Unique variants in gene KRAS

Information The variants shown are described using the NM_004985.3 transcript reference sequence.

52 entries on 1 page. Showing entries 1 - 52.
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Effect     

Reported     

Exon     

AscendingDNA change (cDNA)     

RNA change     

Protein     

Classification method     

Clinical classification     

DNA change (genomic) (hg19)     

DNA change (hg38)     

Published as     

ISCN     

DB-ID     

Variant remarks     

Reference     

ClinVar ID     

dbSNP ID     

Origin     

Segregation     

Frequency     

Re-site     

VIP     

Methylation     

Owner     
-?/. 2 - c.24A>G r.(?) p.(Val8=) - likely benign g.25398295T>C g.25245361T>C KRAS(NM_033360.4):c.24A>G (p.V8=) - KRAS_000033 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC, VKGL-NL_Nijmegen
?/. 1 2 c.32_35delinsGTGC r.(?) p.(Ala11_Gly12delinsGlyAla) - VUS g.25398284_25398287delinsGCAC g.25245350_25245353delinsGCAC - - KRAS_000007 - - - - Somatic - - - - - Johan den Dunnen
?/., +?/. 2 1 c.34G>A r.(?) p.(Gly12Ser) - VUS, likely pathogenic g.25398285C>T g.25245351C>T KRAS(NM_033360.3):c.34G>A (p.G12S) - KRAS_000012 VKGL data sharing initiative Nederland PubMed: Joyce 2016 - rs121913530 CLASSIFICATION record, Unknown ? - - - - VKGL-NL_Rotterdam, Pia Ostergaard
?/. 1 2 c.34_35delinsCT r.(?) p.(Gly12Leu) - VUS g.25398284_25398285delinsAG g.25245350_25245351delinsAG - - KRAS_000006 - - - - Somatic - - - - - Johan den Dunnen
?/., +/. 2 2 c.35G>A r.(?) p.(Gly12Asp) - VUS, pathogenic g.25398284C>T g.25245350C>T - - KRAS_000001 VKGL data sharing initiative Nederland - - - Somatic, CLASSIFICATION record - - - - - Phil Chambers, VKGL-NL_Nijmegen
+/. 3 2 c.35G>T r.(?) p.(Gly12Val) - pathogenic g.25398284C>A g.25245350C>A - - KRAS_000002 VKGL data sharing initiative Nederland - - - Somatic, CLASSIFICATION record, Germline - - - - - Phil Chambers, VKGL-NL_Nijmegen, Andreas Laner
?/., +/. 2 2 c.37G>T r.(?) p.(Gly13Cys) - VUS, pathogenic g.25398282C>A g.25245348C>A - - KRAS_000008 - PubMed: Tarailo-Graovac 2016, Journal: Tarailo-Graovac 2016 - - Somatic - - - - - Johan den Dunnen
+?/., +/. 3 2 c.38G>A r.(?) p.(Gly13Asp) - likely pathogenic, pathogenic g.25398281C>T g.25245347C>T KRAS(NM_033360.3):c.38G>A (p.G13D) - KRAS_000003 VKGL data sharing initiative Nederland - - - CLASSIFICATION record, Somatic - - - - - VKGL-NL_Rotterdam, Phil Chambers, VKGL-NL_Nijmegen
+/., +?/. 4 - c.40G>A r.(?) p.(Val14Ile) - pathogenic, likely pathogenic (dominant), likely pathogenic g.25398279C>T g.25245345C>T - - KRAS_000032 VKGL data sharing initiative Nederland PubMed: Grozeva 2015, Journal: Grozeva 2015 - rs104894365 CLASSIFICATION record, Germline/De novo (untested), Somatic - - - - - VKGL-NL_Nijmegen, Johan den Dunnen, Lisa-Marie Niestroj
+?/. 1 - c.53C>T r.(?) p.(Ala18Val) - likely pathogenic g.25398266G>A g.25245332G>A - - KRAS_000031 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
?/. 1 2 c.64C>A r.(?) p.(Gln22Lys) - VUS g.25398255G>T g.25245321G>T - - KRAS_000009 - - - - Somatic - - - - - Johan den Dunnen
+/. 1 - c.65A>G r.(?) p.(Gln22Arg) - pathogenic g.25398254T>C g.25245320T>C - - KRAS_000030 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
+?/. 1 - c.68T>G r.(?) p.(Leu23Arg) - likely pathogenic g.25398251A>C g.25245317A>C - - KRAS_000029 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
-?/. 1 - c.90C>T r.(?) p.(Asp30=) - likely benign g.25398229G>A g.25245295G>A KRAS(NM_033360.4):c.90C>T (p.D30=) - LYRM5_000014 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC
