Full data view for gene KRAS

Information The variants shown are described using the NM_004985.3 transcript reference sequence.

59 entries on 1 page. Showing entries 1 - 59.
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Effect     

Exon     

AscendingDNA change (cDNA)     

ClassClinical     

RNA change     

Protein     

Allele     

DNA change (genomic) (hg19)     

DNA change (hg38)     

Published as     

ISCN     

DB-ID     

Variant remarks     

Reference     

ClinVar ID     

dbSNP ID     

Origin     

Segregation     

Frequency     

Re-site     

VIP     

Methylation     

Template     

Technique     

Tissue     

Remarks     

Disease     

ID_report     

Reference     

Remarks     

Gender     

Consanguinity     

Country     

Population     

Age/Death     

VIP     

Data_av     

Treatment     

Panel size     

Owner     
-?/. - c.24A>G likely benign r.(?) p.(=) Unknown g.25398295T>C - KRAS(NM_033360.3):c.24A>G (p.=) - KRAS_000033 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. 2 c.32_35delinsGTGC - r.(?) p.(Ala11_Gly12delinsGlyAla) Unknown g.25398284_25398287delinsGCAC g.25245350_25245353delinsGCAC - - KRAS_000007 - - - - Somatic - - - 0 - DNA MCA, SEQ - - ACLC - - - - - France - - 0 - - 1 Johan den Dunnen
+?/. 1 c.34G>A - r.(?) p.(Gly12Ser) Unknown g.25398285C>T g.25245351C>T - - KRAS_000012 - PubMed: Joyce 2016 - rs121913530 Unknown ? - - 0 - DNA SEQ blood - NS-3 - PubMed: Joyce 2016 - M - (United Kingdom (Great Britain)) - - 0 - - 1 Pia Ostergaard
?/. - c.34G>A VUS r.(?) p.(Gly12Ser) Unknown g.25398285C>T - KRAS(NM_033360.3):c.34G>A (p.G12S) - KRAS_000012 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. 2 c.34_35delinsCT - r.(?) p.(Gly12Leu) Unknown g.25398284_25398285delinsAG g.25245350_25245351delinsAG - - KRAS_000006 - - - - Somatic - - - 0 - DNA MCA, SEQ - - CRC - - - - - France - - 0 - - 1 Johan den Dunnen
?/. 2 c.35G>A - r.(?) p.(Gly12Asp) Unknown g.25398284C>T g.25245350C>T - - KRAS_000001 - - - - Somatic - - - 0 - DNA SEQ-NG-I - - CRC - - - - - - - - 0 - - 1 Phil Chambers
+/. - c.35G>A pathogenic r.(?) p.(Gly12Asp) Unknown g.25398284C>T - KRAS(NM_004985.3):c.35G>A (p.Gly12Asp) - KRAS_000001 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
+/. 2 c.35G>T - r.(?) p.(Gly12Val) Unknown g.25398284C>A g.25245350C>A - - KRAS_000002 - - - - Somatic - - - 0 - DNA SEQ-NG-I - - CRC - - - - - - - - 0 - - 1 Phil Chambers
+/. - c.35G>T - r.(?) p.(Gly12Val) Parent #1 g.25398284C>A g.25245350C>A - - KRAS_000002 - - - - Germline - - - 0 - DNA SEQ - - - - - - - - Germany - - 0 - - 1 Andreas Laner
?/. 2 c.37G>T - r.(?) p.(Gly13Cys) Unknown g.25398282C>A g.25245348C>A - - KRAS_000008 - - - - Somatic - - - 0 - DNA MCA, SEQ - - ACLC - - - - - France - - 0 - - 1 Johan den Dunnen
+/. - c.37G>T - r.(?) p.(Gly13Cys) Unknown g.25398282C>A g.25245348C>A - - KRAS_000008 - PubMed: Tarailo-Graovac 2016, Journal: Tarailo-Graovac 2016 - - Somatic - - - 0 - DNA SEQ, SEQ-NG - - RALD;ALPS-4 - PubMed: Tarailo-Graovac 2016, Journal: Tarailo-Graovac 2016 2-generation family, 1 affected, unaffected heterozygous carrier parents M - United States - - 0 - - 1 Johan den Dunnen
+/. 2 c.38G>A - r.(?) p.(Gly13Asp) Unknown g.25398281C>T g.25245347C>T - - KRAS_000003 - - - - Somatic - - - 0 - DNA SEQ-NG-I - - CRC - - - - - - - - 0 - - 1 Phil Chambers
+/. - c.38G>A pathogenic r.(?) p.(Gly13Asp) Unknown g.25398281C>T - KRAS(NM_004985.3):c.38G>A (p.Gly13Asp) - KRAS_000003 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+/. - c.40G>A pathogenic r.(?) p.(Val14Ile) Unknown g.25398279C>T - KRAS(NM_004985.3):c.40G>A (p.Val14Ile) - KRAS_000032 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+?/. - c.40G>A likely pathogenic r.(?) p.(Val14Ile) Unknown g.25398279C>T - - - KRAS_000032 - - - - Somatic - - - 0 - DNA SEQ-NG Brain tissue gene panel ganglioglioma patient15 - - F ? ? (unknown) - - 0 - - 1 Lisa-Marie Niestroj
