HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) - coding DNA reference sequence

(used for variant description)

(last modified October 20, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_031407.5 in the HUWE1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016261.2, covering HUWE1 transcript NM_031407.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       gagttt       c.-421

 .         .         .         .         .         .                g.5066
 gagctgagccgaagcgaggaggctttcgactgagggctagcgaggggagcacggctggag       c.-361

 .         .         .         .         .         .                g.5126
 cagggctggagcagggctggagcagggctggagcagggctgaagcagggccgcggacccc       c.-301

 .         .         .         .         | 02         .             g.5405
 gcacgctcctgcgggccccgcggagccattgcggccgag | gcctcggcaggcgccagcgga    c.-241

 .         .         .         .         .         .                g.5465
 gagctagccgcatcttcgggggcagcccggcagctgccggcggcgcggcgagagagcggc       c.-181

 .         .        | 03.         .         .         .             g.11600
 tgacagaggggatgcgag | gtcctccagcagcctgacctgagtgggttagtgatccagaga    c.-121

 .         .         .         .         .         .                g.11660
 aaccagcaggccaacttggtcaggaaggttcgggaagctgttggagcagtgtggggaatt       c.-61

 .         .         .         .      | 04  .         .             g.37646
 tcccaccaggatgagtatgattggctgtgattttag | atcgtaaagctgaaaattgaaatc    c.-1

          .         .         .         .      | 05  .         .    g.43459
 ATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCT | CCTGCAGACTGCAGA    c.60
 M  K  V  D  R  T  K  L  K  K  T  P  T  E  A   | P  A  D  C  R      p.20

          .         .         .         .         .         .       g.43519
 GCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAG       c.120
 A  L  I  D  K  L  K  V  C  N  D  E  Q  L  L  L  E  L  Q  Q         p.40

          .         .     | 06   .         .         .         .    g.44216
 ATCAAAACATGGAACATTGGAAAG | TGCGAGTTATATCACTGGGTGGACCTGTTGGACCGC    c.180
 I  K  T  W  N  I  G  K   | C  E  L  Y  H  W  V  D  L  L  D  R      p.60

          .         .         .         .         .         .       g.44276
 TTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCATGGATGCTCGTA       c.240
 F  D  G  I  L  A  D  A  G  Q  T  V  E  N  M  S  W  M  L  V         p.80

          .         .         .         .         .         .       g.44336
 TGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACA       c.300
 C  D  R  P  E  R  E  Q  L  K  M  L  L  L  A  V  L  N  F  T         p.100

          .         .         .         .         .  | 07      .    g.46291
 GCCTTGCTCATTGAGTACAGCTTTTCCCGGCATCTGTACAGTTCCATAGAG | CATTTGACA    c.360
 A  L  L  I  E  Y  S  F  S  R  H  L  Y  S  S  I  E   | H  L  T      p.120

          .         .         .         .         .         .       g.46351
 ACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAATCTCCTATATGTA       c.420
 T  L  L  A  S  S  D  M  Q  V  V  L  A  V  L  N  L  L  Y  V         p.140

          .         .         .         .         .         .       g.46411
 TTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTA       c.480
 F  S  K  R  S  N  Y  I  T  R  L  G  S  D  K  R  T  P  L  L         p.160

          .         .     | 08   .         .         .         .    g.57483
 ACTCGGCTACAACATTTGGCAGAG | AGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCA    c.540
 T  R  L  Q  H  L  A  E   | S  W  G  G  K  E  N  G  F  G  L  A      p.180

          .         .        | 09.         .         .         .    g.59214
 GAATGTTGCAGAGACTTGCATATGATG | AAATATCCACCCAGTGCAACTACACTACACTTT    c.600
 E  C  C  R  D  L  H  M  M   | K  Y  P  P  S  A  T  T  L  H  F      p.200

          .         .         .         .      | 10  .         .    g.60146
 GAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGG | ACAACTAGTAACACA    c.660
 E  F  Y  A  D  P  G  A  E  V  K  I  E  K  R   | T  T  S  N  T      p.220

          .         .         .    | 11    .         .         .    g.60290
 CTACATTATATTCACATAGAGCAACTTGACAAG | ATTTCAGAAAGCCCTTCTGAAATCATG    c.720
 L  H  Y  I  H  I  E  Q  L  D  K   | I  S  E  S  P  S  E  I  M      p.240

          .         .         .         .   | 12     .         .    g.60729
 GAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAG | ATGCTGTTATTTACACAC    c.780
 E  S  L  T  K  M  Y  S  I  P  K  D  K  Q   | M  L  L  F  T  H      p.260

          .         .         .         .         .         .       g.60789
 ATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGA       c.840
 I  R  L  A  H  G  F  S  N  H  R  K  R  L  Q  A  V  Q  A  R         p.280

          .         .   | 13     .         .         .         .    g.62168
 CTGCATGCAATATCTATATTAG | TGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATC    c.900
 L  H  A  I  S  I  L  V |   Y  S  N  A  L  Q  E  S  A  N  S  I      p.300

          .         .         .         .         .         .       g.62228
 TTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACGGATAAGCAGCTT       c.960
 L  Y  N  G  L  I  E  E  L  V  D  V  L  Q  I  T  D  K  Q  L         p.320

     | 14    .         .         .         .         .         .    g.62901
 ATG | GAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACT    c.1020
 M   | E  I  K  A  A  S  L  R  T  L  T  S  I  V  H  L  E  R  T      p.340

          .         .         .         .         .         .       g.62961
 CCCAAACTCAGCAGTATTATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCA       c.1080
 P  K  L  S  S  I  I  D  C  T  G  T  A  S  Y  H  G  F  L  P         p.360

          .         .         .     | 15   .         .         .    g.63152
 GTGCTTGTAAGGAACTGTATCCAGGCCATGATTG | ATCCTTCCATGGATCCATACCCTCAC    c.1140
 V  L  V  R  N  C  I  Q  A  M  I  D |   P  S  M  D  P  Y  P  H      p.380

          .         .         .         .         .         .       g.63212
 CAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGT       c.1200
 Q  F  A  T  A  L  F  S  F  L  Y  H  L  A  S  Y  D  A  G  G         p.400

          .         .         .         .   | 16     .         .    g.63885
 GAAGCCTTGGTCTCCTGTGGAATGATGGAAGCCTTATTGAAG | GTCATAAAGTTTCTTGGC    c.1260
 E  A  L  V  S  C  G  M  M  E  A  L  L  K   | V  I  K  F  L  G      p.420

          .         .         .         .         .         .       g.63945
 GATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTTGACCTTATCACC       c.1320
 D  E  Q  D  Q  I  T  F  V  T  R  A  V  R  V  V  D  L  I  T         p.440

          .         .         .         .         .         .       g.64005
 AACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTT       c.1380
 N  L  D  M  A  A  F  Q  S  H  S  G  L  S  I  F  I  Y  R  L         p.460

     | 17    .         .         .         .         .         .    g.64288
 GAG | CATGAAGTAGATTTGTGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAG    c.1440
 E   | H  E  V  D  L  C  R  K  E  C  P  F  V  I  K  P  K  I  Q      p.480

          .         .         .         .          | 18        .    g.66489
 AGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGATG | GAGTCCAGTGT    c.1500
 R  P  N  T  T  Q  E  G  E  E  M  E  T  D  M  D  G |   V  Q  C      p.500

          .         .         .         .         .         .       g.66549
 ATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAA       c.1560
 I  P  Q  R  A  A  L  L  K  S  M  L  N  F  L  K  K  A  I  Q         p.520

          .         .         .  | 19      .         .         .    g.67090
 GACCCTGCTTTCTCAGATGGCATACGACATG | TGATGGATGGTTCTCTGCCTACCTCCCTG    c.1620
 D  P  A  F  S  D  G  I  R  H  V |   M  D  G  S  L  P  T  S  L      p.540

          .         .         .         .         .   | 20     .    g.74298
 AAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTCCTAG | CTACTGAA    c.1680
 K  H  I  I  S  N  A  E  Y  Y  G  P  S  L  F  L  L  A |   T  E      p.560

          .         .         .         .         .         .       g.74358
 GTGGTGACTGTGTTTGTATTTCAAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGA       c.1740
 V  V  T  V  F  V  F  Q  E  P  S  L  L  S  S  L  Q  D  N  G         p.580

          .         .         .          | 21        .         .    g.74610
 TTGACAGATGTCATGCTGCATGCACTGCTTATCAAAGAT | GTTCCTGCTACCCGTGAAGTC    c.1800
 L  T  D  V  M  L  H  A  L  L  I  K  D   | V  P  A  T  R  E  V      p.600

          .         .         .         .         .         .       g.74670
 CTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGAGGTCTTCAGTCT       c.1860
 L  G  S  L  P  N  V  F  S  A  L  C  L  N  A  R  G  L  Q  S         p.620

