:c.496T>A (Tyr166Asn) - KRAS_000022 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
-?/. - c.451-5535A>C likely benign r.(=) p.(=) g.25368380T>G - KRAS:c.565A>C (M189L) - KRAS_000021 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Utrecht
-?/. - c.451-5535A>C likely benign r.(=) p.(=) g.25368380T>G - KRAS:NM_033360,2:c.565A>C (Met189Leu) - KRAS_000021 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
-/. - c.451-9G>A benign r.(=) p.(=) g.25362854C>T - KRAS:c.*5-9G>A - KRAS_000034 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_AMC
-/. - c.451-7A>T benign r.(=) p.(=) g.25362852T>A - KRAS:NM_004985.3:c.451-7A>T (?) - KRAS_000020 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
+/. - c.458A>T pathogenic r.(?) p.(Asp153Val) g.25362838T>A - KRAS:NM_004985.4(KRAS):c.458A>T (Asp153Val) - KRAS_000019 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
-/. - c.519T>C benign r.(=) p.(=) g.25362777A>G - KRAS:c.519T>C (=) - KRAS_000018 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_AMC
-/. - c.519T>C benign r.(=) p.(=) g.25362777A>G - KRAS:NM_033360.3:c.*73T>C (?) - KRAS_000018 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
?/. - c.531_533del VUS r.(?) p.(Lys180del) g.25362763_25362765del - KRAS:c.531_533delGAA (K180del) - KRAS_000017 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Groningen
?/. - c.531_533del VUS r.(?) p.(Lys180del) g.25362763_25362765del - KRAS:NM_001001660.2:c.*5517_*5519del, NM_004985.3:c.531_533del, … - KRAS_000017 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Leiden
-?/. - c.531_533del likely benign r.(?) p.(Lys180del) g.25362763_25362765del - KRAS:NM_004985.3:c.531_533del (Lys180del) - KRAS_000017 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Nijmegen
-?/. 5 c.*177T>G - r.(=) p.(=) g.25362552A>C g.25209618A>C - - KRAS_000010 - PubMed: Almomani 2011 - rs712 Germline - - - 0 - Gerard C.P. Schaafsma
-/. - c.*512T>C benign r.(=) p.(=) g.25362217A>G - KRAS:c.*633T>C - KRAS_000016 VKGL data sharing initiative Nederland; correct HGVS to be checked - - - CLASSIFICATION record - - - 0 - VKGL-NL_Groningen
-?/. 5 c.*2888A>G - r.(=) p.(=) g.25359841T>C g.25206907T>C - - KRAS_000011 - PubMed: Almomani 2011 - rs13096 Germline - - - 0 - Gerard C.P. Schaafsma
Legend