+/. 1 - c.101C>G r.(?) p.(Pro34Arg) - pathogenic g.25398218G>C g.25245284G>C KRAS(NM_033360.3):c.101C>G (p.P34R) - LYRM5_000013 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Groningen
+/. 2 - c.108A>G r.(?) p.(Ile36Met) - pathogenic g.25398211T>C g.25245277T>C KRAS(NM_033360.4):c.108A>G (p.I36M) - KRAS_000028 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC, VKGL-NL_Nijmegen
?/. 1 - c.145G>T r.(?) p.(Glu49Ter) - VUS g.25380313C>A g.25227379C>A - - LYRM5_000012 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
+/. 1 - c.158T>G r.(?) p.(Leu53Trp) - pathogenic g.25380300A>C g.25227366A>C - - LYRM5_000011 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
+/. 1 - c.173C>T r.(?) p.(Thr58Ile) - pathogenic g.25380285G>A - - - LYRM5_000015 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
+?/. 1 2 c.178G>C r.(?) p.(Gly60Arg) - likely pathogenic g.25380280C>G g.25227346C>G - - KRAS_000013 - PubMed: Joyce 2016 - rs104894359 Unknown ? - - - - Pia Ostergaard
+?/. 1 - c.179G>A r.(?) p.(Gly60Asp) - likely pathogenic g.25380279C>T g.25227345C>T KRAS(NM_033360.4):c.179G>A (p.G60D) - KRAS_000037 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC
+?/. 1 - c.182A>C r.(?) p.(Gln61Pro) ACMG likely pathogenic g.25380276T>G g.25227342T>G - - KRAS_000014 - Trujillano et al., submitted - - De novo - - - - - Daniel Trujillano
+?/. 1 3 c.182A>T r.(?) p.(Gln61Leu) - likely pathogenic g.25380276T>A g.25227342T>A - - KRAS_000004 - - - - Somatic - - - - - Phil Chambers
+?/. 1 3 c.183A>T r.(?) p.(Gln61His) - likely pathogenic g.25380275T>A g.25227341T>A - - KRAS_000005 - - - - Somatic - - - - - Phil Chambers
?/. 1 - c.198A>G r.(?) p.(Ala66=) - VUS g.25380260T>C g.25227326T>C KRAS(NM_004985.3):c.198A>G (p.(=)) - LYRM5_000010 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Leiden
+/. 1 - c.211T>C r.(?) p.(Tyr71His) - pathogenic g.25380247A>G g.25227313A>G KRAS(NM_004985.3):c.211T>C (p.(Tyr71His)) - LYRM5_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Leiden
+?/. 1 - c.214A>C r.(?) p.(Met72Leu) - likely pathogenic g.25380244T>G g.25227310T>G - - LYRM5_000008 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
+/. 1 - c.214A>T r.(?) p.(Met72Leu) - pathogenic g.25380244T>A g.25227310T>A - - KRAS_000040 1 heterozygous, no homozygous; Clinindb (India) Faruq 2020, submtted - rs727504662 Germline - 1/2788 individuals - - - Mohammed Faruq
+?/. 1 - c.347A>G r.(?) p.(Asn116Ser) - likely pathogenic g.25378651T>C g.25225717T>C - - KRAS_000027 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
?/. 1 - c.400G>A r.(?) p.(Ala134Thr) - VUS g.25378598C>T g.25225664C>T - - KRAS_000026 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
+/. 1 4 c.440A>G r.(?) p.(Lys147Arg) ACMG pathogenic g.25378558T>C g.25225624T>C - - KRAS_000015 - - - - Germline/De novo (untested) yes - - - - Bernt Popp
-?/. 1 - c.450+3A>G r.spl? p.? - likely benign g.25378545T>C g.25225611T>C KRAS(NM_004985.3):c.450+3A>G (p.?) - LYRM5_000007 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Leiden
-/. 1 - c.451-5749del r.(=) p.(=) - benign g.25368606del g.25215672del KRAS(NM_033360.3):c.451-100delA - KRAS_000036 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Utrecht
-?/. 1 - c.451-5669A>G r.(=) p.(=) - likely benign g.25368514T>C g.25215580T>C - - KRAS_000025 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
