integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2) - coding DNA reference sequence

(used for variant description)

(last modified September 9, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_000211.3 in the ITGB2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000021.8, covering ITGB2 transcript NM_000211.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.12841
        gggccgctctctgacatcagagctgctgtagagcggagaggggcaggggtgaa       c.-181

 .         .         .         .         .         .                g.12901
 gggccacggtggtgcaacccaccacttcctccaaggaggagctgagaggaacaggaagtg       c.-121

 .         .         .         .         .         .                g.12961
 tcaggactttacgacccgcgcctccagctgaggtttctagacgtgacccagggcagactg       c.-61

 .         .         .         .         .         .       | 02     g.23056
 gtagcaaagcccccacgcccagccaggagcaccgccgaggactccagcacaccgagg | gac    c.-1

          .         .         .         .         .         | 03    g.23468
 ATGCTGGGCCTGCGCCCCCCACTGCTCGCCCTGGTGGGGCTGCTCTCCCTCGGGTGCG | TC    c.60
 M  L  G  L  R  P  P  L  L  A  L  V  G  L  L  S  L  G  C  V |       p.20

          .         .         .         .         .         .       g.23528
 CTCTCTCAGGAGTGCACGAAGTTCAAGGTCAGCAGCTGCCGGGAATGCATCGAGTCGGGG       c.120
 L  S  Q  E  C  T  K  F  K  V  S  S  C  R  E  C  I  E  S  G         p.40

          .         .        | 04.         .         .         .    g.26776
 CCCGGCTGCACCTGGTGCCAGAAGCTG | AACTTCACAGGGCCGGGGGATCCTGACTCCATT    c.180
 P  G  C  T  W  C  Q  K  L   | N  F  T  G  P  G  D  P  D  S  I      p.60

          .         .         .         .         .         .       g.26836
 CGCTGCGACACCCGGCCACAGCTGCTCATGAGGGGCTGTGCGGCTGACGACATCATGGAC       c.240
 R  C  D  T  R  P  Q  L  L  M  R  G  C  A  A  D  D  I  M  D         p.80

          .         .         .         .         .         .       g.26896
 CCCACAAGCCTCGCTGAAACCCAGGAAGACCACAATGGGGGCCAGAAGCAGCTGTCCCCA       c.300
 P  T  S  L  A  E  T  Q  E  D  H  N  G  G  Q  K  Q  L  S  P         p.100

          .         .         | 05         .         .         .    g.30335
 CAAAAAGTGACGCTTTACCTGCGACCAG | GCCAGGCAGCAGCGTTCAACGTGACCTTCCGG    c.360
 Q  K  V  T  L  Y  L  R  P  G |   Q  A  A  A  F  N  V  T  F  R      p.120

          .         .         .         .         .         .       g.30395
 CGGGCCAAGGGCTACCCCATCGACCTGTACTATCTGATGGACCTCTCCTACTCCATGCTT       c.420
 R  A  K  G  Y  P  I  D  L  Y  Y  L  M  D  L  S  Y  S  M  L         p.140

          .         .         .         .         .         .       g.30455
 GATGACCTCAGGAATGTCAAGAAGCTAGGTGGCGACCTGCTCCGGGCCCTCAACGAGATC       c.480
 D  D  L  R  N  V  K  K  L  G  G  D  L  L  R  A  L  N  E  I         p.160

          .          | 06        .         .         .         .    g.32146
 ACCGAGTCCGGCCGCATTG | GCTTCGGGTCCTTCGTGGACAAGACCGTGCTGCCGTTCGTG    c.540
 T  E  S  G  R  I  G |   F  G  S  F  V  D  K  T  V  L  P  F  V      p.180

          .         .         .         .         .         .       g.32206
 AACACGCACCCTGATAAGCTGCGAAACCCATGCCCCAACAAGGAGAAAGAGTGCCAGCCC       c.600
 N  T  H  P  D  K  L  R  N  P  C  P  N  K  E  K  E  C  Q  P         p.200

          .         .         .         .         .         .       g.32266
 CCGTTTGCCTTCAGGCACGTGCTGAAGCTGACCAACAACTCCAACCAGTTTCAGACCGAG       c.660
 P  F  A  F  R  H  V  L  K  L  T  N  N  S  N  Q  F  Q  T  E         p.220

          .         .         .         .         .         .       g.32326
 GTCGGGAAGCAGCTGATTTCCGGAAACCTGGATGCACCCGAGGGTGGGCTGGACGCCATG       c.720
 V  G  K  Q  L  I  S  G  N  L  D  A  P  E  G  G  L  D  A  M         p.240

          .         .  | 07      .         .         .         .    g.33402
 ATGCAGGTCGCCGCCTGCCCG | GAGGAAATCGGCTGGCGCAACGTCACGCGGCTGCTGGTG    c.780
 M  Q  V  A  A  C  P   | E  E  I  G  W  R  N  V  T  R  L  L  V      p.260

