regulator of telomere elongation helicase 1 (RTEL1) - coding DNA reference sequence

(used for variant description)

(last modified October 26, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_016434.3 in the RTEL1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000020.10, covering RTEL1 transcript NM_016434.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              agtcagccctgctgccagccagtgccgggtgctggggactcagggag       c.-781

 .         .         .         .         .         .                g.5107
 gcccgccgggaccactgcgggacagtgagccgagcagaagctggaacgcaggagaggaag       c.-721

 .         .         .         .         .         .                g.5167
 gagagggggcggtcagggctctcaggagccgggtcctgggcaaggcgcagccgttttcaa       c.-661

 .         .         .         .         .         .                g.5227
 attttcaggaaagcggtcggctcacactcgagcagtaaaaagatgcctctggggaggagg       c.-601

 .         .         .         .         .         .                g.5287
 cccgtgcagctctccgggcaatggtggtggctcggcctagagaggcggtagtggaacgca       c.-541

 .         .         .         .         .         .                g.5347
 gaccctggtgggggaatgacatcaagggaggagacgggcgggaccccagatttctgcctg       c.-481

 .         .         .         .         .         .                g.5407
 tgggcgatggaagtgaggttcactggccagcggagccggacacagaacgcgcaaaacgcc       c.-421

 .         .         .         .         .         .                g.5467
 gtgtaggcctggaggagccgaagagcaggcggaccccctccgcgggggaacagtttccgc       c.-361

 .         .         .         .         .         .                g.5527
 cgggagcacaaagcaacggaccggaagtggggggcggaagtgcagtgggctcagcgccga       c.-301

 .         .         .         .         .         .                g.5587
 ctgcgcgcctctgcccgcgaaaactctgagctggctgacagctggggacgggtggcggcc       c.-241

 .         .         .         .         .         .                g.5647
 ctcgactggagtcggttgagttcctgagggaccccggttctggaaggttcgccgcggaga       c.-181

 .          | 02        .         .         .         .             g.6473
 caagtgagca | gtctgtgccatagggattctcgaagagaacagcgttgtgtcccagtgcac    c.-121

 .         .         .         .         .         .                g.6533
 atgctcgcatcgcttaccaggagtgcccgagaccctaagatgttcggagtggttttttcg       c.-61

 .         .         .         .         .         .                g.6593
 cacagacccgaatagcctgcccctcagccacgctctgtgcccttctgagaacaggctgat       c.-1

          .         .         .         .         .         .       g.6653
 ATGCCCAAGATAGTCCTGAATGGTGTGACCGTAGACTTCCCTTTCCAGCCCTACAAATGC       c.60
 M  P  K  I  V  L  N  G  V  T  V  D  F  P  F  Q  P  Y  K  C         p.20

          .         .         .         .   | 03     .         .    g.8506
 CAACAGGAGTACATGACCAAGGTCCTGGAATGTCTGCAGCAG | AAGGTGAATGGCATCCTG    c.120
 Q  Q  E  Y  M  T  K  V  L  E  C  L  Q  Q   | K  V  N  G  I  L      p.40

          .         .         .         .         .         .       g.8566
 GAGAGCCCTACGGGTACAGGGAAGACGCTGTGCCTGCTGTGCACCACGCTGGCCTGGCGA       c.180
 E  S  P  T  G  T  G  K  T  L  C  L  L  C  T  T  L  A  W  R         p.60

          .         .         .         .         .         .       g.8626
 GAACACCTCCGAGACGGCATCTCTGCCCGCAAGATTGCCGAGAGGGCGCAAGGAGAGCTT       c.240
 E  H  L  R  D  G  I  S  A  R  K  I  A  E  R  A  Q  G  E  L         p.80