          .         .         .         .         .         .       g.74730
 TTTGTTCAGTGTCAGCCTTTTGAACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTC       c.1920
 F  V  Q  C  Q  P  F  E  R  L  F  K  V  L  L  S  P  D  Y  L         p.640

          .         .         .        | 22.         .         .    g.75924
 CCAGCCATGCGGAGGAGGAGAAGTTCTGATCCCCTTG | GGGATACTGCATCCAACCTGGGG    c.1980
 P  A  M  R  R  R  R  S  S  D  P  L  G |   D  T  A  S  N  L  G      p.660

          .         .         .         .         .         .       g.75984
 AGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGATGCAACGACTGCC       c.2040
 S  A  V  D  E  L  M  R  H  Q  P  T  L  K  T  D  A  T  T  A         p.680

           | 23        .         .         .         .         .    g.77042
 ATCATCAAG | TTACTTGAAGAAATCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAG    c.2100
 I  I  K   | L  L  E  E  I  C  N  L  G  R  D  P  K  Y  I  C  Q      p.700

          .         .         .         .         .         .       g.77102
 AAGCCATCAATCCAGAAGGCAGATGGCACTGCCACTGCTCCTCCCCCAAGGTCTAATCAT       c.2160
 K  P  S  I  Q  K  A  D  G  T  A  T  A  P  P  P  R  S  N  H         p.720

          .         .         .         .         .         .       g.77162
 GCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAGGCCATGCAGAGC       c.2220
 A  A  E  E  A  S  S  E  D  E  E  E  E  E  V  Q  A  M  Q  S         p.740

          .         .         .         .  | 24      .         .    g.82846
 TTTAATTCTACCCAGCAAAATGAAACTGAGCCTAATCAGCA | GGTTGTTGGTACAGAGGAA    c.2280
 F  N  S  T  Q  Q  N  E  T  E  P  N  Q  Q  |  V  V  G  T  E  E      p.760

          .         .         .          | 25        .         .    g.84058
 CGTATTCCTATTCCCCTCATGGATTACATCCTTAATGTG | ATGAAATTTGTGGAATCTATT    c.2340
 R  I  P  I  P  L  M  D  Y  I  L  N  V   | M  K  F  V  E  S  I      p.780

          .         .         .         .         .         .       g.84118
 CTGAGCAACAATACAACAGATGACCACTGCCAGGAATTTGTGAATCAGAAAGGACTGTTG       c.2400
 L  S  N  N  T  T  D  D  H  C  Q  E  F  V  N  Q  K  G  L  L         p.800

          .         .         .         .         .         .       g.84178
 CCTTTGGTTACCATTTTGGGTCTTCCCAATCTGCCCATTGACTTTCCCACATCTGCTGCC       c.2460
 P  L  V  T  I  L  G  L  P  N  L  P  I  D  F  P  T  S  A  A         p.820

          .         .         .       | 26 .         .         .    g.86926
 TGTCAGGCTGTTGCAGGTGTCTGCAAATCCATATTG | ACACTGTCACATGAACCCAAAGTC    c.2520
 C  Q  A  V  A  G  V  C  K  S  I  L   | T  L  S  H  E  P  K  V      p.840

          .         .         .         .         .         .       g.86986
 CTTCAAGAGGGTCTCCTTCAGTTGGACTCCATCCTCTCCTCCCTGGAGCCCTTACACCGC       c.2580
 L  Q  E  G  L  L  Q  L  D  S  I  L  S  S  L  E  P  L  H  R         p.860

          .         .         .         .         .         .       g.87046
 CCCATTGAATCCCCTGGGGGCTCAGTGTTGTTGCGAGAACTGGCTTGCGCAGGCAATGTT       c.2640
 P  I  E  S  P  G  G  S  V  L  L  R  E  L  A  C  A  G  N  V         p.880

          .         .         .         .         .         .       g.87106
 GCTGATGCTACCCTCTCAGCCCAGGCCACACCTCTGCTGCATGCACTCACTGCTGCCCAT       c.2700
 A  D  A  T  L  S  A  Q  A  T  P  L  L  H  A  L  T  A  A  H         p.900

          .         .         .         .   | 27     .         .    g.88253
 GCCTACATCATGATGTTTGTTCATACTTGCAGAGTTGGACAG | AGTGAAATTCGTTCCATC    c.2760
 A  Y  I  M  M  F  V  H  T  C  R  V  G  Q   | S  E  I  R  S  I      p.920

          .         .         .         .         .         .       g.88313
 TCCGTAAACCAGTGGGGCTCTCAATTGGGTCTGAGTGTTTTGAGCAAGCTGAGCCAGTTA       c.2820
 S  V  N  Q  W  G  S  Q  L  G  L  S  V  L  S  K  L  S  Q  L         p.940

          .         .         .         .         .       | 28 .    g.89082
 TACTGTTCCCTGGTGTGGGAAAGCACTGTCCTCCTCTCTCTGTGTACCCCAAACAG | CCTA    c.2880
 Y  C  S  L  V  W  E  S  T  V  L  L  S  L  C  T  P  N  S  |  L      p.960

          .         .         .         .         .         .       g.89142
 CCATCTGGGTGTGAATTTGGCCAGGCAGATATGCAGAAACTGGTTCCAAAGGATGAGAAG       c.2940
 P  S  G  C  E  F  G  Q  A  D  M  Q  K  L  V  P  K  D  E  K         p.980

          .         .         .  | 29      .         .         .    g.91457
 GCAGGTACGACCCAGGGCGGAAAAAGATCAG | ATGGGGAACAGGATGGAGCAGCTGGAAGT    c.3000
 A  G  T  T  Q  G  G  K  R  S  D |   G  E  Q  D  G  A  A  G  S      p.1000

          .         .         .         .         .         .       g.91517
 ATGGATGCTTCTACCCAGGGCTTATTAGAAGGCATTGGGCTAGATGGTGACACATTGGCT       c.3060
 M  D  A  S  T  Q  G  L  L  E  G  I  G  L  D  G  D  T  L  A         p.1020

          .         .         .         .         .         .       g.91577
 CCCATGGAGACAGATGAACCTACTGCTTCAGACTCTAAGGGCAAATCTAAAATCACACCA       c.3120
 P  M  E  T  D  E  P  T  A  S  D  S  K  G  K  S  K  I  T  P         p.1040

          .         .         .         .    | 30    .         .    g.96351
 GCAATGGCTGCCAGAATTAAGCAAATCAAGCCTTTGTTATCAG | CTTCCTCCAGATTAGGC    c.3180
 A  M  A  A  R  I  K  Q  I  K  P  L  L  S  A |   S  S  R  L  G      p.1060

          .         .         .         .         .         .       g.96411
 CGAGCACTTGCTGAGCTATTTGGACTTCTTGTTAAACTTTGTGTGGGATCTCCTGTCCGC       c.3240
 R  A  L  A  E  L  F  G  L  L  V  K  L  C  V  G  S  P  V  R         p.1080

          .         .         .         .         .         .       g.96471
 CAGAGAAGGAGCCATCATGCTGCCAGCACCACTACAGCACCGACACCTGCCGCGCGATCA       c.3300
 Q  R  R  S  H  H  A  A  S  T  T  T  A  P  T  P  A  A  R  S         p.1100

          .         .         .         .         .         .       g.96531
 ACAGCCTCAGCTCTCACTAAGCTCTTGACTAAGGGGTTATCTTGGCAGCCCCCACCATAT       c.3360
 T  A  S  A  L  T  K  L  L  T  K  G  L  S  W  Q  P  P  P  Y         p.1120

          .         . | 31       .         .         .         .    g.97156
 ACACCTACTCCCCGATTCAG | GCTGACATTCTTCATCTGTTCAGTTGGTTTCACATCCCCA    c.3420
 T  P  T  P  R  F  R  |  L  T  F  F  I  C  S  V  G  F  T  S  P      p.1140

          .         .         .         .         .         .       g.97216
 ATGCTGTTTGATGAGAGGAAGTATCCCTACCACCTCATGCTGCAAAAATTTCTCTGCTCC       c.3480
 M  L  F  D  E  R  K  Y  P  Y  H  L  M  L  Q  K  F  L  C  S         p.1160

          .         .    | 32    .         .         .         .    g.98173
 GGAGGCCACAATGCTCTTTTTGA | AACTTTCAACTGGGCTCTGTCCATGGGAGGTAAAGTT    c.3540
 G  G  H  N  A  L  F  E  |  T  F  N  W  A  L  S  M  G  G  K  V      p.1180

          .         .         .         .         .         .       g.98233
 CCTGTTTCTGAGGGATTGGAACACTCAGACTTGCCTGATGGCACAGGAGAATTCCTAGAT       c.3600
 P  V  S  E  G  L  E  H  S  D  L  P  D  G  T  G  E  F  L  D         p.1200

