Unique variants in gene KRAS

Information The variants shown are described using the NM_004985.3 transcript reference sequence.

48 entries on 1 page. Showing entries 1 - 48.
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Effect     

Reported     

Exon     

AscendingDNA change (cDNA)     

ClassClinical     

RNA change     

Protein     

DNA change (genomic) (hg19)     

DNA change (hg38)     

Published as     

ISCN     

DB-ID     

Variant remarks     

Reference     

ClinVar ID     

dbSNP ID     

Origin     

Segregation     

Frequency     

Re-site     

VIP     

Methylation     

Owner     
-?/. 2 - c.24A>G likely benign r.(?) p.(=) g.25398295T>C - KRAS(NM_033360.4):c.24A>G (p.V8=) - KRAS_000033 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC, VKGL-NL_Nijmegen
?/. 1 2 c.32_35delinsGTGC - r.(?) p.(Ala11_Gly12delinsGlyAla) g.25398284_25398287delinsGCAC g.25245350_25245353delinsGCAC - - KRAS_000007 - - - - Somatic - - - - - Johan den Dunnen
?/., +?/. 2 1 c.34G>A VUS r.(?) p.(Gly12Ser) g.25398285C>T g.25245351C>T KRAS(NM_033360.3):c.34G>A (p.G12S) - KRAS_000012 VKGL data sharing initiative Nederland PubMed: Joyce 2016 - rs121913530 CLASSIFICATION record, Unknown ? - - - - VKGL-NL, Pia Ostergaard
?/. 1 2 c.34_35delinsCT - r.(?) p.(Gly12Leu) g.25398284_25398285delinsAG g.25245350_25245351delinsAG - - KRAS_000006 - - - - Somatic - - - - - Johan den Dunnen
?/., +/. 2 2 c.35G>A pathogenic r.(?) p.(Gly12Asp) g.25398284C>T g.25245350C>T - - KRAS_000001 VKGL data sharing initiative Nederland - - - Somatic, CLASSIFICATION record - - - - - Phil Chambers, VKGL-NL
+/. 3 2 c.35G>T pathogenic r.(?) p.(Gly12Val) g.25398284C>A g.25245350C>A - - KRAS_000002 VKGL data sharing initiative Nederland - - - Somatic, CLASSIFICATION record, Germline - - - - - Phil Chambers, VKGL-NL, Andreas Laner
?/., +/. 2 2 c.37G>T - r.(?) p.(Gly13Cys) g.25398282C>A g.25245348C>A - - KRAS_000008 - PubMed: Tarailo-Graovac 2016, Journal: Tarailo-Graovac 2016 - - Somatic - - - - - Johan den Dunnen
+?/., +/. 3 2 c.38G>A likely pathogenic, pathogenic r.(?) p.(Gly13Asp) g.25398281C>T g.25245347C>T KRAS(NM_033360.3):c.38G>A (p.G13D) - KRAS_000003 VKGL data sharing initiative Nederland - - - CLASSIFICATION record, Somatic - - - - - VKGL-NL_Rotterdam, Phil Chambers, VKGL-NL_Nijmegen
+/., +?/. 2 - c.40G>A pathogenic, likely pathogenic r.(?) p.(Val14Ile) g.25398279C>T - - - KRAS_000032 VKGL data sharing initiative Nederland - - - CLASSIFICATION record, Somatic - - - - - VKGL-NL, Lisa-Marie Niestroj
+?/. 1 - c.53C>T likely pathogenic r.(?) p.(Ala18Val) g.25398266G>A - - - KRAS_000031 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
?/. 1 2 c.64C>A - r.(?) p.(Gln22Lys) g.25398255G>T g.25245321G>T - - KRAS_000009 - - - - Somatic - - - - - Johan den Dunnen
+/. 1 - c.65A>G pathogenic r.(?) p.(Gln22Arg) g.25398254T>C - - - KRAS_000030 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+?/. 1 - c.68T>G likely pathogenic r.(?) p.(Leu23Arg) g.25398251A>C - - - KRAS_000029 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-?/. 1 - c.90C>T likely benign r.(?) p.(=) g.25398229G>A - KRAS(NM_033360.4):c.90C>T (p.D30=) - LYRM5_000014 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+/. 1 - c.101C>G pathogenic r.(?) p.(Pro34Arg) g.25398218G>C - KRAS(NM_033360.3):c.101C>G (p.P34R) - LYRM5_000013 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+/. 2 - c.108A>G pathogenic r.(?) p.(Ile36Met) g.25398211T>C - KRAS(NM_033360.4):c.108A>G (p.I36M) - KRAS_000028 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC, VKGL-NL_Nijmegen
?/. 1 - c.145G>T VUS r.(?) p.(Glu49*) g.25380313C>A - - - LYRM5_000012 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+/. 1 - c.158T>G pathogenic r.(?) p.(Leu53Trp) g.25380300A>C - - - LYRM5_000011 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+?/. 1 2 c.178G>C - r.(?) p.(Gly60Arg) g.25380280C>G g.25227346C>G - - KRAS_000013 - PubMed: Joyce 2016 - rs104894359 Unknown ? - - - - Pia Ostergaard
+?/. 1 - c.179G>A likely pathogenic r.(?) p.(Gly60Asp) g.25380279C>T - KRAS(NM_033360.4):c.179G>A (p.G60D) - KRAS_000037 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+?/. 1 - c.182A>C ACMG: 4 r.(?) p.(Gln61Pro) g.25380276T>G g.25227342T>G - - KRAS_000014 - Trujillano et al., submitted - - De novo - - - - - Daniel Trujillano