          .         .         .         .         .         .       g.8686
 TTCCCGGATCGGGCCTTGTCATCCTGGGGCAACGCTGCTGCTGCTGCTGGAGACCCCATA       c.300
 F  P  D  R  A  L  S  S  W  G  N  A  A  A  A  A  G  D  P  I         p.100

   | 04      .         .         .         .         .         .    g.9099
 G | CTTGCTACACGGACATCCCAAAGATTATTTACGCCTCCAGGACCCACTCGCAACTCACA    c.360
 A |   C  Y  T  D  I  P  K  I  I  Y  A  S  R  T  H  S  Q  L  T      p.120

          .         .         .      | 05  .         .         .    g.9761
 CAGGTCATCAACGAGCTTCGGAACACCTCCTACCG | GCCTAAGGTGTGTGTGCTGGGCTCC    c.420
 Q  V  I  N  E  L  R  N  T  S  Y  R  |  P  K  V  C  V  L  G  S      p.140

          .         .         .         .         .        | 06.    g.10022
 CGGGAGCAGCTGTGCATCCATCCTGAGGTGAAGAAACAAGAGAGTAACCATCTACAG | ATC    c.480
 R  E  Q  L  C  I  H  P  E  V  K  K  Q  E  S  N  H  L  Q   | I      p.160

          .         .         .         .         .         | 07    g.13196
 CACTTGTGCCGTAAGAAGGTGGCAAGTCGCTCCTGTCATTTCTACAACAACGTAGAAG | AA    c.540
 H  L  C  R  K  K  V  A  S  R  S  C  H  F  Y  N  N  V  E  E |       p.180

          .         .         .         .         .         .       g.13256
 AAAAGCCTGGAGCAGGAGCTGGCCAGCCCCATCCTGGACATTGAGGACTTGGTCAAGAGC       c.600
 K  S  L  E  Q  E  L  A  S  P  I  L  D  I  E  D  L  V  K  S         p.200

          .     | 08   .         .         .         .         .    g.14705
 GGAAGCAAGCACAG | GGTGTGCCCTTACTACCTGTCCCGGAACCTGAAGCAGCAAGCCGAC    c.660
 G  S  K  H  R  |  V  C  P  Y  Y  L  S  R  N  L  K  Q  Q  A  D      p.220

          .         .         .          | 09        .         .    g.19767
 ATCATATTCATGCCGTACAATTACTTGTTGGATGCCAAG | AGCCGCAGAGCACACAACATT    c.720
 I  I  F  M  P  Y  N  Y  L  L  D  A  K   | S  R  R  A  H  N  I      p.240

          .         .         .         .      | 10  .         .    g.21145
 GACCTGAAGGGGACAGTCGTGATCTTTGACGAAGCTCACAACGTG | GAGAAGATGTGTGAA    c.780
 D  L  K  G  T  V  V  I  F  D  E  A  H  N  V   | E  K  M  C  E      p.260

          .         .         .         .         .         .       g.21205
 GAATCGGCATCCTTTGACCTGACTCCCCATGACCTGGCTTCAGGACTGGACGTCATAGAC       c.840
 E  S  A  S  F  D  L  T  P  H  D  L  A  S  G  L  D  V  I  D         p.280

          .         .         .         .         .         .       g.21265
 CAGGTGCTGGAGGAGCAGACCAAGGCAGCGCAGCAGGGTGAGCCCCACCCGGAGTTCAGC       c.900
 Q  V  L  E  E  Q  T  K  A  A  Q  Q  G  E  P  H  P  E  F  S         p.300

          .          | 11        .         .         .         | 12 g.25460
 GCGGACTCCCCCAGCCCAG | GGCTGAACATGGAGCTGGAAGACATTGCAAAGCTGAAGA | TG c.960
 A  D  S  P  S  P  G |   L  N  M  E  L  E  D  I  A  K  L  K  M |    p.320

          .         .         .         .         .         .       g.25520
 ATCCTGCTGCGCCTGGAGGGGGCCATCGATGCTGTTGAGCTGCCTGGAGACGACAGCGGT       c.1020
 I  L  L  R  L  E  G  A  I  D  A  V  E  L  P  G  D  D  S  G         p.340