          .         .         .         .         .         .       g.98293
 GCCTGGCTTATGCTGGTGGAGAAGATGGTGAATCCCACCACGGTGCTTGAATCTCCACAT       c.3660
 A  W  L  M  L  V  E  K  M  V  N  P  T  T  V  L  E  S  P  H         p.1220

          .         .         .         .         .         .       g.98353
 TCGCTGCCTGCCAAATTGCCTGGAGGTGTCCAGAACTTTCCCCAGTTCAGTGCACTGCGC       c.3720
 S  L  P  A  K  L  P  G  G  V  Q  N  F  P  Q  F  S  A  L  R         p.1240

          .         .  | 33      .         .         .         .    g.99148
 TTCCTTGTGGTAACTCAGAAA | GCAGCCTTTACTTGCATCAAAAACTTATGGAACCGGAAA    c.3780
 F  L  V  V  T  Q  K   | A  A  F  T  C  I  K  N  L  W  N  R  K      p.1260

          .         .         .         .         .         .       g.99208
 CCCCTGAAGGTATATGGTGGACGAATGGCTGAATCGATGCTGGCCATTCTATGCCACATC       c.3840
 P  L  K  V  Y  G  G  R  M  A  E  S  M  L  A  I  L  C  H  I         p.1280

          .         .         .         .         .         .       g.99268
 CTCCGAGGAGAACCTGTGATTCGAGAGAGACTAAGCAAGGAGAAGGAGGGGTCTCGAGGA       c.3900
 L  R  G  E  P  V  I  R  E  R  L  S  K  E  K  E  G  S  R  G         p.1300

          .         .         .         .         .         .       g.99328
 GAAGAGGATACAGGGCAAGAGGAAGGTGGCTCCCGCCGGGAACCTCAAGTCAACCAGCAA       c.3960
 E  E  D  T  G  Q  E  E  G  G  S  R  R  E  P  Q  V  N  Q  Q         p.1320

          .   | 34     .         .         .         .         .    g.100663
 CAACTGCAACAG | CTCATGGACATGGGCTTCACAAGGGAACATGCAATGGAGGCACTGTTG    c.4020
 Q  L  Q  Q   | L  M  D  M  G  F  T  R  E  H  A  M  E  A  L  L      p.1340

          .         .         .         .         .         .       g.100723
 AACACCAGCACCATGGAGCAGGCCACAGAGTACCTTTTAACCCACCCTCCTCCAATCATG       c.4080
 N  T  S  T  M  E  Q  A  T  E  Y  L  L  T  H  P  P  P  I  M         p.1360

          .      | 35  .         .         .         .         .    g.101283
 GGAGGAGTTGTTCGG | GATCTCAGCATGTCTGAAGAGGACCAGATGATGAGAGCAATTGCT    c.4140
 G  G  V  V  R   | D  L  S  M  S  E  E  D  Q  M  M  R  A  I  A      p.1380

          .         .         .         .         .  | 36      .    g.101930
 ATGTCTCTGGGACAGGATATTCCAATGGATCAAAGGGCAGAGTCACCTGAG | GAAGTTGCT    c.4200
 M  S  L  G  Q  D  I  P  M  D  Q  R  A  E  S  P  E   | E  V  A      p.1400

          .         .         .         .         .         .       g.101990
 TGCCGGAAGGAGGAAGAGGAACGGAAAGCTCGGGAAAAGCAGGAGGAGGAAGAGGCTAAA       c.4260
 C  R  K  E  E  E  E  R  K  A  R  E  K  Q  E  E  E  E  A  K         p.1420

          .         .         .         .         .         .       g.102050
 TGTCTAGAGAAGTTCCAGGATGCTGACCCGTTGGAACAAGATGAGCTCCACACTTTCACA       c.4320
 C  L  E  K  F  Q  D  A  D  P  L  E  Q  D  E  L  H  T  F  T         p.1440

          .         .         .         .         .         .       g.102110
 GATACTATGTTGCCAGGCTGCTTCCACCTTCTTGATGAGCTGCCAGACACAGTATACCGT       c.4380
 D  T  M  L  P  G  C  F  H  L  L  D  E  L  P  D  T  V  Y  R         p.1460

          .         .         .         .         .         .       g.102170
 GTGTGTGACCTGATCATGACAGCAATCAAACGTAATGGAGCAGATTATCGTGACATGATT       c.4440
 V  C  D  L  I  M  T  A  I  K  R  N  G  A  D  Y  R  D  M  I         p.1480

          .         .  | 37      .         .         .         .    g.103242
 CTGAAGCAAGTAGTCAATCAG | GTGTGGGAAGCTGCTGATGTATTGATCAAAGCTGCTCTT    c.4500
 L  K  Q  V  V  N  Q   | V  W  E  A  A  D  V  L  I  K  A  A  L      p.1500

          .         .         .         .         .         .       g.103302
 CCCCTGACAACAAGTGACACAAAAACCGTGTCAGAGTGGATAAGTCAGATGGCCACACTG       c.4560
 P  L  T  T  S  D  T  K  T  V  S  E  W  I  S  Q  M  A  T  L         p.1520

          .         .         .         .         .     | 38   .    g.104834
 CCCCAGGCCTCCAATTTGGCTACTAGAATCTTGCTTTTAACGCTACTTTTTGAG | GAGTTG    c.4620
 P  Q  A  S  N  L  A  T  R  I  L  L  L  T  L  L  F  E   | E  L      p.1540

          .         .         .         .         .         .       g.104894
 AAGCTACCTTGTGCTTGGGTGGTTGAATCAAGTGGCATCCTTAATGTCCTAATCAAACTC       c.4680
 K  L  P  C  A  W  V  V  E  S  S  G  I  L  N  V  L  I  K  L         p.1560

          .         .         .         .         .         .       g.104954
 TTGGAAGTGGTTCAGCCCTGCCTCCAGGCAGCCAAGGAGCAGAAGGAAGTCCAGACCCCA       c.4740
 L  E  V  V  Q  P  C  L  Q  A  A  K  E  Q  K  E  V  Q  T  P         p.1580

    | 39     .         .         .         .         .         .    g.105224
 AA | GTGGATCACACCAGTGTTGCTCCTGATTGATTTCTATGAAAAGACAGCCATCTCCTCA    c.4800
 K  |  W  I  T  P  V  L  L  L  I  D  F  Y  E  K  T  A  I  S  S      p.1600

          .         .     | 40   .         .         .         .    g.106585
 AAAAGGAGAGCCCAGATGACTAAG | TACCTGCAATCCAACAGCAACAACTGGCGCTGGTTT    c.4860
 K  R  R  A  Q  M  T  K   | Y  L  Q  S  N  S  N  N  W  R  W  F      p.1620

          .         .         .         .         .         .       g.106645
 GATGATCGCTCTGGGCGTTGGTGTAGTTACAGTGCAAGCAACAATAGCACTATTGATTCT       c.4920
 D  D  R  S  G  R  W  C  S  Y  S  A  S  N  N  S  T  I  D  S         p.1640

          .         .         .         .         .         .       g.106705
 GCCTGGAAATCTGGAGAGACAAGCGTGCGATTCACTGCAGGCCGAAGAAGATACACGGTC       c.4980
 A  W  K  S  G  E  T  S  V  R  F  T  A  G  R  R  R  Y  T  V         p.1660

          .         .  | 41      .         .         .         .    g.107431
 CAATTCACTACAATGGTGCAG | GTTAATGAGGAAACAGGGAACCGACGCCCTGTGATGCTG    c.5040
 Q  F  T  T  M  V  Q   | V  N  E  E  T  G  N  R  R  P  V  M  L      p.1680

          .         .         .         .         .         .       g.107491
 ACTCTCCTCAGGGTACCTCGGCTGAATAAAAATTCAAAAAACAGCAATGGACAGGAACTA       c.5100
 T  L  L  R  V  P  R  L  N  K  N  S  K  N  S  N  G  Q  E  L         p.1700

          .         .         .         .         .         .       g.107551
 GAGAAGACGCTGGAAGAAAGCAAAGAAATGGATATCAAACGTAAAGAAAATAAAGGCAAT       c.5160
 E  K  T  L  E  E  S  K  E  M  D  I  K  R  K  E  N  K  G  N         p.1720

   | 42      .         .         .         .         .         .    g.107880
 G | ATACCCCTTTGGCCCTAGAGAGTACAAACACTGAAAAGGAGACAAGCCTGGAGGAAACA    c.5220
 D |   T  P  L  A  L  E  S  T  N  T  E  K  E  T  S  L  E  E  T      p.1740

          .         .         .         .         .         .       g.107940
 AAAATCGGGGAGATCCTGATCCAGGGCTTGACAGAAGATATGGTGACTGTTTTAATCCGG       c.5280
 K  I  G  E  I  L  I  Q  G  L  T  E  D  M  V  T  V  L  I  R         p.1760

          .         .         .         .         .         .       g.108000
 GCCTGCGTGAGCATGCTGGGAGTCCCTGTGGACCCAGATACTTTGCATGCCACCCTTCGT       c.5340
 A  C  V  S  M  L  G  V  P  V  D  P  D  T  L  H  A  T  L  R         p.1780