+?/. - c.53C>T likely pathogenic r.(?) p.(Ala18Val) Unknown g.25398266G>A - KRAS(NM_033360.2):c.53C>T (p.Ala18Val) - KRAS_000031 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. 2 c.64C>A - r.(?) p.(Gln22Lys) Unknown g.25398255G>T g.25245321G>T - - KRAS_000009 - - - - Somatic - - - 0 - DNA MCA, SEQ - - CRC - - - - - France - - 0 - - 1 Johan den Dunnen
+/. - c.65A>G pathogenic r.(?) p.(Gln22Arg) Unknown g.25398254T>C - KRAS(NM_033360.3):c.65A>G (p.Gln22Arg) - KRAS_000030 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+?/. - c.68T>G likely pathogenic r.(?) p.(Leu23Arg) Unknown g.25398251A>C - KRAS(NM_033360.3):c.68T>G (p.Leu23Arg) - KRAS_000029 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+/. - c.108A>G pathogenic r.(?) p.(Ile36Met) Unknown g.25398211T>C - KRAS(NM_004985.3):c.108A>G (p.Ile36Met) - KRAS_000028 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+/. - c.108A>G pathogenic r.(?) p.(Ile36Met) Unknown g.25398211T>C - KRAS(NM_004985.3):c.108A>G (p.Ile36Met) - KRAS_000028 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
+?/. 2 c.178G>C - r.(?) p.(Gly60Arg) Unknown g.25380280C>G g.25227346C>G - - KRAS_000013 - PubMed: Joyce 2016 - rs104894359 Unknown ? - - 0 - DNA SEQ blood - NS-3 - PubMed: Joyce 2016 - M - (United Kingdom (Great Britain)) - - 0 - - 1 Pia Ostergaard
+?/. - c.179G>A likely pathogenic r.(?) p.(Gly60Asp) Unknown g.25380279C>T - KRAS(NM_033360.3):c.179G>A (p.G60D) - KRAS_000037 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+?/. - c.182A>C ACMG: 4 r.(?) p.(Gln61Pro) Unknown g.25380276T>G g.25227342T>G - - KRAS_000014 - Trujillano et al., submitted - - De novo - - - 0 - DNA SEQ, SEQ-NG - - RALD;ALPS-4 - Trujillano et al., submitted unaffected non-carrier parents - - - - - 0 - - 1 Daniel Trujillano
+?/. 3 c.182A>T - r.(?) p.(Gln61Leu) Unknown g.25380276T>A g.25227342T>A - - KRAS_000004 - - - - Somatic - - - 0 - DNA SEQ-NG-I - - CRC - - - - - - - - 0 - - 1 Phil Chambers
+?/. 3 c.183A>T - r.(?) p.(Gln61His) Unknown g.25380275T>A g.25227341T>A - - KRAS_000005 - - - - Somatic - - - 0 - DNA SEQ-NG-I - - CRC - - - - - - - - 0 - - 1 Phil Chambers
+/. - c.211T>C pathogenic r.(?) p.(Tyr71His) Unknown g.25380247A>G - KRAS(NM_004985.3):c.211T>C (p.(Tyr71His)) - LYRM5_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
+?/. - c.214A>C likely pathogenic r.(?) p.(Met72Leu) Unknown g.25380244T>G - KRAS(NM_033360.2):c.214A>C (p.(Met72Leu)) - LYRM5_000008 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
+?/. - c.347A>G likely pathogenic r.(?) p.(Asn116Ser) Unknown g.25378651T>C - KRAS(NM_033360.2):c.347A>G (p.Asn116Ser) - KRAS_000027 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.400G>A VUS r.(?) p.(Ala134Thr) Unknown g.25378598C>T - KRAS(NM_033360.2):c.400G>A (p.Ala134Thr) - KRAS_000026 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+/. 4 c.440A>G ACMG: 5 r.(?) p.(Lys147Arg) Unknown g.25378558T>C g.25225624T>C - - KRAS_000015 - - - - Germline/De novo (untested) yes - - 0 - DNA SEQ-NG - - NS-3 S_009 - - F no - - - 0 - - 1 Bernt Popp
-?/. - c.450+3A>G likely benign r.spl? p.? Unknown g.25378545T>C - KRAS(NM_004985.3):c.450+3A>G (p.?) - LYRM5_000007 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.451-5749del benign r.(=) p.(=) Unknown g.25368606del - KRAS(NM_033360.3):c.451-100delA - KRAS_000036 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.451-5669A>G likely benign r.(=) p.(=) Unknown g.25368514T>C - KRAS(NM_033360.2):c.451-20A>G (p.spl?) - KRAS_000025 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.451-5622G>A VUS r.(=) p.(=) Unknown g.25368467C>T - KRAS(NM_033360):c.478G>A (p.Val160Met) - KRAS_000023 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.451-5617G>A benign r.(=) p.(=) Unknown g.25368462C>T - KRAS(NM_033360.3):c.483G>A (p.R161=) - KRAS_000035 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.451-5617G>A benign r.(=) p.(=) Unknown g.25368462C>T - KRAS(NM_033360.3):c.483G>A (p.R161=) - KRAS_000035 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.451-5609G>A likely benign r.