          .        | 13.         .         .         .         .    g.27082
 GTCACCAAGCCAGGGAG | CTACATCTTTGAGCTGTTTGCTGAAGCCCAGATCACGTTTCAG    c.1080
 V  T  K  P  G  S  |  Y  I  F  E  L  F  A  E  A  Q  I  T  F  Q      p.360

          .         .         .         .         .      | 14  .    g.27859
 ACCAAGGGCTGCATCCTGGACTCGCTGGACCAGATCATCCAGCACCTGGCAGGAC | GTGCT    c.1140
 T  K  G  C  I  L  D  S  L  D  Q  I  I  Q  H  L  A  G  R |   A      p.380

          .         .         .         .         .  | 15      .    g.32722
 GGAGTGTTCACCAACACGGCCGGACTGCAGAAGCTGGCGGACATTATCCAG | ATTGTGTTC    c.1200
 G  V  F  T  N  T  A  G  L  Q  K  L  A  D  I  I  Q   | I  V  F      p.400

          .         .         .         .         .         .       g.32782
 AGTGTGGACCCCTCCGAGGGCAGCCCTGGTTCCCCAGCAGGGCTGGGGGCCTTACAGTCC       c.1260
 S  V  D  P  S  E  G  S  P  G  S  P  A  G  L  G  A  L  Q  S         p.420

        | 16 .         .         .         .         .         .    g.33035
 TATAAG | GTGCACATCCATCCTGATGCTGGTCACCGGAGGACGGCTCAGCGGTCTGATGCC    c.1320
 Y  K   | V  H  I  H  P  D  A  G  H  R  R  T  A  Q  R  S  D  A      p.440

          .         .         | 17         .         .         .    g.34860
 TGGAGCACCACTGCAGCCAGAAAGCGAG | GGAAGGTGCTGAGCTACTGGTGCTTCAGTCCC    c.1380
 W  S  T  T  A  A  R  K  R  G |   K  V  L  S  Y  W  C  F  S  P      p.460

          .         .         .         .         .         .       g.34920
 GGCCACAGCATGCACGAGCTGGTCCGCCAGGGCGTCCGCTCCCTCATCCTTACCAGCGGC       c.1440
 G  H  S  M  H  E  L  V  R  Q  G  V  R  S  L  I  L  T  S  G         p.480

          .         .         .         .  | 18      .         .    g.35146
 ACGCTGGCCCCGGTGTCCTCCTTTGCTCTGGAGATGCAGAT | CCCTTTCCCAGTCTGCCTG    c.1500
 T  L  A  P  V  S  S  F  A  L  E  M  Q  I  |  P  F  P  V  C  L      p.500

          .         .         .         .         .         .       g.35206
 GAGAACCCACACATCATCGACAAGCACCAGATCTGGGTGGGGGTCGTCCCCAGAGGCCCC       c.1560
 E  N  P  H  I  I  D  K  H  Q  I  W  V  G  V  V  P  R  G  P         p.520

          .         .         .      | 19  .         .         .    g.35354
 GATGGAGCCCAGTTGAGCTCCGCGTTTGACAGACG | GTTTTCCGAGGAGTGCTTATCCTCC    c.1620
 D  G  A  Q  L  S  S  A  F  D  R  R  |  F  S  E  E  C  L  S  S      p.540

          .       | 20 .         .         .         .         .    g.35535
 CTGGGGAAGGCTCTGG | GCAACATCGCCCGCGTGGTGCCCTATGGGCTCCTGATCTTCTTC    c.1680
 L  G  K  A  L  G |   N  I  A  R  V  V  P  Y  G  L  L  I  F  F      p.560

          .         .         .         .   | 21     .         .    g.35736
 CCTTCCTATCCTGTCATGGAGAAGAGCCTGGAGTTCTGGCGG | GCCCGCGACTTGGCCAGG    c.1740
 P  S  Y  P  V  M  E  K  S  L  E  F  W  R   | A  R  D  L  A  R      p.580