          .         .         .         .         .         .       g.108060
 CTCTGTCTGAGGCTCACCCGGGACCACAAATATGCCATGATGTTTGCAGAACTGAAGAGT       c.5400
 L  C  L  R  L  T  R  D  H  K  Y  A  M  M  F  A  E  L  K  S         p.1800

          .         .         .         .         .         .       g.108120
 ACCCGCATGATCTTGAATTTGACCCAGAGCTCAGGCTTCAATGGGTTTACTCCCCTGGTC       c.5460
 T  R  M  I  L  N  L  T  Q  S  S  G  F  N  G  F  T  P  L  V         p.1820

          .         .         .         .         .         .       g.108180
 ACCCTTCTCTTAAGACACATCATTGAGGACCCCTGTACCCTTCGTCATACCATGGAAAAG       c.5520
 T  L  L  L  R  H  I  I  E  D  P  C  T  L  R  H  T  M  E  K         p.1840

  | 43       .         .         .         .         .         .    g.110771
  | GTTGTTCGCTCAGCAGCTACAAGTGGAGCTGGTAGCACTACCTCTGGTGTTGTGTCTGGC    c.5580
  | V  V  R  S  A  A  T  S  G  A  G  S  T  T  S  G  V  V  S  G      p.1860

          .         .         .         .         .         .       g.110831
 AGCCTCGGCTCTCGGGAGATCAACTACATCCTTCGTGTCCTTGGGCCAGCCGCATGCCGC       c.5640
 S  L  G  S  R  E  I  N  Y  I  L  R  V  L  G  P  A  A  C  R         p.1880

          .         .         .         .         .         .       g.110891
 AATCCAGACATATTCACAGAAGTGGCCAACTGCTGTATCCGCATCGCCCTTCCTGCCCCT       c.5700
 N  P  D  I  F  T  E  V  A  N  C  C  I  R  I  A  L  P  A  P         p.1900

          .       | 44 .         .         .         .         .    g.114714
 CGAGGCTCAGGAACTG | CTTCAGATGATGAATTTGAGAATCTTAGAATTAAAGGCCCTAAT    c.5760
 R  G  S  G  T  A |   S  D  D  E  F  E  N  L  R  I  K  G  P  N      p.1920

          .         .         .         .         .         .       g.114774
 GCTGTACAGCTGGTGAAGACCACCCCTTTGAAGCCCTCACCTCTGCCTGTCATCCCTGAT       c.5820
 A  V  Q  L  V  K  T  T  P  L  K  P  S  P  L  P  V  I  P  D         p.1940

          .         .         .         .         .         .       g.114834
 ACTATCAAGGAAGTGATCTATGATATGCTGAATGCTCTGGCTGCATACCATGCTCCAGAG       c.5880
 T  I  K  E  V  I  Y  D  M  L  N  A  L  A  A  Y  H  A  P  E         p.1960

      | 45   .         .         .         .         .         .    g.116005
 GAAG | CAGATAAATCTGATCCTAAACCTGGGGTTATGACCCAAGAGGTTGGCCAGCTCCTG    c.5940
 E  A |   D  K  S  D  P  K  P  G  V  M  T  Q  E  V  G  Q  L  L      p.1980

          .         .         .         .         .         .       g.116065
 CAAGACATGGGTGATGATGTATACCAGCAGTACCGGTCACTTACGCGTCAGAGCAGTGAC       c.6000
 Q  D  M  G  D  D  V  Y  Q  Q  Y  R  S  L  T  R  Q  S  S  D         p.2000

          .         .         . | 46       .         .         .    g.116546
 TTTGATACGCAGTCAGGTTTTTCCATTAAT | AGTCAGGTCTTTGCTGCAGATGGTGCCTCC    c.6060
 F  D  T  Q  S  G  F  S  I  N   | S  Q  V  F  A  A  D  G  A  S      p.2020

          .         .         .        | 47.         .         .    g.117796
 ACTGAGACTTCCGCATCTGGGACCTCCCAAGGAGAGG | CTTCAACTCCAGAGGAGTCTCGA    c.6120
 T  E  T  S  A  S  G  T  S  Q  G  E  A |   S  T  P  E  E  S  R      p.2040

          .         .         .         .         .         .       g.117856
 GATGGGAAGAAAGATAAAGAAGGGGACCGGGCCTCTGAGGAAGGCAAACAGAAAGGCAAG       c.6180
 D  G  K  K  D  K  E  G  D  R  A  S  E  E  G  K  Q  K  G  K         p.2060

          .         .         .         .         .         .       g.117916
 GGCAGCAAACCTTTAATGCCTACCTCCACTATCCTTCGTCTTCTGGCAGAGTTGGTGAGG       c.6240
 G  S  K  P  L  M  P  T  S  T  I  L  R  L  L  A  E  L  V  R         p.2080

          .         .         .         .         .         .       g.117976
 TCCTATGTTGGTATTGCTACCCTGATTGCCAACTACAGCTACACTGTGGGCCAGTCTGAA       c.6300
 S  Y  V  G  I  A  T  L  I  A  N  Y  S  Y  T  V  G  Q  S  E         p.2100

          .   | 48     .         .         .         .         .    g.121958
 CTGATCAAAGAG | GACTGCAGTGTGCTAGCTTTTGTTCTGGACCACCTGCTCCCACATACC    c.6360
 L  I  K  E   | D  C  S  V  L  A  F  V  L  D  H  L  L  P  H  T      p.2120

          .         .         .         .         .         .       g.122018
 CAGAATGCAGAAGACAAGGACACCCCTGCCTTGGCCCGCCTGTTCCTCGCAAGCCTGGCT       c.6420
 Q  N  A  E  D  K  D  T  P  A  L  A  R  L  F  L  A  S  L  A         p.2140

          .         .         .         .         .         .       g.122078
 GCTGCAGGGAGTGGCACAGATGCCCAGGTGGCCCTAGTGAATGAAGTAAAAGCAGCCCTT       c.6480
 A  A  G  S  G  T  D  A  Q  V  A  L  V  N  E  V  K  A  A  L         p.2160

          .         .         .         .     | 49   .         .    g.122879
 GGACGGGCACTGGCTATGGCTGAGAGTACAGAGAAACATGCCAG | GCTTCAGGCAGTGATG    c.6540
 G  R  A  L  A  M  A  E  S  T  E  K  H  A  R  |  L  Q  A  V  M      p.2180

          .         .         .         .         .         .       g.122939
 TGTATCATCAGTACTATCATGGAGTCCTGCCCCTCCACCTCCAGCTTCTACAGCAGTGCC       c.6600
 C  I  I  S  T  I  M  E  S  C  P  S  T  S  S  F  Y  S  S  A         p.2200

          .         .         .         .         .         .       g.122999
 ACAGCGAAGACCCAGCACAATGGCATGAACAACATCATTCGGCTTTTCCTGAAGAAGGGA       c.6660
 T  A  K  T  Q  H  N  G  M  N  N  I  I  R  L  F  L  K  K  G         p.2220

          .         .         .         .        | 50.         .    g.126510
 CTGGTTAATGACCTGGCCAGAGTACCTCACAGCTTAGACCTGTCCAG | TCCCAACATGGCC    c.6720
 L  V  N  D  L  A  R  V  P  H  S  L  D  L  S  S  |  P  N  M  A      p.2240

          .         .         .         .         .         .       g.126570
 AACACAGTCAATGCTGCTCTGAAGCCTTTGGAAACACTTTCCCGGATTGTGAACCAGCCC       c.6780
 N  T  V  N  A  A  L  K  P  L  E  T  L  S  R  I  V  N  Q  P         p.2260

          .         .         .         .         .         .       g.126630
 AGTAGCCTTTTTGGCAGCAAGAGTGCTTCTAGCAAGAACAAGTCTGAGCAGGATGCCCAA       c.6840
 S  S  L  F  G  S  K  S  A  S  S  K  N  K  S  E  Q  D  A  Q         p.2280

          .         .         .         . | 51       .         .    g.127034
 GGAGCCTCTCAAGATTCCAGTAGCAACCAGCAGGACCCAG | GCGAGCCTGGGGAAGCAGAA    c.6900
 G  A  S  Q  D  S  S  S  N  Q  Q  D  P  G |   E  P  G  E  A  E      p.2300

          .         .         .         .         .         .       g.127094
 GTGCAGGAGGAGGATCATGATGTCACTCAGACAGAGGTGGCAGATGGGGATATCATGGAT       c.6960
 V  Q  E  E  D  H  D  V  T  Q  T  E  V  A  D  G  D  I  M  D         p.2320