(=) p.(=) Unknown g.25368454C>T - KRAS(NM_033360.2):c.491G>A (p.(Arg164Gln)) - LYRM5_000006 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.451-5604T>A likely benign r.(=) p.(=) Unknown g.25368449A>T - KRAS(NM_033360.3):c.496T>A (p.Tyr166Asn) - KRAS_000022 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.451-5560T>A VUS r.(=) p.(=) Unknown g.25368405A>T - KRAS(NM_033360.2):c.540T>A (p.(Cys180Ter)) - LYRM5_000005 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.451-5535A>C likely benign r.(=) p.(=) Unknown g.25368380T>G - KRAS(NM_033360.3):c.565A>C (p.M189L) - KRAS_000021 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.451-5535A>C likely benign r.(=) p.(=) Unknown g.25368380T>G - KRAS(NM_033360.3):c.565A>C (p.M189L) - KRAS_000021 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.451-5535A>C likely benign r.(=) p.(=) Unknown g.25368380T>G - KRAS(NM_033360.3):c.565A>C (p.M189L) - KRAS_000021 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. - c.451-5521G>A likely benign r.(=) p.(=) Unknown g.25368366C>T - KRAS(NM_033360.3):c.*4+5G>A - LYRM5_000004 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.451-18A>G benign r.(=) p.(=) Unknown g.25362863T>C - KRAS(NM_033360.3):c.*5-18A>G - LYRM5_000003 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-/. - c.451-9G>A benign r.(=) p.(=) Unknown g.25362854C>T - KRAS(NM_033360.3):c.*5-9G>A - KRAS_000034 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.451-7A>T benign r.(=) p.(=) Unknown g.25362852T>A - KRAS(NM_004985.3):c.451-7A>T (p.?) - KRAS_000020 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
+/. - c.458A>T pathogenic r.(?) p.(Asp153Val) Unknown g.25362838T>A - KRAS(NM_004985.4):c.458A>T (p.Asp153Val) - KRAS_000019 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.519T>C benign r.(?) p.(=) Unknown g.25362777A>G - KRAS(NM_004985.4):c.519T>C (p.D173=) - KRAS_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.519T>C benign r.(?) p.(=) Unknown g.25362777A>G - KRAS(NM_004985.4):c.519T>C (p.D173=) - KRAS_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-/. - c.519T>C benign r.(?) p.(=) Unknown g.25362777A>G - KRAS(NM_004985.4):c.519T>C (p.D173=) - KRAS_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.531_533del VUS r.(?) p.(Lys180del) Unknown g.25362768_25362770del - KRAS(NM_004985.4):c.531_533delGAA (p.K180del) - KRAS_000017 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
?/. - c.531_533del VUS r.(?) p.(Lys180del) Unknown g.25362768_25362770del - KRAS(NM_004985.4):c.531_533delGAA (p.K180del) - KRAS_000017 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. - c.531_533del likely benign r.(?) p.(Lys180del) Unknown g.25362768_25362770del - KRAS(NM_004985.4):c.531_533delGAA (p.K180del) - KRAS_000017 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
-?/. 5 c.*177T>G - r.(=) p.(=) Parent #1 g.25362552A>C g.25209618A>C - - KRAS_000010 - PubMed: Almomani 2011 - rs712 Germline - - - 0 - DNA SEQ-NG - - autism, BMD/DMD, TSC - PubMed: Almomani 2011 - - - - - - 0 - - 1 LOVD-team, but with Curator vacancy
-/. - c.*512T>C benign r.(=) p.(=) Unknown g.25362217A>G - KRAS(NM_033360.3):c.*633T>C - KRAS_000016 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - 0 - - - - - - - - - - - - - - - - - - -
-?/. 5 c.*2888A>G - r.(=) p.(=) Parent #1 g.25359841T>C g.25206907T>C - - KRAS_000011 - PubMed: Almomani 2011 - rs13096 Germline - - - 0 - DNA SEQ-NG - - - - PubMed: Almomani 2011 - - - - - - 0 - - 1 LOVD-team, but with Curator vacancy
-?/. - c.*5484C>A likely benign r.(=) p.(=) Unknown g.25357245G>T - LYRM5(NM_001001660.2):c.272G>T (p.(Ter91LeuextTer5)) - LYRM5_000002 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
?/. - c.*5578C>T VUS r.(=) p.(=) Unknown g.25357151G>A - LYRM5(NM_001001660.2):c.178G>A (p.(Glu60Lys)) - LYRM5_000001 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - - - - - - - - - - - - - - - - - - -
Legend