          .         .         .         .         .         .       g.35796
 AAGATGGAGGCGCTGAAGCCGCTGTTTGTGGAGCCCAGGAGCAAAGGCAGCTTCTCCGAG       c.1800
 K  M  E  A  L  K  P  L  F  V  E  P  R  S  K  G  S  F  S  E         p.600

  | 22       .         .         .         .         .         .    g.36305
  | ACCATCAGTGCTTACTATGCAAGGGTTGCCGCCCCTGGGTCCACCGGCGCCACCTTCCTG    c.1860
  | T  I  S  A  Y  Y  A  R  V  A  A  P  G  S  T  G  A  T  F  L      p.620

          .         | 23         .         .         .         .    g.36734
 GCGGTCTGCCGGGGCAAG | GCCAGCGAGGGGCTGGACTTCTCAGACACGAATGGCCGTGGT    c.1920
 A  V  C  R  G  K   | A  S  E  G  L  D  F  S  D  T  N  G  R  G      p.640

          .         .         .         .         .         .       g.36794
 GTGATTGTCACGGGCCTCCCGTACCCCCCACGCATGGACCCCCGGGTTGTCCTCAAGATG       c.1980
 V  I  V  T  G  L  P  Y  P  P  R  M  D  P  R  V  V  L  K  M         p.660

          .         .         .         .      | 24  .         .    g.36955
 CAGTTCCTGGATGAGATGAAGGGCCAGGGTGGGGCTGGGGGCCAG | TTCCTCTCTGGGCAG    c.2040
 Q  F  L  D  E  M  K  G  Q  G  G  A  G  G  Q   | F  L  S  G  Q      p.680

          .         .         .         .         .         .       g.37015
 GAGTGGTACCGGCAGCAGGCGTCCAGGGCTGTGAACCAGGCCATCGGGCGAGTGATCCGG       c.2100
 E  W  Y  R  Q  Q  A  S  R  A  V  N  Q  A  I  G  R  V  I  R         p.700

          .         .         .         .  | 25      .         .    g.37296
 CACCGCCAGGACTACGGAGCTGTCTTCCTCTGTGACCACAG | GTTCGCCTTTGCCGACGCA    c.2160
 H  R  Q  D  Y  G  A  V  F  L  C  D  H  R  |  F  A  F  A  D  A      p.720

          .         .         .         .         .         .       g.37356
 AGAGCCCAACTGCCCTCCTGGGTGCGTCCCCACGTCAGGGTGTATGACAACTTTGGCCAT       c.2220
 R  A  Q  L  P  S  W  V  R  P  H  V  R  V  Y  D  N  F  G  H         p.740

          .         .         .         .      | 26  .         .    g.37499
 GTCATCCGAGACGTGGCCCAGTTCTTCCGTGTTGCCGAGCGAACT | ATGCCAGCGCCGGCC    c.2280
 V  I  R  D  V  A  Q  F  F  R  V  A  E  R  T   | M  P  A  P  A      p.760

          .         .         .         .         .         .       g.37559
 CCCCGGGCTACAGCACCCAGTGTGCGTGGAGAAGATGCTGTCAGCGAGGCCAAGTCGCCT       c.2340
 P  R  A  T  A  P  S  V  R  G  E  D  A  V  S  E  A  K  S  P         p.780

          .         .         .         .         .         .       g.37619
 GGCCCCTTCTTCTCCACCAGGAAAGCTAAGAGTCTGGACCTGCATGTCCCCAGCCTGAAG       c.2400
 G  P  F  F  S  T  R  K  A  K  S  L  D  L  H  V  P  S  L  K         p.800

          .    | 27    .         .         .         .         .    g.38042
 CAGAGGTCCTCAG | GGTCACCAGCTGCCGGGGACCCCGAGAGTAGCCTGTGTGTGGAGTAT    c.2460
 Q  R  S  S  G |   S  P  A  A  G  D  P  E  S  S  L  C  V  E  Y      p.820