          .         .         .         .         .         .       g.127154
 GGGGAGGCTGAAACCGACTCAGTGGTGATTGCTGGGCAGCCTGAGGTGCTCAGTTCACAA       c.7020
 G  E  A  E  T  D  S  V  V  I  A  G  Q  P  E  V  L  S  S  Q         p.2340

           | 52        .         .         .         .         .    g.127966
 GAGATGCAG | GTTGAGAATGAGCTGGAGGACCTGATAGATGAGTTGCTTGAGAGGGATGGC    c.7080
 E  M  Q   | V  E  N  E  L  E  D  L  I  D  E  L  L  E  R  D  G      p.2360

          .         .      | 53  .         .         .         .    g.128842
 GGATCTGGGAACAGTACAATTATAG | TGAGCAGAAGTGGAGAGGATGAATCACAAGAGGAC    c.7140
 G  S  G  N  S  T  I  I  V |   S  R  S  G  E  D  E  S  Q  E  D      p.2380

          .         .         .         .         .         .       g.128902
 GTGCTGATGGATGAAGCTCCTTCCAACCTCAGCCAAGCTTCCACCTTGCAGGCCAACCGA       c.7200
 V  L  M  D  E  A  P  S  N  L  S  Q  A  S  T  L  Q  A  N  R         p.2400

      | 54   .         .         .         .         .         .    g.129548
 GAAG | ATTCCATGAATATCCTGGACCCTGAGGATGAGGAGGAGCACACTCAGGAAGAGGAC    c.7260
 E  D |   S  M  N  I  L  D  P  E  D  E  E  E  H  T  Q  E  E  D      p.2420

          .         .         .         .         .         .       g.129608
 AGCAGTGGCAGTAACGAGGATGAGGATGATAGTCAGGATGAAGAGGAGGAGGAGGAGGAA       c.7320
 S  S  G  S  N  E  D  E  D  D  S  Q  D  E  E  E  E  E  E  E         p.2440

          .         | 55         .         .         .         .    g.129854
 GATGAGGAAGATGATCAG | GAGGATGATGAAGGTGAAGAGGGAGATGAAGACGATGACGAC    c.7380
 D  E  E  D  D  Q   | E  D  D  E  G  E  E  G  D  E  D  D  D  D      p.2460

          .         .         .         .         .         .       g.129914
 GATGGCTCTGAGATGGAATTGGATGAGGATTATCCTGATATGAACGCTTCTCCCTTGGTC       c.7440
 D  G  S  E  M  E  L  D  E  D  Y  P  D  M  N  A  S  P  L  V         p.2480

          .         .         .         .         .         .       g.129974
 CGATTTGAGCGCTTTGACCGGGAGGATGATCTCATCATTGAGTTTGACAACATGTTCTCC       c.7500
 R  F  E  R  F  D  R  E  D  D  L  I  I  E  F  D  N  M  F  S         p.2500

         | 56.         .         .         .         .         .    g.131373
 AGTGCTA | CAGACATCCCCCCATCCCCAGGAAATATCCCTACCACCCATCCACTGATGGTG    c.7560
 S  A  T |   D  I  P  P  S  P  G  N  I  P  T  T  H  P  L  M  V      p.2520

          .         .         .         .         .         .       g.131433
 CGCCATGCAGACCACAGTTCTCTGACACTGGGCAGTGGCTCTTCAACAACTCGTCTCACC       c.7620
 R  H  A  D  H  S  S  L  T  L  G  S  G  S  S  T  T  R  L  T         p.2540

          .         .         .         .         .         .       g.131493
 CAGGGCATCGGGCGCAGTCAGAGGACCCTAAGGCAGCTGACGGCCAATACTGGCCACACC       c.7680
 Q  G  I  G  R  S  Q  R  T  L  R  Q  L  T  A  N  T  G  H  T         p.2560

          .         .         .         .         .       | 57 .    g.132208
 ATTCATGTTCACTACCCTGGGAATCGCCAGCCCAACCCTCCTCTTATACTGCAGAG | GTTG    c.7740
 I  H  V  H  Y  P  G  N  R  Q  P  N  P  P  L  I  L  Q  R  |  L      p.2580

          .         .         .         .         .         .       g.132268
 CTTGGTCCCTCAGCTGCTGCTGACATCCTTCAGCTGAGCAGCAGCCTTCCCCTACAAAGC       c.7800
 L  G  P  S  A  A  A  D  I  L  Q  L  S  S  S  L  P  L  Q  S         p.2600

          .         .         .         .         .         .       g.132328
 CGGGGTCGGGCCCGCCTCCTGGTAGGCAACGATGACGTCCACATCATCGCCCGTTCTGAT       c.7860
 R  G  R  A  R  L  L  V  G  N  D  D  V  H  I  I  A  R  S  D         p.2620

          .         .         .         .         .      | 58  .    g.132681
 GATGAGCTGCTGGATGACTTTTTCCATGATCAGAGCACAGCTACCAGCCAAGCAG | GAACC    c.7920
 D  E  L  L  D  D  F  F  H  D  Q  S  T  A  T  S  Q  A  G |   T      p.2640

          .         .         .         .         .         .       g.132741
 CTGTCCAGCATCCCCACAGCCCTGACCCGCTGGACAGAAGAATGCAAAGTTCTCGATGCT       c.7980
 L  S  S  I  P  T  A  L  T  R  W  T  E  E  C  K  V  L  D  A         p.2660

          .         .      | 59  .         .         .         .    g.132962
 GAGAGCATGCATGACTGTGTTTCAG | TGGTTAAAGTGTCCATTGTCAATCACCTGGAATTC    c.8040
 E  S  M  H  D  C  V  S  V |   V  K  V  S  I  V  N  H  L  E  F      p.2680

          .         .         .         .         .         .       g.133022
 CTGAGGGATGAGGAGCTGGAAGAAAGGCGAGAGAAGCGCAGGAAACAACTGGCTGAGGAA       c.8100
 L  R  D  E  E  L  E  E  R  R  E  K  R  R  K  Q  L  A  E  E         p.2700

          .         .         .         .         .         .       g.133082
 GAAACAAAGATAACTGATAAAGGCAAAGAAGATAAGGAGAACAGGGATCAGAGTGCACAG       c.8160
 E  T  K  I  T  D  K  G  K  E  D  K  E  N  R  D  Q  S  A  Q         p.2720

  | 60       .         .         .         .       | 61 .         . g.136830
  | TGTACTGCATCTAAGTCAAATGACTCCACTGAACAGAATCTCTCAG | ATGGGACGCCTATG c.8220
  | C  T  A  S  K  S  N  D  S  T  E  Q  N  L  S  D |   G  T  P  M   p.2740

          .         .         .         .         .         .       g.136890
 CCTGACAGCTACCCAACAACCCCATCTTCAACTGATGCAGCTACATCTGAGTCCAAGGAG       c.8280
 P  D  S  Y  P  T  T  P  S  S  T  D  A  A  T  S  E  S  K  E         p.2760

          .         .         .         .         .         .       g.136950
 ACCCTTGGCACTCTGCAATCCTCACAACAGCAACCAACACTCCCAACCCCACCAGCTTTG       c.8340
 T  L  G  T  L  Q  S  S  Q  Q  Q  P  T  L  P  T  P  P  A  L         p.2780

          .         .         .         .         .         .       g.137010
 GGAGAGGTTCCTCAGGAGCTGCAGTCTCCAGCTGGAGAAGGGGGCAGCTCTACACAGCTA       c.8400
 G  E  V  P  Q  E  L  Q  S  P  A  G  E  G  G  S  S  T  Q  L         p.2800

          .         .         .         .         .         .       g.137070
 TTGATGCCTGTAGAGCCAGAGGAATTGGGTCCCACAAGGCCAAGTGGGGAAGCAGAAACA       c.8460
 L  M  P  V  E  P  E  E  L  G  P  T  R  P  S  G  E  A  E  T         p.2820

          .         .         .     | 62   .         .         .    g.138869
 ACTCAGATGGAGTTATCCCCAGCTCCCACTATAA | CCTCACTTTCCCCAGAGAGAGCTGAG    c.8520
 T  Q  M  E  L  S  P  A  P  T  I  T |   S  L  S  P  E  R  A  E      p.2840

          .         .         .         .         .         .       g.138929
 GATTCTGATGCACTGACGGCTGTCAGCAGTCAGCTAGAAGGCTCTCCTATGGATACAAGC       c.8580
 D  S  D  A  L  T  A  V  S  S  Q  L  E  G  S  P  M  D  T  S         p.2860

          .         .         .         .         .         .       g.138989
 AGCCTGGCTTCCTGTACCTTAGAGGAGGCTGTGGGTGACACTTCAGCAGCTGGCAGTTCT       c.8640
 S  L  A  S  C  T  L  E  E  A  V  G  D  T  S  A  A  G  S  S         p.2880

          .         .         .         .         .         .       g.139049
 GAGCAGCCCAGAGCAGGCAGCTCCACTCCTGGGGATGCCCCACCAGCTGTGGCGGAAGTG       c.8700
 E  Q  P  R  A  G  S  S  T  P  G  D  A  P  P  A  V  A  E  V         p.2900