          .         .         .         .         .         .       g.33462
 TTTGCCACTGATGACGGCTTCCATTTCGCGGGCGACGGGAAGCTGGGCGCCATCCTGACC       c.840
 F  A  T  D  D  G  F  H  F  A  G  D  G  K  L  G  A  I  L  T         p.280

          .         .         .         .         .        | 08.    g.34679
 CCCAACGACGGCCGCTGTCACCTGGAGGACAACTTGTACAAGAGGAGCAACGAATTC | GAC    c.900
 P  N  D  G  R  C  H  L  E  D  N  L  Y  K  R  S  N  E  F   | D      p.300

          .         .         .         .         .         .       g.34739
 TACCCATCGGTGGGCCAGCTGGCGCACAAGCTGGCTGAAAACAACATCCAGCCCATCTTC       c.960
 Y  P  S  V  G  Q  L  A  H  K  L  A  E  N  N  I  Q  P  I  F         p.320

          .         .         .    | 09    .         .         .    g.38805
 GCGGTGACCAGTAGGATGGTGAAGACCTACGAG | AAACTCACCGAGATCATCCCCAAGTCA    c.1020
 A  V  T  S  R  M  V  K  T  Y  E   | K  L  T  E  I  I  P  K  S      p.340

          .         .         .         .         .         .       g.38865
 GCCGTGGGGGAGCTGTCTGAGGACTCCAGCAATGTGGTCCAACTCATTAAGAATGCTTAC       c.1080
 A  V  G  E  L  S  E  D  S  S  N  V  V  Q  L  I  K  N  A  Y         p.360

     | 10    .         .         .         .         .         .    g.40351
 AAT | AAACTCTCCTCCAGGGTCTTCCTGGATCACAACGCCCTCCCCGACACCCTGAAAGTC    c.1140
 N   | K  L  S  S  R  V  F  L  D  H  N  A  L  P  D  T  L  K  V      p.380

          .         .         .         .         .         .       g.40411
 ACCTACGACTCCTTCTGCAGCAATGGAGTGACGCACAGGAACCAGCCCAGAGGTGACTGT       c.1200
 T  Y  D  S  F  C  S  N  G  V  T  H  R  N  Q  P  R  G  D  C         p.400

          .         .     | 11   .         .         .         .    g.41878
 GATGGCGTGCAGATCAATGTCCCG | ATCACCTTCCAGGTGAAGGTCACGGCCACAGAGTGC    c.1260
 D  G  V  Q  I  N  V  P   | I  T  F  Q  V  K  V  T  A  T  E  C      p.420

          .         .         .         .         .         .       g.41938
 ATCCAGGAGCAGTCGTTTGTCATCCGGGCGCTGGGCTTCACGGACATAGTGACCGTGCAG       c.1320
 I  Q  E  Q  S  F  V  I  R  A  L  G  F  T  D  I  V  T  V  Q         p.440

          .         .         .         .         .         .       g.41998
 GTTCTTCCCCAGTGTGAGTGCCGGTGCCGGGACCAGAGCAGAGACCGCAGCCTCTGCCAT       c.1380
 V  L  P  Q  C  E  C  R  C  R  D  Q  S  R  D  R  S  L  C  H         p.460

          .         .         .   | 12     .         .         .    g.43644
 GGCAAGGGCTTCTTGGAGTGCGGCATCTGCAG | GTGTGACACTGGCTACATTGGGAAAAAC    c.1440
 G  K  G  F  L  E  C  G  I  C  R  |  C  D  T  G  Y  I  G  K  N      p.480

          .         .         .         .         .         .       g.43704
 TGTGAGTGCCAGACACAGGGCCGGAGCAGCCAGGAGCTGGAAGGAAGCTGCCGGAAGGAC       c.1500
 C  E  C  Q  T  Q  G  R  S  S  Q  E  L  E  G  S  C  R  K  D         p.500

          .         .         .         .         .         .       g.43764
 AACAACTCCATCATCTGCTCAGGGCTGGGGGACTGTGTCTGCGGGCAGTGCCTGTGCCAC       c.1560
 N  N  S  I  I  C  S  G  L  G  D  C  V  C  G  Q  C  L  C  H         p.520

          .         .         .         .         .         .       g.43824
 ACCAGCGACGTCCCCGGCAAGCTGATATACGGGCAGTACTGCGAGTGTGACACCATCAAC       c.1620
 T  S  D  V  P  G  K  L  I  Y  G  Q  Y  C  E  C  D  T  I  N         p.540