+?/. 1 3 c.182A>T - r.(?) p.(Gln61Leu) g.25380276T>A g.25227342T>A - - KRAS_000004 - - - - Somatic - - - - - Phil Chambers
+?/. 1 3 c.183A>T - r.(?) p.(Gln61His) g.25380275T>A g.25227341T>A - - KRAS_000005 - - - - Somatic - - - - - Phil Chambers
?/. 1 - c.198A>G VUS r.(?) p.(=) g.25380260T>C - KRAS(NM_004985.3):c.198A>G (p.(=)) - LYRM5_000010 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+/. 1 - c.211T>C pathogenic r.(?) p.(Tyr71His) g.25380247A>G - KRAS(NM_004985.3):c.211T>C (p.(Tyr71His)) - LYRM5_000009 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+?/. 1 - c.214A>C likely pathogenic r.(?) p.(Met72Leu) g.25380244T>G - - - LYRM5_000008 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+?/. 1 - c.347A>G likely pathogenic r.(?) p.(Asn116Ser) g.25378651T>C - - - KRAS_000027 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
?/. 1 - c.400G>A VUS r.(?) p.(Ala134Thr) g.25378598C>T - - - KRAS_000026 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+/. 1 4 c.440A>G ACMG: 5 r.(?) p.(Lys147Arg) g.25378558T>C g.25225624T>C - - KRAS_000015 - - - - Germline/De novo (untested) yes - - - - Bernt Popp
-?/. 1 - c.450+3A>G likely benign r.spl? p.? g.25378545T>C - KRAS(NM_004985.3):c.450+3A>G (p.?) - LYRM5_000007 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-/. 1 - c.451-5749del benign r.(=) p.(=) g.25368606del - KRAS(NM_033360.3):c.451-100delA - KRAS_000036 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-?/. 1 - c.451-5669A>G likely benign r.(=) p.(=) g.25368514T>C - - - KRAS_000025 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-/. 1 - c.451-5658A>G benign r.(=) p.(=) g.25368503T>C - - - KRAS_000024 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
?/. 1 - c.451-5622G>A VUS r.(=) p.(=) g.25368467C>T - - - KRAS_000023 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-/. 2 - c.451-5617G>A benign r.(=) p.(=) g.25368462C>T - KRAS(NM_033360.3):c.483G>A (p.R161=), KRAS(NM_033360.4):c.483G>A (p.R161=) - KRAS_000035 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC, VKGL-NL_Groningen
-?/. 1 - c.451-5609G>A likely benign r.(=) p.(=) g.25368454C>T - - - LYRM5_000006 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-?/. 1 - c.451-5604T>A likely benign r.(=) p.(=) g.25368449A>T - - - KRAS_000022 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-?/. 3 - c.451-5535A>C likely benign r.(=) p.(=) g.25368380T>G - KRAS(NM_033360.3):c.565A>C (p.M189L) - KRAS_000021 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Rotterdam, VKGL-NL_Nijmegen, VKGL-NL_Utrecht
-?/. 1 - c.451-5521G>A likely benign r.(=) p.(=) g.25368366C>T - KRAS(NM_033360.4):c.*4+5G>A - LYRM5_000004 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-/. 1 - c.451-18A>G benign r.(=) p.(=) g.25362863T>C - KRAS(NM_033360.4):c.*5-18A>G - LYRM5_000003 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-/. 1 - c.451-9G>A benign r.(=) p.(=) g.25362854C>T - KRAS(NM_033360.4):c.*5-9G>A - KRAS_000034 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-/. 1 - c.451-7A>T benign r.(=) p.(=) g.25362852T>A - - - KRAS_000020 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
+/. 1 - c.458A>T pathogenic r.(?) p.(Asp153Val) g.25362838T>A - - - KRAS_000019 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-/. 3 - c.519T>C benign r.(?) p.(=) g.25362777A>G - KRAS(NM_004985.4):c.519T>C (p.D173=), KRAS(NM_004985.5):c.519T>C (p.D173=) - KRAS_000018 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_Groningen, VKGL-NL_AMC, VKGL-NL_Nijmegen
-?/., ?/. 3 - c.531_533del likely benign, VUS r.(?) p.(Lys180del) g.25362768_25362770del - 1 more item - KRAS_000017 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL_AMC, VKGL-NL_Leiden, VKGL-NL_Groningen
-?/. 1 5 c.*177T>G - r.(=) p.(=) g.25362552A>C g.25209618A>C - - KRAS_000010 - PubMed: Almomani 2011 - rs712 Germline - - - - - Gerard C.P. Schaafsma
-/. 1 - c.*512T>C benign r.(=) p.(=) g.25362217A>G - KRAS(NM_033360.3):c.*633T>C - KRAS_000016 VKGL data sharing initiative Nederland - - - CLASSIFICATION record - - - - - VKGL-NL
-?/. 1 5 c.*2888A>G - r.(=) p.(=) g.25359841T>C g.25206907T>C - - KRAS_000011 - PubMed: Almomani 2011 - rs13096 Germline - - - - - Gerard C.P. Schaafsma
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