          .         .         .         .         . | 63       .    g.139305
 CAAGGCAGGAGTGATGGGTCAGGGGAATCTGCCCAGCCACCTGAGGACAG | CTCCCCACCT    c.8760
 Q  G  R  S  D  G  S  G  E  S  A  Q  P  P  E  D  S  |  S  P  P      p.2920

          .         .         .         .         .         .       g.139365
 GCATCCTCTGAGAGCTCTTCCACCAGAGATTCTGCCGTGGCCATTTCTGGAGCAGATTCC       c.8820
 A  S  S  E  S  S  S  T  R  D  S  A  V  A  I  S  G  A  D  S         p.2940

          .         .         .         .         .         .       g.139425
 CGAGGAATCCTAGAAGAGCCGTTGCCTTCAACAAGCAGTGAAGAAGAAGATCCCCTTGCG       c.8880
 R  G  I  L  E  E  P  L  P  S  T  S  S  E  E  E  D  P  L  A         p.2960

   | 64      .         .         .         .         .         .    g.140315
 G | GTATCAGTCTCCCTGAAGGTGTGGACCCCTCTTTTCTGGCTGCCCTGCCTGATGACATC    c.8940
 G |   I  S  L  P  E  G  V  D  P  S  F  L  A  A  L  P  D  D  I      p.2980

          .         .         .         .         .         .       g.140375
 CGTCGGGAAGTTCTACAGAACCAGCTAGGCATTCGTCCACCAACCCGGACTGCCCCCTCC       c.9000
 R  R  E  V  L  Q  N  Q  L  G  I  R  P  P  T  R  T  A  P  S         p.3000

          .         .         .         .         .         .       g.140435
 ACAAATAGCTCAGCGCCTGCAGTGGTGGGGAATCCTGGTGTGACTGAAGTGAGCCCTGAG       c.9060
 T  N  S  S  A  P  A  V  V  G  N  P  G  V  T  E  V  S  P  E         p.3020

          .         .         .       | 65 .         .         .    g.140571
 TTTCTGGCTGCCCTGCCTCCAGCCATTCAGGAGGAA | GTACTGGCACAGCAGAGAGCTGAG    c.9120
 F  L  A  A  L  P  P  A  I  Q  E  E   | V  L  A  Q  Q  R  A  E      p.3040

          .         .         .         .         .         .       g.140631
 CAGCAGCGACGAGAACTAGCACAGAATGCCAGCTCAGACACCCCTATGGACCCTGTGACC       c.9180
 Q  Q  R  R  E  L  A  Q  N  A  S  S  D  T  P  M  D  P  V  T         p.3060

          .         .         .         .         .         .       g.140691
 TTCATCCAGACTCTGCCCTCAGACCTGCGCCGTAGTGTCCTAGAGGATATGGAGGACAGT       c.9240
 F  I  Q  T  L  P  S  D  L  R  R  S  V  L  E  D  M  E  D  S         p.3080

          .         .         .         .         .         .       g.140751
 GTGTTAGCTGTGATGCCACCTGACATTGCAGCTGAGGCTCAAGCCCTGAGACGAGAGCAA       c.9300
 V  L  A  V  M  P  P  D  I  A  A  E  A  Q  A  L  R  R  E  Q         p.3100

          .         .         .         .         .         .       g.140811
 GAAGCCCGGCAGCGACAGCTCATGCATGAGCGTCTGTTTGGGCACAGTAGCACCTCCGCA       c.9360
 E  A  R  Q  R  Q  L  M  H  E  R  L  F  G  H  S  S  T  S  A         p.3120

          .         .      | 66  .         .         .         .    g.141003
 CTCTCTGCTATTCTCCGAAGCCCGG | CTTTCACCAGTCGCTTAAGTGGCAACCGTGGGGTC    c.9420
 L  S  A  I  L  R  S  P  A |   F  T  S  R  L  S  G  N  R  G  V      p.3140

          .         .         .         .         .         .       g.141063
 CAGTATACTCGCCTTGCTGTGCAGAGAGGTGGCACCTTCCAGATGGGGGGTAGCAGCAGC       c.9480
 Q  Y  T  R  L  A  V  Q  R  G  G  T  F  Q  M  G  G  S  S  S         p.3160

          | 67         .         .         .         .         .    g.142283
 CATAACAG | GCCTTCTGGCAGTAATGTAGATACTCTCCTCCGCCTCCGAGGACGGCTCCTT    c.9540
 H  N  R  |  P  S  G  S  N  V  D  T  L  L  R  L  R  G  R  L  L      p.3180

          .         .         .         .         .         .       g.142343
 CTGGACCACGAAGCCCTTTCTTGTCTCTTGGTCCTACTTTTTGTGGATGAGCCAAAGCTC       c.9600
 L  D  H  E  A  L  S  C  L  L  V  L  L  F  V  D  E  P  K  L         p.3200

          .         .         .         .         .         .       g.142403
 AATACTAGCCGTCTACACCGAGTACTGAGAAATCTCTGCTACCATGCCCAGACCCGCCAC       c.9660
 N  T  S  R  L  H  R  V  L  R  N  L  C  Y  H  A  Q  T  R  H         p.3220

          .         .         .         .         .         .       g.142463
 TGGGTCATCCGCAGTCTGCTCTCCATCTTGCAGCGCAGCAGTGAGAGTGAGCTATGCATT       c.9720
 W  V  I  R  S  L  L  S  I  L  Q  R  S  S  E  S  E  L  C  I         p.3240

          .         .         .         .         .         .       g.142523
 GAAACACCCAAACTCACTACAAGTGAGGAAAAGGGCAAAAAGTCGAGCAAGAGCTGTGGG       c.9780
 E  T  P  K  L  T  T  S  E  E  K  G  K  K  S  S  K  S  C  G         p.3260

          .         .         .         .         .         .       g.142583
 TCAAGTAGCCATGAGAACCGTCCCCTGGACCTGCTACACAAGATGGAGTCAAAGAGCTCC       c.9840
 S  S  S  H  E  N  R  P  L  D  L  L  H  K  M  E  S  K  S  S         p.3280

          .         .         .         .         .         .       g.142643
 AACCAGCTTTCCTGGCTCTCAGTATCCATGGATGCAGCCCTAGGCTGCAGGACTAATATA       c.9900
 N  Q  L  S  W  L  S  V  S  M  D  A  A  L  G  C  R  T  N  I         p.3300

          .         .         .         .         .         .       g.142703
 TTTCAGATCCAGCGTTCAGGGGGGCGTAAACATACCGAGAAGCATGCAAGCGGTGGCTCC       c.9960
 F  Q  I  Q  R  S  G  G  R  K  H  T  E  K  H  A  S  G  G  S         p.3320

          .         .         .         .         .         .       g.142763
 ACCGTCCACATCCATCCCCAAGCTGCTCCTGTTGTCTGCAGACACGTTTTGGATACACTC       c.10020
 T  V  H  I  H  P  Q  A  A  P  V  V  C  R  H  V  L  D  T  L         p.3340

          .      | 68  .         .         .         .         .    g.143508
 ATTCAATTGGCCAAG | GTATTTCCCAGCCACTTCACACAGCAGCGGACCAAAGAAACAAAC    c.10080
 I  Q  L  A  K   | V  F  P  S  H  F  T  Q  Q  R  T  K  E  T  N      p.3360

          .         .         .         .         .         .       g.143568
 TGTGAGAGTGATCGGGAAAGGGGCAATAAGGCCTGTAGCCCATGCTCCTCACAGTCCTCC       c.10140
 C  E  S  D  R  E  R  G  N  K  A  C  S  P  C  S  S  Q  S  S         p.3380

          .         .         .         .         .         .       g.143628
 AGCAGTGGCATTTGCACAGACTTCTGGGACTTATTGGTAAAACTGGACAACATGAATGTC       c.10200
 S  S  G  I  C  T  D  F  W  D  L  L  V  K  L  D  N  M  N  V         p.3400

          .         .         .         .         .         .       g.143688
 AGCCGGAAAGGCAAGAACTCCGTGAAGTCAGTGCCAGTGAGCGCTGGCGGTGAGGGGGAA       c.10260
 S  R  K  G  K  N  S  V  K  S  V  P  V  S  A  G  G  E  G  E         p.3420

          .         .         .         .         .         .       g.143748
 ACCTCTCCATACAGCCTCGAGGCCTCTCCACTGGGGCAGCTCATGAACATGTTGTCACAC       c.10320
 T  S  P  Y  S  L  E  A  S  P  L  G  Q  L  M  N  M  L  S  H         p.3440

          .         .         .         .         .         .       g.143808
 CCAGTCATCCGCCGGAGCTCTCTCTTAACTGAGAAACTCCTCAGACTCCTTTCTCTCATC       c.10380
 P  V  I  R  R  S  S  L  L  T  E  K  L  L  R  L  L  S  L  I         p.3460