          .         .         .        | 13.         .         .    g.44366
 TGTGAGCGCTACAACGGCCAGGTCTGCGGCGGCCCGG | GGAGGGGGCTCTGCTTCTGCGGG    c.1680
 C  E  R  Y  N  G  Q  V  C  G  G  P  G |   R  G  L  C  F  C  G      p.560

          .         .         .         .         .         .       g.44426
 AAGTGCCGCTGCCACCCGGGCTTTGAGGGCTCAGCGTGCCAGTGCGAGAGGACCACTGAG       c.1740
 K  C  R  C  H  P  G  F  E  G  S  A  C  Q  C  E  R  T  T  E         p.580

          .         .         .         .         .         .       g.44486
 GGCTGCCTGAACCCGCGGCGTGTTGAGTGTAGTGGTCGTGGCCGGTGCCGCTGCAACGTA       c.1800
 G  C  L  N  P  R  R  V  E  C  S  G  R  G  R  C  R  C  N  V         p.600

          .         .         .         .         .         .       g.44546
 TGCGAGTGCCATTCAGGCTACCAGCTGCCTCTGTGCCAGGAGTGCCCCGGCTGCCCCTCA       c.1860
 C  E  C  H  S  G  Y  Q  L  P  L  C  Q  E  C  P  G  C  P  S         p.620

          .        | 14.         .         .         .         .    g.44986
 CCCTGTGGCAAGTACAT | CTCCTGCGCCGAGTGCCTGAAGTTCGAAAAGGGCCCCTTTGGG    c.1920
 P  C  G  K  Y  I  |  S  C  A  E  C  L  K  F  E  K  G  P  F  G      p.640

          .         .         .         .         .         .       g.45046
 AAGAACTGCAGCGCGGCGTGTCCGGGCCTGCAGCTGTCGAACAACCCCGTGAAGGGCAGG       c.1980
 K  N  C  S  A  A  C  P  G  L  Q  L  S  N  N  P  V  K  G  R         p.660

          .         .         .         .         .         .       g.45106
 ACCTGCAAGGAGAGGGACTCAGAGGGCTGCTGGGTGGCCTACACGCTGGAGCAGCAGGAC       c.2040
 T  C  K  E  R  D  S  E  G  C  W  V  A  Y  T  L  E  Q  Q  D         p.680

          .         .         .         . | 15       .         .    g.46956
 GGGATGGACCGCTACCTCATCTATGTGGATGAGAGCCGAG | AGTGTGTGGCAGGCCCCAAC    c.2100
 G  M  D  R  Y  L  I  Y  V  D  E  S  R  E |   C  V  A  G  P  N      p.700

          .         .         .         .         .         .       g.47016
 ATCGCCGCCATCGTCGGGGGCACCGTGGCAGGCATCGTGCTGATCGGCATTCTCCTGCTG       c.2160
 I  A  A  I  V  G  G  T  V  A  G  I  V  L  I  G  I  L  L  L         p.720

          .         .         .         .         .         .       g.47076
 GTCATCTGGAAGGCTCTGATCCACCTGAGCGACCTCCGGGAGTACAGGCGCTTTGAGAAG       c.2220
 V  I  W  K  A  L  I  H  L  S  D  L  R  E  Y  R  R  F  E  K         p.740

          .         .        | 16.         .         .         .    g.47441
 GAGAAGCTCAAGTCCCAGTGGAACAAT | GATAATCCCCTTTTCAAGAGCGCCACCACGACG    c.2280
 E  K  L  K  S  Q  W  N  N   | D  N  P  L  F  K  S  A  T  T  T      p.760

          .         .         .                                     g.47471
 GTCATGAACCCCAAGTTTGCTGAGAGTTAG                                     c.2310
 V  M  N  P  K  F  A  E  S  X                                       p.769

          .         .         .         .         .         .       g.47531
 gagcacttggtgaagacaaggccgtcaggacccaccatgtctgccccatcacgcggccga       c.*60

          .         .         .         .         .         .       g.47591
 gacatggcttgccacagctcttgaggatgtcaccaattaaccagaaatccagttattttc       c.*120

          .         .         .         .         .         .       g.47651
 cgccctcaaaatgacagccatggccggccgggtgcttctgggggctcgtcggggggacag       c.*180

          .         .         .         .         .         .       g.47711
 ctccactctgactggcacagtctttgcatggagacttgaggagggagggcttgaggttgg       c.*240

          .         .         .         .         .         .       g.47771
 tgaggttaggtgcgtgtttcctgtgcaagtcaggacatcagtctgattaaaggtggtgcc       c.*300

          .         .         .         .         .         .       g.47831
 aatttatttacatttaaacttgtcagggtataaaatgacatcccattaattatattgtta       c.*360

          .         .         .         .         .                 g.47886
 atcaatcacgtgtatagaaaaaaaataaaacttcaatacaggctgtccatggaaa            c.*415

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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