          .         .         .         .         .         .       g.38102
 GAGCAGGAGCCAGTTCCTGCCCGGCAGAGGCCCAGGGGGCTGCTGGCCGCCCTGGAGCAC       c.2520
 E  Q  E  P  V  P  A  R  Q  R  P  R  G  L  L  A  A  L  E  H         p.840

          .         .         .       | 28 .         .         .    g.38956
 AGCGAACAGCGGGCGGGGAGCCCTGGCGAGGAGCAG | GCCCACAGCTGCTCCACCCTGTCC    c.2580
 S  E  Q  R  A  G  S  P  G  E  E  Q   | A  H  S  C  S  T  L  S      p.860

          .         .         .         .         .         .       g.39016
 CTCCTGTCTGAGAAGAGGCCGGCAGAAGAACCGCGAGGAGGGAGGAAGAAGATCCGGCTG       c.2640
 L  L  S  E  K  R  P  A  E  E  P  R  G  G  R  K  K  I  R  L         p.880

          .   | 29     .         .         .         .         .    g.40043
 GTCAGCCACCCG | GAGGAGCCCGTGGCTGGTGCACAGACGGACAGGGCCAAGCTCTTCATG    c.2700
 V  S  H  P   | E  E  P  V  A  G  A  Q  T  D  R  A  K  L  F  M      p.900

          .         .         .         .         .         .       g.40103
 GTGGCCGTGAAGCAGGAGTTGAGCCAAGCCAACTTTGCCACCTTCACCCAGGCCCTGCAG       c.2760
 V  A  V  K  Q  E  L  S  Q  A  N  F  A  T  F  T  Q  A  L  Q         p.920

          .         .         .         .         .         .       g.40163
 GACTACAAGGGTTCCGATGACTTCGCCGCCCTGGCCGCCTGTCTCGGCCCCCTCTTTGCT       c.2820
 D  Y  K  G  S  D  D  F  A  A  L  A  A  C  L  G  P  L  F  A         p.940

          .         .         .  | 30      .         .         .    g.40362
 GAGGACCCCAAGAAGCACAACCTGCTCCAAG | GCTTCTACCAGTTTGTGCGGCCCCACCAT    c.2880
 E  D  P  K  K  H  N  L  L  Q  G |   F  Y  Q  F  V  R  P  H  H      p.960

          .         .         .         .         .         .       g.40422
 AAGCAGCAGTTTGAGGAGGTCTGTATCCAGCTGACAGGACGAGGCTGTGGCTATCGGCCT       c.2940
 K  Q  Q  F  E  E  V  C  I  Q  L  T  G  R  G  C  G  Y  R  P         p.980

          .         .         .         .         .   | 31     .    g.41570
 GAGCACAGCATTCCCCGAAGGCAGCGGGCACAGCCGGTCCTGGACCCCACTG | GAAGAACG    c.3000
 E  H  S  I  P  R  R  Q  R  A  Q  P  V  L  D  P  T  G |   R  T      p.1000

          .         .         .         .         .         .       g.41630
 GCGCCGGATCCCAAGCTGACCGTGTCCACGGCTGCAGCCCAGCAGCTGGACCCCCAAGAG       c.3060
 A  P  D  P  K  L  T  V  S  T  A  A  A  Q  Q  L  D  P  Q  E         p.1020

          .         .         .         .          | 32        .    g.41942
 CACCTGAACCAGGGCAGGCCCCACCTGTCGCCCAGGCCACCCCCAACAG | GAGACCCTGGC    c.3120
 H  L  N  Q  G  R  P  H  L  S  P  R  P  P  P  T  G |   D  P  G      p.1040

          .         .         .         .         .         .       g.42002
 AGCCAACCACAGTGGGGGTCTGGAGTGCCCAGAGCAGGGAAGCAGGGCCAGCACGCCGTG       c.3180
 S  Q  P  Q  W  G  S  G  V  P  R  A  G  K  Q  G  Q  H  A  V         p.1060