          .         .         .         .         .         .       g.143868
 TCAATTGCTCTCCCAGAAAACAAGGTGTCAGAAGCACAGGCTAATTCTGGCAGCGGTGCT       c.10440
 S  I  A  L  P  E  N  K  V  S  E  A  Q  A  N  S  G  S  G  A         p.3480

          .         .         .         .         .         .       g.143928
 TCCTCCACCACCACTGCCACCTCAACCACATCTACCACCACCACCACTGCCGCCTCCACC       c.10500
 S  S  T  T  T  A  T  S  T  T  S  T  T  T  T  T  A  A  S  T         p.3500

          .         .         .         .         .         .       g.143988
 ACGCCCACACCCCCTACTGCACCCACCCCTGTCACTTCTGCTCCAGCCCTGGTTGCTGCC       c.10560
 T  P  T  P  P  T  A  P  T  P  V  T  S  A  P  A  L  V  A  A         p.3520

          .         .         .         .         .         .       g.144048
 ACGGCTATTTCCACCATTGTCGTAGCTGCTTCGACCACAGTGACTACCCCCACGACTGCT       c.10620
 T  A  I  S  T  I  V  V  A  A  S  T  T  V  T  T  P  T  T  A         p.3540

          .       | 69 .         .         .         .         .    g.144955
 ACCACTACTGTTTCAA | TTTCTCCCACTACTAAGGGCAGCAAATCTCCAGCGAAGGTGAGT    c.10680
 T  T  T  V  S  I |   S  P  T  T  K  G  S  K  S  P  A  K  V  S      p.3560

          .         .         .         .         .         .       g.145015
 GATGGGGGCAGCAGCAGTACAGACTTTAAGATGGTGTCCTCTGGCCTCACTGAAAACCAG       c.10740
 D  G  G  S  S  S  T  D  F  K  M  V  S  S  G  L  T  E  N  Q         p.3580

          .         | 70         .         .         .         .    g.145186
 CTACAGCTCTCTGTAGAG | GTGTTGACATCCCACTCTTGTTCTGAGGAAGGCTTAGAGGAT    c.10800
 L  Q  L  S  V  E   | V  L  T  S  H  S  C  S  E  E  G  L  E  D      p.3600

          .         .         .         .         .         .       g.145246
 GCAGCCAACGTACTACTGCAGCTCTCCCGGGGGGACTCTGGGACCCGGGACACTGTTCTC       c.10860
 A  A  N  V  L  L  Q  L  S  R  G  D  S  G  T  R  D  T  V  L         p.3620

          .         .         .         .         .      | 71  .    g.146580
 AAGCTGCTACTGAATGGAGCCCGCCATCTGGGTTATACCCTTTGTAAACAAATAG | GTACC    c.10920
 K  L  L  L  N  G  A  R  H  L  G  Y  T  L  C  K  Q  I  G |   T      p.3640

          .         .         .         .         .         .       g.146640
 CTGCTGGCCGAGCTGCGGGAATACAACCTCGAGCAGCAGCGGCGAGCCCAATGTGAAACC       c.10980
 L  L  A  E  L  R  E  Y  N  L  E  Q  Q  R  R  A  Q  C  E  T         p.3660

          .         .         .         .         .         .       g.146700
 CTCTCTCCTGATGGCCTGCCTGAGGAGCAGCCACAGACCACCAAGCTGAAGGGCAAAATG       c.11040
 L  S  P  D  G  L  P  E  E  Q  P  Q  T  T  K  L  K  G  K  M         p.3680

          | 72         .         .         .         .         .    g.147026
 CAGAGCAG | GTTTGACATGGCTGAGAATGTGGTAATTGTGGCATCTCAGAAGCGACCTTTG    c.11100
 Q  S  R  |  F  D  M  A  E  N  V  V  I  V  A  S  Q  K  R  P  L      p.3700

          .         .         .         .         .         .       g.147086
 GGTGGCCGGGAGCTCCAGCTGCCTTCTATGTCCATGTTGACATCCAAGACATCTACCCAG       c.11160
 G  G  R  E  L  Q  L  P  S  M  S  M  L  T  S  K  T  S  T  Q         p.3720

          .         .         .         .         .         .       g.147146
 AAGTTCTTCTTGAGGGTACTACAGGTCATCATCCAGCTCCGGGACGACACGCGCCGGGCT       c.11220
 K  F  F  L  R  V  L  Q  V  I  I  Q  L  R  D  D  T  R  R  A         p.3740

          .         .         .  | 73      .         .         .    g.147797
 AACAAGAAAGCCAAGCAGACAGGCAGGCTAG | GTTCCTCCGGTTTAGGCTCAGCTAGCAGC    c.11280
 N  K  K  A  K  Q  T  G  R  L  G |   S  S  G  L  G  S  A  S  S      p.3760

          .         .         .         .         .         .       g.147857
 ATCCAGGCAGCTGTTCGGCAGCTGGAGGCTGAGGCTGATGCCATTATACAAATGGTACGT       c.11340
 I  Q  A  A  V  R  Q  L  E  A  E  A  D  A  I  I  Q  M  V  R         p.3780

          .         .         .          | 74        .         .    g.149218
 GAGGGTCAAAGGGCGCGGAGACAGCAACAAGCAGCAACG | TCGGAGTCTAGCCAGTCAGAG    c.11400
 E  G  Q  R  A  R  R  Q  Q  Q  A  A  T   | S  E  S  S  Q  S  E      p.3800

          .         .         .         .         .         .       g.149278
 GCGTCTGTCCGGAGGGAGGAATCACCCATGGATGTGGACCAGCCATCTCCCAGTGCTCAA       c.11460
 A  S  V  R  R  E  E  S  P  M  D  V  D  Q  P  S  P  S  A  Q         p.3820

          .       | 75 .         .         .         .         .    g.151968
 GATACTCAATCCATTG | CCTCCGATGGAACCCCACAGGGGGAGAAGGAAAAGGAAGAAAGA    c.11520
 D  T  Q  S  I  A |   S  D  G  T  P  Q  G  E  K  E  K  E  E  R      p.3840

          .         .         .         .         .         .       g.152028
 CCACCTGAGTTACCCCTGCTCAGCGAGCAGCTGAGTTTGGACGAGCTGTGGGACATGCTT       c.11580
 P  P  E  L  P  L  L  S  E  Q  L  S  L  D  E  L  W  D  M  L         p.3860

          .         .         .         .         .   | 76     .    g.152664
 GGGGAGTGTCTAAAGGAACTAGAGGAATCCCATGACCAGCATGCGGTGCTAG | TGCTACAG    c.11640
 G  E  C  L  K  E  L  E  E  S  H  D  Q  H  A  V  L  V |   L  Q      p.3880

          .         .         .         .         .         .       g.152724
 CCTGCTGTCGAGGCCTTCTTTCTGGTCCATGCCACAGAGCGGGAGAGCAAGCCTCCTGTC       c.11700
 P  A  V  E  A  F  F  L  V  H  A  T  E  R  E  S  K  P  P  V         p.3900

          .         .         .         .         .         .       g.152784
 CGAGACACCCGTGAGAGCCAGCTGGCACACATCAAGGACGAGCCTCCTCCACTCTCCCCT       c.11760
 R  D  T  R  E  S  Q  L  A  H  I  K  D  E  P  P  P  L  S  P         p.3920

          .         .         .         .         .         .       g.152844
 GCCCCCTTAACCCCAGCCACGCCTTCCTCCCTTGACCCATTCTTCTCCCGGGAGCCCTCA       c.11820
 A  P  L  T  P  A  T  P  S  S  L  D  P  F  F  S  R  E  P  S         p.3940

          .         .         .         .         .         | 77    g.153284
 TCTATGCACATCTCCTCAAGCCTGCCCCCTGACACACAGAAGTTCCTTCGCTTTGCAG | AG    c.11880
 S  M  H  I  S  S  S  L  P  P  D  T  Q  K  F  L  R  F  A  E |       p.3960

          .         .         .         .         .         .       g.153344
 ACTCACCGCACTGTGTTAAACCAGATCCTACGGCAGTCCACGACCCACCTTGCTGATGGG       c.11940
 T  H  R  T  V  L  N  Q  I  L  R  Q  S  T  T  H  L  A  D  G         p.3980

          .         .         .         .         .       | 78 .    g.154044
 CCTTTTGCTGTCCTGGTAGACTACATTCGTGTCCTCGACTTTGATGTCAAGCGCAA | ATAT    c.12000
 P  F  A  V  L  V  D  Y  I  R  V  L  D  F  D  V  K  R  K  |  Y      p.4000

          .         .         .         .         .         .       g.154104
 TTCCGCCAAGAGCTGGAGCGTTTAGATGAGGGGCTCCGGAAAGAAGACATGGCTGTGCAT       c.12060
 F  R  Q  E  L  E  R  L  D  E  G  L  R  K  E  D  M  A  V  H         p.4020