-/. 1 - c.451-5658A>G r.(=) p.(=) - benign g.25368503T>C g.25215569T>C - - KRAS_000024 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
?/. 1 - c.451-5622G>A r.(=) p.(=) - VUS g.25368467C>T g.25215533C>T - - KRAS_000023 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
-/. 2 - c.451-5617G>A r.(=) p.(=) - benign g.25368462C>T g.25215528C>T KRAS(NM_033360.3):c.483G>A (p.R161=), KRAS(NM_033360.4):c.483G>A (p.R161=) - KRAS_000035 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC, VKGL-NL_Groningen
-?/. 1 - c.451-5609G>A r.(=) p.(=) - likely benign g.25368454C>T g.25215520C>T - - LYRM5_000006 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
-?/. 1 - c.451-5604T>A r.(=) p.(=) - likely benign g.25368449A>T g.25215515A>T - - KRAS_000022 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
-?/. 4 - c.451-5535A>C r.(=) p.(=) - likely benign g.25368380T>G g.25215446T>G KRAS(NM_033360.3):c.565A>C (p.M189L), KRAS(NM_033360.4):c.565A>C (p.M189L) - KRAS_000021 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC, VKGL-NL_Rotterdam, VKGL-NL_Nijmegen, VKGL-NL_Utrecht
-?/. 1 - c.451-5521G>A r.(=) p.(=) - likely benign g.25368366C>T g.25215432C>T KRAS(NM_033360.4):c.*4+5G>A - LYRM5_000004 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC
-?/. 2 - c.451-240G>A r.(=) p.(=) - likely benign g.25363085C>T g.25210151C>T - - KRAS_000039 138 heterozygous; Clinindb (India), 5 homozygous; Clinindb (India) Faruq 2020, submtted - rs61763587 Germline - 138/2794 individuals, 5/2794 individuals - - - Mohammed Faruq
-/. 1 - c.451-18A>G r.(=) p.(=) - benign g.25362863T>C g.25209929T>C KRAS(NM_033360.4):c.*5-18A>G - LYRM5_000003 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC
-?/., -/. 2 - c.451-9G>A r.(=) p.(=) - likely benign, benign g.25362854C>T g.25209920C>T KRAS(NM_004985.3):c.451-9G>A (p.(=)), KRAS(NM_033360.4):c.*5-9G>A - KRAS_000034 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Leiden, VKGL-NL_AMC
-/. 1 - c.451-7A>T r.(=) p.(=) - benign g.25362852T>A g.25209918T>A - - KRAS_000020 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
+/. 1 - c.458A>T r.(?) p.(Asp153Val) - pathogenic g.25362838T>A g.25209904T>A - - KRAS_000019 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Nijmegen
-/. 3 - c.519T>C r.(?) p.(Asp173=) - benign g.25362777A>G g.25209843A>G KRAS(NM_004985.4):c.519T>C (p.D173=), KRAS(NM_004985.5):c.519T>C (p.D173=) - KRAS_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Groningen, VKGL-NL_AMC, VKGL-NL_Nijmegen
-?/., ?/. 3 - c.531_533del r.(?) p.(Lys180del) - likely benign, VUS g.25362768_25362770del g.25209834_25209836del 1 more item - KRAS_000017 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC, VKGL-NL_Leiden, VKGL-NL_Groningen
-?/. 1 5 c.*177T>G r.(=) p.(=) - likely benign g.25362552A>C g.25209618A>C - - KRAS_000010 - PubMed: Almomani 2011 - rs712 Germline - - - - - Gerard C.P. Schaafsma
-/. 1 - c.*512T>C r.(=) p.(=) - benign g.25362217A>G g.25209283A>G KRAS(NM_033360.3):c.*633T>C - KRAS_000016 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Groningen
-?/. 2 - c.*2505T>G r.(=) p.(=) - likely benign g.25360224A>C g.25207290A>C - - KRAS_000038 102 heterozygous; Clinindb (India), 3 homozygous; Clinindb (India) Faruq 2020, submtted - rs61764370 Germline - 102/2749 individuals, 3/2749 individuals - - - Mohammed Faruq
-?/. 1 5 c.*2888A>G r.(=) p.(=) - likely benign g.25359841T>C g.25206907T>C - - KRAS_000011 - PubMed: Almomani 2011 - rs13096 Germline - - - - - Gerard C.P. Schaafsma
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