          .         .         .         .         .         .       g.42062
 AGCGCCTACCTGGCTGATGCCCGCAGGGCCCTGGGGTCCGCGGGCTGTAGCCAACTCTTG       c.3240
 S  A  Y  L  A  D  A  R  R  A  L  G  S  A  G  C  S  Q  L  L         p.1080

          .         .         .         .         .         .       g.42122
 GCAGCGCTGACAGCCTATAAGCAAGACGACGACCTCGACAAGGTGCTGGCTGTGTTGGCC       c.3300
 A  A  L  T  A  Y  K  Q  D  D  D  L  D  K  V  L  A  V  L  A         p.1100

          .         .         .         .    | 33    .         .    g.42273
 GCCCTGACCACTGCAAAGCCAGAGGACTTCCCCCTGCTGCACA | GGTTCAGCATGTTTGTG    c.3360
 A  L  T  T  A  K  P  E  D  F  P  L  L  H  R |   F  S  M  F  V      p.1120

          .         .         .         .         .         .       g.42333
 CGTCCACACCACAAGCAGCGCTTCTCACAGACGTGCACAGACCTGACCGGCCGGCCCTAC       c.3420
 R  P  H  H  K  Q  R  F  S  Q  T  C  T  D  L  T  G  R  P  Y         p.1140

          .         .         .         .         .         .       g.42393
 CCGGGCATGGAGCCACCGGGACCCCAGGAGGAGAGGCTTGCCGTGCCTCCTGTGCTTACC       c.3480
 P  G  M  E  P  P  G  P  Q  E  E  R  L  A  V  P  P  V  L  T         p.1160

          .          | 34        .         .         .         .    g.42559
 CACAGGGCTCCCCAACCAG | GCCCCTCACGGTCCGAGAAGACCGGGAAGACCCAGAGCAAG    c.3540
 H  R  A  P  Q  P  G |   P  S  R  S  E  K  T  G  K  T  Q  S  K      p.1180

          .         .         .         .         .         .       g.42619
 ATCTCGTCCTTCCTTAGACAGAGGCCAGCAGGGACTGTGGGGGCGGGCGGTGAGGATGCA       c.3600
 I  S  S  F  L  R  Q  R  P  A  G  T  V  G  A  G  G  E  D  A         p.1200

          .         .         .         .         .   | 35     .    g.42976
 GGTCCCAGCCAGTCCTCAGGACCTCCCCACGGGCCTGCAGCATCTGAGTGGG | GCCTCTAG    c.3660
 G  P  S  Q  S  S  G  P  P  H  G  P  A  A  S  E  W  G |   L  X      p.1219

          .         .         .         .         .         .       g.43036
 gatgtgcccagcctgccacaccgcctccaggaagcagagcgtcatgcaggtcttctggcc       c.*60

          .         .         .         .         .         .       g.43096
 agagccccagtgagtgcccacggaggcccccagcacacccaacgtggcttgatcacctgc       c.*120

          .         .         .         .         .         .       g.43156
 ctgtccagctctggtgggccaagaacccacccaacagaataggccagcccatgccagccg       c.*180

          .         .         .         .         .         .       g.43216
 gcttggcccgctgcaggcctcaggcaggcggggcccatggttggtccctgcggtgggacc       c.*240

          .         .         .         .         .         .       g.43276
 ggatctgggcctgcctctgagaagccctgagctaccttggggtctggggtgggtttctgg       c.*300

          .         .         .         .         .         .       g.43336
 gaaagtgcttccccagaacttccctggctcctggcctgtgagtggtgccacaggggcacc       c.*360

          .         .         .         .         .         .       g.43396
 ccagctgagcccctcaccgggaaggaggagacccccgtgggcacgtgtccacttttaatc       c.*420

          .         .         .         .                           g.43444
 aggggacagggctctctaataaagctgctggcagtgcccaggacggtg                   c.*468

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Regulator of telomere elongation helicase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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