          .         .         .         .         .         .       g.154164
 GTCCGTCGTGACCATGTGTTTGAAGACTCCTATCGTGAGCTGCATCGCAAATCCCCCGAA       c.12120
 V  R  R  D  H  V  F  E  D  S  Y  R  E  L  H  R  K  S  P  E         p.4040

          .        | 79.         .         .         .         .    g.155112
 GAAATGAAGAATCGATT | GTATATAGTATTTGAAGGAGAAGAAGGGCAGGATGCTGGTGGG    c.12180
 E  M  K  N  R  L  |  Y  I  V  F  E  G  E  E  G  Q  D  A  G  G      p.4060

          .         .         .         .         .         .       g.155172
 CTCCTGCGGGAGTGGTATATGATCATCTCTCGAGAGATGTTTAACCCTATGTATGCCTTG       c.12240
 L  L  R  E  W  Y  M  I  I  S  R  E  M  F  N  P  M  Y  A  L         p.4080

          .         .         .         .         .         .       g.155232
 TTCCGTACCTCACCTGGTGATCGAGTCACCTACACCATCAATCCATCTTCCCACTGCAAC       c.12300
 F  R  T  S  P  G  D  R  V  T  Y  T  I  N  P  S  S  H  C  N         p.4100

          .         .         .         .         .         .       g.155292
 CCCAACCACCTCAGCTACTTCAAGTTTGTCGGACGCATTGTGGCCAAAGCTGTATATGAC       c.12360
 P  N  H  L  S  Y  F  K  F  V  G  R  I  V  A  K  A  V  Y  D         p.4120

          .         .         .         .         .         .       g.155352
 AACCGTCTTCTGGAGTGCTACTTTACTCGATCCTTTTACAAACACATCTTGGGCAAGTCA       c.12420
 N  R  L  L  E  C  Y  F  T  R  S  F  Y  K  H  I  L  G  K  S         p.4140

       | 80  .         .         .         .         .         .    g.155539
 GTCAG | ATATACAGATATGGAGAGTGAAGATTACCACTTCTACCAAGGTCTGGTTTATCTG    c.12480
 V  R  |  Y  T  D  M  E  S  E  D  Y  H  F  Y  Q  G  L  V  Y  L      p.4160

          .         .         .         .         .  | 81      .    g.156244
 CTGGAAAATGATGTCTCCACACTAGGCTATGACCTCACCTTCAGCACTGAG | GTCCAAGAG    c.12540
 L  E  N  D  V  S  T  L  G  Y  D  L  T  F  S  T  E   | V  Q  E      p.4180

          .         .         .         .         .         .       g.156304
 TTTGGAGTTTGTGAAGTTCGTGACCTCAAACCCAATGGGGCCAACATCTTGGTAACAGAG       c.12600
 F  G  V  C  E  V  R  D  L  K  P  N  G  A  N  I  L  V  T  E         p.4200

          .         .         .         .          | 82        .    g.157050
 GAGAATAAGAAGGAGTATGTACACCTGGTATGCCAGATGAGAATGACAG | GAGCCATCCGC    c.12660
 E  N  K  K  E  Y  V  H  L  V  C  Q  M  R  M  T  G |   A  I  R      p.4220

          .         .         .         .         .         .       g.157110
 AAGCAGTTGGCGGCTTTCTTAGAAGGCTTCTATGAGATCATTCCAAAGCGCCTCATTTCC       c.12720
 K  Q  L  A  A  F  L  E  G  F  Y  E  I  I  P  K  R  L  I  S         p.4240

          .         .         .         .         .         .       g.157170
 ATCTTCACTGAGCAGGAGTTAGAGCTGCTTATATCAGGACTGCCCACCATTGACATCGAT       c.12780
 I  F  T  E  Q  E  L  E  L  L  I  S  G  L  P  T  I  D  I  D         p.4260

          .         .         .         .         .  | 83      .    g.157548
 GATCTGAAATCCAACACTGAATACCACAAGTACCAGTCCAACTCTATTCAG | ATCCAGTGG    c.12840
 D  L  K  S  N  T  E  Y  H  K  Y  Q  S  N  S  I  Q   | I  Q  W      p.4280

          .         .         .         .         .         .       g.157608
 TTCTGGAGAGCATTGCGTTCTTTCGATCAAGCTGACCGTGCCAAGTTCCTCCAGTTTGTC       c.12900
 F  W  R  A  L  R  S  F  D  Q  A  D  R  A  K  F  L  Q  F  V         p.4300

          .         .         .         .         .         .       g.157668
 ACGGGTACTTCCAAGGTACCCCTGCAAGGCTTTGCTGCCCTCGAAGGCATGAATGGCATT       c.12960
 T  G  T  S  K  V  P  L  Q  G  F  A  A  L  E  G  M  N  G  I         p.4320

          .         .         .         .         .         .       g.157728
 CAGAAGTTTCAGATCCATCGAGATGACAGGTCCACAGATCGCCTGCCTTCAGCTCACACA       c.13020
 Q  K  F  Q  I  H  R  D  D  R  S  T  D  R  L  P  S  A  H  T         p.4340

    | 84     .         .         .         .         .         .    g.158383
 TG | TTTTAATCAGCTGGATCTGCCTGCCTATGAGAGCTTTGAGAAGCTCCGCCACATGCTA    c.13080
 C  |  F  N  Q  L  D  L  P  A  Y  E  S  F  E  K  L  R  H  M  L      p.4360

          .         .         .         .                           g.158428
 CTGTTGGCTATCCAGGAGTGCTCTGAAGGCTTTGGGCTGGCCTAA                      c.13125
 L  L  A  I  Q  E  C  S  E  G  F  G  L  A  X                        p.4374

          .         .         .         .         .         .       g.158488
 taaggccctgcccaactccgtggggttttttttaccattgttggacctggggagggggga       c.*60

          .         .         .         .         .         .       g.158548
 gttaaaaaaagaaccagaaagaaattgtcaaaaaccaataaatgaaatccaccaactcac       c.*120

          .         .         .         .         .         .       g.158608
 cgtgtgtgtcccagctgccccatcttccccagcgcatacctgttcctcttctcattctct       c.*180

          .         .         .         .         .         .       g.158668
 ccccgccgcctgtttcctcaccttctctcccctttccatgccgtccatgatccccacccc       c.*240

          .         .         .         .         .         .       g.158728
 atgtgttttaaaaaggcagtagcctttgcagggacctgtctgtcccaactgtttgaacag       c.*300

          .         .         .         .         .         .       g.158788
 tgtgctcctcagattctgtgttcagaaggatttgctgcattgagacttgaaacctttgga       c.*360

          .         .         .         .         .         .       g.158848
 taggggaaaaaattatatatatatatatttttttgttctgtttgcatttcttaatttgtg       c.*420

          .         .         .         .         .         .       g.158908
 cttggaatgtgttgatgtgcacagctaatgattcaatgcgagacaagattggcgtctgtg       c.*480

          .         .         .         .         .         .       g.158968
 ttgtggaggtttcaaataaagagcactcttcataactcacttttcacaatggagtttttt       c.*540

          .         .         .         .         .         .       g.159028
 tcaaacttaaaaaaaaaaacaaaaaactcttaagcacatgctaggcatctggagaaaaga       c.*600

          .         .         .         .         .         .       g.159088
 tggattctccaggaaaccatccctgccctacccgcttgcccacctgcctccaccactggt       c.*660

          .         .         .         .         .         .       g.159148
 gcaacttcctccttcagagtcagtttctgcagtcaggagagatgagcagttcaccaggaa       c.*720

          .         .         .         .         .         .       g.159208
 ttgggggtgggggcatctgttttttttttttagaatgggagctgcacttggggatggtga       c.*780

          .         .         .         .         .         .       g.159268
 tggtgttagagattgcagcccaggacaaagcatcaccttgctcaaggggaacaaactgca       c.*840

          .         .         .         .         .         .       g.159328
 gcaggttgtacaaaacattcagagagctcacttgacccaaccgagggttttacttggtga       c.*900

          .         .         .         .         .         .       g.159388
 gcctttctagtagtcttgagtctggggctcagttttagatttttatttcattaatgtttg       c.*960

          .         .         .         .         .         .       g.159448
 tttatttctaataaattttaataagcgagtaatttaactaggtcgccagaagaccattat       c.*1020

          .         .         .         .         .         .       g.159508
 ttttgtttgtctatttttgttgtcgtcactccctctctcgtcatctgtctgccagtctgt       c.*1080

          .         .         .         .         .         .       g.159568
 tcacagatcaccttgtagtcccttgtggtttttactccatccagtgcttaaagctgatct       c.*1140

          .         .         .         .         .         .       g.159628
 aaggacttcgatggttccagccttcaaagaaaaaataatttaataaaaatttagttagaa       c.*1200

          .                                                         g.159641
 aaaataaccccaa                                                      c.*1213

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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